Special Issue "State-of-the-Art Research on Acupuncture Treatment"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Epidemiology & Public Health".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editors

Dr. Younbyoung Chae
Website
Guest Editor
Acupuncture & Meridian Science Research Center, Kyung Hee University, Seoul, Korea
Interests: acupuncture; pain; efficacy; data mining; big data; mechanisms
Dr. Myeong Soo Lee
Website
Guest Editor
Korea Institute of Oriental Medicine, Daejeon, Korea
Interests: integrative medicine; clinical trials; systematic review; meta-analysis; clinical practice guideline
Dr. Yi-Hung Chen

Guest Editor
China Medical University, Taichung, Taiwan
Interests: neuroscience; pain; addiction; acupuncture; neurobiology

Special Issue Information

Dear Colleagues,

Acupuncture is one of the medical treatments which involve needle insertion into the body. In recent years, this treatment has been applied and validated for many disorders. It has been well-established that acupuncture stimulation can influence many target organs through the central and peripheral nervous system. Furthermore, there are rapidly expanding applications of big data and machine learning to acupuncture research. For an upcoming Special Issue in the Journal of Clinical Medicine (PubMed indexed), we encourage researchers and clinicians to submit original research articles that apply various methods (e.g., neuroimaging, neurobiology, clinical trials or machine learning), as well as review articles that will stimulate continuing efforts to gain new insights into mechanisms of acupuncture treatment and the current status of acupuncture treatment.

Dr. Younbyoung Chae
Dr. Myeong Soo Lee
Dr. Yi-Hung Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acupuncture
  • big data
  • data mining
  • efficacy
  • mechanisms

Published Papers (5 papers)

