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Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition)
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Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 5716

Special Issue Editors

Dr. Jacek Matys

E-Mail Website
Guest Editor
Dental Surgery Department, Wroclaw Medical University, 50-367 Wrocław, Poland
Interests: medical and dental lasers; laser surface processing; laser decontamination; laser ablation; laser in bone surgery; photobiomodulation
Special Issues, Collections and Topics in MDPI journals
Dr. Kinga Grzech-Lesniak

E-Mail Website
Guest Editor
1. Department of Integrated Dentistry, Faculty of Dentistry, Wroclaw Medical University, 50-367 Wrocław, Poland
2. Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA
Interests: dental lasers; decontamination; laser surface cleaning; dentistry; periodontics; prosthodontics; implantology; photobiomodulation; bone surgery; bone regenerations; periodontal therapy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Tomasz Gedrange

E-Mail Website
Guest Editor
1. Department of Orhodontics, Technical University Dresden, 01069 Dresden, Germany
2. Department of Oral Surgery, Wroclaw Medical University, 50-367 Wrocław, Poland
Interests: transbond XT; orthodontic brackets; in vitro and in vivo studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to be able to invite you to submit a manuscript to the forthcoming Special Issue, “Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition)”, for the Journal of Clinical Medicine (IF: 3.0).

This second edition of the Special Issue continues to address a broad spectrum of topics related to the application of modern devices and materials in medicine and dentistry across various levels of research, from pre-clinical to clinical studies.

This Special Issue aims to publish studies at a pre-clinical to clinical level that consider how to apply novel advanced devices, e.g., lasers, piezosurgery, CAD/CAM technology, and CBCT, in order to prevent, diagnose, and treat diseases and other disorders of the oral cavity. Papers describing the application of methods and therapies, such as novel treating methods, laser technology, or tissue-guided regeneration, are welcome. This Special Issue will accept the most advanced pre-clinical to clinical research and advancements in regenerative materials for oral and maxillofacial surgery, periodontology, and implantology. Finally, studies that facilitate an enhanced understanding of how we can apply modern technologies to decrease bacterial, viral, and fungal contamination in a dental office will be considered for publication in the SI.

Dr. Jacek Matys
Dr. Kinga Grzech-Lesniak
Prof. Dr. Tomasz Gedrange
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral medicine
  • tissue regeneration
  • lasers
  • photobiomodulation
  • periodontology
  • dentistry
  • biological safety

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Related Special Issue

Published Papers (6 papers)

