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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Biochemical and Molecular Changes in Reproductive Disorders

edited by

Kuo-Hu Chen

submission deadline 31 Jan 2027 | Viewed by 85 | Submission Open

Keywords: reproductive disorder; gynecologic malignancies; chemotherapy; target therapy; tumor marker; benign gynecologic diseases; endometriosis; PCOS

(This special issue belongs to the Section Molecular Biology)

Glutathione Deficiency and Health Conditions

edited by Vishwanath Venketaraman

submission deadline 31 Jan 2027 | Viewed by 85 | Submission Open

Keywords: neurological disorders; neurodegenerative diseases; ARDS; COPD; aging; cancer; diabetes; glutathione; HIV; tuberculosis

(This special issue belongs to the Section Biochemistry)

Physiological and Molecular Mechanisms of Fruit Growth, Development and Ripening

edited by

Orhan Karakaya

submission deadline 31 Jan 2027 | Viewed by 84 | Submission Open

Keywords: fruit development; fruit ripening; plant physiology; gene expression; metabolomics; hormonal regulation; postharvest biology; fruit quality; abiotic stress; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Toxicity and Genotoxicity Screening of Environmental Stressors

edited by

Karolina Sunjog

submission deadline 31 Jan 2027 | Viewed by 83 | Submission Open

Keywords: environmental stressors; toxicity; genotoxicity; environmental pollutants; emerging contaminants; in vitro models; in vivo models; biomarker analysis; environmental risk assessment

(This special issue belongs to the Section Molecular Toxicology)

Synthetic Lethality and Genome Stability in Cancer: From Molecular Mechanisms to Precision Therapy

edited by Sandra Bell

submission deadline 31 Jan 2027 | Viewed by 82 | Submission Open

Keywords: synthetic lethality; DNA repair; PARP inhibitors; genome instability; therapeutic resistance mechanisms; replication stress; DNA damage response; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Computational Models in Oncology: From Tumor Initiation to Progression to Treatment

edited by Cecilia Ana Suárez

submission deadline 31 Jan 2027 | Viewed by 81 | Submission Open

Keywords: cancer; computational oncology; multiscale modeling; systems biology; multi-omics; tumor dynamics; deep medical radiomics; hybrid computational frameworks; digital twins; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Damage-Associated Molecular Patterns in Cancer: From Molecular Mechanisms to Immune Regulation and Therapeutic Intervention

edited by

Ngar Woon Kam

submission deadline 31 Jan 2027 | Viewed by 79 | Submission Open

Keywords: damage-associated molecular patterns (DAMPs); cellular stress responses; cell–cell communication; immune regulation; therapeutic resistance; biomarker discovery; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Exercise Physiology and Human Performance

edited by

Adrián De La Rosa

submission deadline 31 Jan 2027 | Viewed by 79 | Submission Open

Keywords: exercise physiology; exercise training; sports nutrition; molecular adaptations; oxidative stress and redox biology; recovery; human performance

(This special issue belongs to the Section Molecular Biology)

Pathophysiology and Therapeutic Targets in Cardiovascular Disease

edited by Adrijan Sarajlija and Nikola Ilić

submission deadline 31 Jan 2027 | Viewed by 79 | Submission Open

Keywords: cardiovascular disease; pathophysiology; therapeutic targets; precision medicine; cardiomyopathy; heart failure; vascular biology; genetics; artificial intelligence; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

AI-Facilitated Drug Discovery Against Membrane Ion Channels

edited by

Jian Shi

submission deadline 31 Jan 2027 | Viewed by 76 | Submission Open

Keywords: artificial intelligence; membrane ion channel; drug development; drug design; drug synthesis

(This special issue belongs to the Section Molecular Pharmacology)

Advances and Applications of Gold Nanotherapeutics

edited by

Anand Thirupathi

submission deadline 31 Jan 2027 | Viewed by 75 | Submission Open

Keywords: gold nanoparticles (AuNPs) and nanotheranostics; oxidative stress; ROS-mediated signaling; redox-mediated signaling; physical exercise and exerkines; low-intensity pulsed ultrasound; redox homeostasis and mitochondrial function; neuroplasticity; neurodegenerative diseases; cardiac diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Role of Pyroptosis in Human Physiology, Diseases, and Therapy

edited by Xiaolong Yang

submission deadline 31 Jan 2027 | Viewed by 73 | Submission Open

Keywords: pyroptosis; gasdermin; inflammasome; programmed cell death; tumor immune microenvironment; cancer therapy; inflammatory diseases; innate immunity; targeted therapy; caspases

(This special issue belongs to the Section Molecular Biology)

