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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neurohormones in Cardiac Fibrosis and Heart Failure
edited by
submission deadline 20 Jan 2026 | Viewed by 134 | Submission Open
Keywords: heart failure; neurohormones; cardiac fibrosis; angiotensin II; aldosterone; endothelin; catecholamines
(This special issue belongs to the Section Molecular Biology)
Advancements in Cytopathology: Challenges and Changes
edited by Panagiota Mikou
submission deadline 20 Jan 2026 | Viewed by 132 | Submission Open
Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology
(This special issue belongs to the Section Molecular Biology)
Protein Structure and Its Interactions
edited by
submission deadline 20 Jan 2026 | Viewed by 33 | Submission Open
Keywords: protein– protein interactions (PPIs); protein– ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis
(This special issue belongs to the Section Molecular Biology)
Endothelial Cells in Healthy submission deadline 20 Jan 2026 | Viewed by 31 | Submission Open
Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair
(This special issue belongs to the Section Molecular Biology)
From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension
edited by
submission deadline 25 Jan 2026 | Viewed by 60 | Submission Open
Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation
(This special issue belongs to the Section Molecular Biology)
Nutritional Modulators of Healthy Longevity: Mechanisms and Interventions
edited by
submission deadline 30 Jan 2026 | Viewed by 56 | Submission Open
Keywords: aging; healthspan; nutrient signaling; oxidative stress; inflammation; autophagy; sarcopenia; bioactive compounds; molecular nutrition; protein metabolism
(This special issue belongs to the Section Molecular Biology)
Metals and Metal Ions in Human Health, Diseases, and Environment submission deadline 30 Jan 2026 | Viewed by 14 | Submission Open
Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution
(This special issue belongs to the Section Molecular Biology)
Fish Nutrition, Biochemical Pathways, and Physiological Adaptations
edited by Paula Simó-Mirabet and Fernando Naya-Català
submission deadline 31 Jan 2026 | Viewed by 70 | Submission Open
Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture
(This special issue belongs to the Section Molecular Biology)
Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies
edited by Juliana Luporini Dreyfuss
submission deadline 31 Jan 2026 | Viewed by 59 | Submission Open
Keywords: angiogenesis; vascular endothelial growth factor (VEGF); novel compounds; endothelial cells; drug development; advanced molecular biology; omics technologies; innovation
(This special issue belongs to the Section Molecular Biology)
Advances in Animal Nutrition and Muscle Biology
edited by Usuk Jung
submission deadline 31 Jan 2026 | Viewed by 24 | Submission Open
Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis
(This special issue belongs to the Section Molecular Biology)
Fish Genomics and Developmental Biology, 2nd Edition submission deadline 20 Feb 2026 | 4 articles | Viewed by 3369 | Submission Open
Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker
(This special issue belongs to the Section Molecular Biology)
Sperm Oxidative Stress and Male Infertility
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2117 | Submission Open
Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility
(This special issue belongs to the Section Molecular Biology)
Micro(nano) Plastics and Estrogens as Endocrine Disruptors Meet the Female Reproductive System, Breast and Colon: What Is Going On? submission deadline 20 Feb 2026 | 1 articles | Viewed by 1719 | Submission Open
Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon
(This special issue belongs to the Section Molecular Biology)
Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 405 | Submission Open
Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines
(This special issue belongs to the Section Molecular Biology)
Redox Systems in Humans, Animals, Plants and Aquatic Ecosystems and Their Microbiomes submission deadline 20 Feb 2026 | Viewed by 372 | Submission Open
Keywords: redox systems; aging and disease; nutraceuticals; probiotics; animals; plants; aquatic ecosystems; microbiomes
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition
edited by , María José Cuevas-González and Chun-Jung Huang
submission deadline 20 Feb 2026 | Viewed by 213 | Submission Open
Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics
(This special issue belongs to the Section Molecular Biology)
Understanding Aging in Health and Disease
edited by
submission deadline 25 Feb 2026 | Viewed by 83 | Submission Open
Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging
(This special issue belongs to the Section Molecular Biology)
Obesity: From Cellular Mechanism to Potential Molecular Therapies
edited by
submission deadline 25 Feb 2026 | Viewed by 36 | Submission Open
Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer
(This special issue belongs to the Section Molecular Biology)
Current Trends and Future Directions in Antimicrobial Peptide Research
edited by
submission deadline 28 Feb 2026 | Viewed by 51 | Submission Open
Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance
(This special issue belongs to the Section Molecular Biology)
Dermatological Perspectives on Connective Tissue Diseases
edited by Yoshihide Asano
submission deadline 28 Feb 2026 | Viewed by 18 | Submission Open
Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy
(This special issue belongs to the Section Molecular Biology)
Protein Aggregation and Proteinopathies
edited by Hongyu Hu
submission deadline 20 Mar 2026 | 2 articles | Viewed by 5060 | Submission Open
Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy
(This special issue belongs to the Section Molecular Biology)
Mitochondria: Central Players in Cancer submission deadline 20 Mar 2026 | 2 articles | Viewed by 1985 | Submission Open
Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Engineering of Antimicrobial Agents: From Structure-Function Insights to Combinatorial Therapies
edited by Mingrui Liao
submission deadline 25 Mar 2026 | Viewed by 26 | Submission Open
Keywords: antimicrobial amphiphiles; antimicrobial resistance; structure– activity relationship; synergistic antimicrobial therapy; drug delivery systems
(This special issue belongs to the Section Molecular Biology)
Stem Cells in Health and Disease: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2608 | Submission Open
Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity
(This special issue belongs to the Section Molecular Biology)
Fascial Anatomy and Histology: Advances in Molecular Biology
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 12071 | Submission Open
Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan
(This special issue belongs to the Section Molecular Biology)
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