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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biotic and Abiotic Stress Responses of Vegetable Crops

edited by Yongqiang Tian

submission deadline 30 Jun 2025 | Viewed by 168 | Submission Open

Keywords: vegetable crops; biotic stress; abiotic stress; physiological responses; molecular mechanisms; genetic mechanisms; resistance breeding; resistance biotechnology; management strategies

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Antioxidant and Anti-Inflammatory Properties of Bioactive Compounds

edited by

Gang Ye

submission deadline 30 Jun 2025 | Viewed by 168 | Submission Open

Keywords: antioxidant; anti-inflammatory; bioactive compounds; artificial intelligence; multiomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Immunotherapy of Breast Cancer

edited by Mariangela Ciccarese, Elisabetta De Matteis and Laura Orlando

submission deadline 30 Jun 2025 | Viewed by 166 | Submission Open

Keywords: subgroups of BC; biomarkers; tumour microenvironment; TIL; PD-1/PD-L1; vaccines

(This special issue belongs to the Section Molecular Oncology)

Tissue Culture-Free Plant Genome Editing and Transgenesis

edited by Degao Liu

submission deadline 30 Jun 2025 | Viewed by 166 | Submission Open

Keywords: CRISPR/Cas; genome editing; plant; tissue culture free; transgenesis

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Targeted Cancer Therapy and Side-Effect Management

edited by Wei-Min Chang

submission deadline 30 Jun 2025 | Viewed by 163 | Submission Open

Keywords: targeted cancer therapy; novel therapy approaches; personalized treatment; small molecule inhibitors; combination strategies; multi-omics integration; proton therapy; reduced cancer treatment side effects; therapeutic resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Radiolabeled Compounds for Theranostic Applications in Oncology

edited by

Cyril Fersing

submission deadline 30 Jun 2025 | Viewed by 161 | Submission Open

Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling

(This special issue belongs to the Section Molecular Oncology)

Electromagnetic Field Interactions with Biomolecules

edited by Samina Masood

submission deadline 30 Jun 2025 | Viewed by 157 | Submission Open

Keywords: magnetic field; biomolecules; medicine; drug delivery; protective methods; disease control

(This special issue belongs to the Section Biochemistry)

Neural Stem Cells: Latest Applications and Future Perspectives

edited by

Evangelos Delivopoulos

submission deadline 30 Jun 2025 | Viewed by 157 | Submission Open

Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease

(This special issue belongs to the Section Molecular Biology)

Emerging Molecular Research in Microfluidics

edited by

Guorui Zhu

submission deadline 30 Jun 2025 | Viewed by 153 | Submission Open

Keywords: molecular; microfluidics; single-cell; digital microfluidics; microfluidic sensor

(This special issue belongs to the Section Biochemistry)

Chronic Kidney Disease: Novel Advances in Pathophysiology and Therapeutics

edited by

Shihping Hsu

submission deadline 30 Jun 2025 | Viewed by 151 | Submission Open

Keywords: anti-fibrosis; anti-inflammation; biomarker; chronic kidney disease; complement; glucagon-like peptide-1 receptor agonist; immuno modulaton; sodium– glucose cotransporter-2 inhibitor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Plant Breeding Research

edited by Qiang Zhang

submission deadline 30 Jun 2025 | Viewed by 146 | Submission Open

Keywords: crop quality; crop yield; gene editing; excellent germplasm; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

The Disulfide Stress in Health and Diseases

edited by

Marlena Brzozowa-Zasada

submission deadline 30 Jun 2025 | Viewed by 144 | Submission Open

Keywords: disulfide stress; oxidative Stress; redox metabolism; redox Balance; glutathione; ROS

(This special issue belongs to the Section Biochemistry)

Coenzyme Q Redox State and Cellular Homeostasis: Implications for Clinical Practice

edited by

Iain P. Hargreaves

submission deadline 30 Jun 2025 | Viewed by 143 | Submission Open

Keywords: coenzyme Q; cellular homeostasis; cellular energy production; antioxidant defense

