Chronic Kidney Disease: Global Dimension and Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 28 October 2025 | Viewed by 600

Special Issue Editor


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Guest Editor
Institute of Pathology, Ansbach, Germany
Interests: kidney; atherosclerosis; diabetes; CKD; glomerulonephritis; inflammation; hypoxia

Special Issue Information

Dear Colleagues,

Our Special Issue aims to delve into the complexities of acute and chronic kidney conditions, aiming to shed light on key diagnostic, therapeutic, and research challenges. Risk factors for the development and progression of CKD include a low nephron number at birth, nephron loss due to increasing age, and acute or chronic kidney injuries caused by toxic exposures or diseases. CKD frequently occurs in association with diabetes and hypertension. There are also other causes, including obesity and, less commonly, polycystic kidney disease, and other issues include glomerulonephritis, lupus nephritis, and kidney cancer. We are pleased to invite you to share your insights and bridge the gap between research, practice, and diagnosis for the benefit of CKD patients. The aim of our Special Issues is to support ongoing research efforts in diabetes and hypertension, kidney function, and diagnosis and treatment of CKD.

Our aim is to drive together perspectives and advancements to improve kidney health. Original research articles and reviews are welcome to be submitted. Research areas may include the following: hypertension, diabetes, histological changes, diagnosis and treatment of CKD, kidney failure management, and treatment strategies, including approaches targeting inflammation and fibrosis.

Join us on a journey of discovery in the realm of kidney failure and stay up to date with the newest advancements in chronic kidney disease research. We look forward to receiving your contributions.

Dr. Valentina Câmpean
Guest Editor

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Keywords

  • histological changes
  • renal dysfunction
  • kidney diseases
  • glomerulonephritis
  • polycystic kidney disease
  • kidney failure
  • kidney cancer
  • atherosclerosis
  • heart disease
  • renal and renovascular hypertension

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Published Papers (1 paper)

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Review

9 pages, 567 KiB  
Review
Prognostic Factors of Proteinuria Remission in Primary Membranous Nephropathy
by Kornelia Krakowska-Jura, Anna Natalia Kler, Weronika Wajerowska, Andrzej Konieczny and Mirosław Banasik
J. Clin. Med. 2025, 14(9), 2880; https://doi.org/10.3390/jcm14092880 - 22 Apr 2025
Viewed by 306
Abstract
Primary membranous nephropathy is a leading cause of nephrotic syndrome in adults, characterized by immune complex deposition in the glomerular basement membrane. Predicting proteinuria remission is essential for guiding treatment decisions, optimizing immunosuppressive therapy, and improving renal outcomes. Traditional prognostic markers, such as [...] Read more.
Primary membranous nephropathy is a leading cause of nephrotic syndrome in adults, characterized by immune complex deposition in the glomerular basement membrane. Predicting proteinuria remission is essential for guiding treatment decisions, optimizing immunosuppressive therapy, and improving renal outcomes. Traditional prognostic markers, such as anti-PLA2R antibody status and baseline proteinuria levels, offer valuable insights into disease progression. However, recent research has identified additional biomarkers that may enhance risk stratification and refine individualized treatment strategies. Serum-based markers, such as uric acid and inflammatory indices, may indicate systemic changes that impact disease progression. Urinary biomarkers, including microhematuria, α1-microglobulin, and CXCL13, have been proposed as potential predictors of disease activity and remission likelihood. Furthermore, histopathological features, such as glomerular basement membrane thickness, tubulointerstitial injury, and acute kidney injury, provide structural correlates that may inform prognosis. This review explores both established and emerging prognostic indicators across various biological domains. Understanding these predictors can aid in developing personalized therapeutic strategies, optimizing disease management, and improving patient outcomes in primary membranous nephropathy. Full article
(This article belongs to the Special Issue Chronic Kidney Disease: Global Dimension and Perspectives)
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