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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 Jul 2025 | 6 articles | Viewed by 17057 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

State-of-the-Art Molecular Pharmacology in USA

edited by

Anastasios Lymperopoulos

William C. (Trey) Putnam

Khosrow Kashfi

Kamyar Zahedi

and

Gaetano Santulli

submission deadline 20 Jul 2025 | 4 articles | Viewed by 17050 | Submission Open

Keywords: signal transduction; receptor; animal models; preclinical; pharmacodynamics; pharmacokinetics; drug development; drug metabolism

(This special issue belongs to the Section Molecular Pharmacology)

Pro-inflammatory and Anti-inflammatory Interleukins in Various Diseases 2.0

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 20 Jul 2025 | 7 articles | Viewed by 15902 | Submission Open

Keywords: cytokines; inflammation; interleukins; IL-1; IL-2; IL-3; IL-4; IL-5; IL-6; IL-7; IL-8; IL-9; IL-10; IL-11; IL-12; IL-17; IL-18; IL-22; IL-37; IL-38; IFN-α ; IFN-β ; IFN-γ ; TGF-β ; TNF-α ; TNF-β ; allergy; TNF-α ; chemokines; interferon; gut inflammation; systemic inflammation; infection

(This special issue belongs to the Section Molecular Immunology)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases 2.0

edited by

Yasemin M. Akay

submission deadline 20 Jul 2025 | 7 articles | Viewed by 15589 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression

edited by Sonam Mittal

submission deadline 20 Jul 2025 | 6 articles | Viewed by 15533 | Submission Open

Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapies of Chronic Obstructive Pulmonary Disease

edited by

Marija Stankovic

submission deadline 20 Jul 2025 | 6 articles | Viewed by 15437 | Submission Open

Keywords: COPD; molecular mechanism; inflammation; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Dysbiosis in Chronic Diseases

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Jul 2025 | 5 articles | Viewed by 15155 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; microorganism; metabolites; clinical practices; prebiotics; probiotics

(This special issue belongs to the Section Molecular Microbiology)

Lung Cancers: An Update on Molecular Diagnostics and Therapy

edited by

Mariusz Chabowski

submission deadline 20 Jul 2025 | 6 articles | Viewed by 15124 | Submission Open

Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Peripheral Nerve Regeneration

edited by

Cinzia Fabrizi

submission deadline 20 Jul 2025 | 7 articles | Viewed by 14762 | Submission Open

Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth

(This special issue belongs to the Section Molecular Neurobiology)

Network Pharmacology: An Emerging Field in Drug Discovery

edited by

Weiwei Han

submission deadline 20 Jul 2025 | 10 articles | Viewed by 14401 | Submission Open

Keywords: network pharmacology; machine learning; databases; drug discovery; computer-aided drug design (CADD); data mining

(This special issue belongs to the Section Molecular Pharmacology)

New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 3rd Edition

edited by

Yutang Wang

and

Dianna Magliano

submission deadline 20 Jul 2025 | 7 articles | Viewed by 14351 | Submission Open

Keywords: cardiovascular disease; myocardial infarction; stroke; transient ischaemic attack; hypertension; diabetes mellitus; atherosclerosis; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Aryl Hydrocarbon Receptor in Immune Modulation

edited by

Jörg Lehmann

submission deadline 20 Jul 2025 | 5 articles | Viewed by 13880 | Submission Open

(This special issue belongs to the Section Biochemistry)

Mitochondrial Dysfunction in Autoimmune Diseases

edited by

Biji Theyilamannil Kurien

submission deadline 20 Jul 2025 | 1 articles | Viewed by 13759 | Submission Open

Keywords: autoimmune diseases; autoantibodies; autophagy; mitophagy; mitochondrial hyperpolarization; mitochondrial dysfunction; oxidative phosphorylation; oxidative damage; fatigue; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Medicinal Plants and Natural Products

edited by

Ana Paula Coelho Duarte

and

Ângelo Luís

submission deadline 20 Jul 2025 | 7 articles | Viewed by 13283 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Tomato Breeding and Molecular Research

edited by Silvana Grandillo,

Gianfranco Diretto

and

Maria Cammareri

submission deadline 20 Jul 2025 | 6 articles | Viewed by 13198 | Submission Open

Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 4th Edition

edited by

Grzegorz Wegrzyn

submission deadline 20 Jul 2025 | 8 articles | Viewed by 13066 | Submission Open

Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Steroid Biosynthesis and Metabolism

edited by Amanda C. Swart

submission deadline 20 Jul 2025 | 6 articles | Viewed by 12865 | Submission Open

Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neurometabolic Disorders in the Adults

edited by

Klary Niezen-Koning

and

Tom J. de Koning

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12732 | Submission Open

Keywords: Neurometabolic; Metabolic/biochemical pathways; Genetic defects; Pathological phenotypes

