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New Advances in Erythrocyte Biology and Functions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1676

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Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy
Interests: neurodegenerative disorders and non-communicable diseases; neuroprotective role of antioxidants
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Special Issue Information

Dear Colleagues,

In recent years, there has been a rapid proliferation of knowledge regarding health and the clinical approach to red-blood-cell-related diseases. Long assumed to be inert oxygen carriers, red blood cells (RBCs) are emerging as important modulators of the innate immune response. Furthermore, developments in novel red blood functions, blood bank storage methods, and red-blood-cell-based therapies have been reported. We are pleased to invite you to contribute original articles, reviews, and communications covering the entire field of RBC research, including, but not limited to, the following: Red blood cell (RBC) aging; pathological RBCs; immunological RBCs; blood bank storage; RBCs and vascular function; RBCs under stress (warming, hypoxia, sport ); engineered RBCs; RBCs and drug interaction; and xenobiotics.

Prof. Dr. Francesco Misiti
Guest Editor

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Keywords

  • erythrocyte
  • red blood cells
  • red blood functions
  • vascular function
  • blood bank storage

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Published Papers (1 paper)

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Research

12 pages, 476 KiB  
Article
Resolution of RHCE Haplotype Ambiguities in Transfusion Settings
by Caroline Izard, Laurine Laget, Sophie Beley, Nelly Bichel, Lugdivine De Boisgrollier, Christophe Picard, Jacques Chiaroni and Julie Di Cristofaro
Int. J. Mol. Sci. 2024, 25(11), 5868; https://doi.org/10.3390/ijms25115868 - 28 May 2024
Viewed by 1192
Abstract
Red blood cell (RBC) transfusion, limited by patient alloimmunization, demands accurate blood group typing. The Rh system requires specific attention due to the limitations of serological phenotyping methods. Although these have been compensated for by molecular biology solutions, some RhCE ambiguities remain unresolved. [...] Read more.
Red blood cell (RBC) transfusion, limited by patient alloimmunization, demands accurate blood group typing. The Rh system requires specific attention due to the limitations of serological phenotyping methods. Although these have been compensated for by molecular biology solutions, some RhCE ambiguities remain unresolved. The RHCE mRNA length is compatible with full-length analysis and haplotype discrimination, but the RHCE mRNA analyses reported so far are based on reticulocyte isolation and molecular biology protocols that are fastidious to implement in a routine context. We aim to present the most efficient reticulocyte isolation method, combined with an RT-PCR sequencing protocol that embraces the phasing of all haplotype configurations and identification of any allele. Two protocols were tested for reticulocyte isolation based either on their size/density properties or on their specific antigenicity. We show that the reticulocyte sorting method by antigen specificity from EDTA blood samples collected up to 48 h before processing is the most efficient and that the combination of an RHCE-specific RT-PCR followed by RHCE allele-specific sequencing enables analysis of cDNA RHCE haplotypes. All samples analyzed show full concordance between RHCE phenotype and haplotype sequencing. Two samples from the immunohematology laboratory with ambiguous results were successfully analyzed and resolved, one of them displaying a novel RHCE allele (RHCE*03 c.340C>T). Full article
(This article belongs to the Special Issue New Advances in Erythrocyte Biology and Functions)
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