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Research

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18 pages, 1436 KiB  
Article
Application of Platelet-Rich Fibrin and Concentrated Growth Factors as Carriers for Antifungal Drugs—In Vitro Study
by Wojciech Niemczyk, Małgorzata Kępa, Jacek Żurek, Ali Aboud, Dariusz Skaba and Rafał Wiench
J. Clin. Med. 2025, 14(14), 5111; https://doi.org/10.3390/jcm14145111 - 18 Jul 2025
Viewed by 298
Abstract
Background: Fungal infections, particularly those caused by Candida species, pose a serious threat to immunocompromised individuals, and therapeutic options are limited due to toxicity and resistance concerns. This in vitro study aimed to explore the feasibility of using liquid fractions of autologous [...] Read more.
Background: Fungal infections, particularly those caused by Candida species, pose a serious threat to immunocompromised individuals, and therapeutic options are limited due to toxicity and resistance concerns. This in vitro study aimed to explore the feasibility of using liquid fractions of autologous platelet concentrates (APCs), namely concentrated platelet-rich fibrin (c-PRF) and liquid-phase concentrated growth factor (LPCGF), as carriers for antifungal drugs. Methods: The research was conducted in two phases: first, to evaluate the inherent antifungal properties of different APCs; and second, to assess their effectiveness as drug carriers for fluconazole and voriconazole against Candida albicans, Candida glabrata, and Candida krusei. Results: Results showed that APCs alone exhibited no direct antifungal effects. However, when combined with antifungal agents, notable inhibition zones were observed—especially with voriconazole against C. krusei and fluconazole against C. glabrata using c-PRF. Both c-PRF and LPCGF were compatible with the drugs and did not hinder clot formation. Conclusions: These findings suggest that APCs can act as effective vehicles for localized antifungal drug delivery and warrant further investigation for clinical application in treating fungal-related oral diseases. Full article
(This article belongs to the Special Issue Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition))
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20 pages, 3249 KiB  
Article
The Effect of the I-Arch on the Buccal Alveolar Crest in Comparison with the Traditional Archwire Sequence: A Randomized Controlled Clinical Trial
by Salam Mouhamad Omar Nakawah, Mohamed Hasan Youssef, Ornella Rossi, Giovanna Perrotti and Tiziano Testori
J. Clin. Med. 2025, 14(3), 1026; https://doi.org/10.3390/jcm14031026 - 6 Feb 2025
Viewed by 1121
Abstract
Background/Objectives: The nature, diameter, and cross-section of orthodontic archwires affect tooth movement and the surrounding alveolar bone. Researchers have explored different features of archwires to optimize treatment outcomes. In this context, this study aimed to evaluate the properties of the I-arch for [...] Read more.
Background/Objectives: The nature, diameter, and cross-section of orthodontic archwires affect tooth movement and the surrounding alveolar bone. Researchers have explored different features of archwires to optimize treatment outcomes. In this context, this study aimed to evaluate the properties of the I-arch for its effects on alveolar bone height, dehiscence, fenestration, and treatment duration. Methods: Forty patients (eight males, and thirty-two females; mean age: 20.97 ± 2.41 years) with dental crowding ≤ 6 mm and Class I malocclusion were treated without extractions. They were randomly divided into two groups: the experimental group (EG, n = 20), treated with the I-arch, and the control group (CG, n = 20), treated with traditional archwires of the MBT technique. Two CBCT scans were taken for each patient, one before treatment (T0) and one after leveling (T2). The studied teeth were upper and lower centrals, canines, and second premolars. The treatment duration was measured across three periods: T0–T1, T1–T2, and T0–T2. Results: Alveolar bone resorption, dehiscence, and fenestration were lower in the EG. Total treatment duration (T0–T2) was similar between groups, but the first period (T0–T1) was significantly shorter in the EG (p < 0.05). Conclusions: The I-arch resulted in fewer side effects on alveolar bone height during leveling and alignment. Full article
(This article belongs to the Special Issue Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition))
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11 pages, 7718 KiB  
Article
Intraoral Approach Through the Nasal Floor for Surgical Removal of Inverted Mesiodens: Protocol and Case Series
by Horatiu Urechescu, Ancuta Banu, Felicia Streian, Florin Urtila, Cristiana Cuzic, Stefania Dinu and Marius Pricop
J. Clin. Med. 2024, 13(24), 7831; https://doi.org/10.3390/jcm13247831 - 22 Dec 2024
Viewed by 1221
Abstract
Background/Objectives: The most common form of supernumerary teeth is represented by the mesiodens. Very often, they are impacted, usually palatially, but can be found buccally or between the roots of the permanent central incisors. Their position can be normal, inclined, or inverted. In [...] Read more.
Background/Objectives: The most common form of supernumerary teeth is represented by the mesiodens. Very often, they are impacted, usually palatially, but can be found buccally or between the roots of the permanent central incisors. Their position can be normal, inclined, or inverted. In the possible case where the impacted mesiodens crown is oriented upwards towards the nasal cavity, they are called inverted mesiodens. The inverted mesiodens are mainly asymptomatic, and the main diagnostic methods are radiological, especially CBCT. Methods: This paper presents the intraoral approach through the nasal floor as a very reliable method for the surgical removal of inverted mesiodens. We report a protocol, including the diagnosis process, criteria for choosing this surgical approach, and description of the surgical procedure. Preoperative CBCT is mandatory for diagnosis and choice of the surgical approach. This is chosen based on measurements on the cross-sectional view of the CBCT investigation and is in compliance with our criteria related to the appropriate surgical approach. Results: Using this approach, the mesiodens were extracted without intraoperative or postoperative complications or accidents, and operating times were relatively short. Conclusions: The intraoral approach through the nasal floor for surgical removal of inverted mesiodens satisfies all the conditions to be a predictable, safe, and time-efficient technique. It has its limitations, mainly regarding the surgical skills of the operating team. The cone–beam computed tomography (CBCT) has a fundamental role in the diagnosis and treatment of included mesiodens. Full article
(This article belongs to the Special Issue Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition))
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Review