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Coagulation Proteins

edited by

Arijit Biswas

submission deadline 30 Jun 2025 | Viewed by 142 | Submission Open

Keywords: coagulation proteins; hemostasis; thrombosis; structural biology; Cryo-EM; inherited coagulation disorders

(This special issue belongs to the Section Molecular Biology)

Biological Study of Plant Bioactive Compounds

edited by

Anna Weronika Sobańska

submission deadline 30 Jun 2025 | Viewed by 140 | Submission Open

Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Unraveling the Mechanisms Underlying Colorectal Inflammation

edited by

Soonjae Hwang

submission deadline 30 Jun 2025 | Viewed by 135 | Submission Open

Keywords: gut microbes; gut commensal; toxins; dysbiosis; colitis; inflammation; colorectal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 30 Jun 2025 | Viewed by 133 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Herpesviruses (2nd Edition)

edited by

Marisa Granato

submission deadline 30 Jun 2025 | Viewed by 130 | Submission Open

Keywords: α -herpesviridae; β -herpesviridae; γ -herpesviridae; herpesviruses associated diseases

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of mRNA Transcriptional Regulation: 3rd Edition

edited by

Andrey Turchinovich

submission deadline 30 Jun 2025 | Viewed by 130 | Submission Open

Keywords: transcriptoion factors (TFs); cis-regulatory elements (CREs); long non-coding RNAs (lncRNAs); short non-coding RNAs (sncRNAs); small nuclear RNAs (snRNAs); microRNA (miRNA); circular RNA (circRNA); DNA methylation; chromatin regulators

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Depression

edited by

Aleksandra Szczepankiewicz

submission deadline 30 Jun 2025 | Viewed by 126 | Submission Open

Keywords: antidepressants; molecular action; comorbid diseases; epigenetics; noncoding RNA; transcriptome; proteome; animal models; in vitro models; clinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 30 Jun 2025 | Viewed by 124 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and New Therapies for Breast Cancer: 2nd Edition

edited by Mary Lou Cutler

submission deadline 30 Jun 2025 | Viewed by 121 | Submission Open

Keywords: management of metastatic disease; neoadjuvant therapy; chemotherapy and immunotherapy combination; novel biologics; aromatase inhibitors; outcome research; quality of life during and after breast cancer therapy; new targets for TNBC

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies

edited by

Jacek Baj

submission deadline 30 Jun 2025 | Viewed by 120 | Submission Open

Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer

(This special issue belongs to the Section Molecular Oncology)

Role of Mitochondria in Neurodegenerative Diseases

edited by Małgorzata Wojtkowska

submission deadline 30 Jun 2025 | Viewed by 119 | Submission Open

Keywords: mitochondria; ccfDNA; Parkinson’ s disease’ Alzheimer’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Proteases and Their Inhibitors: From Biochemistry to Applications

edited by

Gonzalo Izaguirre

submission deadline 30 Jun 2025 | Viewed by 115 | Submission Open

Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics

(This special issue belongs to the Section Molecular Biology)

Mechanisms of Resistance to Melanoma Immunotherapy

edited by Marko B. Lens

submission deadline 30 Jun 2025 | Viewed by 110 | Submission Open

Keywords: melanoma; immune checkpoint inhibitors; PD-1

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress Responses in Cardiovascular Diseases

edited by Vladimir Jakovljevic

submission deadline 30 Jun 2025 | Viewed by 110 | Submission Open

Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites

edited by

Jose Roberto Meyer-Fernandes

submission deadline 30 Jun 2025 | Viewed by 107 | Submission Open

Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Therapeutic Challenges, and Pathogenesis of Complications in Liver Cirrhosis

edited by

Hiroteru Kamimura

submission deadline 30 Jun 2025 | Viewed by 103 | Submission Open

Keywords: muscle spasm; pruritus; sleep disturbances; sarcopenia; osteoporosis; infection; hepatopulmonary syndrome; hepatorenal syndrome; cirrhotic cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Antibody Glycosylation As Immunomodulator

edited by

Maria Franzini

submission deadline 30 Jun 2025 | Viewed by 100 | Submission Open

Keywords: antibodies; glycosylation pattern; immune system; inflammation; autoimmunity; glycans biosynthesis

