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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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3D Printing and Biomaterials for Hearing and Balance Restoration
edited by
submission deadline 31 Dec 2026 | Viewed by 454 | Submission Open
Keywords: hearing; balancing; 3D printing; biomaterial
(This special issue belongs to the Section Materials Science)
Molecular Advances in Three-Dimensional Cell Culture: From Bioengineering Innovation and Therapeutic Application
edited by Jong-Young Kwak
submission deadline 31 Dec 2026 | 1 articles | Viewed by 446 | Submission Open
Keywords: 3D culture; biomaterials; scaffold; tissue engineering; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Novel Therapeutic Strategies for Hepatocellular Carcinoma
edited by
submission deadline 31 Dec 2026 | Viewed by 442 | Submission Open
Keywords: hepatocellular carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; radiotherapy; embolization; surgery; transplantation
(This special issue belongs to the Section Molecular Oncology)
Molecular Study of Foodborne Pathogens submission deadline 31 Dec 2026 | Viewed by 438 | Submission Open
Keywords: foodborne pathogens; microbiology; molecular analysis; foodborne outbreak investigation; epidemiology; listeria monocytogenes; salmonella; campylobacter; virulence genes; antimicrobial gene; WGS; NGS
(This special issue belongs to the Section Molecular Microbiology)
Advances in Plant–Pathogen Interactions (4th Edition)
edited by
submission deadline 31 Dec 2026 | Viewed by 437 | Submission Open
Keywords: host; effection; pathogenicity; pathogen; plant immunity; interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Cutting-Edge Research and Advancements in Neurodegenerative Diseases
edited by Meera Soundararajan
submission deadline 31 Dec 2026 | Viewed by 430 | Submission Open
Keywords: neurodegenerative disorders; neurons; Alzheimer’s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington disease
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Dynamics of the Oral Microbiome in Periodontal Health and Disease
edited by
submission deadline 31 Dec 2026 | Viewed by 424 | Submission Open
Keywords: oral microbiome; periodontics; tissue regeneration; bioinformatics; biomarkers; host–microbiome interactions; molecular dynamics
(This special issue belongs to the Section Molecular Microbiology)
Serum Amyloid A: Established Roles and Emerging Questions in Health and Disease
edited by Preetha Shridas
submission deadline 31 Dec 2026 | Viewed by 412 | Submission Open
Keywords: Serum Amyloid A; high-density lipoprotein; acute inflammation; chronic inflammatory
(This special issue belongs to the Section Biochemistry)
Recent Advances in Optoelectronic Materials
edited by Muhammad Umair Shahid
submission deadline 31 Dec 2026 | Viewed by 412 | Submission Open
Keywords: organic solar cells; DSSCs; perovskite solar cells; donor–acceptor systems; optoelectronic devices; charge separation; sensors; quantum dots; 2D materials; machine learning in materials science
(This special issue belongs to the Section Materials Science)
Mechanisms Linking Gut Microbiota to Metabolic Diseases
edited by Jing Ji, and Aman Khan
submission deadline 31 Dec 2026 | Viewed by 390 | Submission Open
Keywords: gut microbiota; metabolic diseases; probiotics; prebiotics; obesity; microbial metabolites; host–microbe interaction; metabolic inflammation; intestinal barrier; hyperuricemia; diabetes; non-alcoholic fatty liver disease
(This special issue belongs to the Section Molecular Microbiology)
Research into Biomarkers for Psychiatric Disorders submission deadline 31 Dec 2026 | Viewed by 389 | Submission Open
Keywords: psychiatric disorders; molecular biomarkers; single-cell transcriptomics; neuroimmune interface; peripheral blood mononuclear cells (PBMCs); precision psychiatry; multi-omics integration; extracellular vesicles; liquid biopsy; neurogenomics
(This special issue belongs to the Section Molecular Neurobiology)
Targeted Anticancer Therapeutics: Mechanisms, Resistance, Tumor Microenvironment, and Translational Advances
edited by Shakti Prasad Pattanayak
submission deadline 31 Dec 2026 | 1 articles | Viewed by 388 | Submission Open
Keywords: cancer metabolism; drug resistance; tumor microenvironment; immunometabolism; targeted therapy; anticancer therapeutics; autophagy; oxidative stress; cancer immunotherapy; translational oncology
(This special issue belongs to the Section Molecular Oncology)
Functional Genomics of Rare Variants in Human Disease
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 388 | Submission Open
Keywords: rare genetic variants; functional genomics; variant interpretation; next-generation sequencing; genome editing; neurodevelopmental disorders; Mendelian diseases; multi-omics integration; gene regulation; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Protein Dynamics, Binding and Allostery
