Mechanism of SARS-CoV-2 Interactions with Tissue Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 132
Editors
Interests: COVID 19; SARS-CoV-2; hematology
2. CEINGE-Biotecnologie Avanzate, Scarl, via Gaetano Salvatore 486, 80145 Naples, Italy
Interests: COVID-19; cystic fibrosis; congenital defects of cholesterol metabolism; metabolomics; congenital diarrhea
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The COVID 19 pandemic has highlighted the complexity of the cellular and molecular mechanisms that regulate the interaction between SARS-CoV-2 and different human tissues, revealing specific pathogenic pathways and contributing to the heterogeneity of clinical outcomes. Despite significant scientific advances, important gaps remain in our understanding of viral tropism, epithelial and endothelial dysfunction, inflammatory pathway modulation, tissue‑specific immune regulation, and the persistent effects associated with the acute and post‑acute phases of COVID‑19. This Special Issue will gather original research articles, systematic reviews, translational investigations, and clinical analyses that deepen current knowledge on fundamental biological mechanisms related to viral entry, replication, immune responses, and cellular injury.
This Special Issue will stimulate scientific contributions on topics such as the dynamics of virus–receptor interactions; structural and functional alterations to epithelial and endothelial barriers; mechanisms of exacerbated inflammation and immunopathology; and innate and adaptive immune responses across pulmonary, cardiovascular, hematopoietic, renal, gastrointestinal, and neurological systems. Studies employing in vitro and in vivo models, multi‑omics approaches, and analyses of clinical and laboratory biomarkers, as well as investigations into cellular and tissue impacts and their relationships with clinical outcomes, are strongly encouraged.
By integrating experimental and clinical perspectives, this Special Issue will provide an updated and interdisciplinary synthesis of the cellular mechanisms involved in the pathogenesis of COVID‑19, contributing to the development of new therapeutic strategies, the refinement of diagnostic methods, and the strengthening of public health policies. It is expected that the contributions gathered here will expand our understanding of the biological determinants of SARS-CoV-2 infection and indicate pathways for more effective interventions in future epidemiological scenarios.
Dr. Matias Nunes Frizzo
Dr. Monica Gelzo
Guest Editors
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Keywords
- SARS‑CoV‑2
- virus–cell interaction
- viral pathogenesis
- immune response
- inflammation and tissue injury
- clinical and laboratory biomarkers
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