Dear Colleagues,

In recent years, it has emerged that mutations in genes encoding proteins of innate or cell-intrinsic immunity may underlie rare primary immunodeficiencies in humans. Seminal advances have been made in the identification and functional immunological characterization of novel genetic defects predisposing to severe viral infections with herpesviruses, such as HSV-1, HSV-2, VZV, and HHV6. There is now solid evidence to support a role for these herpesviruses not only in causing meningitis and encephalitis, but also in the development of certain autoimmune and neurodegenerative conditions, such as multiple sclerosis and Alzheimer’s disease. These novel insights have been gained through studies on basic epidemiology, genetics, virology, and immunology on the one hand, and the identification of patients with a rare but severe infectious phenotypes, who may directly benefit from our findings in terms of choosing optimal prophylactic and treatment strategies on the other hand. This Special Issue will focus on medically important herpesviruses and describe the basic virology, immune evasion, and immunology relevant for these viruses to gain knowledge of the pathogenesis of severe viral infections in the central nervous system (CNS) and how this knowledge may be used to improve diagnosis, prophylaxis, and treatment of patients.

Prof. Dr. Trine Mogensen
Guest Editor

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• Herpesvirus
• Encephalitis
• Innate immunology
• Interferon
• CNS inflammation
• Inborn errors of immunity
• Immune evasion
• Autophagy