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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unraveling Apoptosis: Deciphering Molecular Mechanisms

edited by

Gabriella Simbula

submission deadline 20 Nov 2025 | Viewed by 739 | Submission Open

Keywords: apoptosis; development; microenvironment; mitochondria dysfunction; molecular mechanisms; tumors; degenerative diseases; diabetes; metabolic diseases; neurodegenerative disease; novel pharmacological strategies

(This special issue belongs to the Section Biochemistry)

Precision Medicine in Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 20 Nov 2025 | Viewed by 683 | Submission Open

Keywords: precision medicine; cancer biomarkers; targeted therapy; genomic profiling; personalized treatment; tumor heterogeneity; molecular diagnostics; clinical research

(This special issue belongs to the Section Molecular Oncology)

MicroRNA (miRNA) Technology in Cancer

edited by

Duncan Ayers

submission deadline 20 Nov 2025 | 1 articles | Viewed by 676 | Submission Open

Keywords: miRNA; microRNA; cancer; oncology; drug delivery; technology; non-coding RNA

(This special issue belongs to the Section Molecular Oncology)

Molecular and Physiological Analysis of Stress in Plants

edited by

Yong Li

submission deadline 20 Nov 2025 | 1 articles | Viewed by 654 | Submission Open

Keywords: plant stress; biotic stress; abiotic stress; stress response; gene expression; epigenetic stress memory; ABA; SA

(This special issue belongs to the Section Molecular Plant Sciences)

Endothelial Dysfunction, Inflammation and Cognition

edited by Christelle Basset and Anne S. Prigent-Tessier

submission deadline 20 Nov 2025 | Viewed by 552 | Submission Open

Keywords: inflammation; endothelial dysfunction; cognition; nitric oxide (NO); BDNF; physical exercise

(This special issue belongs to the Section Molecular Biology)

Genetic Testing in Molecular Pathology and Diagnosis

edited by

Marco Fabiani

submission deadline 20 Nov 2025 | Viewed by 496 | Submission Open

Keywords: genetic testing; molecular pathology; personalized medicine; genetic diagnostics; disease mechanisms; novel genetic tests; clinical integration; patient management

(This special issue belongs to the Section Molecular Biology)

Nucleolus, Nucleolar Stress, and Ribosome Biogenesis in the Nervous System

edited by

Theologos Michaelidis

submission deadline 20 Nov 2025 | Viewed by 476 | Submission Open

Keywords: nucleolus; nucleolar stress; nucleolar homeostasis; polymerase I; rDNA transcription; ribosome biogenesis; translation; ribosomopathies; apoptosis; autophagy; senescence; neurodegeneration; tumorigenesis

(This special issue belongs to the Section Molecular Neurobiology)

Diabetes: Genetics and Genomics, Hormone Regulation, and Metabolic Control

edited by Maria Stathopoulou

submission deadline 20 Nov 2025 | Viewed by 464 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; monogenic diabetes; polygenic risk factors; gestational diabetes (GDM); maturity-onset diabetes of the young (MODY); latent autoimmune diabetes in adults (LADAs); genome-wide association studies (GWASs); single nucleotide polymorphisms (SNPs); epigenetic modifications in diabetes; insulin production regulation; hormone action and metabolic control; β -cell dysfunction; gene-environment interactions in diabetes; precision medicine in diabetes treatment; genetics; genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Crosstalk Between Bone and Inflammation

edited by Jessica Cottrell

submission deadline 20 Nov 2025 | Viewed by 424 | Submission Open

Keywords: bone; inflammation; immunology; bone metabolism; inflammatory disease

(This special issue belongs to the Section Molecular Immunology)