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism of Immune Response

edited by Marisa Mariel Fernández

submission deadline 30 Jun 2025 | Viewed by 89 | Submission Open

Keywords: training of the innate immune response; antigen recognition; cell migration; autoimmune processes; cell differentiation; tolerance; molecular responses of epithelial cells to foreign stimuli; alterations in immune checkpoints; modulation of immune responses; mechanisms of hypersensitivity

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Mitochondrial Function and Oxidative Stress

edited by Sonia Silvestri and Patrick Orlando

submission deadline 30 Jun 2025 | Viewed by 76 | Submission Open

Keywords: life sciences; mitochondria functionality; mitochondrial nutrients; oxidative stress; bioactive molecules; aging-associated diseases

(This special issue belongs to the Section Biochemistry)

Molecular Research of Neonicotinoid Toxicity

edited by

Fatima Smagulova

submission deadline 30 Jun 2025 | Viewed by 64 | Submission Open

Keywords: neonicotinoids; sex-specific effects; brain– gut– microbiome; endocrine organs; genotoxic effects; epigenetic effects

(This special issue belongs to the Section Molecular Toxicology)

The Cellular, Synaptic and Molecular Mechanisms of Action of Central Nervous System Drugs 2.0

edited by

M. Bruce MacIver

submission deadline 10 Jul 2025 | 4 articles | Viewed by 14867 | Submission Open

Keywords: CNS; drug; addiction; memory; consciousness; loss of consciousness; recovery of consciousness; coma; anesthesia; anaesthesia; anesthetic; inhalant; abuse; GABA; glutamate; 5-HT; adrenaline; noradrenaline; serotonin; dopamine; adenosine; reanimation; electrical stimulation

(This special issue belongs to the Section Molecular Neurobiology)

Understanding Allergy and Asthma at the Molecular Level

edited by

Cenk Suphioglu

submission deadline 10 Jul 2025 | 1 articles | Viewed by 3417 | Submission Open

Keywords: allergy; asthma; allergens; allergic asthma; thunderstorm asthma; cell culture; biomarkers; proteomics; metabolomics; lipidomics; genomics; recombinant allergens; recombinant hypoallergens; signalling; inhibitors; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders

edited by Thomas Paparrigopoulos

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1435 | Submission Open

Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system

(This special issue belongs to the Section Molecular Neurobiology)

Therapeutic Potential: Exploring Membrane Transporters and Channels as Drug Targets

edited by

Jinwei Zhang

submission deadline 10 Jul 2025 | Viewed by 710 | Submission Open

Keywords: membrane transporters; channels; drug targets; therapeutic potential; neurological disorders; metabolic syndromes; methodologies; mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ischemia–Reperfusion Syndrome: A Complex Puzzle in Physiopathology, Pharmacology and Therapeutic Advances

edited by René Ferrera,

Thierry Hauet

Joan Roselĺo-Catafau

and

Arnau Panisello-Roselló

submission deadline 10 Jul 2025 | Viewed by 249 | Submission Open

Keywords: ischemia– reperfusion injury; graft dysfunction and organ preservation; solid organ transplantation; machine perfusion strategies (HOPE/NMP); mitochondria dysfunction; cell signaling pathways; organ preconditioning/postconditioning; therapeutic surgical and drug strategies; redox stress and inflammation mediators; cell lines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer

edited by

Daniel Gabriel Pons

submission deadline 10 Jul 2025 | Viewed by 186 | Submission Open

Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Molecular Updates and Applications in Forensic Medicine

