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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Adaptive Strategies of Plants to Water Stress
edited by Weitao Jia
submission deadline 31 Jan 2027 | Viewed by 266 | Submission Open
Keywords: adaptive strategies; submergence; post-submergence; waterlogging; drought; plant physiology; phenotypic plasticity; omics; epigenetic regulation; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Panomics Approaches for Deciphering Salinity Stress Tolerance in Plants submission deadline 31 Jan 2027 | Viewed by 262 | Submission Open
Keywords: salinity stress; panomics integration; multi-omics; salt tolerance; spatial transcriptomics; AI-driven breeding; systems biology; climate-smart crops; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Polymer–Surfactant Systems: Interactions, Self-Assembly, and Functional Applications
edited by Francisco Ríos
submission deadline 31 Jan 2027 | Viewed by 257 | Submission Open
Keywords: polymer–surfactant interactions; molecular self-assembly; colloidal and interfacial systems; soft matter chemistry; micellization; nanostructured materials; stimuli-responsive polymers; molecular modeling and simulations
(This special issue belongs to the Section Materials Science)
Molecular Nutrition and Gut Health in Production Animals
edited by Shimeng Huang
submission deadline 31 Jan 2027 | 1 articles | Viewed by 254 | Submission Open
Keywords: production animals; molecular nutrition; gut health; gut microbiota; intestinal barrier; mucosal immunity; host–microbe interactions; microbial metabolites; feed additives; amino acid nutrition; probiotics; prebiotics; mycotoxins; multi-omics; animal performance
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Studies on Bioactive Natural Products for Human Health
edited by
submission deadline 31 Jan 2027 | Viewed by 253 | Submission Open
Keywords: medicinal and aromatic plants; bioactive natural products; phytochemistry; phenolic compounds; metabolomics; antioxidant activity; anticancer activity; molecular mechanisms; phytochemical profiling; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
DNA Repair Mechanisms in Neurological Disorders
edited by Camila Araújo Bernardino Garcia
submission deadline 31 Jan 2027 | Viewed by 249 | Submission Open
Keywords: DNA repair; somatic mosaicism; focal cortical dysplasia; epilepsy genetics; cortical malformations; neurodevelopmental disorders; genomic instability; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Polymer Biomaterials in Urology: Innovations and Applications
edited by
submission deadline 31 Jan 2027 | Viewed by 249 | Submission Open
Keywords: polymer biomaterials; polymer implants; protheses; injectables; drug delivery systems; reconstruction
(This special issue belongs to the Section Macromolecules)
Platelet-Mediated Immune Regulation in Cancer
edited by
submission deadline 31 Jan 2027 | Viewed by 244 | Submission Open
Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis
(This special issue belongs to the Section Molecular Immunology)
Design and Engineering of Polymeric Systems for Biomedical Applications submission deadline 31 Jan 2027 | Viewed by 240 | Submission Open
Keywords: polymers; polymer systems; drug delivery; tissue engineering; medical devices; regenerative medicine
(This special issue belongs to the Section Macromolecules)
Advancements of Nanomaterials in Applied Molecular Science
edited by , and Pollyana Souza Castro
submission deadline 31 Jan 2027 | Viewed by 239 | Submission Open
Keywords: nanotechnology; nanomaterials; molecular science; microfluidics; biosensors
(This special issue belongs to the Section Molecular Nanoscience)
Plant Gaseous Signaling Molecules
edited by
submission deadline 31 Jan 2027 | Viewed by 239 | Submission Open
Keywords: gasotransmitters; plants; signaling pathway; biotic and abiotic stresses; growth and development
(This special issue belongs to the Section Molecular Plant Sciences)
Research on Plant-Microbe Interaction