edited by Huawei Zhang
submission deadline 31 Dec 2026 | Viewed by 374 | Submission Open
Keywords: protein dynamics; protein interaction; allostery; conformational regulation; drug design
(This special issue belongs to the Section Molecular Biology)
New Perspectives in Molecular Plant Pathology submission deadline 31 Dec 2026 | Viewed by 369 | Submission Open
Keywords: molecular plant pathology; real-time PCR; gene expression; molecular markers; marker-assisted selection; genetic diversity; pathogen diagnostics; transcriptomics; genome editing; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Research Advances in Food Packaging Materials
edited by Marília Miotto and
submission deadline 31 Dec 2026 | Viewed by 369 | Submission Open
Keywords: active food packaging; intelligent packaging; smart packaging; biodegradable polymers; bio-based materials; food safety; antimicrobial packaging; antioxidant packaging; sustainable packaging; shelf-life extension
(This special issue belongs to the Section Materials Science)
Molecular Advances on Sickle Cell Disease
edited by
submission deadline 31 Dec 2026 | Viewed by 368 | Submission Open
Keywords: sickle cell disease; hemoglobinopathy; vaso-occlusion; fetal hemoglobin induction; genome editing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Adipose Tissue Dysfunction in Obesity and Metabolic Diseases
edited by Andressa Bolsoni-Lopes
submission deadline 31 Dec 2026 | Viewed by 363 | Submission Open
Keywords: adipose tissue dysfunction; obesity; metabolic diseases; insulin resistance; adipose tissue inflammation; lipid metabolism; fatty acid signaling; extracellular matrix remodeling; metabolic dysfunction-associated steatotic liver disease (MASLD); G protein-coupled receptors (GPCRs)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pancreatic Cancer: Biomarkers and New Drug Development
edited by Yi-Ming Arthur Chen
submission deadline 31 Dec 2026 | Viewed by 358 | Submission Open
Keywords: pancreatic ductal adenocarcinoma; biomarkers; transcriptomic subtypes; new drug development; target therapy; immunotherapy; KRAS inhibitors; precision medicine; health supplements
(This special issue belongs to the Section Molecular Oncology)
Immunotherapies of Solid Tumors
edited by
submission deadline 31 Dec 2026 | Viewed by 358 | Submission Open
Keywords: immune; solid tumors; anti-tumor; molecular pathways; immunotherapy; tumor microenvironment; checkpoint; CAR T cell; adoptive cell
(This special issue belongs to the Section Molecular Immunology)
Applications of Machine Learning and Chemoinformatics in Molecular Prediction and Drug Discovery
edited by Saurav Mallik
submission deadline 31 Dec 2026 | Viewed by 351 | Submission Open
Keywords: drug discovery; epigenetics; immunology; cancer biology; aging; graph mining; neural network; structural biology
(This special issue belongs to the Section Molecular Informatics)
Unraveling Affective Disorders: From Pathogenesis to Drug Therapy
edited by Lawrence Shih-Hsin Wu
submission deadline 31 Dec 2026 | Viewed by 347 | Submission Open
Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene–environment interactions; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Genetic and Metabolic Liver Disorders: Advances in Diagnosis, Disease Mechanisms and Treatment submission deadline 31 Dec 2026 | Viewed by 320 | Submission Open
Keywords: genetic liver disease; metabolic disorders; disease mechanisms; genotype–phenotype correlation; compound heterozygosity; pathogenetic mutations; VUS mutations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Multi-Omics in Fruit Quality Development and Sustainability
edited by
submission deadline 31 Dec 2026 | Viewed by 314 | Submission Open
Keywords: transcriptome; proteome; metabolome; fruit appearance quality; fruit nutrient and taste quality; post-harvest storage; biotic and abiotic stress; identification and evaluation of fruit germplasm; horticultural technique of artificial intelligence
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology: 2nd Edition submission deadline 31 Dec 2026 | Viewed by 297 | Submission Open
Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines
(This special issue belongs to the Section Molecular Immunology)
Idiosyncratic Drug Induced Liver Injury
edited by
submission deadline 31 Dec 2026 | Viewed by 277 | Submission Open
Keywords: updated RUCAM; iDILI; immune iDILI; autoimmune iDILI; classic idiosyncratic DILI (iDILI); drug-induced autoimmune hepatitis (DIAIH); idiosyncratic drug-induced anti-CYP autoimmune hepatitis; HLA-based immune iDILI; immune iDILI with SJS/TEN; immune iDILI by ICIs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Functional Activities of Natural Products
