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Topical Collection "One Health Model: A Multisectoral Approach for Protecting Human Health and the Environment"

Editor

Prof. Dr. Marcello Iriti
E-Mail Website
Guest Editor
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20133 Milan, Italy
Interests: essential oils; bioactive phytochemicals; ethnopharmacology; antimicrobial resistance; one health; food security
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

The One Health paradigm claims that the health of humans is connected to the health of animals, plants, and the environment. Indeed, an estimated 60% of human pathogens originate in animals, about three-quarters of which are of wildlife origin. This holistic vision implies a coordinated, collaborative, multidisciplinary, and cross-sectoral approach to tackle threats that can originate at the environment–plant–animal–human interface while protecting biodiversity. Because the health of people, animals, plants, and the environment is interconnected, this integrated approach needs specialists in complementary sectors that work together to address environment-related human and animal health risks, as well as to prevent and control diseases shared between animals (including livestock, wildlife, and pets) and humans. Furthermore, the application of a One Health approach is pivotal for achieving the UN Sustainable Development Goals according to the 2030 Agenda for Sustainable Development. Relevant topics in the One Health model include human and animal health, plant health, antimicrobial resistance, food security, food safety, and no less important sustainable agriculture. Indeed, good agricultural practices are essential to manage plant diseases and produce enough food free from mycotoxins and pesticide residues to feed all people. In other words, the One Health vision is a unifying force to safeguard human and animal health, to reduce disease threats, and to ensure a safe food supply through effective and responsible management of natural resources.

Within this broad context, this Topical Collection welcomes original research and review articles focusing on biochemical and molecular aspects at the base of the One Health approach.

Prof. Dr. Marcello Iriti
Guest Editor

Manuscript Submission Information

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Keywords

  • infectious diseases
  • infection disease surveillance
  • emerging diseases
  • zoonoses
  • environmental medicine
  • plant health and diseases
  • biodiversity
  • food security and safety
  • feed security and safety
  • malnutrition
  • mycotoxins and mycotoxicosis
  • pesticides
  • public health
  • global climate change

Published Papers (1 paper)

2021

Article
Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations
Int. J. Mol. Sci. 2021, 22(19), 10693; https://doi.org/10.3390/ijms221910693 - 02 Oct 2021
Cited by 8 | Viewed by 1158
Abstract
Considering the current dramatic and fatal situation due to the high spreading of SARS-CoV-2 infection, there is an urgent unmet medical need to identify novel and effective approaches for prevention and treatment of Coronavirus disease (COVID 19) by re-evaluating and repurposing of known [...] Read more.
Considering the current dramatic and fatal situation due to the high spreading of SARS-CoV-2 infection, there is an urgent unmet medical need to identify novel and effective approaches for prevention and treatment of Coronavirus disease (COVID 19) by re-evaluating and repurposing of known drugs. For this, tomatidine and patchouli alcohol have been selected as potential drugs for combating the virus. The hit compounds were subsequently docked into the active site and molecular docking analyses revealed that both drugs can bind the active site of SARS-CoV-2 3CLpro, PLpro, NSP15, COX-2 and PLA2 targets with a number of important binding interactions. To further validate the interactions of promising compound tomatidine, Molecular dynamics study of 100 ns was carried out towards 3CLpro, NSP15 and COX-2. This indicated that the protein-ligand complex was stable throughout the simulation period, and minimal backbone fluctuations have ensued in the system. Post dynamic MM-GBSA analysis of molecular dynamics data showed promising mean binding free energy 47.4633 ± 9.28, 51.8064 ± 8.91 and 54.8918 ± 7.55 kcal/mol, respectively. Likewise, in silico ADMET studies of the selected ligands showed excellent pharmacokinetic properties with good absorption, bioavailability and devoid of toxicity. Therefore, patchouli alcohol and especially, tomatidine may provide prospect treatment options against SARS-CoV-2 infection by potentially inhibiting virus duplication though more research is guaranteed and secured. Full article
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