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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Periodontology and Dental Implants: State of the Art and Future Perspectives

edited by Magda Mensi and

Davide Farronato

submission deadline 17 Apr 2026 | Viewed by 100 | Submission Open

Keywords: periodontology; dental implants; regenerative dentistry; peri-implant diseases; digital dentistry; implant surface modifications; tissue engineering; oral microbiome; risk assessment; personalized treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Haemodialysis and Peritoneal Dialysis: Current Clinical Practices and Innovations

edited by

Susanne Angermann

submission deadline 17 Apr 2026 | Viewed by 88 | Submission Open

Keywords: haemodialysis; peritoneal dialysis; end-stage kidney disease; chronic kidney disease; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Clinical Management of Corneal Diseases

edited by Hyeck Soo Son

submission deadline 18 Apr 2026 | 1 articles | Viewed by 784 | Submission Open

Keywords: corneal diseases; keratoconus; corneal dystrophy; corneal ectasia; corneal transplantation; DMEK; DSAEK; kerato-prosthesis; crosslinking; ICRS; CAIRS; Bowman layer transplantation; treatment outcomes; clinical management

(This special issue belongs to the Section Ophthalmology)

Treatment Personalization in Clinical Psychology and Psychotherapy

edited by

Dariusz Krok

submission deadline 20 Apr 2026 | 11 articles | Viewed by 30015 | Submission Open

Keywords: treatment personalization; clinical psychology; psychotherapy; personalized treatment; psychosomatic interventions; coping and personalization

(This special issue belongs to the Section Mental Health)

Metabolic Syndrome and Its Burden on Global Health

edited by Umberto Goglia, Luca Monge,

Elena Succurro

Livia Pisciotta

and

Salvatore De Rosa

submission deadline 20 Apr 2026 | 8 articles | Viewed by 20971 | Submission Open

Keywords: insulin resistance; chronic low-grade inflammation; gut microbiota; energy balance; obesity; hyperlipidemia; metabolic dysfunction-associated steatotic liver (MASLD); type 2 diabetes mellitus; heart failure; diabetic cardiomyopathy; cardio-nephro-metabolic syndrome; metabolic syndrome sex differences; metabolic syndrome and health inequity; metabolic syndrome health-economic burden

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Advances in Artificial Intelligence in Urology

edited by

Theodoros Tokas

submission deadline 20 Apr 2026 | 8 articles | Viewed by 14450 | Submission Open

Keywords: artificial intelligence; deep learning; artificial neural networks; computer; AI; machine learning

(This special issue belongs to the Section Nephrology & Urology)

Clinical Highlights in Chronic Obstructive Pulmonary Disease (COPD)

edited by

Richard Zuwallack

and Dimosthenis Lykouras

submission deadline 20 Apr 2026 | 4 articles | Viewed by 11102 | Submission Open

Keywords: COPD treatment; inhalers; patient-reported outcomes; COPD rehabilitation; cardiovascular risk

(This special issue belongs to the Section Respiratory Medicine)

Facial Plastic and Cosmetic Medicine

edited by

Neelam Vashi

submission deadline 20 Apr 2026 | 3 articles | Viewed by 9690 | Submission Open

Keywords: cosmetics; aesthetics; plastic surgery; skin rejuvenation; beauty; procedures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Status, Challenges and Future Directions in Aortic Valve Replacement

edited by Guglielmo Saitto and Giovanni Alfonso Chiariello

submission deadline 20 Apr 2026 | 5 articles | Viewed by 9205 | Submission Open

Keywords: aortic valve; aortic valve replacement; minimally invasive surgery; robotic surgery; TAVI; ross operation; root enlargement techniques; heart team; lifetime management

(This special issue belongs to the Section Cardiology)

New Insights into Physical Therapy

edited by

Patsaki Irini

and

George A. Koumantakis

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8847 | Submission Open

Keywords: physical rehabilitation; new technologies; virtual reality; augmented reality; telerehabilitation; clinical pilates; blood flow restriction; manual therapy; motor imagery; electrophysical modalities; therapeutic exercises; neurology; musculoskeletal; geriatric; respiratory; acute illness; cardiovascular

(This special issue belongs to the Section Sports Medicine)

Clinical Advances in Child Neurology

edited by Claire Marie Rangon and

Debopam Samanta

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8181 | Submission Open

Keywords: non-invasive; invasive; neuromodulation; children; neurodevelopmental disorders; autism spectrum disease; refractory epilepsy; vagus nerve stimulation

(This special issue belongs to the Section Clinical Pediatrics)

Chronic Renal Disease: Diagnosis, Treatment, and Management

edited by

Anna Clementi

submission deadline 20 Apr 2026 | 3 articles | Viewed by 8087 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; cardio– renal syndromes; clinical nephrology; diagnosis and management

(This special issue belongs to the Section Nephrology & Urology)