edited by
submission deadline 31 Dec 2026 | Viewed by 276 | Submission Open
Keywords: phytochemicals; biological products; pharmacological actions; plant extracts; structural-activity; functional foods; well-being
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Trends and Prospects in Biomaterials
edited by Gabriela Graziani and
submission deadline 31 Dec 2026 | Viewed by 266 | Submission Open
Keywords: biomaterials; orthopaedics; wound healing; additive manufacturing; infection; tissue modelling; tissue regeneration; orthopaedics; wound healing; antibacterial materials; regenerative medicine; reparative medicine
(This special issue belongs to the Section Materials Science)
Leishmaniasis: Pathogenesis and Emerging Therapeutic Strategies
edited by
submission deadline 31 Dec 2026 | Viewed by 245 | Submission Open
Keywords: leishmaniasis; host–parasite; immune regulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Structure and Functional Dynamics of Bacterial Toxins in Pathogenesis and Biomedical Innovation
edited by and Aijaz Malik
submission deadline 31 Dec 2026 | Viewed by 242 | Submission Open
Keywords: bacterial toxins; structural biology; host–pathogen interactions; toxin mechanisms; protein engineering; immunotoxins; synthetic biology; antimicrobial strategies; drug delivery; translational research
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in tRNA Research and Therapeutics submission deadline 31 Dec 2026 | Viewed by 239 | Submission Open
Keywords: tRNA; genetic code; RNA therapies; transcription; translation; RNA-mediated regulation
(This special issue belongs to the Section Molecular Biology)
Deep Learning-Driven Drug Discovery
edited by
submission deadline 31 Dec 2026 | Viewed by 227 | Submission Open
Keywords: deep learning; drug discovery; AI-driven drug design; molecular interactions; compound optimi-zation; virtual screening; biomarker discovery; drug repurposing; multi-omics integration; toxicity prediction
(This special issue belongs to the Section Molecular Informatics)
Soil Nutrient Cycling and Microbial Driving Mechanisms
edited by
submission deadline 31 Dec 2026 | Viewed by 221 | Submission Open
Keywords: soil nutrient cycling; microbial driving mechanisms; soil–plant–microbe interactions; carbon, nitrogen, and phosphorus dynamics; soil biogeochemistry; microbial communities and functions; rhizosphere processes; climate change impacts on soils; sustainable nutrient management; biochar and nanotechnology applications; soil health and fertility; biogeochemical transformations; stress environments (salinity, drought, contamination)
(This special issue belongs to the Section Molecular Microbiology)
Transformative Computational and AI Approaches for Precision Drug Discovery
edited by Danishuddin and
submission deadline 31 Dec 2026 | Viewed by 220 | Submission Open
Keywords: precision drug discovery; AI-driven drug design; computational drug discovery; molecular docking and simulation; machine learning and deep learning; multi-omics integration; ADME/toxicity prediction; network pharmacology; precision medicine and therapeutics; bioinformatics
(This special issue belongs to the Section Molecular Informatics)
Seed Development and Germination submission deadline 31 Dec 2026 | Viewed by 219 | Submission Open
Keywords: seed development; seed germination; seed quality assessment; seedborne pathogens; abiotic stress and seeds; seed omics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Neurodevelopment, Neuroprotection, and Brain Health submission deadline 31 Dec 2026 | Viewed by 213 | Submission Open
Keywords: cerebral ischemia; neurovascular coupling; brain plasticity; endothelial dysfunction; neu-roinflammation; tissue repair; imaging biomarkers; stroke recovery; molecular neurobiology; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Pathogenesis of Common Pregnancy Complications
edited by Radzisław Mierzyñski and
submission deadline 31 Dec 2026 | Viewed by 207 | Submission Open
Keywords: pregnancy complications; maternal and fetal health; preterm delivery; intra-amniotic infection; hypertensive disorders; metabolic syndrome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dietary Modulation of the Gut Microbiome: Functional Additives and Their Role in Health and Disease
edited by
submission deadline 31 Dec 2026 | Viewed by 204 | Submission Open
Keywords: gut microbiota; gut health; dietary modulation; functional additives: probiotics, prebiotics and postbiotics; infection; animal production; poultry; microbial metabolites
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Ocular Inflammation and Infection
edited by Kofi Asiedu
submission deadline 31 Dec 2026 | Viewed by 196 | Submission Open