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Research

Open AccessArticle
Identification of Acupoint Indication from Reverse Inference: Data Mining of Randomized Controlled Clinical Trials
J. Clin. Med. 2020, 9(9), 3027; https://doi.org/10.3390/jcm9093027 - 20 Sep 2020
Abstract
The specificity of acupoint indication (i.e., reverse inference—diseases for which an acupoint could be used) might differ from the specificity of acupoint selection (i.e., forward inference—acupoints used for a disease). In this study, we explore acupoint specificity through reverse inferences from the dataset [...] Read more.
The specificity of acupoint indication (i.e., reverse inference—diseases for which an acupoint could be used) might differ from the specificity of acupoint selection (i.e., forward inference—acupoints used for a disease). In this study, we explore acupoint specificity through reverse inferences from the dataset of prescribed acupoints for a certain disease in clinical trials. We searched acupuncture treatment regimens in randomized controlled trials included in the Cochrane Database of Systematic Reviews. For forward inference, the acupoints prescribed for each disease were quantified. For reverse inference, diseases for each acupoint were quantified. Data were normalized using Z-scores. Bayes factor correction was performed to adjust for the prior probability of diseases. The specificities of acupoint selections in 30 diseases were determined using forward inference. The specificities of acupoint indications regarding 49 acupoints were identified using reverse inference and then subjected to Bayes factor correction. Two types of acupoint indications were identified for 24 acupoints: regional and distal. Our approach suggests that the specificity of acupoint indication can be inferred from clinical data using reverse inference. Acupoint indication will improve our understanding of acupoint specificity and will lead to the establishment of a new model of analysis and educational resources for acupoint characteristics. Full article
(This article belongs to the Special Issue State-of-the-Art Research on Acupuncture Treatment)
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Open AccessArticle
Neuroimaging-Based Scalp Acupuncture Locations for Dementia
J. Clin. Med. 2020, 9(8), 2477; https://doi.org/10.3390/jcm9082477 - 01 Aug 2020
Abstract
Scalp acupuncture is a modality of acupuncture in which acupuncture needles are inserted into a certain layer of the scalp in order to affect the function of corresponding areas of the cerebral cortex and relieve symptoms. Clinical studies have demonstrated the potential of [...] Read more.
Scalp acupuncture is a modality of acupuncture in which acupuncture needles are inserted into a certain layer of the scalp in order to affect the function of corresponding areas of the cerebral cortex and relieve symptoms. Clinical studies have demonstrated the potential of scalp acupuncture as a non-pharmacological treatment for dementia. Unfortunately, recent findings from brain neuroimaging studies on dementia have not been incorporated into scalp acupuncture. This study aims to integrate meta-analysis, resting-state functional connectivity, and diffusion tensor imaging (DTI) to identify potential locations of scalp acupuncture for treatment of dementia. We found that the prefrontal cortex, the medial prefrontal cortex, the middle and superior temporal gyrus, the temporal pole, the supplementary motor area, the inferior occipital gyrus, and the precuneus are involved in the pathophysiology of dementia and, therefore, may be the target areas of scalp acupuncture for dementia treatment. The neuroimaging-based scalp acupuncture protocol developed in this study may help to refine the locations for the treatment of dementia. Integrating multidisciplinary methods to identify key surface cortical areas associated with a certain disorder may shed light on the development of scalp acupuncture and other neuromodulation methods such as transcranial electrical current stimulation, particularly in the domain of identifying stimulation locations. Full article
(This article belongs to the Special Issue State-of-the-Art Research on Acupuncture Treatment)
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Open AccessArticle
Intensive Motion Style Acupuncture Treatment (MSAT) Is Effective for Patients with Acute Whiplash Injury: A Randomized Controlled Trial
J. Clin. Med. 2020, 9(7), 2079; https://doi.org/10.3390/jcm9072079 - 02 Jul 2020
Cited by 1
Abstract
In this single-center, parallel, randomized controlled trial, we aim to examine the effects and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) on pain reduction and functional improvement in patients with whiplash-associated disorders (WADs). Ninety-seven patients with [...] Read more.
In this single-center, parallel, randomized controlled trial, we aim to examine the effects and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) on pain reduction and functional improvement in patients with whiplash-associated disorders (WADs). Ninety-seven patients with cervical pain admitted to the Bucheon Jaseng Hospital of Korean Medicine, South Korea, due to acute whiplash injury were treated with integrative Korean medicine (IKM) with (MSAT group, 48 patients) or without (control group, 49 patients) an additional 3-day MSAT during hospitalization (5–14 days) and followed-up for 90 days. The mean numeric rating scale (NRS) scores of the MSAT and control groups at baseline were 5.67 (95% confidence interval (CI), 5.33, 6.01) and 5.44 (95% CI, 5.06, 5.82), respectively, and on day 5, 3.55 (95% CI, 3.04, 4.06) and 4.59 (95% CI, 4.10–5.07), respectively. The NRS change difference between the groups was −1.07 (95% CI, −1.76, −0.37). The rate of recovery of neck pain (NRS score change ≥ 2 points) was significantly faster in the MSAT than in the control group (log-rank test p = 0.0055). IKM treatment combined with MSAT may be effective in reducing the pain and improving the range of motion in patients with WADs. Full article
(This article belongs to the Special Issue State-of-the-Art Research on Acupuncture Treatment)
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Open AccessArticle
Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain
J. Clin. Med. 2020, 9(6), 1719; https://doi.org/10.3390/jcm9061719 - 03 Jun 2020
Cited by 1
Abstract
Chronic low back pain (cLBP) is a common disorder with unsatisfactory treatment options. Acupuncture has emerged as a promising method for treating cLBP. However, the mechanism underlying acupuncture remains unclear. In this study, we investigated the modulation effects of acupuncture on resting state [...] Read more.
Chronic low back pain (cLBP) is a common disorder with unsatisfactory treatment options. Acupuncture has emerged as a promising method for treating cLBP. However, the mechanism underlying acupuncture remains unclear. In this study, we investigated the modulation effects of acupuncture on resting state functional connectivity (rsFC) of the periaqueductal gray (PAG) and ventral tegmental area (VTA) in patients with cLBP. Seventy-nine cLBP patients were recruited and assigned to four weeks of real or sham acupuncture. Resting state functional magnetic resonance imaging data were collected before the first and after the last treatment. Fifty patients completed the study. We found remission of pain bothersomeness in all treatment groups after four weeks, with greater pain relief after real acupuncture compared to sham acupuncture. We also found that real acupuncture can increase VTA/PAG rsFC with the amygdala, and the increased rsFC was associated with decreased pain bothersomeness scores. Baseline PAG-amygdala rsFC could predict four-week treatment response. Our results suggest that acupuncture may simultaneously modulate the rsFC of key regions in the descending pain modulation (PAG) and reward systems (VTA), and the amygdala may be a key node linking the two systems to produce antinociceptive effects. Our findings highlight the potential of acupuncture for chronic low back pain management. Full article
(This article belongs to the Special Issue State-of-the-Art Research on Acupuncture Treatment)
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Open AccessArticle
Bibliometric Analysis of Moxibustion Research Trends Over the Past 20 Years
J. Clin. Med. 2020, 9(5), 1254; https://doi.org/10.3390/jcm9051254 - 26 Apr 2020
Cited by 1
Abstract
Objectives: A bibliometric approach using network analysis was applied to identify the development and research trends for moxibustion. This study also examined the network hub of moxibustion research by investigating the collaborative work of organizations and authors. Methods: Academic articles on moxibustion research [...] Read more.
Objectives: A bibliometric approach using network analysis was applied to identify the development and research trends for moxibustion. This study also examined the network hub of moxibustion research by investigating the collaborative work of organizations and authors. Methods: Academic articles on moxibustion research published from 2000 to 2019 were retrieved from the Web of Science database. Extracted records were analyzed according to publication year, research area, journal title, country, organization, and authors. The VOSviewer program was utilized to visualize the trends in moxibustion research and to explore the influential organizations and authors. Results: Analyses of 1146 original and review articles written in English demonstrated that the number of publications related to moxibustion research has increased consistently over the last 20 years. China issued the most articles in this field, and the most represented research area was integrative complementary medicine. A network analysis based on the co-occurrence and publication year of keywords identified the relevant characteristics and trends of moxibustion research. By assessing the total link strength of organizations and authors, influential organizations and authors who have contributed to moxibustion research were identified. Conclusions: The current study examined research on moxibustion using bibliometric analysis and identified a time-based development of moxibustion research and a global network hub of moxibustion research. Full article
(This article belongs to the Special Issue State-of-the-Art Research on Acupuncture Treatment)
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