Algal Biotechnology for Circular Bioeconomy: Molecular Advances and Sustainable Applications

edited by

Ramachandran Sivaramakrishnan

submission deadline 31 Jan 2027 | Viewed by 72 | Submission Open

Keywords: algal biotechnology; microalgae; macroalgae; seaweed; molecular biology; genomics; transcriptomics; metabolomics; proteomics; synthetic biology; genetic engineering; metabolic engineering; algal biorefineries; bioactive compounds; phytochemicals; high-value metabolites; natural products; nutraceuticals; bioproducts; biomass valorization; circular bioeconomy; sustainable biotechnology; environmental remediation; carbon capture; biofuels; omics technologies; algal cultivation; systems biology; marine biotechnology; blue biotechnology

(This special issue belongs to the Section Molecular Biology)

Craniofacial Engineering in Dental and Regenerative Medicine

edited by

Alexander Tsouknidas

submission deadline 31 Jan 2027 | Viewed by 71 | Submission Open

Keywords: craniofacial engineering; dental biomaterials; oral biomechanics; finite element analysis; implant dentistry; digital dentistry; tissue engineering; mechanobiology; prosthodontics; orthodontics

(This special issue belongs to the Section Materials Science)

Novel Chemical Compounds and Natural Modulators in Anticancer Therapy: Synthesis, Biological Activity, and Mechanisms of Action

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 31 Jan 2027 | Viewed by 71 | Submission Open

Keywords: anticancer therapy; medicinal chemistry; natural products; synthetic compounds; biological activity; molecular mechanisms; drug discovery; cancer signaling; structure–activity relationship; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Emerging Therapeutic Strategies for Glioblastoma

edited by Inan Olmez

submission deadline 31 Jan 2027 | Viewed by 71 | Submission Open

Keywords: glioblastoma; preclinical; combination therapy; overcoming resistance; translational

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research on Chitosan

edited by

Antonella Piozzi

Iolanda Francolini

and

Clarissa Ciarlantini

submission deadline 31 Jan 2027 | Viewed by 70 | Submission Open

Keywords: chitosan; chitosan derivatives; biopolymer engineering; functional materials; nanostructured systems; drug delivery; tissue engineering; environmental remediation; water treatment; sustainable industrial applications

(This special issue belongs to the Section Macromolecules)

Design and Evaluation of Metal-Based Anticancer Drugs and Crucial Peptide Inhibitors

edited by

Sujoy Das

submission deadline 31 Jan 2027 | Viewed by 70 | Submission Open

Keywords: metal-based drugs; anticancer agents; peptide inhibitors; medicinal chemistry; drug discovery; enzyme inhibitors; peptide inhibitors; structure–activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Controlled Synthesis of Sustainable Carbon Nanostructures

edited by

Ádám Juhász

submission deadline 31 Jan 2027 | Viewed by 69 | Submission Open

Keywords: carbon nanostructures; controlled synthesis; sustainable nanomaterials; continuous-flow chemistry; carbon quantum dots; surface functionalization; reproducibility; optoelectronics; biosensing

(This special issue belongs to the Section Materials Science)

Acquired Macular Diseases: New Systemic/Ocular Biomarkers and Novel Pharmacological Targets

edited by

Maria Consiglia Trotta

submission deadline 31 Jan 2027 | Viewed by 68 | Submission Open

Keywords: age-related macular degeneration; biomarkers; molecular biology; retinal degeneration; oxidative stress; inflammation; omics technologies; pharmacological targets; precision medicine; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

iPSCs in Disease Modeling and Regenerative Strategies

edited by

Tadahisa Sugiura

submission deadline 31 Jan 2027 | Viewed by 65 | Submission Open

Keywords: gene editing; functional genomics; organoids; tissue engineering; molecular mechanisms; cell differentiation and maturation; extracellular vesicles; drug discovery; toxicity testing; immune modulation

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms in Skin Endocrinology and Dermatology

edited by

Terrence Piva

and

Beatrice Bălăceanu-Gurău

submission deadline 31 Jan 2027 | Viewed by 65 | Submission Open

Keywords: skin endocrinology; molecular dermatology; hormonal signaling; skin aging; inflammatory dermatoses; skin microbiome; cutaneous immune response; esthetic and regenerative dermatology; oncodermatology; nanocarrier-based drug delivery

(This special issue belongs to the Section Molecular Biology)

Multi-Omics Analysis of PTSD and Stress-Related Disorders

edited by

Ruoting Yang

submission deadline 31 Jan 2027 | Viewed by 65 | Submission Open

Keywords: PTSD and stress-related disorders; human multi-omics; biomarker discovery; treatment response; diagnosis and prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Pathogenic Microbial Biofilms: Mechanisms, Resistance, and Therapeutic Strategies

edited by

Maria Do Socorro Costa

submission deadline 31 Jan 2027 | Viewed by 64 | Submission Open

Keywords: microbial biofilms; antimicrobial resistance; quorum sensing; microbial interactions; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

