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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Jan 2026 | 3 articles | Viewed by 9301 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood– brain barrier; blood– cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment

edited by

Ilaria Mormile

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8486 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation; molecular pathway; biomarkers; target therapy

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection

edited by

Vito D’Agnano

submission deadline 20 Jan 2026 | 7 articles | Viewed by 8095 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunology; pathophysiology; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7728 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition

edited by

Balik Dzhambazov

submission deadline 20 Jan 2026 | 6 articles | Viewed by 6319 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies

edited by

Renata Stawerska

submission deadline 20 Jan 2026 | 5 articles | Viewed by 6313 | Submission Open

Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition

edited by

Bernhard Biersack

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6232 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Progression of Genetics in Breeding of Farm Animals

edited by

Karel Novák

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6120 | Submission Open

Keywords: farm animal; livestock; genome sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Aspects of Bacterial Infection

edited by

María Soledad Ramírez

submission deadline 20 Jan 2026 | 5 articles | Viewed by 5719 | Submission Open

Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Protein and Protein Interactions

edited by Wu Xu

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5331 | Submission Open

Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics

(This special issue belongs to the Section Molecular Biology)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5016 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers

edited by

Susana Coimbra

Flávio Reis

and

Alice Santos-Silva

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4914 | Submission Open

Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition

edited by

Paramjit S. Tappia

and

Bram Ramjiawan

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4833 | Submission Open

Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms

edited by

Mariusz Cycoń

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4819 | Submission Open

Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils

(This special issue belongs to the Section Molecular Microbiology)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by

Miguel Hueso

and

Alfredo Vellido

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4586 | Submission Open

Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning

(This special issue belongs to the Section Molecular Informatics)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4488 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Landscape of Pulmonary Arterial Hypertension

edited by Cármen Brás-Silva

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4175 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy

(This special issue belongs to the Section Molecular Biology)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3815 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

New Insights into Satellite DNAs

edited by

Isidoro Feliciello

and

Đurđica Ugarković

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3813 | Submission Open

Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing

(This special issue belongs to the Section Molecular Biology)

Respiratory Virus Infection

edited by Nikolaos Siafakas

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3013 | Submission Open

Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus

(This special issue belongs to the Section Molecular Microbiology)

The Structures, Syntheses of Natural Products, and Their Biological Effects

edited by

Ran Jia

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2706 | Submission Open

Keywords: structures of natural products; syntheses; biological effects; biomedical applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Bone and Soft Tissue Tumors

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2646 | Submission Open

Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications

edited by Jordi Olloquequi and M. Emília Juan

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2539 | Submission Open

Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanism and Pathogenesis of Cardiac Disease

edited by Yu-Hsun Kao

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2394 | Submission Open

Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection

edited by

Vishwanath Venketaraman

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2295 | Submission Open

Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Immunology)

Lipid Peroxidation and Protein Carbonylation in Human Diseases

edited by

Galina Nikolova

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2289 | Submission Open

Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes

(This special issue belongs to the Section Biochemistry)

Fat and Obesity: Molecular Mechanisms and Pathogenesis

edited by

Seon-Yong Jeong

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2282 | Submission Open

Keywords: obesity; weight gain; adipogenesis; lipolysis; energy balance; hormones; fat oxidation; nutrition; phytomedicine; drug development; cohort studies; genetics and genomics studies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective

edited by Andra Valentina Krauze

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2256 | Submission Open

Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights

(This special issue belongs to the Section Molecular Informatics)

Novel Insights into Molecular Mechanisms of Pulmonary Pathology

edited by Qiaozhen Liu

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2196 | Submission Open

Keywords: fibrosis; infection; COPD; asthma; IPF; pneumonia; lung cancer; molecular mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research and Innovations in Green Monomers and Macromolecular Materials

edited by

Joanna Rydz

Marta Musioł

and

Wanda Sikorska

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2151 | Submission Open

Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products

(This special issue belongs to the Section Materials Science)

Pathophysiology and Treatment of Congenital Neuromuscular Disorders

edited by Johan Lindqvist

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1940 | Submission Open

Keywords: nemaline myopathy; hereditary neuromuscular disorder; genetic mutations; pathogenesis; pathophysiology; therapy; myofilament dysfunction; congenital neuromuscular disorders; congenital muscular dystrophy; spinal muscular atrophy; Duchenne muscular dystrophy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress in Human Diseases

edited by

Galina Nikolova

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1826 | Submission Open

Keywords: inflammation; oxidative stress; free radicals; proteins; lipids; DNA damage; biomarkers

(This special issue belongs to the Section Biochemistry)

Hemophilia: From Pathophysiology to Novel Therapies

edited by

Mingching Shen

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1775 | Submission Open

Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Networks and Their Signaling

edited by

Ashok Kumar

and

Vladimir N. Uversky

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1691 | Submission Open

Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design

(This special issue belongs to the Section Molecular Biology)

Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment

edited by

Marco Valerio Mariani

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1624 | Submission Open

Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by

Mrigya Babuta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy and Kidney Diseases

edited by Francesco Reggiani

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1507 | Submission Open

Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Signal Transduction in the Nucleus

edited by Jaekyung Shim

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1462 | Submission Open

Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation

(This special issue belongs to the Section Molecular Biology)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1426 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Molecular Breeding and Genetic Regulation of Crops, 2nd Edition

edited by

Chiara Biselli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1192 | Submission Open

Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications

(This special issue belongs to the Section Molecular Plant Sciences)

Role of HLA (Human Leucocyte Antigen) in Human Diseases

edited by

Jeane Eliete Laguila Visentainer

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1170 | Submission Open

Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1022 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Precision Medicine Approaches to Antifibrotic Therapy

edited by Karim Daliri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 981 | Submission Open

Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Male Infertility and Sperm Biology

edited by

Monica Muratori

submission deadline 20 Jan 2026 | 1 articles | Viewed by 855 | Submission Open

Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Ligia Petrica

submission deadline 20 Jan 2026 | 1 articles | Viewed by 761 | Submission Open

Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Jan 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 20 Jan 2026 | 1 articles | Viewed by 713 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Pathogenesis and Therapy of Oral Carcinogenesis, 3rd Edition

edited by

Marko Tarle

and

Ivica Lukšić

submission deadline 20 Jan 2026 | Viewed by 668 | Submission Open

Keywords: oral cancer; oral premalignant disorders; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis

(This special issue belongs to the Section Molecular Oncology)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 20 Jan 2026 | 1 articles | Viewed by 630 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

Latest Advances in Nanoparticles for Modern Biomedicine (2nd Edition)

edited by

Sebastian Schwaminger

submission deadline 20 Jan 2026 | Viewed by 586 | Submission Open

Keywords: nanoparticles; nanotherapeutics; nanomedicine; biomedicine; selective targeting of nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 3201-3250 on page 65 of 68.

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