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The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders

Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
J. Clin. Med. 2014, 3(4), 1490-1510; https://doi.org/10.3390/jcm3041490
Received: 2 September 2014 / Revised: 20 November 2014 / Accepted: 20 November 2014 / Published: 17 December 2014
(This article belongs to the Special Issue iPS Cells for Modelling and Treatment of Human Diseases)
More than 500 rare genetic bone disorders have been described, but for many of them only limited treatment options are available. Challenges for studying these bone diseases come from a lack of suitable animal models and unavailability of skeletal tissues for studies. Effectors for skeletal abnormalities of bone disorders may be abnormal bone formation directed by osteoblasts or anomalous bone resorption by osteoclasts, or both. Patient-specific induced pluripotent stem cells (iPSCs) can be generated from somatic cells of various tissue sources and in theory can be differentiated into any desired cell type. However, successful differentiation of hiPSCs into functional bone cells is still a challenge. Our group focuses on the use of human iPSCs (hiPSCs) to identify osteoclast defects in craniometaphyseal dysplasia. In this review, we describe the impact of stem cell technology on research for better treatment of such disorders, the generation of hiPSCs from patients with rare genetic bone disorders and current protocols for differentiating hiPSCs into osteoclasts. View Full-Text
Keywords: induced pluripotent stem cells; osteoclast; rare genetic bone disorders induced pluripotent stem cells; osteoclast; rare genetic bone disorders
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Chen, I.-P. The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders. J. Clin. Med. 2014, 3, 1490-1510.

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