Novel Chemical Compounds and Natural Modulators in Anticancer Therapy: Synthesis, Biological Activity, and Mechanisms of Action
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 30
Editors
Interests: anticancer activity; apoptosis; cell death; combination therapy; cu-proptosis; cytotoxicity; DNA damage; DNA repair; drug design; ferroptosis; necroptosis; proliferation; pyra-zoles; tetrazoles; triazines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer remains one of the leading causes of mortality worldwide, underscoring the urgent need for innovative therapeutic strategies. The discovery of novel synthetic compounds and bioactive natural modulators has significantly expanded the repertoire of potential anticancer agents, offering new opportunities to improve efficacy, overcome drug resistance, and reduce adverse effects. Advances in medicinal chemistry, molecular pharmacology, and cancer biology have accelerated the identification of compounds targeting key signaling pathways and molecular mechanisms involved in tumor initiation, progression, and metastasis. We are pleased to invite you to contribute to this Special Issue entitled "Novel Chemical Compounds and Natural Modulators in Anticancer Therapy: Synthesis, Biological Activity, and Mechanisms of Action". This Special Issue aims to present recent advances in the design, synthesis, biological evaluation, and mechanistic investigation of novel chemical compounds and natural modulators with anticancer potential. The topic is intended to provide a multidisciplinary platform for researchers in medicinal chemistry, molecular biology, pharmacology, toxicology, and related fields, highlighting studies that contribute to the development of innovative anticancer therapies and deepen our understanding of their molecular mechanisms of action. Original research articles, communications, and comprehensive review articles are welcome. Research areas may include, but are not limited to:
- Design and synthesis of novel anticancer compounds;
- Natural products and natural modulators with anticancer activity;
- Structure–activity relationship (SAR) studies;
- Molecular mechanisms of anticancer action;
- Targeted therapies and modulation of cancer signaling pathways;
- Drug resistance and strategies to overcome resistance;
- Combination therapies involving synthetic and natural agents;
- In vitro and in vivo biological evaluation of anticancer candidates;
- Computational approaches, molecular docking, and AI-assisted drug discovery;
- Preclinical studies supporting anticancer drug development.
We look forward to receiving your contributions.
Dr. Mateusz Kciuk
Dr. Damian Kołat
Guest Editors
Manuscript Submission Information
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Keywords
- anticancer therapy
- medicinal chemistry
- natural products
- synthetic compounds
- biological activity
- molecular mechanisms
- drug discovery
- cancer signaling
- structure–activity relationship
- drug resistance
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