Photodynamic Therapy for Cancer: Nanomedicine-Based Photosensitizers and Cancer Targeting

edited by

Young-Il Jeong

submission deadline 31 Jan 2027 | Viewed by 63 | Submission Open

Keywords: photodynamic therapy; nanomedicine; cancer; drug delivery system; stimuli-sensitive; diagnosis; reactive oxygen species

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of DNA Replication and Repair

edited by Sneha Saxena

submission deadline 31 Jan 2027 | Viewed by 63 | Submission Open

Keywords: DNA replication; DNA repair; replication stress response; genomic instability; DNA damage response

(This special issue belongs to the Section Molecular Genetics and Genomics)

Interplay Between the Human Microbiome and Diseases, 2nd Edition

edited by

Tihamer Molnar

and

Zoltán Péterfi

submission deadline 31 Jan 2027 | Viewed by 61 | Submission Open

Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

AI-Guided Molecular Design and Advanced Nanodelivery of Functional Nucleic Acids and Bioactive Compounds

edited by

Jingjing Tian

and

Longjiao Zhu

submission deadline 31 Jan 2027 | Viewed by 60 | Submission Open

Keywords: artificial intelligence; molecular design; machine learning; functional nucleic acids; molecular recognition; nanodelivery systems; bioactive compounds; nanomedicine

(This special issue belongs to the Section Molecular Biology)

Dietary Bioactives and Microbiome in Health

edited by

Mónica Carrera

submission deadline 31 Jan 2027 | Viewed by 59 | Submission Open

Keywords: dietary bioactives; microbiome; multi-omics; proteomics; metabolomics; artificial intelligence; precision nutrition; food by-products; nanotechnology; systems biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Systemic Lupus Erythematosus Pathogenesis

edited by

Cecilia Contreras-Cubas

submission deadline 31 Jan 2027 | Viewed by 57 | Submission Open

Keywords: systemic lupus erythematosus; pathogenesis; cellular and molecular mechanisms; immune dysregulation; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Molecular Mechanisms and Therapeutic Strategies in Host–Pathogen–Drug Interactions

edited by

Umar Saeed

submission deadline 31 Jan 2027 | Viewed by 57 | Submission Open

Keywords: host–pathogen interactions; molecular pathogenesis; immune evasion; microbial virulence; host-directed therapy; antimicrobial resistance; antiviral therapeutics; cellular signaling; drug–pathogen interactions; precision infectious-disease therapy

(This special issue belongs to the Section Molecular Microbiology)

Advances in Chronic Wound Healing: Immune Responses, Biomarkers and Novel Therapies

edited by Marek Kucharzewski

submission deadline 31 Jan 2027 | Viewed by 56 | Submission Open

Keywords: chronic wounds; wound healing; inflammation; immune signaling; biomarkers; angiogenesis; extracellular matrix; oxidative stress; cellular senescence; regenerative medicine

(This special issue belongs to the Section Molecular Immunology)

Artificial Intelligence and Machine Learning in Genomics and Molecular Genetics

edited by Lei Ma

submission deadline 31 Jan 2027 | Viewed by 55 | Submission Open

Keywords: genomics; molecular genetics; multi-omics analysis; computational biology

(This special issue belongs to the Section Molecular Informatics)

Cholesterol and Oxysterols as Signaling Molecules in Human Pathophysiology

edited by

Anne Vejux

submission deadline 31 Jan 2027 | Viewed by 55 | Submission Open

Keywords: cholesterol; oxysterols; cancer; cardiovascular disease; neurodegenerative disease; lysosomal disease; cell signaling; age-related diseases; therapy; cell death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Parkinson's Disease

edited by

Jorge Hernández-Vara

submission deadline 31 Jan 2027 | Viewed by 53 | Submission Open

Keywords: Parkinson’s disease; molecular mechanisms; neurodegeneration; biomarkers; translational research; α-synuclein; neuroinflammation; mitochondrial dysfunction; computational modelling