Anticancer, Antioxidant, and Anti-Inflammatory Properties of Natural Products

edited by

Rita Carneiro Alves

, Nelson Andrade and Cláudia Silva

submission deadline 20 Nov 2025 | 1 articles | Viewed by 394 | Submission Open

Keywords: bioactive compounds; natural extracts; health promotion/disease prevention; oxidative stress modulation; inflammatory pathway regulation; anticancer and antitumoral effects; cellular mechanisms; in vitro and in vivo bioactivity studies

(This special issue belongs to the Section Molecular Pharmacology)

Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments

edited by

Amit Roy

and

Amrita Chakraborty

submission deadline 20 Nov 2025 | Viewed by 388 | Submission Open

Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms

(This special issue belongs to the Section Molecular Biology)

Genetic Testing and Tailored Treatment for Thyroid Disorders: Molecular Basis and New Trends

edited by

Kyoung Sik Park

submission deadline 20 Nov 2025 | Viewed by 384 | Submission Open

Keywords: thyroid diseases; genetics; personalized medicine; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 Nov 2025 | Viewed by 383 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

Therapeutics and Pathophysiology of Cognitive Dysfunction

edited by

Maheedhar Kodali

submission deadline 20 Nov 2025 | Viewed by 382 | Submission Open

Keywords: cognition; neurologic diseases; neuroinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 361 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular, Translational and Clinical Research of Cancer Structural Biomarkers

edited by

Sabine Mai

submission deadline 20 Nov 2025 | Viewed by 356 | Submission Open

Keywords: structural biomarker; extracellular matrix; nuclear organization; discovery research; translational research; clinical research; cancer staging and prognosis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2025 | 1 articles | Viewed by 328 | Submission Open

Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Thermodynamic and Spectral Studies of Complexes

edited by Michał Zabiszak

submission deadline 20 Nov 2025 | 1 articles | Viewed by 325 | Submission Open

Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Chemical and Biotechnological Strategies to Tailor the Properties of Biomaterials

edited by

Eduardo García-Junceda

and

Julia Revuelta

submission deadline 20 Nov 2025 | Viewed by 318 | Submission Open

Keywords: biomaterial functionalization; green chemistry in biomaterials; biotechnological modification; stimuli-responsive materials; translational biomaterials

(This special issue belongs to the Section Materials Science)

Synthesis and Application of Chiral Ligands and Heterocycles in Pharmacological Studies

edited by

István Szatmári

submission deadline 20 Nov 2025 | Viewed by 308 | Submission Open

Keywords: nonracemic amino acids; enantioselective synthesis; chiral catalysis; enantiopure bioconjugates; electron-rich hydroxyquinoline; indole; β -carboline; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Structure–Activity Relationships Within Pharmaceutical Interactions and the Discovery of Molecular Targets

edited by

Yoshihiro Uesawa

submission deadline 20 Nov 2025 | Viewed by 306 | Submission Open

Keywords: molecular dynamics; docking simulation; QSAR; moleular initiating event

(This special issue belongs to the Section Molecular Pharmacology)

Cancer Models: Development and Applications

edited by

Yong Teng

submission deadline 20 Nov 2025 | Viewed by 303 | Submission Open

Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

ABC Transporters: Where Are We 45 Years On? (2nd Edition)

edited by

Anthony M George

submission deadline 20 Nov 2025 | 1 articles | Viewed by 299 | Submission Open

Keywords: nucleotide-binding cassette; transmembrane binding domain; drug resistance; X-ray and cryo-EM structures; molecular dynamics simulations; ABC transporter

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis

edited by Katharina Proestling and

Iveta Yotova

submission deadline 20 Nov 2025 | Viewed by 293 | Submission Open

Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Extracellular Vesicles in Diseases

edited by

Gorjana Rackov

and

Aoife Ward Gahlawat

submission deadline 20 Nov 2025 | Viewed by 289 | Submission Open

Keywords: extracellular vesicles (EVs); biomarkers; disease pathophysiology; miRNAs; intercellular communication; therapeutic targets; mitochondrial transfer; cancer; neurodegenerative disorders; precision medicine

(This special issue belongs to the Section Biochemistry)

