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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunological Regulation as Determinant of Outcomes in Critically Sick Patients

edited by

Krzysztof Laudanski

submission deadline 20 Sep 2025 | Viewed by 96 | Submission Open

Keywords: critical illness; outcome; immune system; inflammation; homeostasis; epigenetic; microbiome; central nervous system; dysregulation; recovery

(This special issue belongs to the Section Molecular Immunology)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 20 Sep 2025 | Viewed by 84 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Transcription Factors in Cancer

edited by

Tomasz Wilanowski

submission deadline 20 Sep 2025 | Viewed by 81 | Submission Open

Keywords: transcription factor; oncogene; tumor suppressor; nuclear receptor; genetic regulation; post-translational regulation; biomarker; drug target

(This special issue belongs to the Section Molecular Oncology)

The Future of Biomaterials in Dentistry: Innovations in Drug Delivery and Regenerative Medicine

edited by

Victor Martin

submission deadline 20 Sep 2025 | Viewed by 78 | Submission Open

Keywords: dentistry; regenerative medicine; drug delivery; tissue engineering; biomaterials; tooth; periodontal

(This special issue belongs to the Section Materials Science)

The Role of Medicinal Plants in the Treatment of Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives

edited by

Katarzyna E. Stȩpnik

submission deadline 20 Sep 2025 | Viewed by 77 | Submission Open

Keywords: medicinal plants; neuroprotection; neurodegeneration; plant secondary metabolites; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanosensitive Ion Channels in the Nervous System

edited by

Rashid Giniatullin

submission deadline 20 Sep 2025 | Viewed by 73 | Submission Open

Keywords: mechanosensitive ion channels; Piezo1; Piezo2; mechanosensitive K2P channels; mechanical pain; pulsating blood flow; tissue stiffness; mechanobiology of glymphatic system; chemical agonists of mechanosensitive channels; mechanosensitive TRP channels; neuron; glial cells

(This special issue belongs to the Section Molecular Neurobiology)

Targeting Tyrosine Kinase Receptors in Cancer: Mechanisms, Resistance and Therapeutic Advances

edited by

Athina-Myrto Chioni

and

Richard Grose

submission deadline 20 Sep 2025 | Viewed by 67 | Submission Open

Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Damage to Plants and Microorganisms Caused by Heavy Metal Toxicity

edited by

Xiaomeng Chen

submission deadline 20 Sep 2025 | Viewed by 64 | Submission Open

Keywords: metal; oxidative stress; stress response; molecular function; gene regulation; metabolic regulation; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

RNA in Biology and Medicine (2nd Edition)

edited by

Roberto Patarca

and William A. Haseltine

submission deadline 20 Sep 2025 | Viewed by 57 | Submission Open

Keywords: noncoding RNAs; coding RNAs; RNA-based therapy; RNA vaccine; RNA structure; RNA function

(This special issue belongs to the Section Molecular Biology)

Genetic and Molecular Susceptibility in Human Diseases: 3rd Edition

edited by

Roberto Madeddu

submission deadline 20 Sep 2025 | Viewed by 53 | Submission Open

Keywords: genetic susceptibility; proteomics; gene expression; apoptosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Reproduction and Reproductive Diseases

edited by

Sung Tae Kim

submission deadline 22 Sep 2025 | Viewed by 111 | Submission Open

Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products in Lifestyle-Related Diseases: Molecular Mechanisms, Prevention and Treatments

edited by

Takanobu Takata

submission deadline 25 Sep 2025 | 3 articles | Viewed by 4051 | Submission Open

Keywords: natural products; crude drugs; lifestyle-related diseases; diabetes mellitus; cardiovascular disease; non-alcoholic hepatosteatosis; cancer; sarcopenia; Alzheimer’ s disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Periodontal Disease, Association with Systemic Conditions and Periodontal Pathogens: 2nd Edition

edited by Evangelos Papathanasiou

submission deadline 25 Sep 2025 | 2 articles | Viewed by 1781 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal medicine; periodontal– systemic interactions; immune response; periodontal pathogens

