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  • Article
  • Open Access

Activities of Daily Living in Dementia Differentially Contribute to Factors of Caregiver Burden

  • Elizabeth Cousins-Whitus,
  • Karlee Patrick,
  • John Martin,
  • Christopher Was,
  • Jennifer Drost and
  • Mary Beth Spitznagel

Background: Performance of daily activities (Activities of Daily Living [ADLs] and Instrumental ADLs [IADLs]) is key to independent functioning in dementia, and greater I/ADL dependence contributes to burden in caregivers. We investigated how domains...

  • Review
  • Open Access
387 Views
30 Pages

Integrating Artificial Intelligence with Biomarkers to Meet the Challenges of Dementia

  • Claire Ginn,
  • Robert Walker,
  • Garth Cruickshank and
  • Bipin Patel

Dementia, the most common subtype of which is Alzheimer’s disease, represents a significant global and social health challenge. Its effective management is currently hindered by poor access to diagnostic services, a lack of effective treatments...

  • Systematic Review
  • Open Access
428 Views
27 Pages

Background: Early diagnosis of Alzheimer’s disease (AD) is constrained by invasive and costly tests. Aggregation of β-amyloid and the Aβ42/Aβ40 ratio in cerebrospinal fluid (CSF) and blood are key biomarkers. Fluorescent probes c...

  • Review
  • Open Access
652 Views
20 Pages

Neuroimaging Biomarkers in Alzheimer’s Disease

  • Shailendra Mohan Tripathi,
  • Porimita Chutia and
  • Alison D. Murray

Alzheimer’s disease accounts for approximately 50% to 80% of all causes of dementia. Co-existence of AD with other diseases causing dementia poses a diagnostic challenge, as we are still far from diagnosing AD accurately in order to manage it a...

  • Review
  • Open Access
568 Views
19 Pages

Aim: As the global population ages, the number of bilingual individuals living with dementia is increasing, yet their communication needs remain underrepresented in both clinical practice and research. This evidence review examines the intersection o...

  • Article
  • Open Access
492 Views
15 Pages

Background: Timely intervention and effective control of Alzheimer’s disease (AD) have been shown to limit memory loss and preserve cognitive function and the ability to perform simple activities in older adults. In addition, magnetic resonance...

  • Article
  • Open Access
519 Views
13 Pages

Virtual Team-Based Care Planning for Older Adults with Dementia: Enablers, Barriers, and Lessons from Hospital-to-Long-Term Care Transitions

  • Lillian Hung,
  • Paulina Santaella,
  • Denise Connelly,
  • Mariko Sakamoto,
  • Jim Mann,
  • Ian Chan,
  • Karen Lok Yi Wong,
  • Mona Upreti,
  • Harleen Hundal and
  • Marie Lee Yous
  • + 1 author

Background: Transitions from hospital to long-term care (LTC) facilities are critical periods for older adults living with dementia, often involving complex medical, cognitive, and psychosocial needs. Virtual team-based care has emerged as a promisin...

  • Article
  • Open Access
1,032 Views
13 Pages

Background/Objectives: With the expected growth in the number of people with dementia and the effect it has on their daily life, physical therapists will be required to provide competent care across all settings for people with dementia. This study a...

  • Review
  • Open Access
2,033 Views
14 Pages

Therapeutic Modalities Targeting Tau Protein in Alzheimer’s Disease

  • Thomas Gabriel Schreiner,
  • Liviu Iacob,
  • Carmen Vasilache and
  • Oliver Daniel Schreiner

Alzheimer’s disease (AD), the most frequent neurodegenerative disorder worldwide, is characterized by two key pathological features: extracellular amyloid beta plaques and intracellular highly phosphorylated tau protein aggregates known as neur...

  • Article
  • Open Access
720 Views
19 Pages

Background/Objectives: This study analyzes the database of the National Alzheimer’s Coordinating Center (NACC) to examine the correlation between the age of onset and the prevalence of cognitive impairment with the number of subjects carrying A...

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J. Dement. Alzheimer's Dis. - ISSN 3042-4518Creative Common CC BY license