Evolution of Breast Reconstruction: Current Techniques, Advances and Future Directions

edited by

Dung Nguyen

and Andrea Moreira

submission deadline 20 Apr 2026 | 4 articles | Viewed by 7903 | Submission Open

Keywords: breast reconstruction; microsurgery; robot-assisted surgery; breast neurotization; lymphatic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Artificial Intelligence and Eye Disease

edited by

Andrzej Grzybowski

Louis Arnould

and

Haoyu Chen

submission deadline 20 Apr 2026 | 6 articles | Viewed by 7558 | Submission Open

Keywords: Artificial Intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorder

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Diabetes, Obesity, and Hypertension

edited by

Piotr Matłosz

and

Justyna Wyszyńska

submission deadline 20 Apr 2026 | 5 articles | Viewed by 7206 | Submission Open

Keywords: obesity; hypertension; diabetes; lifestyle; physical activity; risk factors

(This special issue belongs to the Section Endocrinology & Metabolism)

Patient-Oriented Treatments for Heart Failure

edited by Elisa Fabbri

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6102 | Submission Open

Keywords: heart failure; personalized care; patient-centered treatment; aging; comorbidity; multimorbidity; frailty

(This special issue belongs to the Section Cardiology)

Current Progress in Inflammatory Bowel Disease (IBD)

edited by

Dan Lucian Dumitrascu

and Simona Grad

submission deadline 20 Apr 2026 | 5 articles | Viewed by 5908 | Submission Open

Keywords: assessment and diagnosis of IBD; diet and nutrition in IBD; Microbiota and IBD; RCTs in IBD; new therapies in IBD; meta-analyses and systematic reviews in IBD; psychological impact and quality of life in IBD; imaging techniques in IBD; pathogenesis of IBD (including the impact of disrupted barrier function)

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Treatment and Future Options of Ischemic Stroke

edited by Raluca Elena Sandu and Carmen Valeria Albu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5897 | Submission Open

Keywords: ischemic stroke; stroke; neuroinflammation; cerebral ischemia; thrombolysis; neuroprotection; rehabilitation strate-gies; stroke biomarkers; extracellular vesicles; stem cell therapy; post-stroke recovery; cerebral ischemia; advanced imaging in stroke; personalized stroke treatment

(This special issue belongs to the Section Clinical Neurology)

Artificial Intelligence and Deep Learning in Medical Imaging

edited by Eros Montin and Giuseppe Carluccio

submission deadline 20 Apr 2026 | 6 articles | Viewed by 5182 | Submission Open

Keywords: magnetic resonance imaging; radiomics; artificial intelligence (AI); deep learning; clinical and translational medicine; MRI safety; radiogenomics; multiomics

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Advances in Anesthesia and Intensive Care During Perioperative Period

edited by

Philipp Simon

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5167 | Submission Open

Keywords: general anesthesia; intensive care medicine; post intensive care syndrome; perioperative management; fast track; pain management; complications; postoperative outcome; digitalization; big data; AI; closed-loop systems; machine learning; clinical decision support; telemedicine

(This special issue belongs to the Section Intensive Care)

Cardiovascular Risks in Autoimmune and Inflammatory Diseases

edited by

Elena Rezus

and

Ciprian Rezus

submission deadline 20 Apr 2026 | 5 articles | Viewed by 5006 | Submission Open

Keywords: autoimmune diseases; inflammation; cardiovascular risk; atherosclerosis; biological therapy; immunomodulatory therapy; lipid metabolism; cardiovascular risk factors; thrombosis; endothelial dysfunction

(This special issue belongs to the Section Immunology & Rheumatology)

Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities

edited by Shany Sherman

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4702 | Submission Open

Keywords: healthcare utilization; inflammatory skin diseases; photodermatoses; collagen vascular disease; immunobullous disorders; graft-versus-host disease

(This special issue belongs to the Section Dermatology)

Advances in Clinical Anesthesia and Analgesia: Novel Approaches for Optimal Patient Safety and Comfort

edited by Cesare Gregoretti and Giuliano Lo Bianco

submission deadline 20 Apr 2026 | 5 articles | Viewed by 3925 | Submission Open

Keywords: pain management; pain medicine; anesthesia; analgesia; anesthesiology

(This special issue belongs to the Section Anesthesiology)

Immunotherapy of Hematological Malignancies: The State of the Art

edited by

Anca Colita

and

Romeo Gabriel Mihaila

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3572 | Submission Open

Keywords: antibody-drug conjugates; bispecific antibodies; chimeric antigen receptor-engineered natural killer cell; chimeric antigen receptor T-cells; cytokine release syndrome; immune checkpoint in-hibitors; immunosuppression; immunotherapy; monoclonal antibodies; neurotoxicities

(This special issue belongs to the Section Hematology)

