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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms Underlying Natural Products for Metabolic Disease Treatment submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open
Keywords: metabolic diseases; natural products; MAFLD
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Glycoproteomics—Developments in Methodology and Biological Applications
edited by and Jianjun Li
submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open
Keywords: glycoproteomics; glycomics; mass spectrometry; glycobiology; biomarker
(This special issue belongs to the Section Biochemistry)
Molecular Synapse: Diversity, Function and Signaling
edited by
submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open
Keywords: synaptic signaling; synaptic plasticity; brain disorders; synapse diversity; molecular composition of synapse
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Biology of Hypoxia: 2nd Edition
edited by Yuji Arai
submission deadline 31 Mar 2026 | Viewed by 71 | Submission Open
Keywords: hypoxia; HIFs; normoxic environment
(This special issue belongs to the Section Molecular Biology)
Emerging Insights into the Pathobiology and Biomarkers of Traumatic Brain Injury (TBI)
edited by Jessica Gill
submission deadline 31 Mar 2026 | Viewed by 71 | Submission Open
Keywords: traumatic brain injury (TBI); blood-based biomarkers; neuroinflammation; axonal injury; neurodegeneration; precision medicine; omics approaches (genomics; proteomics; metabolomics); translational neuroscience; TBI recovery and outcomes; neurovascular injury
(This special issue belongs to the Section Molecular Neurobiology)
Plant Responses to Environmental Stresses: Physiological and Molecular Mechanisms submission deadline 31 Mar 2026 | Viewed by 70 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress; oxidative stress; antioxidant enzymes; reactive oxygen species (ROS); phytoremediation; biomonitoring; secondary metabolites; molecular mechanisms; omics approaches; bryophytes; heavy metals; plant– microbe interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Pharmacological Approaches in Inflammation, Aging, and Cardiovascular Diseases
edited by and
submission deadline 31 Mar 2026 | Viewed by 69 | Submission Open
Keywords: inflammation; aging; cardiovascular diseases; approaches; translational research; therapeutic targets
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Spermatogenesis and Male Infertility, 2nd Edition
edited by Wanxi Yang
submission deadline 31 Mar 2026 | Viewed by 68 | Submission Open
Keywords: male reproduction; hormone regulation; blood– testis barrier; male reproductive diseases; male infertility
(This special issue belongs to the Section Molecular Biology)
Regulation by Non-Coding RNAs: 2nd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open
Keywords: lncRNAs; circRNAs; miRNAs
(This special issue belongs to the Section Molecular Biology)
Advances in Alzheimer’s Disease: From Metabolic Dysregulation to Molecular Pathophysiology and Therapeutics
edited by Pedro Cisternas
submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open
Keywords: Alzheimer’ s disease; metabolic dysregulation; brain insulin resistance; neuroenergetics; mitochondrial dysfunction; adipokines; neuroinflammation; gut– brain axis; multi-omics biomarkers; therapeutics and precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Genome-Wide Association Studies of Complex Diseases and Related Endophenotypes and Biomarkers
edited by M. Ilyas Kamboh
submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open
Keywords: genome-wide association studies; complex diseases; endophenotypes; biomarkers; rare variants; copy number variants; diverse populations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms of Nephrotoxicity: From Environmental Toxins to Therapeutic Agents
edited by
submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open
Keywords: pesticides; emerging pollutants; environmental toxicants; therapeutic strategies; nephrology; toxicology; public health
(This special issue belongs to the Section Molecular Toxicology)
Plant Secretomes: Ways in Shaping Soil Ecosystems
edited by
submission deadline 31 Mar 2026 | Viewed by 66 | Submission Open
Keywords: plants; metabolites; proteins; peptides; enzymes; small molecules; mass spectrometry; chromatography; ecosystem; ecosystem functions; ecosystem services
(This special issue belongs to the Section Molecular Plant Sciences)
Polymer Biocomposites: Synthesis, Applications and End-Life submission deadline 31 Mar 2026 | Viewed by 66 | Submission Open
Keywords: polymer biocomposites; biodegradable polymers; molecular design and synthesis; functional modifications; biodegradation
(This special issue belongs to the Section Materials Science)
Plant–Microbe Interactions in Alleviation of Abiotic Stress in Plants submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open
Keywords: abiotic stresses; plant– microbe interactions; symbiotic microbes; stress adaptation; stress-responsive genes; physio-logical responses
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Landscape of Endometrial and Ovarian Dysfunction in Polycystic Ovary Syndrome: Insights into Disease Mechanisms
edited by and
submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open
Keywords: polycystic ovarian syndrome (PCOS); molecular mechanisms; endometrial dysfunction; ovarian dysfunction; pathophysiology; biomarkers; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Molecular Properties Through Molecular Modeling
edited by
submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open
Keywords: molecular modeling; molecular properties; structure– activity relationships; QSAR; prediction; drug design; materials science; virtual screening; in-silico synthesis; computational chemistry; cheminformatics
