Recent Advances in Antiphospholipid Syndrome

A special issue of Immuno (ISSN 2673-5601).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 8960

Special Issue Editor


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Guest Editor
UOC Medicina, Fatebenefratelli Hospital of Naples, 80131 Naples, Italy
Interests: internal medicine; management of internal medicine; thrombotic disease
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Special Issue Information

Dear colleagues,

Although guidelines of international society of thrombosis and haemostatis (ISTH) and America rheumatology association are available from several years to suggest diagnosis and treatments for primary and secondary antiphospholipid syndrome several issues are frequently debated in the daily clinical practice.

Immunomediated thrombosis recognises different pathophysiological mechanisms from traditional arterial and venous thrombosis and new pathophysiological mechanisms are recently described.

Furthermore, clinical presentation differs in young patients or adult patients, and also, therapeutic support offers different outcomes in patients with primary or secondary antiphospholipid syndrome.

Furthermore, the follow-up strategy of carriers of asymptomatic abnormal values of antiphospholipid antibodies is still debated.

Therefore, this Special Issue is dedicated to scholars that may offer their clinical and laboratory experience in the management of clinical overt antiphospholipid syndrome or asymptomatic carriers of antiphospholipid antibodies.

We think that this is still an intriguing clinical issue, and we hope that scholars around world agree.

Dr. Pierpaolo Di Micco
Guest Editor

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Keywords

  • antiphospholipid syndrome
  • antiphospholipid antibodies
  • lupus anticoagulant
  • venous thromboembolism
  • miscarriage
  • atherothrombosis

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Published Papers (1 paper)

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Review

13 pages, 968 KiB  
Review
Catastrophic Antiphospholipid Syndrome: A Review
by Carmine Siniscalchi, Manuela Basaglia, Michele Riva, Michele Meschi, Tiziana Meschi, Giampiero Castaldo and Pierpaolo Di Micco
Immuno 2024, 4(1), 1-13; https://doi.org/10.3390/immuno4010001 - 25 Dec 2023
Cited by 6 | Viewed by 8133
Abstract
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic or obstetric events occurring in individuals who have persistent antiphospholipid antibodies. Catastrophic antiphospholipid syndrome (CAPS) is a rare and potentially fatal form of APS characterized by severe thrombotic complications occurring in multiple [...] Read more.
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic or obstetric events occurring in individuals who have persistent antiphospholipid antibodies. Catastrophic antiphospholipid syndrome (CAPS) is a rare and potentially fatal form of APS characterized by severe thrombotic complications occurring in multiple organs over a short period of time or simultaneously. CAPS is associated with a high (50%) death rate. Infections, multi-organ failure, and cerebral and heart thrombosis represent the main complications of this syndrome. Generally, anticoagulants, glucocorticoids, therapeutic plasmapheresis (TPE), and intravenous immunoglobulin (IVIG) are used in combination for treatment. Multidisciplinary care involving different specialists from hematology, rheumatology, nephrology, infectious disease, critical care, and obstetrics is often required due to the complexity of the disease. Recent data emphasize the effectiveness of biologics such as anti-TNF-a monoclonal antibodies (adalimumab, certolizumab), anti-CD38 monoclonal antibody (daratumumab), BAFF/Blys inhibitor (belimumab), and BTK inhibitor (zanubrutinib) against CAPS. In order to understand the underlying causes of CAPS, one future possibility involves investigating and characterizing the hereditary and acquired risk factors associated with CAPS. Full article
(This article belongs to the Special Issue Recent Advances in Antiphospholipid Syndrome)
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