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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Signaling and Stress Adaptation in Plants

edited by

Kangdi Hu

and

Yi Han

submission deadline 20 May 2025 | 7 articles | Viewed by 4260 | Submission Open

Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Renal Dysfunction, Uremic Compounds, and Other Factors (3rd Edition)

edited by

Giovana S. Di Marco

and

Marcus Brand

submission deadline 20 May 2025 | 3 articles | Viewed by 4244 | Submission Open

Keywords: renal dysfunction; acute kidney disease; chronic kidney disease; soluble mediators; uremic toxins; disease progression; organ cross-talk; therapy; new techniques

(This special issue belongs to the Section Molecular Toxicology)

Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition)

edited by

Qichang Yang

and

Byoung Ryong Jeong

submission deadline 20 May 2025 | 4 articles | Viewed by 4233 | Submission Open

Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake

(This special issue belongs to the Section Molecular Plant Sciences)

Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition

edited by

Balik Dzhambazov

submission deadline 20 May 2025 | 2 articles | Viewed by 4212 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovation in Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Helena Felgueiras

submission deadline 20 May 2025 | 1 articles | Viewed by 4119 | Submission Open

Keywords: natural and synthetic polymers; bioactive agents; antimicrobial activity; regenerative properties; tissue regeneration; biocompatibility; biodegradation; tissue integration

(This special issue belongs to the Section Materials Science)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 20 May 2025 | 2 articles | Viewed by 4061 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Caenorhabditis elegans: A Model Organism for Human Health and Disease

edited by Andreia Teixeira-Castro

submission deadline 20 May 2025 | 4 articles | Viewed by 4060 | Submission Open

Keywords: human physiology; human disease; therapy; novel C. elegans methods; novel C. elegans models; disease models

(This special issue belongs to the Section Molecular Biology)

Novel Molecular Research on Natural Bioactive Compounds in Human Health

edited by

Antonio Palumbo Piccionello

submission deadline 20 May 2025 | 2 articles | Viewed by 3991 | Submission Open

Keywords: aromatic heterocycles; bioactive compounds; drug design; natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on the Drug Toxicity

edited by

Annagiulia Di Trana

submission deadline 20 May 2025 | 2 articles | Viewed by 3988 | Submission Open

Keywords: drug toxicity; new psychoactive substances; toxicology; drug metabolism; drug intoxication

(This special issue belongs to the Section Molecular Toxicology)

Advances in Synaptic Transmission and Plasticity

edited by

Manuela Dicarlo

submission deadline 20 May 2025 | 2 articles | Viewed by 3888 | Submission Open

Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases

(This special issue belongs to the Section Molecular Neurobiology)

FTIR Miscrospectroscopy: Opportunities and Challenges

edited by Simona Sabbatini

submission deadline 20 May 2025 | 2 articles | Viewed by 3819 | Submission Open

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Molecular Dynamics Simulation of Chemical and Biomedical Systems

edited by

Sandra Nunes

Tânia Cova

and

Carla Vitorino

submission deadline 20 May 2025 | 2 articles | Viewed by 3746 | Submission Open

Keywords: molecular dynamics simulation; chemical and biomedical systems; molecular-level processes; protein structures; drug binding mechanisms; biomolecular behavior; drug design; biomedicine materials

(This special issue belongs to the Section Molecular Informatics)

Extreme Biocatalysts: From Basic Research to Biotechnological Applications 2.0

edited by

Salvatore Fusco

submission deadline 20 May 2025 | 2 articles | Viewed by 3730 | Submission Open

Keywords: whole-cell biocatalysts; extremozymes; enzyme assays; protein engineering; extremophiles

(This special issue belongs to the Section Biochemistry)

Molecular Research on Nanotoxicology

edited by

Oleg Lunov

submission deadline 20 May 2025 | 2 articles | Viewed by 3640 | Submission Open

Keywords: nanotoxicology; nanodrugs; nanoparticles; adverse drug reactions; cytotoxicity

(This special issue belongs to the Section Molecular Nanoscience)