ROS Signalling and Cell Turnover

edited by

Micol Silic-Benussi

submission deadline 20 Nov 2025 | Viewed by 284 | Submission Open

Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death

(This special issue belongs to the Section Biochemistry)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 274 | Submission Open

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Signaling Pathways in Chronic Inflammatory Disorders

edited by

Martina Schmidt

and

Karim Rafie

submission deadline 20 Nov 2025 | Viewed by 260 | Submission Open

Keywords: blood– brain barrier; inducible pluripotent stem cells; organoids; scaffolds; neuroinflammation; microglia; mitochondria; endothelial cells; drug screening; virus infections; cryo-EM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Nov 2025 | Viewed by 238 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mesenteric Adipose Tissue: The New Player in Health and Disease

edited by Eva Pardina and Jose M. Balibrea

submission deadline 20 Nov 2025 | Viewed by 227 | Submission Open

Keywords: mesenteric adipose tissue; obesity; inflammatory bowel diseases; Chron’ s disease; MASLD; metabolic inflammation; metabolic syndrome; mesenteric resections

(This special issue belongs to the Section Molecular Biology)

Deciphering the Multifaceted Mechanisms of Antimicrobial Peptides

edited by

Xiumin Wang

submission deadline 20 Nov 2025 | Viewed by 218 | Submission Open

Keywords: antimicrobial peptides; antimicrobial activity; mechanisms of action; membrane disruption; inhibition of cellular processes; immune modulation

(This special issue belongs to the Section Macromolecules)

Nucleic Acid Aptamers in Molecular Medicine

edited by

Silvia Catuogno

submission deadline 20 Nov 2025 | Viewed by 217 | Submission Open

Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery

(This special issue belongs to the Section Molecular Biology)

Advances in Yeast Engineering and Stress Responses

edited by

Joaquin Ariño

and

Pau Ferrer

submission deadline 20 Nov 2025 | Viewed by 214 | Submission Open

Keywords: stress tolerance; cellular adaptation; nutrient limitation; gene expression; metabolic engineering; synthetic biology; strain robustness; fermentation efficiency; bioprocess optimization

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Performances of Photocatalysis

edited by

Shaojun Yuan

submission deadline 20 Nov 2025 | Viewed by 210 | Submission Open

Keywords: photocatalytic materials; photocatalysis; energy conversion; environmental remediation; carbon dioxide reduction; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Neuroinflammation: From Molecular Mechanisms to Therapy

edited by

Silvia Alboni

and Miriam Ciani

submission deadline 20 Nov 2025 | Viewed by 195 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; psychiatric disorders; molecular and cellular targets

(This special issue belongs to the Section Molecular Neurobiology)

Preparations and Applications of Aerogels and/or Cryogels: From a Molecular Perspective

edited by

Angelika Kmita

and

Dorota Lachowicz

submission deadline 20 Nov 2025 | Viewed by 188 | Submission Open

Keywords: inorganic and/or organic aerogels; hybrid materials; eco-friendly materials; diagnosis

(This special issue belongs to the Section Materials Science)

Molecular Studies on the Impact of Microbiome on Anticancer Drug Resistance

edited by

Francesca Benedetti

and

Davide Zella

submission deadline 20 Nov 2025 | Viewed by 184 | Submission Open

Keywords: microbiome; cancer; anticancer drugs; chemoresistance; immune modulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Potential New Antidepressant Drugs

edited by

Marta Jóźwiak-Bębenista

and

Anna Stasiak

submission deadline 20 Nov 2025 | Viewed by 183 | Submission Open

Keywords: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems (serotonin; norepinephrine; dopamine); preclinical research (in vitro; in vivo; in silico); psychiatric disorders

