jcm-logo

Journal Browser

Journal Browser

Novel Methods for Prevention and Treatment of Periprosthetic Joint Infections

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3774

Special Issue Editor


E-Mail Website
Guest Editor
Cleveland Clinic Florida, Cleveland, FL, USA
Interests: hip arthroplasty; knee arthroplasty; shoulder arthroplasty; periprosthetic joint infection; PJI; infection

Special Issue Information

Dear Colleagues,

Periprosthetic joint infection (PJI) is the most common cause of failure of total joint arthroplasty and results in a significant reduction in quality of life when compared to the general population. Additionally, the cost to the health system is burdensome and frequently increases morbidity and especially mortality of patients within 5 years. To deal with this complication, several preventative and treatment methods have been recommended. Preventative approaches range from preoperative (patient optimization, antibiotic prophylaxis, skin cleansing) and intraoperative (proper sealing and draping of skin, meticulous surgical site preparation, wound irrigation, management of surgical theater environment) to postoperative ones (blood preservation). Additionally, there is novel evidence related to perioperative management of medications, controlling operating room traffic air flow, and choice of wound dressing or vacuum-assisted devices. For treatment of PJI, two-stage arthroplasty is the present gold standard surgical procedure in the US. However, new evidence supports the use of one-stage arthroplasty in selective PJI cases, and research is still underway. While many preventative and treatment protocols are in place, there are voids in the literature. Additionally, such strategies may different in knees, hips, and shoulder arthroplasties. As a result, further research is encouraged to practice evidence-based medicine. In the current focused Special Issue, we intend to describe the utility of novel preventative and treatment strategies in the setting of PJI.

Dr. Carlos A. Higuera
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periprosthetic joint infections
  • PJI
  • hip arthroplasty
  • knee arthroplasty
  • shoulder arthroplasty
  • prevention of PJI
  • treatment of PJI

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

9 pages, 420 KiB  
Article
Comparing the Diagnostic Value of Serum D-Dimer to CRP and IL-6 in the Diagnosis of Chronic Prosthetic Joint Infection
by Thomas Ackmann, Burkhard Möllenbeck, Georg Gosheger, Jan Schwarze, Tom Schmidt-Braekling, Kristian Nikolaus Schneider, Adrien Frommer, Ralf Dieckmann and Christoph Theil
J. Clin. Med. 2020, 9(9), 2917; https://doi.org/10.3390/jcm9092917 - 10 Sep 2020
Cited by 23 | Viewed by 3479
Abstract
Introduction: D-dimer is a diagnostic criterion for periprosthetic joint infection (PJI) of the Musculoskeletal Infection Society (MSIS) in 2018. The aim of this study was to evaluate the serum D-dimer values in comparison to C-reactive protein (CRP) and interleukin-6 (IL-6) for the diagnosis [...] Read more.
Introduction: D-dimer is a diagnostic criterion for periprosthetic joint infection (PJI) of the Musculoskeletal Infection Society (MSIS) in 2018. The aim of this study was to evaluate the serum D-dimer values in comparison to C-reactive protein (CRP) and interleukin-6 (IL-6) for the diagnosis of PJI. Materials and Methods: We included 119 patients (50 women, 69 men; 71 knees, 48 hips) undergoing revision arthroplasty with preoperative assessment of CRP, IL-6, and serum D-dimer. Cases were classified as infected or aseptic based on the MSIS criteria of 2018. Receiver operating curves and Youden’s index were used to define an ideal cut-off value and sensitivity and specificity for the individual parameters, and respective combinations were calculated using cross-tables. Results: The median D-dimer level (2320 vs. 1105 ng/mL; p < 0.001), the median CRP level (4.0 vs. 0.5 mg/dL; p < 0.001), and the median IL-6 level (21.0 vs. 5.0 pg/mL; p < 0.001) were significantly higher in the group of PJI compared to the group with aseptic failure. The calculated optimal cut-off values were 2750 ng/mL (AUC 0.767) for D-dimer, 1.2 mg/dL (AUC 0.914) for CRP, and 10.0 pg/mL (AUC 0.849) for IL-6. D-dimer showed a sensitivity of 38% and specificity of 94%, whereas the CRP and IL-6 had sensitivities of 88% and 76%, and specificities of 87% and 92%, respectively. Conclusion: In comparison with CRP and IL-6, serum D-dimer showed low sensitivity and specificity in our cohort. While CRP and IL-6 combination had the highest sensitivity, a combination of Il-6 and D-dimer or CRP and IL-6 had the highest specificity. Full article
Show Figures

Figure 1

Back to TopTop