(This special issue belongs to the Section Molecular Immunology)

Antitumor Activity of Natural Products

edited by

Spiro Mihaylov Konstantinov

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1313 | Submission Open

Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Neurodegeneration

edited by

Oscar Arias-Carrión

submission deadline 25 Sep 2025 | 1 articles | Viewed by 901 | Submission Open

Keywords: neurodegeneration; molecular mechanisms; protein aggregation; neuroinflammation; oxidative stress; mitochondrial dysfunction; Alzheimer’ s disease; Parkinson’ s disease; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Accelerating Therapeutic Innovation: Advances in Computer-Aided Drug Discovery

edited by Pietro Delre and

Antonio Lavecchia

submission deadline 25 Sep 2025 | 1 articles | Viewed by 486 | Submission Open

Keywords: CADD; drug discovery; machine learning; virtual screening; drug-target interaction

(This special issue belongs to the Section Molecular Informatics)

Unveiling Molecular Mysteries of Brain Barriers

edited by Ana Catarina Duarte

submission deadline 25 Sep 2025 | Viewed by 143 | Submission Open

Keywords: blood– brain barrier; blood– cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Epigenetic Mechanisms in Cognition

edited by Sabrina Venditti

submission deadline 25 Sep 2025 | Viewed by 122 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; noncoding RNAs; cognition; learning and memory; neuroplasticity; neurodegeneration; ASD; training

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Magnetic Materials: Synthesis, and Applications

edited by Artur Chrobak

submission deadline 25 Sep 2025 | Viewed by 101 | Submission Open

Keywords: magnetic materials; properties; synthesis; applications

(This special issue belongs to the Section Materials Science)

Biomarker Discovery in Oral Diseases: Integrating Connected Health and Digital Biomarkers for Advanced Diagnostics and Personalized Care

edited by

Shahnawaz Khijmatgar

submission deadline 25 Sep 2025 | Viewed by 84 | Submission Open

Keywords: oral diseases; biomarker; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Metabolic Dependencies of the Influence of Intestinal Microbiota During Pregnancy, Childbirth and Infancy

edited by Małgorzata Szczuko and Maciej Ziętek

submission deadline 25 Sep 2025 | Viewed by 43 | Submission Open

Keywords: microbiota; dysbiosis; intestinal microbiome; LPS; zonulin; calprotectin; occludin; SCFA; citrulline; glucagon-like peptide (GLP)-2; LPS binding protein (LBP); amyloid A; intestinal leakage

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Amino Acid Nutrition and Human Health

edited by

Terrence Piva

submission deadline 28 Sep 2025 | Viewed by 67 | Submission Open

Keywords: amino acids; dietary intake; metabolic disease; starvation; obesity; supplementation; parental nutrition; gene expression; tumour metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Advances in Oxidative Stress and Brain Injury

edited by

Vittorio Fineschi

submission deadline 28 Sep 2025 | Viewed by 54 | Submission Open

Keywords: measurement of ROS; pathology of brain injuries; traumatic brain injuries; hypoxic– ischemic brain damage; experimental models of brain injury; targeted therapy of brain injuries; drug abuse and ROS; histological diagnosis of brain injuries; epigenetics of brain injuries; miRNA and prognosis of neural damage; novel approaches and proofs of principle in therapy; quality of life after brain injury

(This special issue belongs to the Section Molecular Neurobiology)

Health Impacts of Environmental Pollution on the Urogenital and Reproductive Systems

edited by

Anna Perri

and

Silvestro Antonio Ruffolo

submission deadline 28 Sep 2025 | Viewed by 43 | Submission Open

Keywords: pollution; endocrine toxicity; endocrine disruptors; human biomonitoring; infertility; cancer; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Breeding: High-Yield and Quality, Stress-Resistant Trait Genetic Improvement and Application

edited by Juwu Gong

submission deadline 29 Sep 2025 | 1 articles | Viewed by 534 | Submission Open

Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization

(This special issue belongs to the Section Molecular Plant Sciences)