(This special issue belongs to the Section Molecular Neurobiology)

Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?

edited by

Dimitrios Kanakis

submission deadline 20 Jul 2025 | 5 articles | Viewed by 12729 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD）; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Cell Division: A Focus on Molecular Mechanisms

edited by Stefano Sechi and Antonino Colanzi

submission deadline 20 Jul 2025 | 9 articles | Viewed by 12637 | Submission Open

Keywords: cell cycle; cell division; post-translational modification (PTM); mitosis/meiosis; cell organelles; cytokinesis; membrane trafficking; disease; therapeutic target; model organisms

(This special issue belongs to the Section Molecular Biology)

Liver Diseases: From Molecular Basis to Potential Therapy

edited by

Giuliano Ramadori

submission deadline 20 Jul 2025 | 5 articles | Viewed by 12546 | Submission Open

Keywords: TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Molecular Mechanisms of Inflammatory Diseases

edited by

Vlatka Sotosek

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12383 | Submission Open

Keywords: immunity; inflammation; inflammatory disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gene Doping Control

edited by

Teruaki Tozaki

submission deadline 20 Jul 2025 | 5 articles | Viewed by 12328 | Submission Open

Keywords: cell therapy; cell doping; gene doping; gene editing; gene silencing; gene therapy; transgene; CRISPR; therapeutic oligonucleotide

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-Alcoholic Fatty Liver Disease (NAFLD): 2nd Edition

edited by

Eva Kassi

Ioannis Kyrou

and

Harpal S. Randeva

submission deadline 20 Jul 2025 | 7 articles | Viewed by 12013 | Submission Open

Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12011 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Immune-Inflammatory and Oxidative Stress Signaling Pathways Involved in Human Disorders

edited by

Alessio Ardizzone

and

Emanuela Esposito

submission deadline 20 Jul 2025 | 3 articles | Viewed by 11838 | Submission Open

Keywords: inflammation; neuroinflammation; immune system; oxidative stress

(This special issue belongs to the Section Molecular Immunology)

Neurotrophins: Roles and Function in Human Diseases 2.0

edited by

Marco Fiore

submission deadline 20 Jul 2025 | 4 articles | Viewed by 11786 | Submission Open

Keywords: neuroinflammation; brain; toxicology; cell growth; neurogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Sphingolipid Metabolism and Signaling in Health and Diseases

edited by Gergana M. Deevska

submission deadline 20 Jul 2025 | 5 articles | Viewed by 11528 | Submission Open

Keywords: ceramide; ceramide-1-phosphate; sphingosine; sphingosine-1-phosphate; sphingomyelin; glycosphingolipids; metabolic syndrome; obesity; diabetes; cancer; neurodegeneration; neuroinflammation; autoimmunity

(This special issue belongs to the Section Molecular Biology)

New Insights into the Effects of Microbiome-Derived Metabolites on Health and Disease

edited by Kinga Jaworska

submission deadline 20 Jul 2025 | 5 articles | Viewed by 11498 | Submission Open

Keywords: bacterial metabolites; short-chain fatty acids; trimethylamine N-oxide; gut microbiome; molecular pathways; intestinal barrier

(This special issue belongs to the Section Molecular Microbiology)

Advances in Cell Signaling Pathways and Signal Transduction

edited by Katsuhiko Muraki and

Susumu Ohya

submission deadline 20 Jul 2025 | 6 articles | Viewed by 11379 | Submission Open

Keywords: Ca2+ signaling; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell metabolism; cell senescence; protein phosphorylation/dephosphorylation; membrane trafficking; cell proliferation; differentiation; and apoptosis; cytokine/chemokine signaling

(This special issue belongs to the Section Biochemistry)

Plant Hormone Signaling

edited by

Ewa Muszyńska

and

Kinga Dziurka

submission deadline 20 Jul 2025 | 9 articles | Viewed by 11312 | Submission Open

Keywords: hormonal regulation; cross-talk between phytohormones and other metabolites; signaling; gene expression; defense mechanisms; abiotic and biotic stress; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 2nd Edition

edited by

Shanfa Lu

submission deadline 20 Jul 2025 | 9 articles | Viewed by 11171 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

Challenges and Future Perspectives in Treatment for Lung Cancer

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 20 Jul 2025 | 7 articles | Viewed by 11135 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery

(This special issue belongs to the Section Molecular Oncology)

Research in iPSC-Based Disease Models

edited by

Eric Deneault

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10787 | Submission Open

Keywords: iPSCs; disease model; organoid; gene editing; mutation correction; isogenic control

(This special issue belongs to the Section Molecular Biology)

