Recent Advances in Management of Hidradenitis Suppurativa and Related Comorbidities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 5095

Special Issue Editor


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Guest Editor
Hospital Universitario Marques de Valdecilla | HUMV · Servicio de Dermatología, Santander, Spain
Interests: inflammatory cutaneous diseases; hidradenitis suppurativa: psoriasis; comorbidities; cutaneous vasculitis

Special Issue Information

Dear Colleagues,

Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory disease that affects approximately 1% of the general population. HS is an underdiagnosed and undertreated condition that severely impairs the quality of life of patients. There is growing evidence that HS is not only a skin disease but also a multisystem inflammatory disease. As a disease of systemic inflammation, HS is associated with numerous comorbidities, including other immune-mediated diseases, metabolic disorders, cardiovascular risk factors, and psychological/psychiatric disorders.

The treatment of HS remains a challenge, although recent advances in understanding the pathogenesis of the disease are allowing the investigation of promising new therapies. In any case, approaches to patients with HS must be comprehensive and multidisciplinary, requiring an early diagnosis of the associated comorbidities as well as the implementation of the preventive and therapeutic measures necessary to avoid future complications. In this sense, it is a topic of great interest to know the potential effect that biological drugs could have in the prevention and control of cardiometabolic comorbidities associated with the systemic inflammation in HS.


This Special Issue invites articles concerning recent advances in the management of HS and related comorbidities and hopes to provide more information that will be useful in future research, as well as in daily practice

Dr. Marcos Antonio González-López
Guest Editor

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Keywords

  • hidradenitis suppurativa
  • diagnostics
  • treatment
  • comorbidities
  • biological therapy

Published Papers (2 papers)

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12 pages, 796 KiB  
Article
Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
by Manuel Sánchez-Díaz, Luis Salvador-Rodríguez, Trinidad Montero-Vílchez, Antonio Martínez-López, Salvador Arias-Santiago and Alejandro Molina-Leyva
J. Clin. Med. 2021, 10(22), 5222; https://doi.org/10.3390/jcm10225222 - 9 Nov 2021
Cited by 7 | Viewed by 1848
Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential [...] Read more.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study; the male/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 μm. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk. Full article
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Review

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10 pages, 243 KiB  
Review
Efficacy and Toxicity of Classical Immunosuppressants, Retinoids and Biologics in Hidradenitis Suppurativa
by Kinnor Das, Steven Daveluy, George Kroumpouzos, Komal Agarwal, Indrashis Podder, Katherine Farnbach, Alex G. Ortega-Loayza, Jacek C. Szepietowski, Stephan Grabbe and Mohamad Goldust
J. Clin. Med. 2022, 11(3), 670; https://doi.org/10.3390/jcm11030670 - 27 Jan 2022
Cited by 3 | Viewed by 2707
Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the apocrine glands characterized by recurrent episodes. Although several therapies exist, none is completely curative. Several immunosuppressives have been studied with encouraging results and targeted approaches. In this review, we highlight the various immunosuppressives [...] Read more.
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the apocrine glands characterized by recurrent episodes. Although several therapies exist, none is completely curative. Several immunosuppressives have been studied with encouraging results and targeted approaches. In this review, we highlight the various immunosuppressives used in this condition along with their salient features to enable physicians to choose the correct therapy for their patients. The search of the peer-reviewed literature included clinical trials, scientific reviews, case series, case reports, and guidelines. The literature was identified from electronic databases (MEDLINE and PubMed) through November 2021; additional articles were included from the references of the identified articles. Full article
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