Regulation and Activation of Immune Cells through the Mitochondria

edited by

Špela Konjar

submission deadline 20 May 2025 | 2 articles | Viewed by 3619 | Submission Open

Keywords: mitophagy in immune cells; autophagy and mitochondria in immune cells; fission and fusion of mitochondria in immune cells; oxphos and mitochondria in immune cells; glycolysis and mitochondria in immune cells; tissue residency of immune cells and their mitochondria; tumor infiltrating lymphocytes and their mitochondria; mitochondria in inflammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by

Miguel Hueso

and

Alfredo Vellido

submission deadline 20 May 2025 | 1 articles | Viewed by 3609 | Submission Open

Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning

(This special issue belongs to the Section Molecular Informatics)

Arteriogenesis, Angiogenesis and Vascular Remodeling, 2nd Edition

edited by

Paul Quax

and

Elisabeth Deindl

submission deadline 20 May 2025 | 2 articles | Viewed by 3578 | Submission Open

Keywords: arteriogenesis; angiogenesis; collateral formation; peripheral arterial disease; vascular remodeling; atherosclerosis; restenosis; intimal hyperplasia; vein grafting; cardiovascular diseases; cell and gene therapy; critical limb ischemia; therapeutic angiogenesis; collateral circulation; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone/Receptor System in Human Diseases

edited by

Elena Zocchi

submission deadline 20 May 2025 | 2 articles | Viewed by 3561 | Submission Open

Keywords: characteristics of hormones; mechanisms of hormone action; structure; subunits and complexes of receptors; receptor function; expression and regulation; hormone/receptor signaling; interactions between receptors and hormones

(This special issue belongs to the Section Molecular Pharmacology)

Role of Mitochondria in Cancer

edited by Hirofumi Arakawa, Takeshi Uchiumi and

Manabu Futamura

submission deadline 20 May 2025 | 2 articles | Viewed by 3529 | Submission Open

Keywords: metabolism; apoptosis; fusion and fission; mitochondrial DNA; mitochondrial RNA; mitochondrial proteins; mitophagy; lipid; cardiolipin; phase separation; oxidative phosphorylation; proteostasis; mitochondrial quality control; TFAM; anti-cancer drug; imaging; cancer therapy; cancer diagnosis; Warburg effect

(This special issue belongs to the Section Molecular Oncology)

Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition

edited by

Rüdiger Greinert

submission deadline 20 May 2025 | 2 articles | Viewed by 3484 | Submission Open

Keywords: epigenetics; cancer stem cells; noncoding RNA (miRNA); personalized diagnostic (medicine); personalized medicine; DNA repair; skin cancer biomarker; skin cancer prevention; genomics; transcriptomics; immunomodulation; ctDNA; circulating tumor cells; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances and Perspectives in Rheumatic Diseases

edited by

Luciana Breda

submission deadline 20 May 2025 | 2 articles | Viewed by 3447 | Submission Open

Keywords: rheumatic diseases; molecular biology; inflammatory pathways; cytokines; molecular diagnostics; biologics; drug development; genetic factors; epigenetics; environmental influences

(This special issue belongs to the Section Molecular Immunology)

Small Cell Lung Cancer Entering the Sphere of Personalized Treatment

edited by

Anna Grenda

, Michał Szczyrek and Izabela Chmielewska

submission deadline 20 May 2025 | 2 articles | Viewed by 3425 | Submission Open

Keywords: small cell lung cancer; SCLC; pathological subtypes; molecular subtypes; DNA; RNA; NGS; next-generation sequencing transcriptome; mutations; molecular analysis

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Melanoma Therapy

edited by

Terrence Piva

submission deadline 20 May 2025 | 1 articles | Viewed by 3405 | Submission Open

Keywords: melanoma; anti-cancer; immunotherapy; targeted therapy; signaling pathway; Polyphenolic compounds; cannabinoids; pharmacotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Bioactive Compounds: Antioxidant, Anti-inflammatory and Anticancer Effects

edited by

Dana Maria Copolovici

submission deadline 20 May 2025 | 2 articles | Viewed by 3344 | Submission Open

Keywords: anticancer; antioxidant; anti-inflammatory; bioactive compounds; chemical biology; molecular biology; metabolic diseases; nutrition.