Cardiogenic Shock and Cardiac Arrest: Updates, Challenges and Opportunities

edited by

Torben K. Becker

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3272 | Submission Open

Keywords: cardiac arrest; extracorporeal membrane oxygenation; extracorporeal CPR; cardiopulmonary resuscitation; cardiogenic shock; resuscitation; prognostication

(This special issue belongs to the Section Cardiology)

Spine Surgery: Current Practice and Future Directions

edited by Claudio Bernucci and Francesco Costa

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3076 | Submission Open

Keywords: degenerative; spinal trauma; spine tumors; neurosurgery; spine surgery; spinal deformity; scoliosis; robotics surgery; spinal cord injury; clinical practices; regenerative therapies

(This special issue belongs to the Section Clinical Neurology)

Imaging in Diagnosis and Treatment of Musculoskeletal Disorders

edited by Francesco Porta and

Florentin Ananu Vreju

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3062 | Submission Open

Keywords: ultrasound; ultrasound-guided injections; imaging-guided procedures

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Targeted Medicine in Postoperative Pain Management

edited by

Martina Rekatsina

and Eleni Moka

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2893 | Submission Open

Keywords: precision medicine; postoperative analgesia; pain control; drug delivery systems; surgical pain management; personalized interventions

(This special issue belongs to the Section Anesthesiology)

News in the Pathogenesis, Diagnosis and Treatment of Systemic Sclerosis

edited by Mayka Freire and Bernardo Sopeña

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2788 | Submission Open

Keywords: systemic sclerosis; scleroderma; capillaroscopy; autoantibodies; pathogenesis

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Management of Pediatric Heart Diseases

edited by

Michele Lioncino

submission deadline 20 Apr 2026 | 3 articles | Viewed by 2577 | Submission Open

Keywords: pediatric heart diseases; children; pediatric cardiology; congenital heart disease; clinical management; congenital heart surgery; outcome

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types

edited by Andrea Paradisi

submission deadline 20 Apr 2026 | 3 articles | Viewed by 2056 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)

(This special issue belongs to the Section Dermatology)

Oral Cancer: Clinical Updates and Perspectives

edited by

Jutta Ries

Mayte Buchbender

and

Ulrike Simone Speth

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1982 | Submission Open

Keywords: oral cancer; oral surgery; dental implant; tooth extraction; oral health; early detection; biomarkers; targeted therapy; immunotherapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Prostatectomy: Clinical Updates and Perspectives

edited by Antonio Nacchia

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1966 | Submission Open

Keywords: single port; prostatectomy; robotics; RARP; prostate cancer

(This special issue belongs to the Section Nephrology & Urology)

Advances in the Management of Oral Lichen Planus: A Comprehensive Clinical Perspective

edited by Zuzanna Ślebioda and

Elzbieta Paszynska

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1956 | Submission Open

Keywords: oral lichen planus; treatment; topical treatment; systemic treatment; oral mucosa; oral pathology; immunosuppressive therapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Neuropathic Pain: From Prevention to Diagnosis and Management

edited by Enrico Martin

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1940 | Submission Open

Keywords: neuropathic pain; clinical research; TMR; RPNI; preclinical studies; QoL; PROMS; translational medicine; pain mechanisms

(This special issue belongs to the Section Clinical Neurology)

Application of Echocardiography in the Diagnosis and Management of Cardiac Diseases

edited by

Calin Pop

and

Antoniu Petris

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1734 | Submission Open

Keywords: echocardiography; cardiac diseases; 3D echo; stress; myocardial strain; intracardiac; subclinical cardiac disease

(This special issue belongs to the Section Cardiology)

Chronic Disease Management and Rehabilitation in Older Adults

edited by

Justyna Mazurek

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1539 | Submission Open

Keywords: chronic disease; older adults; geriatric rehabilitation; holistic physiotherapy; physical activity; health outcomes; elderly people; geriatric care; health promotion

(This special issue belongs to the Section Geriatric Medicine)

Clinical Management of Frailty

edited by

Alejandro Alvarez-Bustos

, Walter Sepulveda-Loyola and

Isabel Rodríguez-Sánchez

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1453 | Submission Open

Keywords: frailty; comprehensive geriatric assessment; assessment; monitoring; functional decline; physical performance; ex-ercise interventions; nutritional strategies; interventions; adverse outcomes

(This special issue belongs to the Section Geriatric Medicine)

Novel Insights into Clinical Diagnosis and Management of Degenerative Cervical Myelopathy

edited by

Carlo Brembilla

, Francesco Costa and Filippo Maria Polli

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1378 | Submission Open

Keywords: degenerative cervical myelopathy (DCM); cervical spondylotic myelopathy (CSM); cervical spinal stenosis; cervical cord compression; MRI of the cervical spine; cervical spine surgery; physical therapy; rehabilitation; ossification of the posterior longitudinal ligament (OPLL); cervical deformity (e.g.; kyphosis and lordosis); patient-reported out-comes; surgical outcome prediction