Keywords: ocular inflammation; corneal infection; neuroimmunology; immune–nerve interactions; ocular surface disease; cytokines and chemokines; molecular biomarkers; in vivo confocal microscopy
(This special issue belongs to the Section Molecular Immunology)
Bridging Molecular and Translational Research in Chronic Kidney Disease and Dysmetabolism
edited by , , Lida Tartaglione and
submission deadline 31 Dec 2026 | 1 articles | Viewed by 191 | Submission Open
Keywords: chronic kidney disease; translational research; dysmetabolism; biotechnologies; bone diseases; inflammation; oxidative stress; omics; personalize medicine; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Platelet-Based Biomaterials in Regenerative Medicine: Biochemical Insights and Therapeutic Perspectives
edited by , and Maria Rosaria Miranda
submission deadline 31 Dec 2026 | Viewed by 189 | Submission Open
Keywords: PRP; PRF; platelet-based biomaterials; regenerative medicine; tissue regeneration; biochemical pathways; biomaterials; translational medicine; clinical biochemistry
(This special issue belongs to the Section Biochemistry)
Advances in Parasite Biology: Molecular Mechanisms, Host Interactions and Antiparasitic Strategies
edited by
submission deadline 31 Dec 2026 | Viewed by 187 | Submission Open
Keywords: parasite biology; host–parasite interactions; antiparasitic strategies; antiparasitic drugs; drug resistance; vaccine development; molecular parasitology; immune evasion; one health
(This special issue belongs to the Section Molecular Biology)
Advances in Polymer Electrochemical Materials
edited by He Zhang, and Cao Ge
submission deadline 31 Dec 2026 | Viewed by 187 | Submission Open
Keywords: polymer electrochemical materials; flexible electronics; electrochromic devices; bioelectronics; corrosion protection; supercapacitors; batteries; biomaterials; conducting polymers; energy storage
(This special issue belongs to the Section Materials Science)
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Adipose Tissue–Liver Crosstalk: Mechanisms and Therapeutic Opportunities
edited by Lei Hao
submission deadline 31 Dec 2026 | Viewed by 186 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); adipose tissue–liver crosstalk; brown adipose tissue (BAT); beige adipocytes; white adipose tissue (WAT); thermogenesis; adipokines; hepatokines; energy metabolism
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Green Synthesis of Nanomaterials: Cytotoxicity and Drug Delivery
edited by
submission deadline 31 Dec 2026 | Viewed by 182 | Submission Open
Keywords: green synthesis; green-nanomaterials; cytotoxicity; antibacterial activity; drug delivery; biocompatibility; anticancer activity; oxidative stress
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Coordination Chemistry: Thermodynamic, Spectroscopic, and Biological Insights
edited by Michał Zabiszak
submission deadline 31 Dec 2026 | Viewed by 178 | Submission Open
Keywords: coordination chemistry; metal–ligand interactions; thermodynamic studies; spectroscopic characterisation; bioinorganic chemistry; supramolecular chemistry; medicinal inorganic chemistry; biological activity
(This special issue belongs to the Section Biochemistry)
Beyond Docking Scores: Decision-Centric Computer-Aided Drug Discovery submission deadline 31 Dec 2026 | 1 articles | Viewed by 177 | Submission Open
Keywords: computer-aided drug discovery; hit prioritization; prospective validation; polypharmacology; selectivity profiling; developability; false-positive reduction; multi-parameter optimization; uncertainty-aware ranking; translational medicinal chemistry
(This special issue belongs to the Section Molecular Informatics)
Plants and Their Compounds in Drug Design: Molecule to Molecular Dynamics Simulation submission deadline 31 Dec 2026 | Viewed by 174 | Submission Open
Keywords: phytochemicals; computer-aided drug design; molecular docking; molecular dynamics simulation; virtual screening; ADMET profiling; network pharmacology; natural products
(This special issue belongs to the Section Molecular Pharmacology)
The Importance of Circadian Toxicology in Human Lifestyle Diseases
edited by
submission deadline 31 Dec 2026 | Viewed by 171 | Submission Open
Keywords: circadian toxicology; chronotoxicity; phototoxicity; circadian rhythm; artificial light at night; melatonin; human lifestyle diseases
(This special issue belongs to the Section Molecular Toxicology)
Mechanisms of Pain Development and Treatment Strategies
edited by
submission deadline 31 Dec 2026 | Viewed by 171 | Submission Open
Keywords: chronic pain; fibromyalgia; long COVID; post-viral fatigue/pain syndrome; neuropathic pain; neuroinflammation; stress responses; opioid tolerance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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