Aims & Scope

Aims

Journal of Dementia and Alzheimer’s Disease (ISSN 3042-4518) is an international, peer-reviewed, open-access journal. It publishes original research articles, reviews, communications, and other manuscripts spanning basic, clinical, and translational studies of dementia in its various forms, with particular attention to Alzheimer’s disease. The journal sets no maximum length limit, encouraging comprehensive reporting of experimental and theoretical findings to ensure reproducibility and methodological transparency.

Scope

The journal covers all areas of dementia and Alzheimer’s disease research, including but not limited to:

1. Basic Mechanisms and Pathophysiology

• Cellular, molecular, genetic, and epigenetic regulatory mechanisms
• Abnormal protein aggregation, neuroinflammation, glial biology, mitochondrial dysfunction, and oxidative stress
• Synaptic and neural circuit dysfunction and plasticity
• Molecular basis of memory formation and memory disorders
• Cerebrovascular dysfunction and glymphatic system impairment
• Circadian and sleep disturbances in the onset and progression of dementia
• Lipid metabolism and membrane biology

2. Etiology, Epidemiology, and Risk Factors

• Etiology and pathogenesis of Alzheimer’s disease, vascular dementia (VaD), Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and mixed dementia
• Special populations: young-onset (early-onset) dementia, Down syndrome-associated AD, and racial/ethnic minorities
• Disease heterogeneity and subtypes
• Population epidemiology: incidence, prevalence, and demographic differences (geography, age, sex, and ethnicity)
• Modifiable and non-modifiable risk factors: lifestyle, occupation, socioeconomic status, nutrition, and physical activity
• Multi-factor interactions in disease onset and progression
• Global burden of dementia and its temporal trends

3. Diagnosis, Assessment, and Biomarkers

• Early screening, risk prediction, disease staging, and progression
• Clinical diagnosis and differential diagnosis
• Cognitive and behavioral testing and clinical assessment methods
• Neuroimaging: structural and functional imaging, electroencephalography (EEG), PET, and electrophysiological techniques
• Fluid biomarkers: cerebrospinal fluid (Aβ42/40, p-tau, t-tau) and blood markers (p-tau217, p-tau181, NfL, GFAP, Aβ)
• Retinal, digital, and multimodal biomarkers: development and application
• Screening, validation, and clinical translation of dementia-related biomarkers

4. Treatment, Intervention, and Prevention

• Pharmacological interventions: cholinesterase inhibitors, memantine, and disease-modifying therapies
• Development and evaluation of novel targeted drugs
• Non-pharmacological interventions: cognitive training, exercise therapy, cognitive stimulation, rehabilitation, and psychosocial intervention
• Novel therapeutic technologies (e.g., cell and gene therapy)
• Multi-target combined intervention strategies
• Prevention strategies: lifestyle interventions (diet, exercise, cognitive stimulation, sleep), vascular risk factor control, and population-level and public health approaches
• Cognitive reserve, resilience, and resistance: a conceptual framework for prevention and lifelong actions that extend cognitive health span

5. Disease Management and Care

• Long-term clinical management and prevention of neurological, psychiatric, medical, and functional complications
• Behavioral and psychological symptoms of dementia (BPSD): assessment and intervention
• Cognitive and physical rehabilitation therapy: application and optimization
• Healthcare delivery, integrated care, and palliative care
• Support strategies, caregiver burden, and quality of life
• Ethics: capacity and consent, advance directives, end-of-life decision-making, and research ethics in cognitively impaired populations

6. Technology Application and Translational Research

• Novel neuroimaging technologies: development, optimization, and clinical translation
• Wearable devices and sensors for monitoring and intervention guidance
• Artificial-intelligence-assisted diagnosis and digital biomarkers
• Digital therapeutics and telemedicine in dementia management
• Assistive technologies and dementia-friendly design
• Translational pathways from basic research to clinical application
• Precision medicine: translation and application in dementia

7. Comorbidities and Related Physiological Mechanisms

• Mechanisms linking aging and cognitive decline
• Interactions between vascular pathology and dementia
• Mechanisms linking sleep disorders and cognitive impairment
• Comorbidity mechanisms between other neurodegenerative diseases and dementia, and their impact on Alzheimer’s disease
• Mechanisms linking metabolic disorders and dementia, with emphasis on Alzheimer’s disease

MDPI Publication Ethics Statement

MDPI is a member of the Committee on Publication Ethics (COPE). MDPI takes the responsibility to enforce a rigorous peer-review together with strict ethical policies and standards to ensure to add high quality scientific works to the field of scholarly publication. Unfortunately, cases of plagiarism, data falsification, inappropriate authorship credit, and the like, do arise. MDPI takes such publishing ethics issues very seriously and our editors are trained to proceed in such cases with a zero tolerance policy. To verify the originality of content submitted to our journals, we use iThenticate to check submissions against previous publications.

Book Reviews

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Copyright / Open Access

Articles published in JDAD will be Open-Access articles distributed under the terms and conditions of the Creative Commons Attribution License (CC BY). The copyright is retained by the author(s). MDPI will insert the following note at the end of the published text:

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