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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Challenges in Molecularly Imprinted Materials

edited by

Monika Sobiech

submission deadline 20 May 2025 | 1 articles | Viewed by 1453 | Submission Open

Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization

(This special issue belongs to the Section Materials Science)

The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases

edited by Berta Vázquez and Gerardo Ferrer

submission deadline 20 May 2025 | 1 articles | Viewed by 1447 | Submission Open

Keywords: chromatin; DNA damage; DNA repair; gene transcription; DNA replication; chromosome segregation; genome integrity; chromosome organization

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Epigenetic Regulation in Seed Development

edited by

Yifeng Wang

and Qingyun Bu

submission deadline 20 May 2025 | 2 articles | Viewed by 1418 | Submission Open

Keywords: seed development; molecular mechanism; epigenetic modification; gene function; genetic improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Phytochemicals: Molecular Mechanism Research on Antioxidants and Anti-Inflammatory Agents

edited by Shereen Basiouni

submission deadline 20 May 2025 | 1 articles | Viewed by 1418 | Submission Open

Keywords: phytochemicals; bioactive compounds; antioxidant; anti-inflammatory; mechanism of action

(This special issue belongs to the Section Biochemistry)

Pharmacological Treatment of Neuroinflammation

edited by Beatrice Polini

submission deadline 20 May 2025 | 1 articles | Viewed by 1378 | Submission Open

Keywords: microglia; neuroinflammation; neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; therapeutic; natural molecules

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Compounds and Enzyme Inhibitors in Cancer Therapy

edited by

Fabio Altieri

submission deadline 20 May 2025 | 1 articles | Viewed by 1340 | Submission Open

Keywords: bioactive compounds; enzyme inhibitors; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Plant Derived Anti-Cancer Bioactive Molecules

edited by Katarzyna Kotwica-Mojzych

submission deadline 20 May 2025 | 1 articles | Viewed by 1306 | Submission Open

Keywords: natural cell cycle inhibitors; novel anti-cancer bioactive compounds; bioactive antiapoptotic molecules; DNA targeting natural molecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Signal Transduction in the Nucleus

edited by Jaekyung Shim

submission deadline 20 May 2025 | 1 articles | Viewed by 1305 | Submission Open

Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation

(This special issue belongs to the Section Molecular Biology)

Antimicrobial Agents for Wound Healing

edited by Hanif Haidari and

Zlatko Kopecki

submission deadline 20 May 2025 | 1 articles | Viewed by 1288 | Submission Open

Keywords: antimicrobial agents; multifunctional hydrogels; wound healing; chronic wounds; biomaterials; wound dressings; nano-antibiotics; nanomaterials; tissue regeneration; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases

edited by

Hsin-Hou Chang

submission deadline 20 May 2025 | 1 articles | Viewed by 1259 | Submission Open

Keywords: infectious diseases; circulatory dysfunction; coagulation disorders; endothelial activation; platelet aggregation; anticoagulant therapy; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Germ Cell Research

edited by

Sheng-Hsiang Li

submission deadline 20 May 2025 | 2 articles | Viewed by 1245 | Submission Open

Keywords: spermatogenesis; sperm capacitation; oogenesis; oocyte maturation; cumulus cells; fertilization; gene expression; biomarkers; exosomes; infertility

(This special issue belongs to the Section Molecular Biology)

The Role of Purinergic Signaling in Human Health and Disease

edited by Andréia Machado Cardoso

submission deadline 20 May 2025 | 1 articles | Viewed by 1225 | Submission Open

Keywords: purinergic system; purinergic receptors; ectonucleotidases; biomolecular pathways; chronic diseases; infectuous diseases; health conditions

(This special issue belongs to the Section Molecular Biology)

Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Yosep Chong

submission deadline 20 May 2025 | 1 articles | Viewed by 1191 | Submission Open

Keywords: pathology; cytopathology; malignant effusions; biomarker; breast cancer; ovarian cancer; endometrial cancer; cervical cancer; metastasis; immunohistochemistry; immunocytochemistry; immunotherapy; genomics; proteomics; personalized medicine; prognosis and therapy; digital pathology; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Oncology)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 May 2025 | 2 articles | Viewed by 1143 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition

edited by

Vincent C. Lombardi

submission deadline 20 May 2025 | Viewed by 918 | Submission Open

Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances and Applications in Molecular Enzymology

edited by

Gustavo Molina

submission deadline 20 May 2025 | 1 articles | Viewed by 881 | Submission Open

Keywords: microbial enzymes; biosynthesis and bioengineering; drug development and targets; enzymes in the environment; engineered enzymes; enzymes in agri-food; enzymatic formulations; enzyme engineering; enzymes in biomedical sciences; green chemistry/technology; glycans; molecular evolution; nanocatalyst and nanotechnology; pharma enzymes; recombinant proteins production and purification; system and synthetic biology