edited by

Eugenia Carnevali

submission deadline 15 Jul 2025 | 3 articles | Viewed by 3933 | Submission Open

Keywords: forensic genetics; forensic transcriptomics; mitochondrial DNA (mtDNA); next-generation sequencing (NGS); body fluid identification; environmental DNA analysis; forensic entomology; animal and plant forensics; forensic microbiology; paternity testing; time of death; advanced molecular autopsy; disaster victim identification (DVI); ancient DNA; biological age prediction; DNA phenotyping; ancestry; investigative genetic genealogy; ethics in forensic genetics; criminal database; DNA mixture interpretation; activity level; forensic bioinformatics; artificial intelligence; quality assurance

(This special issue belongs to the Section Molecular Biology)

Molecular Paradigm Iconoclasm

edited by

Vance G. Nielsen

submission deadline 15 Jul 2025 | 1 articles | Viewed by 574 | Submission Open

Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology

(This special issue belongs to the Section Biochemistry)

Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes

edited by Maria Victoria Preciado

submission deadline 15 Jul 2025 | Viewed by 178 | Submission Open

Keywords: virus evolution; immune response; host– virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics

(This special issue belongs to the Section Molecular Immunology)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 15 Jul 2025 | Viewed by 165 | Submission Open

Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

New Insights in Natural Bioactive Compounds: 3rd Edition

edited by

Letteria Minutoli

and

Giovanni Pallio

submission deadline 20 Jul 2025 | 22 articles | Viewed by 58836 | Submission Open

Keywords: inflammation; cytokines; ROS; oxidative stress; natural products; flavonoids; cannabinoids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Agents and Novel Drugs Use for the Oncological Diseases Treatment

edited by

Alexandra L. Zakharenko

and

Nadezhda S. Dyrkheeva

submission deadline 20 Jul 2025 | 20 articles | Viewed by 42188 | Submission Open

Keywords: anti-proliferative; cancer; molecular oncology; novel agents; off-label use; target therapy

(This special issue belongs to the Section Molecular Pharmacology)

Focus on Cartilage Biology

edited by

Jácome Bruges-Armas

submission deadline 20 Jul 2025 | 5 articles | Viewed by 24280 | Submission Open

Keywords: cartilage biology; signaling pathways; molecular genetics; osteoarthritis; inflammatory arthropaty; cartilage repair; microbioma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Paroxysmal Nocturnal Hemoglobinuria: Pathophysiology and Novel Therapeutic Approaches

edited by Jun-Ichi Nishimura

submission deadline 20 Jul 2025 | 7 articles | Viewed by 21952 | Submission Open

Keywords: paroxysmal nocturnal hemoglobinuria; complement; intravascular hemolysis; extravascular hemolysis; breakthrough hemolysis; terminal complement inhibitor; proxymal complement inhibitor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microalgal Molecules and Enzymes: 2nd Edition

edited by

Assunta Saide

and

Chiara Lauritano

submission deadline 20 Jul 2025 | 5 articles | Viewed by 18723 | Submission Open

Keywords: microalgae; bioactive molecules; gene expression; drug discovery; molecular mechanism; gene mining; enzymes; industrial applications

(This special issue belongs to the Section Molecular Microbiology)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes

edited by

Daniela Miricescu

submission deadline 20 Jul 2025 | 7 articles | Viewed by 18368 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β ; Ras/Raf/MEK/ERK; Wnt/β -catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Alcohol and Inflammation

edited by

María Candelaria Martín-González

and Emilio González-Reimers

submission deadline 20 Jul 2025 | 7 articles | Viewed by 18189 | Submission Open

Keywords: alcohol; inflammation; alcohol use disorder; alcoholic liver disease; liver disease; alcoholic hepatitis; liver injury; oxidative damage

(This special issue belongs to the Section Molecular Immunology)

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