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Journal of Xenobiotics, Volume 15, Issue 5

October 2025 - 38 articles

Cover Story: Dendritic cells (DCs) are crucial for antiviral defence through nucleic acid sensing in endosomal compartments. In this study, we show that sub-toxic exposure to diesel exhaust particles and PM2.5 does not induce cytotoxicity; however, these particles accumulate within DCs. The reduced uptake of fluorescent tracer particles indicates diminished endocytic and phagocytic activity under these exposure conditions. Additionally, induction of TLR7-dependent interferon-related genes in response to virus-like stimulation is suppressed. These findings indicate that even non-lethal levels of particulate matter can impair immune function by disrupting cellular uptake mechanisms and innate immune signalling, highlighting an overlooked immunotoxic risk associated with chronic low-dose exposure. View this paper
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Articles (38)

  • Review
  • Open Access
2 Citations
1,880 Views
34 Pages

21 October 2025

People are exposed to pesticides daily through food, drinking water, and the environment, both in urban and rural settings. These chemicals, while offering economic and agricultural benefits through pest control and increased productivity, may pose a...

  • Article
  • Open Access
1,564 Views
16 Pages

Association Between Antibiotic Exposure and the Risk of Male Infertility: A Case–Control Study

  • Friday E. Okonofua,
  • Lorretta Favour C. Ntoimo,
  • Titus A. M. Msagati,
  • Oladiran Ayodeji,
  • Michael Aziken,
  • Akhere Omonkhua,
  • Victor Ohenhen,
  • Celestina Olafusi and
  • Moses O. Alfred

21 October 2025

Irregular use of antibiotics is widespread in Nigeria, which has been reported to be associated with the prevalence of antibiotic resistance. As antibiotics have been reported to be associated with declining male infertility in animal models, we inve...

  • Article
  • Open Access
866 Views
19 Pages

20 October 2025

A four-year survey was conducted to monitor the presence of multiple pesticide residues contaminating tomatoes, with the aim of evaluating the potential health and environmental risks. A multiresidue liquid chromatography–triple mass spectromet...

  • Article
  • Open Access
641 Views
16 Pages

Estrogen Degradation Metabolites: Some Effects on Heart Mitochondria

  • Cristina Uribe-Alvarez,
  • Elizabeth Lira-Silva,
  • Lilia Morales-García,
  • Natalia Chiquete-Felix,
  • Francisco Javier Roldán-Gómez,
  • Jesús Vargas-Barrón,
  • José J. García-Trejo,
  • Alejandro Silva-Palacios,
  • Salvador Uribe-Carvajal and
  • Natalia Pavón

18 October 2025

Mitochondria play crucial roles in various cellular functions, including ATP production, apoptosis, and calcium homeostasis. Signaling pathways and hormones such as estrogens regulate the mitochondrial network through genetic, epigenetic, and metabol...

  • Article
  • Open Access
705 Views
20 Pages

Heavy Metals Affect the Antioxidant Defences in the Soil Ciliate Rigidohymena tetracirrata

  • Govindhasamay R. Varatharajan,
  • Antonio Calisi,
  • Santosh Kumar,
  • Daizy Bharti,
  • Arnab Ghosh,
  • Shikha Singh,
  • Amit C. Kharkwal,
  • Martina Coletta,
  • Francesco Dondero and
  • Antonietta La Terza

17 October 2025

In this study, we evaluated the cytotoxicity and antioxidant activity of the soil ciliate Rigidohymena tetracirrata (Gellért, 1942) Berger 2011, exposed to single and bimetallic mixtures of heavy metals (HMs) for 24 h. Ecotoxicological tests s...

  • Article
  • Open Access
405 Views
11 Pages

Two-Step Air/Water Oxidation Process for the Long-Lasting Photoluminescence and Biological Viability (MTT Assay) of Porous Silicon Particles

  • Claudia Castillo Calvente,
  • María F. Gilsanz-Muñoz,
  • Javier Pérez-Piñeiro,
  • Arisbel Cerpa-Naranjo,
  • Rodrigo Blasco,
  • Elvira Bragado-García,
  • María S. Fernández-Alfonso and
  • Darío Gallach-Pérez

17 October 2025

Due to their visible photoluminescence (PL) at room temperature, porous silicon particles (PSps) have gained interest for their potential biomedical applications, making them promising biological markers for in vivo or in vitro use. This study explor...

  • Article
  • Open Access
627 Views
16 Pages

DNA Damage and Bisphenol Levels in Chronic Kidney Disease Patients Undergoing Hemodialysis

  • Cesar Emilio Ruiz,
  • Lourdes Vela,
  • Martí Nadal,
  • Neus González,
  • Ricard Marcos,
  • Alba Hernández,
  • Susana Pastor and
  • Elisabeth Coll

17 October 2025

Bisphenol (BP) compounds are widely present in the environment, primarily due to their use as plastic additives. These substances involve health risks, particularly as endocrine disruptors. While the general population is chronically exposed, patient...

  • Article
  • Open Access
797 Views
25 Pages

QSAR Models for Predicting Oral Bioavailability and Volume of Distribution and Their Application in Mapping the TK Space of Endocrine Disruptors

  • Guillaume Ollitrault,
  • Marco Marzo,
  • Alessandra Roncaglioni,
  • Emilio Benfenati,
  • Olivier Taboureau and
  • Enrico Mombelli

15 October 2025

Toxicokinetic (TK) properties are essential in the framework of chemical risk assessment and drug discovery. Specifically, a TK profile provides information about the fate of chemicals in the human body. In this context, Quantitative Structure–...

  • Review
  • Open Access
2,436 Views
15 Pages

Endocrine-Disrupting Chemicals and Male Infertility: Mechanisms, Risks, and Regulatory Challenges

  • Sofoklis Stavros,
  • Nikolaos Kathopoulis,
  • Efthalia Moustakli,
  • Anastasios Potiris,
  • Ismini Anagnostaki,
  • Spyridon Topis,
  • Nefeli Arkouli,
  • Konstantinos Louis,
  • Charalampos Theofanakis and
  • Themos Grigoriadis
  • + 2 authors

13 October 2025

Male reproductive health is increasingly threatened by endocrine-disrupting chemicals (EDCs), which interfere with hormonal homeostasis and reproductive physiology. Rising rates of male infertility have been linked to greater exposure to pollutants s...

  • Article
  • Open Access
1,830 Views
14 Pages

11 October 2025

Non-nutritive artificial sweeteners (NASs) are xenobiotics widely used in the food industry as sugar substitutes, since they provide few to no calories compared to sucrose. While NASs are considered safe at the acceptable daily intake (ADI) establish...

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J. Xenobiot. - ISSN 2039-4713