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Extremophilic Bacteria and Their Potential Applications in Biotechnology

edited by

Sathiyaraj Srinivasan

submission deadline 20 May 2025 | 1 articles | Viewed by 873 | Submission Open

Keywords: extremophilic bacteria; molecular mechanisms; genomic analysis; transcriptomic responses; proteomic studies; metabolic adaptations; comparative analysis; regulatory networks; stress response systems; biotechnological applications; bioremediation; bioenergy; industrial bioprocesses

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Reproductive Physiology and Endocrinology

edited by

Kamil Gill

submission deadline 20 May 2025 | 2 articles | Viewed by 850 | Submission Open

Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Discovering Novel Bioactive Compounds Against Cancers

edited by

Chung-Pu Wu

submission deadline 20 May 2025 | 1 articles | Viewed by 841 | Submission Open

Keywords: bioactive compounds; cancer therapy; natural products; synthetic chemistry; computational techniques

(This special issue belongs to the Section Molecular Pharmacology)

Cardiac Repair and Regeneration: From Pathogenesis to Therapeutic Perspectives

edited by Marina Leone and Olaf Bergmann

submission deadline 20 May 2025 | Viewed by 787 | Submission Open

Keywords: heart regeneration; cardiomyocyte proliferation; cell cycle; ischemic heart disease; myocardial infarction; stem cells; cardiac repair; polyploidization; tissue engineering; immune cells; metabolism; cell death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Nitrogen Metabolism: Current Status and Future Directions

edited by

Pedro Piedras

submission deadline 20 May 2025 | Viewed by 767 | Submission Open

Keywords: nitrate; ammonium; amides; ureides; nitrogen fixation; reactive nitrogen species; nitrogen signalling; nitrogen molecules in response to stress; nitrogen molecules in mobilization situations; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Interleukin/Cytokines in Psychiatric Disorders

edited by

Kyosuke Yamanishi

submission deadline 20 May 2025 | Viewed by 710 | Submission Open

Keywords: interleukin; cytokines; psychiatric disorders; depression; anxiety; neuroinflammation; neurogenesis; molecular psychiatry; microglia; astrocyte; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies

edited by

Beatriz García-Díaz

, Alejandro Escamilla and

Raquel Sanchez-Varo

submission deadline 20 May 2025 | 1 articles | Viewed by 681 | Submission Open

Keywords: metabolism; therapy; mitochondria; pathogenesis; bioenergetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research in Prostate Cancer

edited by

Shafiq Khan

submission deadline 20 May 2025 | 1 articles | Viewed by 680 | Submission Open

Keywords: cell proliferation; cell migration and invasion; metastasis; growth factor; TGFβ ; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phytochemicals for Diabetes: Natural Plant-Based Therapies

edited by

Prawej Ansari

and

Yasser Abdel-Wahab

submission deadline 20 May 2025 | Viewed by 679 | Submission Open

Keywords: diabetes mellitus; pancreatic beta cells; insulin; glucose; obesity; insulin resistance; metabolism; nutrition; phytoconstituents; medicinal plants

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 20 May 2025 | Viewed by 657 | Submission Open

Keywords: cell adhesion; cell– cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Molecular Research and Potential Effects of Medicinal Plants

edited by

Guan-Jhong Huang

submission deadline 20 May 2025 | 2 articles | Viewed by 635 | Submission Open

Keywords: medicinal plants; natural products; disease treatment; drug screening; bioassays

(This special issue belongs to the Section Molecular Plant Sciences)

Neuromodulation in Neurological and Psychiatric Disorders: Clinical, Physiological and Molecular Evidence

edited by

Christian Saleh

submission deadline 20 May 2025 | Viewed by 624 | Submission Open

Keywords: neuromodulation; deep brain stimulation; transcranial magnetic stimulation; electroconvulsive therapy; vagus nerve stimulation; neurological disorders; psychiatric disorders; molecular mechanisms; safety

(This special issue belongs to the Section Molecular Neurobiology)

Electron Transport Mechanism in Optoelectronic Materials

edited by Paolo Umari

submission deadline 20 May 2025 | Viewed by 623 | Submission Open

Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport

(This special issue belongs to the Section Materials Science)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 May 2025 | Viewed by 621 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Complications of Pregnancy: The Importance of Omics-Based Diagnosis and Therapeutic Approaches

edited by

Alejandra Garcia-Gasca

submission deadline 20 May 2025 | 1 articles | Viewed by 605 | Submission Open

Keywords: pregnancy complications; epigenetics; omics; miRNA-based therapies; microbiome analysis; early diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fibrosis in Inflammation and Cancer

edited by

Antonio Gonzalez

submission deadline 20 May 2025 | Viewed by 590 | Submission Open

(This special issue belongs to the Section Molecular Oncology)