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathology and Treatment of Neuromuscular Disease

edited by Christopher Nelke and Christina B. Schroeter

submission deadline 20 May 2025 | 1 articles | Viewed by 3313 | Submission Open

Keywords: complements; myasthenia gravis; neuromuscular diseases; neuromuscular junction; hereditary disorders; amyotrophic lateral sclerosis; personalized treatments

(This special issue belongs to the Section Molecular Neurobiology)

Editorial Board Members’ Collection Series: “Protein Biophysics”

edited by

Vladimir N. Uversky

and

Assaf Friedler

submission deadline 20 May 2025 | 2 articles | Viewed by 3210 | Submission Open

Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics)

Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation

edited by Rossana Scuri

submission deadline 20 May 2025 | 2 articles | Viewed by 3202 | Submission Open

Keywords: arteriolar networks organization; blood flow supply; cardiovascular disease; endothelial dysfunction; eNOS regulatory activity; oxidative stress; polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Alzheimer’s Disease Treatment: Exploring Novel Approaches and Strategies

edited by

Sunmin Park

submission deadline 20 May 2025 | 2 articles | Viewed by 3185 | Submission Open

Keywords: Alzheimer’ s disease; bioinformatics; novel compounds; in vitro; in vivo; clinical study; Alzheimer’ s disease models

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 20 May 2025 | 2 articles | Viewed by 3138 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Catalytic Materials (Second Edition)

edited by

Julio Macedo

submission deadline 20 May 2025 | 3 articles | Viewed by 3138 | Submission Open

Keywords: synthetic routes; nanomaterials; catalysis; sustainability; biomass; biofuel; photocatalysis; fine chemistry

(This special issue belongs to the Section Materials Science)

Natural Products in Drug Discovery and Development

edited by Tian-Le Gao

submission deadline 20 May 2025 | 4 articles | Viewed by 3122 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

New Perspective on Inflammatory Diseases: Role of Natural Compounds

edited by

Floriana D'Angeli

Carlo Genovese

and

Cristina Russo

submission deadline 20 May 2025 | 2 articles | Viewed by 3103 | Submission Open

Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cytokines in Inflammation and Health

edited by

Jörg Hermann Fritz

submission deadline 20 May 2025 | 3 articles | Viewed by 3087 | Submission Open

Keywords: cytokines; inflammation; ageing; cancer; obesity; novel therapies

(This special issue belongs to the Section Molecular Immunology)

Food Science and Molecular Nutrition

edited by

Hsinjung Ho

submission deadline 20 May 2025 | 1 articles | Viewed by 3079 | Submission Open

Keywords: food science; antioxidants; bioactive compounds; mitochondria; nutrigenomics; metabolomics

(This special issue belongs to the Section Biochemistry)

Cell and Molecular Perspectives in Breast Cancer

edited by Seungbaek Lee

submission deadline 20 May 2025 | 1 articles | Viewed by 3071 | Submission Open

Keywords: breast cancer; molecular biology; cell biology; biomarker; novel therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroplasticity Unveiled: Mechanisms across Neural Networks

edited by Irina I. Stoyanova

submission deadline 20 May 2025 | 1 articles | Viewed by 3070 | Submission Open

Keywords: neuroplasticity; extended reality; cognitive neuroscience; molecular neurobiology; neurodegeneration; brain development; neural networks; synaptic plasticity; neurorehabilitation; neuroadaptive changes

(This special issue belongs to the Section Molecular Neurobiology)

Neuro-Molecular Pathogenetic Mechanisms of Sudden Infant Death Syndrome (SIDS) and Other Infant Neurodevelopmental Disorders

edited by

Anna Maria Lavezzi

submission deadline 20 May 2025 | 2 articles | Viewed by 3045 | Submission Open

Keywords: congenital central hypoventilation syndrome (CCHS); cyclin-dependent kinase-like 5 (CDKL5)) deficiency disorder; GRIN1-related neurodevelopmental disorder ; SIDS; neuropathology; neurodevelopmental alterations; genetic polymorphisms; mutations; pollutants; Pitt-Hopkins syndrome; Rett syndrome; risk factors

(This special issue belongs to the Section Molecular Neurobiology)

Natural and Synthetic Biomaterials in Biomedical Applications

edited by

Adina Magdalena Musuc

submission deadline 20 May 2025 | 2 articles | Viewed by 3044 | Submission Open

Keywords: biocompatibility; biodegradability; tissue engineering; regenerative medicine; drug delivery systems; nanostructured biomaterials; hybrid and composite biomaterials; smart biomaterials; innovative fabrication techniques

