Evaluation of the Potential Biological Activity of Metallo-Drugs, 2nd Edition
A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 11
Special Issue Editor
Interests: transition metal complexes; kinetics; biomolecules; interactions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Cancer remains the second leading cause of death worldwide, following cardiovascular diseases. Among various therapeutic approaches, transition metal complexes have attracted significant attention for their application in chemotherapy. To date, the most successful example of such complexes is cisplatin, a platinum(II) complex that has become a cornerstone in the treatment of various cancers.
Despite its proven efficacy, the clinical use of cisplatin is limited by severe side effects and the development of drug resistance. These drawbacks have prompted researchers to design new platinum-based complexes with structural similarities to cisplatin. Some of these newly synthesized compounds have shown even greater anticancer activity. Current research efforts have also expanded to include complexes of other transition metals, such as palladium(II), gold(III), ruthenium(II), osmium(II), rhodium(III), and copper(II), in the search for more effective and selective anticancer agents. It is well known that the anticancer activity of metal-based drugs primarily arises from their ability to interact with DNA molecules. However, their interaction with sulfur-containing biomolecules can also lead to side effects. To assess the anticancer potential, selectivity, and toxicity of metal-based drugs, it is crucial to study the kinetics and mechanisms of their reactions with both DNA segments and full DNA molecules. Additionally, understanding how these compounds interact with proteins, particularly serum albumins (SAs), the most abundant plasma proteins involved in drug transport, is essential for evaluating their pharmacological behavior and therapeutic efficacy.
The aim of this Special Issue of Inorganics entitled "Evaluation of the Potential Biological Activity of Metallo-Drugs, 2nd Edition" is to highlight recent advances in the design, synthesis, and biological evaluation of transition-metal-based compounds with potential anticancer properties and to encourage ongoing research in this promising field that continues to evolve in response to clinical challenges and therapeutic needs.
Dr. Snežana Jovanović-Stević
Guest Editor
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Keywords
- • Synthesis
- • Metal-based drugs
- • DNA/serum albumin proteins
- • Small molecules
- • Interactions
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