edited by Yelda Özden Çiftçi
submission deadline 31 Jan 2027 | Viewed by 237 | Submission Open
Keywords: biofertilizers; plant-microbe interactome; synthetic symbiosis; rhizosphere engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Neurodegenerative Diseases: Linking Autophagy, Oxidative Stress, ER Stress and Neuroinflammation
edited by
submission deadline 31 Jan 2027 | Viewed by 232 | Submission Open
Keywords: neurodegenerative diseases; autophagy; oxidative stress; endoplasmic reticulum stress; neuroinflammation; microglia; astrocytes; protein aggregation; proteostasis; mitochondrial dysfunction; reactive oxygen species (ROS); unfolded protein response (UPR); neuroprotection; alzheimer's disease
(This special issue belongs to the Section Molecular Neurobiology)
Anticancer Drugs: Molecular Research and Progress submission deadline 31 Jan 2027 | Viewed by 229 | Submission Open
Keywords: anticancer agents; molecular mechanisms; drug design; computational chemistry; experimental oncology
(This special issue belongs to the Section Molecular Oncology)
Immunogenetics in the Era of Genomic Medicine: From Diversity to Clinical Translation
edited by Khalid Sadki
submission deadline 31 Jan 2027 | Viewed by 222 | Submission Open
Keywords: immunogenomics; genetic diversity; disease association; cancer immunology; bioinformatics; artificial intelligence; big data analysis; multi-omics; single-cell sequencing; translational immunology; precision medicine; underrepresented populations
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Advances in Spinal Cord Injury
edited by
submission deadline 31 Jan 2027 | Viewed by 217 | Submission Open
Keywords: spinal cord injury; neural regeneration; regenerative medicine; stem cell therapy; induced pluripotent stem cells; mesenchymal stem cells; neural progenitor cells; biomaterials; neuroinflammation; neuromodulation
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Therapeutic Strategies for Intrahepatic Cholangiocarcinoma submission deadline 31 Jan 2027 | Viewed by 217 | Submission Open
Keywords: intrahepatic cholangiocarcinoma; molecular therapy; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; genomic alterations; liquid biopsy; resistance mechanisms; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Functional Epigenomics in Plants
edited by
submission deadline 31 Jan 2027 | Viewed by 216 | Submission Open
Keywords: epigenomics; crop improvement; epigenetic variation; functional genomics; DNA methylation
(This special issue belongs to the Section Molecular Plant Sciences)
Multi-Omics-Driven Advances in Plant Sciences
edited by Sheikh Mansoor
submission deadline 31 Jan 2027 | Viewed by 216 | Submission Open
Keywords: multi-omics; plant genomics; transcriptomics; metabolomics; crop improvement; abiotic and biotic stress tolerance; plant–microbe interactions; functional genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Biomarker Advances in Gynecologic Oncology
edited by
submission deadline 31 Jan 2027 | Viewed by 214 | Submission Open
Keywords: gynecologic oncology; epithelial ovarian cancer; prognostic biomarkers; tumor microenvironment; systemic inflammation; precision medicine; targeted therapy; clinical risk stratification
(This special issue belongs to the Section Molecular Oncology)
Oxidative Stress in Human Diseases: Molecular Mechanisms, Biomarkers, and Therapeutic Perspectives
edited by , and Sara Spinelli
submission deadline 31 Jan 2027 | Viewed by 211 | Submission Open
Keywords: oxidative stress; ROS; antioxidants; redox biology; inflammation; biomarkers; chronic diseases; neurodegeneration; cancer; metabolism; mitochondria; aging; translational medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Quantum Neuroactivity
edited by
submission deadline 31 Jan 2027 | Viewed by 205 | Submission Open
Keywords: neurosciences; neurochemistry; neurobiology; quantum theory and computation; neuromorphisms; QSAR (quantitative structure-activity relationships); bio- and nano-materials; (artificial) neural networks.