Molecular Mediators of Exercise: Cross-Organ Communication Promoting Health and Combating Disease

edited by

Jan Bilski

and

Tomasz Brzozowski

submission deadline 20 Jul 2025 | 4 articles | Viewed by 10681 | Submission Open

Keywords: exercise physiology; adipokines; myokines; hepatokines; inter-organ communication; inflammation; insulin sensitivity; obesity; type 2 diabetes; gastrointestinal system; cardiovascular system; sarcopenia; aging; osteogenic regulation; neurological health; nutraceuticals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glycobiology in Human Health and Disease

edited by Katrin Mani

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10584 | Submission Open

Keywords: glycans and glycoconjugates; glycoproteins; proteoglycans; glycolipids; glycosylation including glycosyltransferases and glycosidases; carbohydrate and glycan metabolism; glycan structure; disease biomarkers; glycan signaling; glycoimmunology; glycomics

(This special issue belongs to the Section Macromolecules)

Advances in Research on Neurotransmitters

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 20 Jul 2025 | 5 articles | Viewed by 10345 | Submission Open

Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Endothelial Dysfunction and Cardiovascular Diseases

edited by

Olga Kruszelnicka

submission deadline 20 Jul 2025 | 4 articles | Viewed by 10340 | Submission Open

Keywords: chemokines; cytokines; leukocyte trafficking; leukocyte attracting; leukocyte-derived cytokines; nitric oxide; prostacyclin; adhesion molecules; endothelium

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Kidney Injury and Repair

edited by

Rossana Franzin

submission deadline 20 Jul 2025 | 5 articles | Viewed by 10219 | Submission Open

Keywords: kidney injury; renal repair; acute kidney injury (AKI); chronic kidney disease (CKD); sepsis; ischemia-reperfusion (I/R) injury; nephrotoxin exposition; adult renal progenitor cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Head and Neck and Skin Cancer

edited by

Nerina Denaro

Gianluca Nazzaro

and Iorio Giuseppe Carlo

submission deadline 20 Jul 2025 | 3 articles | Viewed by 10207 | Submission Open

Keywords: head and neck cancer; melanoma; nonmelanoma skin cancer; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Organic/Inorganic Nanocomposites on the Basis of 'Three Pillars' (Organic Compounds, Metal Nanoparticles, and Carbon Nanomaterials)

edited by

Tamara Basova

submission deadline 20 Jul 2025 | 7 articles | Viewed by 10177 | Submission Open

Keywords: organic/inorganic composites; hybrid materials; composite materials; organic films; polymers; aromatic molecules; metal nanoparticles; carbon nanomaterials; carbon nanotubes; graphene

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition

edited by

Catherine Davis

submission deadline 20 Jul 2025 | 5 articles | Viewed by 10154 | Submission Open

Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Immunology)

A Molecular Perspective on Reproductive Health, 2nd Edition

edited by

Maria Montserrat Rivera Del Álamo

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9841 | Submission Open

Keywords: reproductive function; molecular bases; male; female; reproductive pathology; reproductive physiology

(This special issue belongs to the Section Biochemistry)

Cardiovascular Diseases: Histopathological and Molecular Diagnostics

edited by

Simona Gurzu

submission deadline 20 Jul 2025 | 7 articles | Viewed by 9673 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Roles of Epithelial and Endothelial Cells

edited by

Lucie Germain

and

Stéphanie Proulx

submission deadline 20 Jul 2025 | 7 articles | Viewed by 9646 | Submission Open

Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier

(This special issue belongs to the Section Biochemistry)

Metal-Based Drugs and Research on Mechanisms of Action

edited by

Elena K. Beloglazkina

submission deadline 20 Jul 2025 | 3 articles | Viewed by 9334 | Submission Open

Keywords: transition metals; metal complexes; metallodrugs; drug development; synthesis; imaging agents; structure– activity ratio

(This special issue belongs to the Section Molecular Pharmacology)

Natural Products in Cancer Prevention and Treatment

edited by

Simona Serini

and

Gabriella Calviello

submission deadline 20 Jul 2025 | 7 articles | Viewed by 9332 | Submission Open

Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Viral Infections and Host Immune Responses

edited by

Barbara Ridolfi

and Maria Teresa Maggiorella

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9188 | Submission Open

Keywords: virus infections; virus– host interaction; innate immunity; adaptive immunity; host factors; co-infections; acute and chronic infections; restriction factors; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery

edited by Fei Guo

submission deadline 20 Jul 2025 | 7 articles | Viewed by 9183 | Submission Open

Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications

(This special issue belongs to the Section Molecular Informatics)

Versatility of Protein Synthesis in a Test Tube

edited by

Tamás Mészáros

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9167 | Submission Open

Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 151-200 on page 4 of 68.

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