(This special issue belongs to the Section Molecular Informatics)
Optical, Raman, and Pathological Imaging Biomarkers for Diagnosis and Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open
Keywords: optical imaging; Raman spectroscopy; pathological imaging; imaging biomarkers; AI-assisted diagnosis; disease prognosis; therapeutic response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Cerebrovascular Diseases submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open
Keywords: cerebrovascular diseases; stroke; vascular dementia; molecular mechanisms; biomarkers; omics; therapeutic targets; translational medicine
(This special issue belongs to the Section Molecular Neurobiology)
Latest Research on Mesenchymal Stem Cells (2nd Edition)
edited by Marcel Costuleanu
submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open
Keywords: mesenchymal stem cell; MSC; niche; tissue homeostasis; exosomes; microvesicles; cancer; mitochondrial exchange; MSC secretome
(This special issue belongs to the Section Molecular Biology)
Apoptosis in Health and Disease: Recent Advances and Future Directions
edited by Shabnam Malik
submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open
Keywords: apoptosis; programmed cell death; health and disease; cellular homeostasis; cancer; neurodegenerative disorders
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Pathophysiology of Sepsis (2nd Edition)
edited by
submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open
Keywords: animal models; therapeutic concepts; biomarkers; sepsis; immune suppression; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Dynamic Interaction Between Large-Pore Channels: Latest Insights
edited by and Viviana Berthoud
submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open
Keywords: connexin hemichannels; pannexin hemichannels; TRP channels; P2X receptors; CAHLM channels
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms of Human Liver Diseases: 3rd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); alcoholic steatohepatitis (ASH); Wilson’ s disease; hemochromatosis; viral hepatitis; autoimmune hepatitis; hepatocellular carcinoma; signaling pathways; molecular mechanisms; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances on Sickle Cell Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 62 | Submission Open
Keywords: sickle cell disease; hemoglobinopathy; vaso-occlusion; fetal hemoglobin induction; genome editing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytokines and Chemokines in Rare Genetic and Lysosomal Disorders: Mechanisms, Biomarkers, and Therapeutic Advances
edited by
submission deadline 31 Mar 2026 | Viewed by 62 | Submission Open
Keywords: cytokines; chemokines; chronic inflammation; immune dysregulation; lysosomal storage diseases (Gaucher; Fabry; Niemann– Pick); rare genetic disorders; neuroinflammation; hepatosplenomegaly and bone pathology; immune-metabolic crosstalk; biomarkers of disease progression; immunomodulatory therapies; enzyme replacement therapy resistance; gene therapy immunology; precision immunology; translational medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Relationships Between Diabetic Retinal Neuropathies and Vascular Pathologies in Diabetic Retinopathy
edited by and David A. Antonetti
submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open
Keywords: retinal neurons; retinal vasculature; diabetic retinopathy; diabetic macular edema (DME); neurovascular coupling; neurovascular unit (NVU); diabetic vascular pathology; diabetic retinal neuropathy; diabetic retinal neurodegeneration; retinal thinning in diabetes; photoreceptor pathology in diabetes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds: Innovative Technologies for Extraction, Synthesis, and Functional Evaluation submission deadline 31 Mar 2026 | Viewed by 60 | Submission Open
Keywords: bioactive compounds; extraction; synthesis; functional evaluation; molecular aspects; mechanism of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Neurodegeneration: Signaling Pathways and Therapeutic Targets
edited by
submission deadline 31 Mar 2026 | Viewed by 59 | Submission Open
Keywords: neurodegeneration; molecular signaling; neuroinflammation; cellular metabolism; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Ameliorating Effect of Natural Bioactive Compounds on Metabolic Diseases and Their Underlying Molecular Mechanisms
edited by Baojun Xu
submission deadline 31 Mar 2026 | Viewed by 59 | Submission Open
Keywords: metabolic diseases; natural bioactive compounds; molecular mechanism; phytochemicals; curing targets; signaling pathway
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Dynamics of Fascia: Cellular, Molecular, and Biochemical Mechanisms
edited by
submission deadline 31 Mar 2026 | Viewed by 58 | Submission Open
Keywords: fascia; homeostasis and pathology; extracellular matrix remodeling; fibroblast signaling; chronic pain; fibrosis and inflammation; hormonal regulation
(This special issue belongs to the Section Biochemistry)
Updates on Human Embryonic Stem Cells
edited by
submission deadline 31 Mar 2026 | Viewed by 58 | Submission Open
Keywords: human embryonic stem cells; pluripotent stem cells; differentiation; pluripotency; cell-based therapy; embryo; disease modeling
(This special issue belongs to the Section Molecular Biology)
Functional and Hybrid Imaging in Molecular Neuroscience
edited by Marija-Magdalena Petrinovic
submission deadline 31 Mar 2026 | Viewed by 58 | Submission Open