(This special issue belongs to the Section Clinical Neurology)

Current Updates and Advances in Hemodialysis

edited by Edita Žiginskienė

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1323 | Submission Open

Keywords: kidney replacement therapy; hemodialysis; hemodiafiltration; vascular access; dialysis membranes; dialysis complications; dialysis adequacy; outcomes

(This special issue belongs to the Section Nephrology & Urology)

Novel Technologies to Assist Emergency Medical Care

edited by

Sangsoo Han

and Young Soon Cho

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1178 | Submission Open

Keywords: emergency medical services; artificial intelligence in emergency medicine; telemedicine and remote patient monitoring; wearable health technologies; point-of-care diagnostics; automated decision support systems; robotics in emergency medicine; pre-hospital care innovations

(This special issue belongs to the Section Emergency Medicine)

Implant Dentistry: New Challenges and Complication Management

edited by Jordi Gargallo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1125 | Submission Open

Keywords: navigation surgery; accuracy; computer-aided surgery; computer-assisted; three-dimensional imaging; fixed implant prostheses; zirconia; CAD/CAM; patient satisfaction; peri-implantitis; quality of life; retreatment; tooth loss; connective tissue; keratinized tissue; soft tissue management; bone regeneration; bone grafting; immediate implant placement; immediate implant loading

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Respiratory Medicine in the Oldest-Old

edited by

Takae Ebihara

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1070 | Submission Open

Keywords: oldest-old; respiratory system with aging; pneumonia; epidemiology; COPD; interstitial lung disease; bronchial asthma; lung cancer; mycobacterial or fungal infections; peri-/post-operative status; respiratory frailty; social problems and end of life

(This special issue belongs to the Section Respiratory Medicine)

Preoperative Optimization in Cardiac Surgery

edited by

Jason M. Ali

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1035 | Submission Open

Keywords: preoperative optimization; cardiac surgery; risk assessment; comorbid conditions; multidisciplinary collaboration; perioperative risks; cardiovascular evaluation

(This special issue belongs to the Section Cardiology)

Current Challenges and Innovations in Spine Deformity: Biomechanics, Imaging and AI-Driven Analysis

edited by Dong-Ho Kang

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1011 | Submission Open

Keywords: spinal deformity; cervical deformity; biomechanics; postural alignment; sagittal imbalance; medical imaging; radiographic analysis; artificial intelligence; machine learning; deep learning; phenotyping; computer-assisted diagnosis; predictive modeling; surgical planning

(This special issue belongs to the Section Orthopedics)

Clinical Care and Rehabilitation for Neuromuscular Diseases

edited by

Hans-Jürgen Gdynia

submission deadline 20 Apr 2026 | Viewed by 926 | Submission Open

Keywords: neuromuscular diseases; myopathy; neuropathy; motor neuron disease; amyotrophic lateral sclerosis; diseases of neuromuscular junction; neurorehabilitation; rehabilitation; clinical care; neuroscience

(This special issue belongs to the Section Clinical Rehabilitation)

Total Joint Arthroplasty: Clinical Advances and Innovations in Surgical Techniques and Rehabilitation

edited by Marco Minelli,

Mattia Loppini

and Federico Della Rocca

submission deadline 20 Apr 2026 | 1 articles | Viewed by 918 | Submission Open

Keywords: total joint arthroplasty; hip replacement; knee arthroplasty; robotic-assisted surgery; minimally invasive techniques; implant design; postoperative rehabilitation; periprosthetic joint infection; surgical innovation

(This special issue belongs to the Section Orthopedics)

Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition

edited by Michael D. Diamantidis

submission deadline 20 Apr 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)

(This special issue belongs to the Section Hematology)

Carotid Artery Disease (CAD) and Its Complications: A Comprehensive Update

edited by Yacob G. Tedla

submission deadline 20 Apr 2026 | 1 articles | Viewed by 658 | Submission Open

Keywords: carotid artery disease; ischemic stroke; vascular dementia; transient ischemic attack; vascular imaging; carotid endarterectomy; carotid stent placement; risk stratification

(This special issue belongs to the Section Vascular Medicine)

Clinical Updates in Pediatric Radiology

edited by

Meriam Koob

and

Farnaz Delavari

submission deadline 20 Apr 2026 | Viewed by 642 | Submission Open

Keywords: pediatric radiology; advances in pediatric imaging; pediatric neuroimaging; artificial in-telligence in pediatric imaging; radiomics and machine learning; low-field MRI techniques; magnetic resonance imaging in pediatrics; computed tomography in pediatrics; radiation dose optimization; patient-centred imaging protocols

(This special issue belongs to the Section Clinical Pediatrics)

Displaying special issue 1101-1150 on page 23 of 31.

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