Dementia progressively erodes autonomy, personal identity, and the ability to manage everyday life, placing growing demands on the people who provide care. Many AI-based assistive tools respond to this challenge by prioritizing what the algorithm can...
Background/Objectives: Population-based risk stratification for dementia is increasingly important in rapidly ageing societies. Developing prediction models for incident dementia using longitudinal survey data remains challenging because new events a...
Background: The clinical adoption of anti-amyloid monoclonal antibodies, including lecanemab and donanemab, has changed Alzheimer’s disease management from primarily symptomatic care toward biologically targeted intervention. This transition su...
Background/Objectives: Healthcare systems worldwide face challenges regarding dementia diagnosis and offered care. The focus within services has been on diagnosis and waiting times monitored through key centralised performance metrics. However, inequ...
Background: Goal setting is a core component of Occupational Therapy (OT), yet its application in people with dementia remains complex due to cognitive impairment and contextual factors. Evidence on how goal setting is implemented in this population...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and women are disproportionately affected. This review examines the evidence that estrogen signaling contributes to this disparity and asks what a molecularly targeted therap...
Background: Alzheimer’s disease (AD) care is increasingly communication-intensive, requiring sustained caregiver education, symptom monitoring, behavioral management, and coordination across fragmented clinical settings. Large language models (...
Sleep loss is increasingly recognized as a potentially modifiable factor in cognitive aging and Alzheimer’s disease (AD). Evidence supports a bidirectional relationship in which sleep disruption may both reflect early AD-related neurodegenerati...
Alzheimer’s and related dementias are not inevitable consequences of aging. This manuscript proposes that they arise when cumulative stress exceeds the repair capacity of three biological systems critical for maintaining brain health: proteosta...
Background: Neuropsychiatric symptoms (NPSs) are among the most clinically disruptive manifestations of major neurocognitive disorder (MND) and major contributors to caregiver distress. However, the differential contribution of specific neuropsychiat...
Background/Objectives: Alzheimer’s disease is a neurodegenerative disorder characterized by the accumulation of both amyloid and tau pathology. Lifestyle factors, including exercise, have been shown to be protective against dementia and warrant...
Background: Apathy is an increasingly recognized predictor of cognitive decline. Although both poor glycemic status and apathy have been independently linked to cognitive decline, whether apathy mediates the relationship between poor glycemic status...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of late-life dementia. As pathology spreads through the brain, affected individuals experience devastating cognitive decline, linguistic impairments, moo...
Background/Objectives: Dementia is a progressive neurocognitive disorder characterized by decline in cognitive, communicative, and functional abilities. Speech and language therapists (SLTs) play a role in managing communication and cognitive–l...
Background/Objectives: Lecanemab, a humanized anti-amyloid-β protofibril antibody, achieves substantial amyloid clearance and modest slowing of clinical decline in early Alzheimer’s disease (AD). Amyloid-related imaging abnormalities (ARIA...
Background/Objectives: Mindfulness-based interventions show promise for reducing stress in people living with dementia, but rigorous evidence against active control conditions remains limited, and little is known about how to adapt mindfulness for th...
Background: Dysregulated brain aging leads to dementia in some older adults. South Asia is one of the most populous regions of the world with a rapidly growing older adult population. Yet, very few studies have focused on quantifying the status and r...
Background/Objectives: This study evaluated the effects of a five-day intensive intervention aboard the Italian Navy sailing vessel Nave Italia for both cognitively healthy older adults and individuals with Alzheimer’s disease, focusing on auto...
Background: People living with dementia (PLWD) are at increased risk for medical complications, including urinary tract infections (UTIs), which are often presented atypically with delirium or behavioral changes. These atypical presentations frequent...
Background/Objectives: Current trends show a significant increase in Alzheimer’s disease and related dementias (ADRD) rates, reflecting a growing need for interventions. Recently, non-pharmacological interventions have received increased recogn...
Background: Alzheimer’s disease (AD) and dementia are growing global health challenges, yet public understanding of these conditions remains poorly characterized. Methods: This study analyzed 17,578 English-language tweets from Twitter/X collec...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder traditionally characterized by the extracellular accumulation of amyloid-beta (Abeta) plaques and the formation of intracellular neurofibrillary tau tangles; however, the prev...
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline, reflecting widespread brain dysfunction across multiple neural systems. Early detection of pathological changes is cri...
Background/Objectives: Persons living with dementia (PLwD) receive informal care services from loved ones, commonly referred to as care partners (CPs). While the symptoms (e.g., depressive affect, cognitive impairment) experienced by PLwD are recogni...
Background/Objectives: Alzheimer’s disease (AD) disproportionately affects women, who account for nearly two-thirds of affected individuals worldwide. This sex imbalance cannot be explained by longevity alone and likely reflects complex interac...
Dementia affects approximately 55 million people worldwide, yet the psychological experience of diagnosis and the determinants of post-diagnostic well-being remain underexplored relative to biomedical research priorities. The existing literature has...