Uncovering the Basis of Plant Nutrient Uptake, Interactions and Homeostasis: Molecular Mechanisms and Their Applications

edited by

Alessio Aprile

submission deadline 20 May 2025 | Viewed by 575 | Submission Open

Keywords: nutrient transport; homeostasis; nutrient signaling and pathways; nitrogen use efficiency; acronutrients; micronutrients; plant nutrition

(This special issue belongs to the Section Molecular Plant Sciences)

Lipopolysaccharide in the Health and Disease

edited by

Gen-Ichiro Soma

and Hiroyuki Inagawa

submission deadline 20 May 2025 | Viewed by 572 | Submission Open

Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Mechanisms of Comorbidities in Rheumatic Diseases

edited by

Marino Paroli

submission deadline 20 May 2025 | Viewed by 568 | Submission Open

Keywords: inflammatory and autoimmune rheumatic diseases; comorbidities; autoimmunity; T-cell response

(This special issue belongs to the Section Molecular Immunology)

Deep Learning and Pathology: Innovative Applications in Cancer Diagnosis and Prognosis

edited by Nicolè Lorenzo

submission deadline 20 May 2025 | Viewed by 567 | Submission Open

Keywords: deep learning; pathology; digital pathology; tissue segmentation; cancer diagnosis; prognosis prediction; multi-dimensional analysis

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 May 2025 | 1 articles | Viewed by 563 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Plasma in Seed and Plant Treatment

edited by

Ricardo Molina

and

Karina Balestrasse

submission deadline 20 May 2025 | Viewed by 539 | Submission Open

Keywords: seed; plant; plasma; germination; dormancy; sterilization; reactive oxygen species; reactive nitrogen species; molecular mechanism; growth promotion; essential oils; plant stem cells; seed coating and pelleting

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Age-Related Cognitive Decline

edited by

Cristovam Wanderley Picanço Diniz

submission deadline 20 May 2025 | Viewed by 537 | Submission Open

Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes

(This special issue belongs to the Section Molecular Neurobiology)

New Research on Anti-Inflammatory Molecules in Diseases

edited by

Antonietta Rossi

and

Fiorentina Roviezzo

submission deadline 20 May 2025 | 1 articles | Viewed by 534 | Submission Open

Keywords: inflammation anti-inflammatory molecules natural products lipid mediators

(This special issue belongs to the Section Molecular Immunology)

Latest Advances in Nanoparticles for Modern Biomedicine (2nd Edition)

edited by

Sebastian Schwaminger

submission deadline 20 May 2025 | Viewed by 533 | Submission Open

Keywords: nanoparticles; nanotherapeutics; nanomedicine; biomedicine; selective targeting of nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Mutant p53 in Cancers

edited by Musaffe Tuna

submission deadline 20 May 2025 | Viewed by 521 | Submission Open

Keywords: mutant p53; cancer; tumor heterogeneity

(This special issue belongs to the Section Molecular Oncology)

Lipid Droplet–Mitochondria Interactions in Health and Disease

edited by Anton Petcherski

submission deadline 20 May 2025 | Viewed by 509 | Submission Open

Keywords: mitochondria; lipid droplets; metabolism; lipotoxicity; metabolically active tissue; triacylglycerides; fatty acid oxidation

(This special issue belongs to the Section Biochemistry)

Type 2 Diabetes: Molecular Pathophysiology and Treatment

edited by

Edit Szabó

submission deadline 20 May 2025 | 1 articles | Viewed by 505 | Submission Open

Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Powerhouse: Mitochondria in Health and Disease

edited by

Eltyeb Abdelwahid

submission deadline 20 May 2025 | Viewed by 489 | Submission Open

Keywords: mitochondria; targeted therapies; metabolism; ROS; bioenergetics; disease

(This special issue belongs to the Section Molecular Biology)

Signaling in GPCR Research

edited by

Zvi Naor

submission deadline 20 May 2025 | Viewed by 485 | Submission Open

Keywords: GPCR; G protein; signaling; drug design; cell surface receptors

(This special issue belongs to the Section Biochemistry)

Toxicants and Their Effects on Innate Immune Function and Inflammatory Response

edited by

James M. Harper

submission deadline 20 May 2025 | Viewed by 483 | Submission Open

Keywords: ecotoxicology; innate immunity; inflammation; pesticides; plasticizers; pattern-recognition receptors

(This special issue belongs to the Section Molecular Toxicology)

Macrophage Polarization and Human Inflammatory Diseases

edited by

Mary Cloud B. Ammons

submission deadline 20 May 2025 | Viewed by 482 | Submission Open

Keywords: macrophage polarization; inflammation; metabolic immunomodulation; epigenetics; in vitro models; in vivo models; diagnostics; therapeutics; infectious disease; metabolic disease

(This special issue belongs to the Section Molecular Pharmacology)

Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

edited by