Current Research for Heart Disease Biology and Therapeutics (Third Edition)

edited by Claudia Kusmic

submission deadline 29 Sep 2025 | Viewed by 136 | Submission Open

Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pharmacology of Cardiovascular Disease, 2nd Edition

edited by

Ada Popolo

submission deadline 30 Sep 2025 | 4 articles | Viewed by 15464 | Submission Open

Keywords: heart failure; internal medicine; cardiovascular disease; metabolic syndrome; pharmacology; cardiology; pharmacodynamics

(This special issue belongs to the Section Molecular Pharmacology)

The Serum Amyloid A (SAA) Family: (Patho)Physiological Functions in (Non)Mammalian Systems

edited by

Ernst Malle

and

János G. Filep

submission deadline 30 Sep 2025 | 5 articles | Viewed by 11605 | Submission Open

Keywords: Serum Amyloid A in (Non)Mammalian systems; phylogenetic overview of different SAA isoforms; expression of SAA1-4 on mRNA and protein level; comparison of SAA with other acute-phase reactants; role of SAA during normal development and inflammation; role of SAA in cancer and other malignancies; potential role of SAA as a suitable biomarker during disease progression

(This special issue belongs to the Section Biochemistry)

Novel Concepts, New Perspectives, and Current Therapies for Parkinson’s Disease: 2nd Edition

edited by

Malgorzata Zaremba

submission deadline 30 Sep 2025 | 7 articles | Viewed by 11518 | Submission Open

Keywords: Parkinson’ s disease; therapy; drug; repurposing; novel compound; neurodegeneration; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Skeletal Muscle Diseases

edited by

Olga Karpicheva

and

Yurii Borovikov

submission deadline 30 Sep 2025 | 5 articles | Viewed by 9075 | Submission Open

Keywords: muscle contraction; calcium regulation; desease-causing mutations; cross-bridge cycling and kinetics; thin filament; ATPase activity; actin– myosin interaction; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Progress of Molecular Biology and Physiology in Lepidopteran Insects

edited by

Hiroko Tabunoki

and

Satomi Adegawa

submission deadline 30 Sep 2025 | 7 articles | Viewed by 8822 | Submission Open

Keywords: silkworm; Bombyx mori; Lepidopteran insects; molecular biology; physiology; genome analysis; mode of action; genome editing

(This special issue belongs to the Section Molecular Biology)

Natural Products with Anti-Inflammatory and Anticancer Activity

edited by

Jacek Tabarkiewicz

submission deadline 30 Sep 2025 | 4 articles | Viewed by 7163 | Submission Open

Keywords: natural products; medicinal plants; inflammation; cancer; malignant tumour; anti-inflammatory; anti-cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gynecologic Diseases: From Molecular Basis to Therapy

edited by Domenico Baldini

submission deadline 30 Sep 2025 | 2 articles | Viewed by 6345 | Submission Open

Keywords: infertility; sterility; gynecologic desease; genetic; IVF; gynecologic therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rice Molecular Breeding and Genetics: 3rd Edition

edited by

Deyong Ren

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5274 | Submission Open

Keywords: molecular genetics and breeding; cell biology; genetic resource innovation; gene cloning; genome editing; abiotic stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Combination Therapies for the Solid Cancers Treatment

edited by

Anne Mary Noonan

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4614 | Submission Open

Keywords: solid cancer; breast cancer; lung cancer; prostate cancer; colorectal cancer; therapeutic efficacy; drug resistance; genetic mutation; tumor microenvironment; immunotherapies; novel combination therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition

edited by

Klaus H. Hoffmann

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4272 | Submission Open

Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology

(This special issue belongs to the Section Molecular Immunology)