(This special issue belongs to the Section Molecular Neurobiology)
Synaptic Dysfunction in Neurodegenerative Diseases: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 31 Jan 2027 | Viewed by 197 | Submission Open
Keywords: synaptic dysfunction; neurodegeneration; synaptic vesicle recycling; cytoskeleton and microtubules; neurotransmission; neuromuscular junction (NMJ); RNA metabolism; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Machine Learning for Peptide and Protein Function Prediction
edited by and Hsin-Nan Lin
submission deadline 31 Jan 2027 | Viewed by 194 | Submission Open
Keywords: protein language models (PLMs); deep learning; sequence-based function prediction; therapeutic peptides; post-translational modification (PTM); sequence-structure mapping; multi-functional peptides; residue-level prediction; bioinformatics; transfer learning
(This special issue belongs to the Section Molecular Informatics)
Research on Plant-Growth-Promoting Rhizobacteria submission deadline 31 Jan 2027 | Viewed by 193 | Submission Open
Keywords: plant growth promoting rhizobacteria; plant–microbe interactions; microbiome-based selection; microbiome engineering; synthetic communities; biofertilization; biocontrol; stress tolerance; smart delivery methods
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Wound Healing: 3rd Edition submission deadline 31 Jan 2027 | Viewed by 185 | Submission Open
Keywords: management of wounds; nanobiomaterials; infection control; chronic wounds; biofilm infections; wound dressings; tissue engineering; wound healing
(This special issue belongs to the Section Molecular Biology)
New Advances in Plant–Microbe Interactions
edited by and Ahmed El Moukhtari
submission deadline 31 Jan 2027 | Viewed by 182 | Submission Open
Keywords: plant–microbe interactions; plant microbiome; plant-beneficial microorganisms; multi-omics; sustainable agriculture; microbial diversity
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights in Urological Cancers
edited by Xuan-Mei Piao
submission deadline 31 Jan 2027 | Viewed by 164 | Submission Open
Keywords: urological cancers; bladder cancer; prostate cancer; kidney cancer; upper urinary tract cancer; testicular cancer; penile cancer; urothelial carcinoma; squamous cell carcinoma; adenocarcinoma; molecular oncology; cancer biomarkers; tumor microenvironment; immunotherapy; multi-omics
(This special issue belongs to the Section Molecular Oncology)
Mitochondrial Dysfunction and Chronic Diseases: Molecular Insight and Therapeutic Opportunities submission deadline 31 Jan 2027 | Viewed by 155 | Submission Open
Keywords: mitochondrial dysfunction; redox signaling; metabolism; mitochondrial dynamics; mitochondrial-targeted therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metalloproteins in Biomedicine: From Molecular Mechanisms and Biomarkers to Diagnostics, Therapeutics and Nanotechnology submission deadline 31 Jan 2027 | Viewed by 145 | Submission Open
Keywords: metalloproteins; biomarkers; nanomedicine; immunology; molecular mechanisms; nanotechnology; biosensing
(This special issue belongs to the Section Biochemistry)
Pseudopeptidases: From Structure to Function in Health and Disease submission deadline 31 Jan 2027 | Viewed by 137 | Submission Open
Keywords: pseudopeptidases; pseudoenzymes; inactive homologs of peptidases; peptidases; protein structure; protein function
(This special issue belongs to the Section Biochemistry)
Mechanisms of Cardiotoxicity in Anticancer Therapies
edited by Sheetalnath Rooge
submission deadline 31 Jan 2027 | Viewed by 136 | Submission Open
Keywords: cardiotoxicity; cardiac hypertrophy; mitochondrial dysfunction; immune response; autophagy; mitophagy; lipophagy; apoptosis; ferroptosis; DNA damage; iron overload; lipid peroxidation; ROS production; Ca2+ homeostasis; microRNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Biochar submission deadline 31 Jan 2027 | Viewed by 136 | Submission Open
Keywords: engineered biochar; molecular mechanisms; surface complexation; heavy metal(loid) immobilization; PFAS; microplastics; colloid-facilitated transport; spectroscopic characterization; density functional theory; machine learning; soil microbiology
(This special issue belongs to the Section Materials Science)
Mechanism of SARS-CoV-2 Interactions with Tissue Cells
edited by Matias Nunes Frizzo and
submission deadline 31 Jan 2027 | Viewed by 131 | Submission Open
Keywords: SARS‑CoV‑2; virus–cell interaction; viral pathogenesis; immune response; inflammation and tissue injury; clinical and laboratory biomarkers
(This special issue belongs to the Section Molecular Immunology)
Ventricular Function and Pathophysiology in Cardiovascular Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 129 | Submission Open
Keywords: heart failure; ventricular function; pressure–volume analysis; cardiac hemodynamics; ventricular remodeling; cardiovascular pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Acute Kidney Injury: From Pathogenesis to Targeted Therapy
edited by
submission deadline 31 Jan 2027 | Viewed by 121 | Submission Open
Keywords: AKI; pathogenesis; biomarkers; targeted therapy; ischemia–reperfusion injury; inflammation; apoptosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
