Special Issue "Multiple Sclerosis and Demyelinating Disorders: Past, Present, and Future"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 528

Special Issue Editors

Laboratory of Experimental Neurology and Neuroimmunology, Department of Neurology, AHEPA University Hospital, Stilponos Kiriakides str. 1, 54636 Thessaloniki, Greece
Interests: neuroscience; multiple sclerosis; demyelinating desease; neurology; neuroimmunology
First Department of Neurology, National and Kapodistrian University of Athens, Aeginition Hospital, Athens, Greece
Interests: neurological diseases; multiple sclerosis; demyelinating diseases; neuroinflammation; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Multiple Sclerosis Center, 2nd Department of Neurology, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
Interests: neuroimaging; cognition disorders; multiple sclerosis; neuroimmunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in diagnostic procedures and therapeutic interventions in Multiple sclerosis have substantially improved disease management and outcome. During the last decade, diagnostic criteria have been refined and allowed an earlier diagnosis, while preclinical conditions such as radiologically isolated syndrome, have been extensively studied. Current research explores the feasibility of the use of advanced neuroimaging techniques and blood biomarkers such as the levels of neurofilament light chains, in clinical practice. Future perspectives include the implementation of digital monitoring tools in everyday clinical practice that may allow early detection and prevention of disease worsening.

This Special Issue of the Journal of clinical medicine seeks commentaries, case reports, original research, short reports, and reviews focusing on the advances in research, diagnosis monitoring and treatment of multiple sclerosis and other demyelinating disorders such as neuromyelitis optica and MOG-associated diseases. This Special Issue aims to provide information about advances in phenotyping people with demyelinating disorders, personalization of treatment and long-term monitoring of these disease entities.

Prof. Dr. Nikolaos Grigoriadis
Dr. Maria Eleptheria Evangelopoulos
Dr. Christos Bakirtzis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple sclerosis
  • demyelination
  • disease modifying therapies
  • neurodegeneration
  • neuromyelitis optica
  • disease monitoring
  • diagnostic criteria

Published Papers (1 paper)

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Review

Review
CNS Ageing in Health and Neurodegenerative Disorders
J. Clin. Med. 2023, 12(6), 2255; https://doi.org/10.3390/jcm12062255 - 14 Mar 2023
Viewed by 382
Abstract
The process of ageing is characteristic of multicellular organisms associated with late stages of the lifecycle and is manifested through a plethora of phenotypes. Its underlying mechanisms are correlated with age-dependent diseases, especially neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) [...] Read more.
The process of ageing is characteristic of multicellular organisms associated with late stages of the lifecycle and is manifested through a plethora of phenotypes. Its underlying mechanisms are correlated with age-dependent diseases, especially neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and multiple sclerosis (MS) that are accompanied by social and financial difficulties for patients. Over time, people not only become more prone to neurodegeneration but they also lose the ability to trigger pivotal restorative mechanisms. In this review, we attempt to present the already known molecular and cellular hallmarks that characterize ageing in association with their impact on the central nervous system (CNS)’s structure and function intensifying possible preexisting pathogenetic conditions. A thorough and elucidative study of the underlying mechanisms of ageing will be able to contribute further to the development of new therapeutic interventions to effectively treat age-dependent manifestations of neurodegenerative diseases. Full article
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