(This special issue belongs to the Section Materials Science)

New Advances in Thrombosis: 3rd Edition

edited by

Isabella Russo

submission deadline 20 May 2025 | 4 articles | Viewed by 3013 | Submission Open

Keywords: thrombosis; platelets; coagulation; diabetes; obesity; insulin resistance; metabolic disease; cardiovascular diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adsorption Mechanism of Novel Porous Materials in Wastewater Treatment, 2nd Edition

edited by

Anna Deryło-Marczewska

submission deadline 20 May 2025 | 3 articles | Viewed by 2972 | Submission Open

Keywords: porous materials; nanominerals; adsorption mechanism; metal– organic framework materials; heavy metals; organic contaminants; pharmaceuticals; molecular simulation; morphology

(This special issue belongs to the Section Materials Science)

Quantum Dots for Biomedical Applications

edited by

Shanmugavel Chinnathambi

submission deadline 20 May 2025 | 2 articles | Viewed by 2970 | Submission Open

Keywords: quantum dots; molecular imaging; tissue imaging: biosensing; medical diagnosis; drug delivery

(This special issue belongs to the Section Materials Science)

Roles of Migration and Invasion in Cancer Metastasis

edited by

Kyung-Chul Choi

submission deadline 20 May 2025 | 1 articles | Viewed by 2946 | Submission Open

Keywords: cancer; metastasis; invasion; migration; tumor microenviornment; epithelial– mesenchymal transition; mesenchymal– epithelial transition; intravasation; extravasation

(This special issue belongs to the Section Molecular Oncology)

Embryonic Development and Differentiation: 2nd Edition

edited by

László Márk

submission deadline 20 May 2025 | 2 articles | Viewed by 2898 | Submission Open

Keywords: blastocyte; embryogenesis; endometrium; implantation; in vitro fertilization (IFV); ICSI; oocyte; pregnancy; seminal plasma; sperm

(This special issue belongs to the Section Molecular Biology)

The Molecular Link Between Nutrition and Obesity

edited by

Elena Azzini

submission deadline 20 May 2025 | 2 articles | Viewed by 2860 | Submission Open

Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Antioxidants in Human Health and Disease, 2nd Edition

edited by

María Herranz-López

submission deadline 20 May 2025 | 1 articles | Viewed by 2859 | Submission Open

Keywords: ROS; oxidative disorders; molecular pathways; inflammation; biotransformation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Heart Diseases: Molecular Pathogenesis, Biomarkers and Therapies

edited by

Nadia Aspromonte

submission deadline 20 May 2025 | 2 articles | Viewed by 2840 | Submission Open

Keywords: heart diseases; biomarkers; molecular pathways; personalized medicine; interventional therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Multiple Sclerosis

edited by Yoshio Bando

submission deadline 20 May 2025 | 3 articles | Viewed by 2804 | Submission Open

Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Materials: State-of-the-Art Research and Development Prospects

edited by

Alina Maria Holban

submission deadline 20 May 2025 | 3 articles | Viewed by 2797 | Submission Open

Keywords: nanobiomaterials; antibacterial materials; anticancer nanomaterials; wound dressings; coatings for bioactive implants; molecular imaging; nanosensors

(This special issue belongs to the Section Materials Science)

Brain Metastasis 2025

edited by

Dario Marchetti

submission deadline 20 May 2025 | 1 articles | Viewed by 2776 | Submission Open

Keywords: brain metastasis; brain microenvironment; pathology; circulating tumor cells; tumor-normal cell crosstalks; new biomarkers and therapies for brain metastasis; cerebral spinal fluid/liquid biopsy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biopolymers for Enhanced Health Benefits—2nd Edition

edited by

Leonard-Ionut Atanase

submission deadline 20 May 2025 | 2 articles | Viewed by 2702 | Submission Open

Keywords: nanocomposites; biomedical materials; stimuli-responsive materials; wound healing; biomaterials; tissue engineering; regenerative medicine; targeted and controlled drug delivery; in vitro and in vivo biological activities; polymers for biomedical application; surface modification and their characterization; antibacterial & antiviral; microbial biofilms; medical-related antimicrobial/antiviral polymers

(This special issue belongs to the Section Macromolecules)

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