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Pediatric Kidney Diseases: From Development to Disease and Therapy

edited by

Naomi Pode-Shakked

submission deadline 31 Jan 2027 | Viewed by 50 | Submission Open

Keywords: pediatric kidney disease; kidney development; kidney organoids/tubuloids; congenital anomalies of the kidney and urinary tract (CAKUT); inherited tubulopathies; Wilms tumor; acute kidney injury (AKI); nephron progenitor cells (NPS); podocytes; kidney tubules; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Environmental Nanotechnology

edited by Ramachandran Sivaramakriahnan

submission deadline 31 Jan 2027 | Viewed by 49 | Submission Open

Keywords: macroalgae; nanotechnology; green synthesis; nanoparticles; environmental remediation; biorefinery; biofuels; algal biomass; biomedical applications; drug delivery; antimicrobial activity; biosensors; wastewater treatment; heavy metal removal; carbon sequestration; circular bioeconomy; sustainable biotechnology; renewable energy; biopolymers; eco-friendly nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Neuroinflammation and Neuroprotection: Molecular Mechanisms, Therapeutic Targets and Translational Perspectives

edited by

Antonio Ibarra

submission deadline 31 Jan 2027 | Viewed by 48 | Submission Open

Keywords: neuroinflammation; neuroprotection; central nervous system; autoimmune diseases; spinal cord injury; traumatic brain injury; neurodegeneration; immunomodulation; glial cells; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Inflammatory Bowel Disease and Microbiome: 2nd Edition

edited by

Abigail Raffner

submission deadline 31 Jan 2027 | Viewed by 48 | Submission Open

Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker

(This special issue belongs to the Section Molecular Microbiology)

Tissue Immunity in Viral Infection and Disease

edited by

Dmitry S. Ushakov

submission deadline 31 Jan 2027 | Viewed by 48 | Submission Open

Keywords: tissue immunity; viral pathogenesis; host–virus interactions; tissue-resident immunity; epithelial barrier immunity; organ-specific infection; innate immunity; adaptive immunity; spatial biology; multi-omics

(This special issue belongs to the Section Molecular Immunology)

Genetic Analysis of Neurodevelopmental Disorders

edited by

Simone Treccarichi

submission deadline 31 Jan 2027 | Viewed by 45 | Submission Open

Keywords: neurodevelopmental disorders; autism spectrum disorder; psychiatric disorder; genetic architecture; next generation sequencing; candidate gene

(This special issue belongs to the Section Molecular Genetics and Genomics)

Stroke: From Pathogenic Mechanisms to Therapeutic Strategies

edited by

Anetta Lasek-Bal

submission deadline 31 Jan 2027 | Viewed by 43 | Submission Open

Keywords: stroke; risk factors; thrombolysis; thrombectomy; outcomes

(This special issue belongs to the Section Molecular Neurobiology)

Precision Cardiovascular Medicine: Molecular Insights and AI-Driven Analytics

edited by

Maria I. Dorobantu

submission deadline 31 Jan 2027 | Viewed by 42 | Submission Open

Keywords: cardiovascular disease; molecular research; cardiovascular genetics; cardiovascular epigenetics; regenerative medicine; biomarkers; artificial intelligence; digital health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Animal Virology: Unraveling Pathogens, Hosts, and Interventions

edited by Xingwen Bai and Hong Yuan

submission deadline 31 Jan 2027 | Viewed by 41 | Submission Open

Keywords: animal virology; One Health; viral discovery; pathogenesis; zoonosis; host immune response; viral evolution; diagnostics; vaccine development; antiviral therapies

(This special issue belongs to the Section Molecular Microbiology)

Diagnosis and Treatment of Diabetes and Its Complications

edited by

Michał Bulc

submission deadline 31 Jan 2027 | Viewed by 40 | Submission Open

Keywords: molecular mechanisms of diabetes; diabetes pathogenesis; diabetes-associated diseases; diabetic complications; novel treatments of diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Surfactants: Design, Synthesis, and Properties

edited by Frans Smit

submission deadline 31 Jan 2027 | Viewed by 38 | Submission Open

Keywords: surfactants; amphiphiles; molecular design; organic synthesis; self-assembly; micellisation; interfacial properties; structure-property relationships; bio-based surfactants; functional materials

(This special issue belongs to the Section Materials Science)

Alternative Splicing: From Biological Functions to Human Disease to Therapeutic Targeting

edited by Elisabetta Morini

submission deadline 31 Jan 2027 | Viewed by 35 | Submission Open

Keywords: alternative splicing; pre-mRNA processing; splicing factors; human diseases; therapeutic targeting; antisense oligonucleotides: small molecule splicing modulators; RNA binding proteins; isoform regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Antifibrotic Drugs and Mechanisms in Pulmonary Fibrosis

edited by

Xinyi Yang

submission deadline 31 Jan 2027 | Viewed by 26 | Submission Open

Keywords: pulmonary fibrosis; fibrogenesis; TGF-β signaling; antifibrotic agents; drug discovery; computational biology; precision therapy

(This special issue belongs to the Section Molecular Pharmacology)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 20 Feb 2027 | 2 articles | Viewed by 5439 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition

edited by

Deguo Han

submission deadline 20 Feb 2027 | 3 articles | Viewed by 2229 | Submission Open

Keywords: plant–pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 2401-2450 on page 49 of 62.

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