Background: Dementia and Type 2 diabetes (T2D) represent two of the most pressing global public health challenges of our time, both exacerbated by physical inactivity. These conditions disproportionately affect Global Majority populations, who experi...
Dietary polyphenols such as quercetin, resveratrol, and (−)-epigallocatechin-3-gallate (EGCG) have shown neuroprotective effects in epidemiologic and experimental studies of Alzheimer’s disease (AD), although clinical evidence remains lim...
Background/Objectives: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which MRI-based AI systems are increasingly used for diagnosis and prognosis. However, many published approaches remain misaligned with the requirem...
Background: The Testamentary Capacity Assessment Tool (ΤCAT) is a brief instrument with good psychometric properties, specifically designed for the assessment of testamentary capacity (TC) in individuals with dementia. It assesses memory, percept...
Introduction: Delirium in older adults is strongly associated with and can predate dementia. While GLP-1 receptor agonists (GLP-1 RAs) may provide neuroprotective benefits, their role in reducing dementia risk among older patients with type 2 diabete...
Background: Sleep disturbance is highly prevalent in dementia syndromes and increasingly viewed as a correlate of disease expression, not just ageing. This study investigated associations between subjective sleep quality, cognitive performance, and s...
Background/Objectives: Amyloid-PET is accurate but costly and capacity-limited. Blood-based biomarkers (BBMs), particularly plasma p-tau217, offer a scalable alternative for triaging patients. Objective of this study is to evaluate the diagnostic acc...
Background/Objectives: Communication decline is a hallmark of dementia, yet speech-language outcomes remain marginal in much of the virtual reality (VR) dementia literature. This evidence review synthesises empirical work on how VR has been used to s...
Background/Objectives: Facilities for persons with Alzheimer disease need to be adapted for them in terms of architecture and interior and exterior design, where the introduction of an artistic dimension is recommended. This raises the question of ex...
Background: Single-target Alzheimer’s disease (AD) therapies have repeatedly failed to modify disease progression, highlighting a critical mismatch between multifactorial pathology and reductionist pharmacology. Methods: We developed a represen...
Alzheimer’s disease (AD) is the most common form of dementia marked by cognitive decline and memory loss. Early detection is essential for timely intervention; however, traditional biomarkers, including cerebrospinal fluid (CSF) assays, neuroim...
Background: Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are increasingly recognized as biologically heterogeneous disorders. Although biomarker-based frameworks have improved disease stratifica...
Background: The global number of individuals living with dementia is projected to rise from 57.4 million in 2019 to 152.8 million by 2050. Alongside this increase, the worldwide economic burden of dementia continues to grow, with the overall societal...
Background: Global dementia policies advocate for early or timely diagnosis, yet evidence on benefits or harms remains limited. This systematic review evaluates quantitative evidence comparing outcomes of early versus late and timely versus untimely...
Introduction: Psychotic symptoms (PS) in Alzheimer’s disease (AD) are associated with unfavorable prognosis, including accelerated functional decline and reduced survival. Multiple neurotransmitter systems have been implicated in the pathophysi...
Background: Older adults with Alzheimer’s Disease and Related Dementias (ADRD) experience a higher risk of falls. However, research lacks evidence on the effect of fall exposure on cognitive impairment and dementia. We investigated the associat...
Background/Objectives: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects the daily lives of older adults, impacting their cognitive abilities as well as speech and language communication. Early detection is cruci...
Background/Objectives: Dementia represents a complex syndrome in which biological, psychological, social, and cultural dimensions intersect. While its clinical features are well documented, less is known about how lived experiences, caregiving contex...
Background/Objectives: People with advanced dementia experience difficulties in navigating, while wayfinding is essential for a level of autonomy. A properly designed building has the strength to facilitate this target group in wayfinding. While unde...
Alzheimer’s disease (AD) is a leading form of dementia, marked by complex neuropathological features such as amyloid-β (Aβ) plaques and tau tangles. Recent research highlights the significant role of unmethylated cytosine–phosph...
Eating behavior disturbances are increasingly recognized as clinically relevant features of dementias. Although underappreciated, such alterations affect nutritional status, metabolic state, and disease burden. Alzheimer’s disease (AD) and fron...
Background/Objective: To examine whether patients with late-onset schizophrenia (LOS) and very-late-onset schizophrenia-like psychosis (VLOS) are at a higher risk of developing dementia than patients with early-onset schizophrenia (EOS). Methods: A r...
Background: International policy increasingly recognises the importance of inclusive, community-based support for people living with dementia. Football, as a culturally significant sport, has the potential to reach older adults and communities dispro...
Type 2 Diabetes Mellitus (T2DM) is a recognized risk factor for Alzheimer’s Disease (AD), as epidemiological research indicates that those with T2DM have a markedly increased risk of experiencing cognitive decline and dementia. Chronic hypergly...