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism of Hypertension-Induced Renal Injury

edited by

Ningjun Li

and Guangbi Li

submission deadline 20 Nov 2025 | Viewed by 179 | Submission Open

Keywords: hypertension; renal injury; molecular mechanisms; chronic kidney disease; pharmacological interventions; vascular biology; renoprotection; blood pressure regulation; toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Protein Post-Translational Modifications in Cancer: Mechanisms and Therapeutic Opportunities

edited by

Mauro Salvi

Wei-Chien Huang

and

Josefa León

submission deadline 20 Nov 2025 | Viewed by 179 | Submission Open

Keywords: phosphorylation; acetylation; methylation; sumoylation; ubiquitination; glycosylation; acylation; signal transduction; inhibitors

(This special issue belongs to the Section Biochemistry)

Genomic Research in Carcinogenesis, Cancer Progression and Recurrence

edited by

Magdalena Orzechowska

submission deadline 20 Nov 2025 | Viewed by 169 | Submission Open

Keywords: genomic profiling; carcinogenesis; metastasis; recurrence; precision medicine; tumor evolution metrics; sequencing; tumor markers

(This special issue belongs to the Section Molecular Oncology)

Molecular Science of Anesthesia

edited by Jose Luis Guerrero Orriach and Maria Dolores Carmona-Luque

submission deadline 20 Nov 2025 | Viewed by 167 | Submission Open

Keywords: anesthesia; nervous system; signal; receptor

(This special issue belongs to the Section Molecular Biology)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 Nov 2025 | Viewed by 164 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer

edited by Rebecca Chin

submission deadline 20 Nov 2025 | Viewed by 157 | Submission Open

Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids

(This special issue belongs to the Section Molecular Oncology)

The Role of Amyloid in Neurological Diseases

edited by Silvia Purro

submission deadline 20 Nov 2025 | Viewed by 151 | Submission Open

Keywords: amyloid-beta (Aβ ); tau protein; TDP43; synuclein; huntingtin; prion-like mechanisms; amyloid structures; genetic factors; cell-to-cell transmission; pathogenesis mechanisms; protein aggregation; Biomarkers; CNS amyloid clearance and degradation

(This special issue belongs to the Section Molecular Neurobiology)

Recent Developments in Obesity: Metabolism, Pathophysiology, and Treatment

edited by

Byungyong Ahn

submission deadline 20 Nov 2025 | Viewed by 126 | Submission Open

Keywords: obesity; pathophysiology; hormones (GLP-1; GIP; glucagon); inflammation; pharmacotherapy; incretin-based treatments; bariatric surgery; lifestyle interventions; personalized medicine; metabolic syndrome

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Actinomycetes-Derived Natural Products

edited by Fong Tian Wong

submission deadline 20 Nov 2025 | Viewed by 104 | Submission Open

Keywords: actinomycetes; natural products; actinobacterial; genome mining; omics; secondary metabolites; genetic engineering; discovery; structural diversity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Tolerance to Stress

edited by

Xingguo Li

submission deadline 20 Nov 2025 | Viewed by 13 | Submission Open

Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications, 3rd Edition

edited by

Urszula Bazylinska

submission deadline 21 Nov 2025 | Viewed by 24 | Submission Open

Keywords: surfactants; disperse systems; colloids; nanoemulsions; lipid nanocarriers; polymeric nanocarriers; lyotropic liquid crystals; colloidal stability; drug delivery; self-organization; templating processes; encapsulation/solubilization processes; theranostics; nanohybrids

(This special issue belongs to the Section Macromolecules)

Hallmarks of Cancer: Emerging Insights and Innovations

edited by

Konstantinos Syrigos

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2732 | Submission Open

Keywords: proliferative signaling; growth suppression evasion; epigenetic reprogramming; immune system evasion; replicative immortality; inflammation and cancer; microbiome and cancer; invasion and metastasis; tumor microenvironment; cellular senescence; genomic instability; metabolic reprogramming; therapeutic resistance; molecular diagnostics; targeted cancer therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3151-3200 on page 64 of 67.

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