Advanced Research in Retina: 3rd Edition

edited by

Juan J. Salazar

and

José A. Fernández-Albarral

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3127 | Submission Open

Keywords: glaucoma; age-related macular degeneration; diabetic retinopathy; neurodegenerative diseases; diagnostic techniques; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Targeted Therapy for Gliomas

edited by Ka-Kit Leung

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2692 | Submission Open

Keywords: targeted therapy; glioma and glioblastoma; treatment strategies; identification of biomarkers; diagnosis; prognosis; molecular pathology; signalling pathways; molecular imaging; tumour microenvironment

(This special issue belongs to the Section Molecular Oncology)

Evolution and Genomics: Relevance to Current Issues

edited by

Roger Dawkins

and Sally Lloyd

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2684 | Submission Open

Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Glioblastoma: From Molecular Mechanisms to Therapies

edited by Lata Adnani

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2629 | Submission Open

Keywords: glioblastoma; heterogeneity; tumor microenvironment; therapy resistance; immunotherapy; extracellular vesicles; biomarkers; vascular endothelial cells; pericytes; blood– brain barrier

(This special issue belongs to the Section Molecular Oncology)

Bioactive Compounds from Natural Products for the Prevention and Treatment of Chronic Diseases, 3rd Edition

edited by

Dong-Sung Lee

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2536 | Submission Open

Keywords: natural products; natural products isolation; bioactive natural compounds; inflammation; neurodegenerative diseases; skin diseases; cancer; metabolic syndrome; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition)

edited by

Vassilis Athanasiadis

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2168 | Submission Open

Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Repurposing in Rare Diseases: From Molecular Insights to Patient Benefits

edited by Claudia Fuchs

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2072 | Submission Open

Keywords: rare diseases/rare genetic diseases; drug repurposing/repositioning; molecular insights; shared molecular pathways; preclinical trials; case studies

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Erythrocyte Biology and Functions

edited by

Francesco Misiti

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1802 | Submission Open

Keywords: erythrocyte; red blood cells; red blood functions; vascular function; blood bank storage

(This special issue belongs to the Section Molecular Biology)

Association Between Oxidative Stress and Metabolic Diseases

edited by

Andrea Silvestrini

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1547 | Submission Open

Keywords: metabolic disease; oxidative stress; low-grade inflammation; antioxidant; endocrine disease; radical species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Approaches for Investigations on Protein Interactions

edited by

Fabrizio Dal Piaz

Francesca Mensitieri

and

Maria Laura Bellone

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1544 | Submission Open

Keywords: protein– protein and protein– ligand interactions; proteomics; innovative approaches; LC-MS/MS; immunometric techniques; interactome; drug discovery and development

(This special issue belongs to the Section Biochemistry)

Hypoxia: Molecular Mechanism and Health Effects

edited by

Pinar Uysal-Onganer

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1462 | Submission Open

Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis

(This special issue belongs to the Section Molecular Biology)

MicroRNAs as Biomarkers and Therapeutic Targets in Human Diseases

edited by Elena V. Bichenkova

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1414 | Submission Open

Keywords: microRNA biomarkers; diagnostic profiling; expression patterns; miRNA therapeutics; antimiRs; miRNA mimics; hybridisation; sequence-specificity; miRNA knockdown

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Bone Diseases

edited by Gaia Palmini

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1316 | Submission Open

Keywords: mineralization; bone diseases; rare bone diseases; non-coding RNAs; fibrous bone dysplasia; tumoral calcinosis; osteosarcoma; Ewing sarcoma; osteoporosis; Gorham-Stout disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Protein Kinase in Health and Diseases

edited by

Manuela Loi

submission deadline 30 Sep 2025 | 4 articles | Viewed by 1201 | Submission Open

Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; metabolic diseases

(This special issue belongs to the Section Biochemistry)

Displaying special issue 1551-1600 on page 32 of 68.

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