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11 pages, 465 KiB  
Review
Obstructive Sleep Apnoea in Patients with Treacher Collins Syndrome—A Narrative Review
by Anna Paradowska-Stolarz, Katarzyna Sluzalec-Wieckiewicz, Marcin Mikulewicz, Conrad Maslowiec, Katarzyna Kokot, Lucia Miralles-Jorda, Martyna Sobanska and Joanna Laskowska
J. Clin. Med. 2025, 14(13), 4741; https://doi.org/10.3390/jcm14134741 - 4 Jul 2025
Viewed by 417
Abstract
Background: Treacher Collins Syndrome (TCS) is a rare, congenital craniofacial syndrome. Its most characteristic feature is mandibular and midface hypoplasia. Due to malformations of the facial skeleton, airway abnormalities can also be observed, predisposing individuals to obstructive sleep apnoea (OSA). OSA in TCS [...] Read more.
Background: Treacher Collins Syndrome (TCS) is a rare, congenital craniofacial syndrome. Its most characteristic feature is mandibular and midface hypoplasia. Due to malformations of the facial skeleton, airway abnormalities can also be observed, predisposing individuals to obstructive sleep apnoea (OSA). OSA in TCS may contribute to significant morbidity, including developmental delays, cardiovascular disorders and reduced quality of life. Objectives: This narrative review aims to present the true prevalence of OSA and the treatment options for TCS patients. Additionally, the pathophysiology and diagnostic tools for this condition were briefly outlined. Methods: The literature search included publications from PubMed, Scopus, Web of Science and Cochrane Library. The chosen period of time for these publications was 2000–2024. Results: The results showed that OSA is a serious problem among TCS patients. Although there is no standardised treatment protocol, the primary methods often include mandibular distraction osteogenesis (MDO) and continuous positive airway pressure (CPAP). Approaches such as hypoglossal nerve stimulation (HNS) need further investigation, especially with longitudinal observations. Conclusions: The development of treatment options seems to be promising, suggesting a favourable outlook for standardising the treatment protocols. Full article
(This article belongs to the Special Issue Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition))
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10 pages, 2445 KiB  
Case Report
Guided Endodontics for a Tooth with Root Fracture: A Case Report
by Monika Kuczmaja and Agata Żółtowska
J. Clin. Med. 2025, 14(12), 4079; https://doi.org/10.3390/jcm14124079 - 9 Jun 2025
Viewed by 835
Abstract
Background: A 19-year-old female patient reported to the Department of Conservative Dentistry, Medical University of Gdańsk, with pain in the left lateral incisor. During the attempt to perform root canal treatment on tooth 22, we encountered difficulties in locating the canal opening, which [...] Read more.
Background: A 19-year-old female patient reported to the Department of Conservative Dentistry, Medical University of Gdańsk, with pain in the left lateral incisor. During the attempt to perform root canal treatment on tooth 22, we encountered difficulties in locating the canal opening, which resulted in treatment failure. Radiographic examinations revealed Pulp Canal Obliteration and a root fracture with a double fracture line, resulting in two root fragments. The prognosis for this tooth was poor, with extraction being the most likely outcome. Methods: To provide effective therapy, a 3D-printed endodontic guide was utilized, allowing for more precise localization of the canal in a tooth with a calcified root canal and complex fracture morphology. An intraoral scan and cone-beam computed tomography (CBCT) were performed, followed by the design of the guide. This facilitated accurate planning of the entry path for endodontic instruments, promoting minimally invasive treatment and reducing the loss of tooth structure. Results: Through navigated endodontics, the treatment became more predictable, and the risk of iatrogenic complications was minimized, significantly improving the prognosis of the therapy. Clinical and radiological examinations conducted after 12 months demonstrated successful treatment and preservation of the tooth in the oral cavity. Conclusions: The obtained results suggest that the use of guided endodontics can improve outcomes in cases with pulp canal obliteration and complex fractures, offering a minimally invasive and predictable approach. Full article
(This article belongs to the Special Issue Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition))
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15 pages, 499 KiB  
Systematic Review
Aligners as a Therapeutic Approach in Impacted Canine Treatment: A Systematic Review
by Mateusz Wolny, Agata Sikora, Aneta Olszewska, Jacek Matys and Agata Czajka-Jakubowska
J. Clin. Med. 2025, 14(10), 3421; https://doi.org/10.3390/jcm14103421 - 14 May 2025
Viewed by 886
Abstract
Background/Objectives: The growing demand for esthetic, less painful, and more comfortable orthodontic treatment has led to increasing use of aligner systems. Initially used for less complicated malocclusions, aligners are now being incorporated into complex treatment plans, including cases involving impacted teeth. While aligners [...] Read more.
Background/Objectives: The growing demand for esthetic, less painful, and more comfortable orthodontic treatment has led to increasing use of aligner systems. Initially used for less complicated malocclusions, aligners are now being incorporated into complex treatment plans, including cases involving impacted teeth. While aligners are a popular alternative to traditional fixed appliances, they still have limitations. This study aims to evaluate the effectiveness of aligner-based orthodontic treatment in patients with impacted or significantly ectopic canines. Methods: This study was conducted in accordance with the PRISMA guidelines. The search terms used were as follows: ‘Clear Aligner’ OR ‘Invisalign’ AND ‘Impacted Canine’ OR ‘Impacted Tooth’ OR ‘Ectopic Tooth’ OR ‘Ectopic Canine.’ A total of 1101 records were identified, of which 170 articles underwent screening. Fifteen articles were assessed for eligibility, and ultimately six case reports and one three-dimensional finite element analysis (FEA) study were included for both quantitative and qualitative synthesis. Results: According to the studies, additional appliances are often required to achieve favorable outcomes when treating impacted canines with aligner systems. Temporary anchorage devices (TADs) were used in 5 out of 9 reported cases for canine traction into the dental arch. In three cases, TADs were combined with sectional wires implemented as cantilevers. Elastics were used in 6 out of 9 cases for traction to the opposite arch, and in 5 out of 9 cases as interarch elastics attached to the aligners. Interarch elastics were applied in various ways, either directly to the aligners or to primary canines using hidden buttons inside pontics or dovetail hooks. Elastics were also anchored to the lower arch with class II, class III, or cross-arch (criss-cross) mechanics. Conclusions: This review highlights the promising potential of aligner systems in the treatment of impacted canines. However, additional auxiliaries, such as TADs, sectional wires, or elastics remain nearly essential for initial canine traction. Aligner systems offer versatile treatment options, and the possibility of reduced treatment time represents a valuable area for future research. Full article
(This article belongs to the Special Issue Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition))
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