Keywords: molecular imaging; functional MRI; PET; multimodal brain imaging; neuroreceptor mapping; neuroinflammation; neurodegeneration; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Translational Research in Cardiovascular Endocrinology, Cardiovascular–Kidney–Metabolic Diseases and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): 3rd Edition submission deadline 31 Mar 2026 | Viewed by 57 | Submission Open
Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Reprogramming of Mitochondrial Signalling and Metabolism in Cancers
edited by
submission deadline 31 Mar 2026 | Viewed by 57 | Submission Open
Keywords: mitochondria; metabolic reprogramming; cancer metabolism; redox signaling
(This special issue belongs to the Section Molecular Oncology)
Recent Approaches for Wound Treatment: 3rd Edition submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open
Keywords: wound healing; inflammation; angiogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Photodynamic Therapy and Photodetection, Third Edition
edited by Sabrina Cavin
submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open
Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser photochemical internalization (PCI); quantum dots; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Artificial Intelligence in Ophthalmology: A New Era for Retinal Disease Detection and Treatment
edited by
submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open
Keywords: artificial intelligence; retina; imaging; transcriptome analysis; protein modeling
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Diagnosis and Treatment of Oral Cancer submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open
Keywords: oral cancer; molecular diagnosis; immunophysiology; tumor microenvironment; drug resistance; oral microbiome
(This special issue belongs to the Section Molecular Oncology)
Research on Stem Cells in Neurological Disorders: Disease Modeling and Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open
Keywords: disease modeling; molecular regulation; therapeutic intervention; neurological disorders
(This special issue belongs to the Section Molecular Neurobiology)
Novel Biomarkers and Treatment Strategies for Parkinson’s Disease
edited by Aron Emmi
submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open
Keywords: Parkinson’ s Disease; alpha-synuclein; disease-modifying therapy; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Cellular Plasticity in Cancer: Mechanisms, Measurement and Therapeutic Opportunities
edited by Costa Frangou
submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open
Keywords: cellular plasticity; cancer progression; EMT/MET; lineage infidelity; therapy-induced reprogramming; stem-like states; single-cell analysis; spatial transcriptomics; lineage tracing; computational modeling; biomarkers; therapeutic re-sistance; metastasis; solid tumors
(This special issue belongs to the Section Molecular Oncology)
Applications of Bioinformatics in Human Disease
edited by Maria Rosaria De Filippo
submission deadline 31 Mar 2026 | Viewed by 53 | Submission Open
Keywords: bioinformatics; omics data; machine learning; biomarker prediction
(This special issue belongs to the Section Molecular Informatics)
Molecular Insights into Photocatalytic Degradation and Biomass Valorization for Green Chemistry Applications
edited by
submission deadline 31 Mar 2026 | Viewed by 52 | Submission Open
Keywords: photocatalysis; advanced oxidation processes; reactive oxygen species; in operando spectroscopy; biomass valorization; lignin depolymerization; green chemistry; emerging contaminants; structure– activity relationships; water reuse and treatment
(This special issue belongs to the Section Biochemistry)
Research Advances in Photodynamic Therapy submission deadline 31 Mar 2026 | Viewed by 52 | Submission Open
Keywords: photodynamic therapy (PDT); photosensitizers and nanocarriers; targeting and molecular selectivity; photophysics and dosimetry; anticancer and antimicrobial applications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Horizons of Innovations, Mechanisms, and Translational Prospects of Chitosan-Based Drug Delivery Therapeutic Interventions
edited by
submission deadline 31 Mar 2026 | Viewed by 51 | Submission Open
Keywords: chemical modification and functionalization; nanostructured and hybrid systems; gene; peptide; and vaccine delivery; mucosal and transdermal applications; biological interactions and mechanistic insights
(This special issue belongs to the Section Molecular Pharmacology)
A Window to the Brain: From Retinal Cellular and Soluble Biomarkers Towards Neurodegeneration submission deadline 31 Mar 2026 | Viewed by 51 | Submission Open
Keywords: retinal signaling; oxidative stress; retinal neurodegeneration; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Lipid Membranes as Multifunctional Platforms for Bioactive Delivery
edited by
submission deadline 31 Mar 2026 | Viewed by 51 | Submission Open
Keywords: lipid-based carriers; drug delivery; bioactive compounds; in silico; in vitro and in vivo models
(This special issue belongs to the Section Macromolecules)
Addressing Autoimmunity in the 21st Century
edited by
submission deadline 31 Mar 2026 | Viewed by 50 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immune-mediated disorders; molecular mechanisms; molecular biomarkers; therapeutic strategies; immunomodulation; immune tolerance
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Mineral Nutrition and Tolerance to Salt and Drought in Plants submission deadline 31 Mar 2026 | Viewed by 49 | Submission Open
Keywords: ionic stress; water stress; salinity; mineral nutrition; uptake and transport; signalling and metabolism; plant-microbe interactions; tolerance mechanisms; plant physiology; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
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