Improving Perinatal Outcomes in Twin and Multiple Pregnancy: Part II

Dear Colleagues,

This Special Issue is the 2^nd edition of “Improving Perinatal Outcomes in Twin and Multiple Pregnancy” (https://www.mdpi.com/journal/jcm/special_issues/Perinatal_Outcomes_Twin_Multiple_Pregnancy).

Multiple pregnancies are a major public health concern due to the significantly higher health risks for both mothers and newborns, as well as the impact on healthcare costs. Despite advances in antenatal care and prenatal diagnosis, twins and multiples remain high-risk pregnancies with excess perinatal mortality and morbidity. Advanced maternal age and assisted reproduction have led to an increase in the number of multiple pregnancies worldwide. Multiple pregnancies are overrepresented in stillbirth, neonatal death, and admission to the neonatal unit. Moreover, the risk of cerebral palsy is 6–7 times higher in twin and higher-order multiple pregnancies. Despite recent reports of a 50% reduction in stillbirth in twin pregnancies in some countries, the risk of complications remains high. It is estimated that twin pregnancies cost about five times more than singletons, while higher-order multiple pregnancies cost nearly 20 times as much.

Over the past few years, a number of studies on the topic have been published, helping to provide a better understanding of the natural history and perinatal outcomes. However, it is also clear that much remains to be learned. The Global Twins and Multiples Priority Setting Partnership have identified the 10 most important research questions related to the future health of multiples and their families in 2019. These included the assessment of growth patterns, short- and long-term outcomes, antenatal risk factors, medical interventions to reduce complications, and measures to reduce admission to the neonatal unit. With this Special Issue, we hope to encourage submissions that discuss the current state-of-the-art, address ongoing knowledge gaps, and focus on ongoing controversies related to twin and multiple pregnancies.

Prof. Dr. Asma Khalil
Prof. Liesbeth Lewi 
Prof. Dr. Enrico Lopriore 
Guest Editors

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• twin pregnancy
• selective fetal growth restriction
• stillbirth
• triplet pregnancy
• preterm birth
• twin to twin transfusion syndrome
• prenatal diagnosis

• Improving Perinatal Outcomes in Twin and Multiple Pregnancy in Journal of Clinical Medicine (17 articles)