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Special Issue "JSOPB 2022–2023 Congress Special Issue – Update on Organ Preservation and Transplantation"

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Special Issue Information

Dear Colleagues,

This Special Issue is a collection of selected papers from the 48th Japanese Society for Organ Preservation and Biology (JSOPB) (http://jognbio.umin.jp/). The Journal of Clinical Medicine (JCM) is providing an opportunity to publish selected data presented at the annual meeting.

The JSOPB was founded in 1974 with the aim of studying organ preservation and rapidly developed during the 1990s following the participation of researchers in various fields of medicine, pharmacology, engineering, veterinary medicine, and basic science. Currently, the JSOPB has more than 700 members and operates under the direction of its president, Prof. Mamoru Kusaka.

The most outstanding presentations made at the 48th annual meeting of the JSOPB—held on 4–5 November 2022, in Hiroshima, Japan under the supervision of Prof. Hideki Ohdan (Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University. Hiroshima, Japan)—were selected and given the opportunity to be published in this Special Issue of JCM.

One of the vital objectives of the annual meeting of the JSOPB is to exchange new research outcomes and create new therapeutic concepts. Therefore, the aim of the present Special Issue as follows:

Molecular and cellular biology of organ preservation and transplantation;
Biology of pharmacology;
Organ/tissue engineering;
Stem cell therapy;
Stem cell biology.

Prof. Dr. Hirofumi Noguchi
Prof. Dr. Takashi Kenmochi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

organ preservation
transplantation
pharmacology
engineering
molecular biology
cellular biology
stem cell therapy

Published Papers (2 papers)

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Research

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Open AccessArticle

Warm Ischemia Induces Spatiotemporal Changes in Lysophosphatidylinositol That Affect Post-Reperfusion Injury in Normal and Steatotic Rat Livers

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J. Clin. Med. 2023, 12(9), 3163; https://doi.org/10.3390/jcm12093163 - 27 Apr 2023

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Abstract

Warm ischemia-reperfusion injury is a prognostic factor for hepatectomy and liver transplantation. However, its underlying molecular mechanisms are unknown. This study aimed to elucidate these mechanisms and identify the predictive markers of post-reperfusion injury. Rats with normal livers were subjected to 70% hepatic warm ischemia for 15, 30, or 90 min, while those with steatotic livers were subjected to 70% hepatic warm ischemia for only 30 min. The liver and blood were sampled at the end of ischemia and 1, 6, and 24 h after reperfusion. The serum alanine aminotransferase (ALT) activity, Suzuki injury scores, and lipid peroxidation (LPO) products were evaluated. The ALT activity and Suzuki scores increased with ischemic duration and peaked at 1 and 6 h after reperfusion, respectively. Steatotic livers subjected to 30 min ischemia and normal livers subjected to 90 min ischemia showed comparable injury. A similar trend was observed for LPO products. Imaging mass spectrometry of normal livers revealed an increase in lysophosphatidylinositol (LPI (18:0)) and a concomitant decrease in phosphatidylinositol (PI (18:0/20:4)) in Zone 1 (central venous region) with increasing ischemic duration; they returned to their basal values after reperfusion. Similar changes were observed in steatotic livers. Hepatic warm ischemia time-dependent acceleration of PI (18:0/20:4) to LPI (18:0) conversion occurs initially in Zone 1 and is more pronounced in fatty livers. Thus, the LPI (18:0)/PI (18:0/20:4) ratio is a potential predictor of post-reperfusion injury. Full article

(This article belongs to the Special Issue JSOPB 2022–2023 Congress Special Issue – Update on Organ Preservation and Transplantation)

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Other

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Open AccessBrief Report

Cryopreservation of Fetal Porcine Kidneys for Xenogeneic Regenerative Medicine

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J. Clin. Med. 2023, 12(6), 2293; https://doi.org/10.3390/jcm12062293 - 15 Mar 2023

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Abstract

Kidney xenotransplantation has been attracting attention as a treatment option for end-stage renal disease. Fetal porcine kidneys are particularly promising grafts because they can reduce rejection through vascularization from host vessels. We are proposing xenogeneic regenerative medicine using fetal porcine kidneys injected with human nephron progenitor cells. For clinical application, it is desirable to establish reliable methods for the preservation and quality assessment of grafts. We evaluated the differentiation potency of vitrified porcine fetal kidneys compared with nonfrozen kidneys, using an in vivo differentiation model. Fetal porcine kidneys connected to the bladder were frozen via vitrification and stored in liquid nitrogen. Several days later, they were thawed and transplanted under the retroperitoneum of immunocompromised mice. After 14 days, the frozen kidneys grew and differentiated into mature nephrons, and the findings were comparable to those of nonfrozen kidneys. In conclusion, we demonstrated that the differentiation potency of vitrified fetal porcine kidneys could be evaluated using this model, thereby providing a practical protocol to assess the quality of individual lots. Full article

(This article belongs to the Special Issue JSOPB 2022–2023 Congress Special Issue – Update on Organ Preservation and Transplantation)

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