State-of-the-Art Molecular Neurobiology in Turkey
edited by Bilal Çiğ, Atay Vural and Aydan Köysüren
submission deadline 31 Jan 2027 | Viewed by 118 | Submission Open
Keywords: molecular neurobiology; ion channels; neurophysiology; neuropharmacology; neuroinflammation; neurodegeneration; glia biology; synaptic signaling; oxidative stress; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular and Cellular Pathology of Cancer Research
edited by and
submission deadline 31 Jan 2027 | 1 articles | Viewed by 115 | Submission Open
Keywords: cancer molecular pathology; cancer genomics; experimental therapeutics; inhibitors; immuno-oncology; tumor heterogeneity; liquid biopsy; organoids; spatial biology; digital PCR; artificial intelligence
(This special issue belongs to the Section Molecular Oncology)
Hydrogel Materials for Regenerative Medicine: Molecular Perspectives
edited by
submission deadline 31 Jan 2027 | Viewed by 115 | Submission Open
Keywords: supramolecular hydrogels; adaptive materials; biomimetic material; stimuli-responsive hydrogels; tissue engineering; regenerative medicine; phase separation hydrogel
(This special issue belongs to the Section Materials Science)
Genomics and Molecular Mechanisms of Cancer submission deadline 31 Jan 2027 | Viewed by 113 | Submission Open
Keywords: carcinogenesis; genetic and epigenetic alterations; cancer molecular mechanisms; cancer regulatory networks
(This special issue belongs to the Section Molecular Oncology)
AI-Powered Precision Nanomedicine for Brain Delivery
edited by João Dias-Ferreira
submission deadline 31 Jan 2027 | Viewed by 112 | Submission Open
Keywords: neuroscience; glioblastoma; AI-driven healthcare; nanotargeted drug delivery; central nervous system; genic edition and therapy
(This special issue belongs to the Section Molecular Pharmacology)
Epithelial Dysfunction in Allergic Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 110 | Submission Open
Keywords: epithelial dysfunction; epithelial barrier theory; allergic diseases; barrier integrity; immune-epithelial crosstalk; type 2 inflammation; mucosal immunology; environmental exposures; tissue remodeling; translational allergy research
(This special issue belongs to the Section Molecular Immunology)
Advanced Functional Materials for Electrochemical Energy Conversion and Storage submission deadline 31 Jan 2027 | Viewed by 107 | Submission Open
Keywords: advanced functional materials; molecular design; electrochemical energy conversion; energy storage; electrocatalysis; hydrogen/oxygen production; batteries; supercapacitors; interface/molecular engineering; charge-transfer mechanisms
(This special issue belongs to the Section Materials Science)
Cellular and Molecular Toxicology of Emerging Environmental Pollutants
edited by
submission deadline 31 Jan 2027 | Viewed by 105 | Submission Open
Keywords: environmental pollutant; cellular toxicology; man-made nanoparticles; toxicological mechanisms; 6PPD/6PPD-Q
(This special issue belongs to the Section Molecular Toxicology)
Gastrointestinal Injury and Inflammation: Molecular Mechanisms and Therapeutic Insights
edited by Rei Kawashima
submission deadline 31 Jan 2027 | Viewed by 102 | Submission Open
Keywords: gastrointestinal mucosa; mucosal injury; intestinal inflammation; mucosal immunity; epithelial barrier; mucin; goblet cells; mechanosensing; host–microbiota interactions; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Therapeutic Mechanisms and Drug Discovery for Obesity and Nephropathy
edited by
submission deadline 31 Jan 2027 | Viewed by 102 | Submission Open
Keywords: obesity; diabetes mellitus; kidney injury; treatment and prevention of nephropathy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Medicinal Chemistry: Design, Synthesis and Application
edited by
submission deadline 31 Jan 2027 | Viewed by 102 | Submission Open
Keywords: medicinal chemistry; drug design; synthesis and analysis; biological chemistry; bioactive natural products
(This special issue belongs to the Section Molecular Pharmacology)
Rare Genetic Diseases: From Molecular Mechanisms to Therapeutic Strategies—2nd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 102 | Submission Open
Keywords: rare genetic disease; innate metabolic errors; neurodegenerative diseases; therapeutic; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Potentials of Phytochemicals: Anti-Inflammatory, Antibacterial, and Antitoxic Functions submission deadline 31 Jan 2027 | Viewed by 101 | Submission Open
Keywords: phytochemicals; natural products; anti-inflammatory activity; antibacterial activity; antitoxic activity; anti-venom activity; molecular mechanisms; oxidative stress; bioactive compounds; drug discovery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Role of Lipids in Sarcopenia and Atrophy of Skeletal Muscle
edited by Sara Baldelli and
submission deadline 31 Jan 2027 | Viewed by 101 | Submission Open
Keywords: sarcopenia; skeletal muscle atrophy; lipid metabolism; oxidative stress
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
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