Recent Advances in tRNA Research and Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 228
Editors
Interests: protein synthesis inhibitors; antibiotic resistance; novel antibiotics; riboswitch inhibitors; RNA inhibitors
Special Issues, Collections and Topics in MDPI journals
Interests: translation of the genetic code; tRNA biology
Interests: noncoding RNA; riboswitch; RNA structure; RNA-protein interaction; nucleic acid crystallography
Special Issues, Collections and Topics in MDPI journals
Interests: ribosomal RNA and transfer RNA biogenesis; T-box riboswitches; RNase P; RNA-mediated regulation of transcription and translation; ribozymes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Transfer RNAs (tRNAs) are quintessential noncoding RNAs that play essential roles in both housekeeping and regulatory functions of the cell. We are in the midst of a blooming renaissance of tRNA research and novel applications in human health and diseases. For instance, tRNAs have recently been discovered to populate the cell surfaces, extracellular vesicles, plant leaves, interiors of viruses, and more. tRNA research has also been at the forefront of developing cutting-edge technologies in RNA modifications, RNA sequencing, RNA structure, RNA–protein interactions, RNA viruses, RNA vaccines, and RNA therapeutics. An exciting new era of tRNA research, applications, and therapeutics, enabled by revolutionary new technologies, has just dawned on us. Powered by recent technological advances in RNA sequencing, RNA modifications, genome editing, Cryo-EM, etc., the tRNA field has been transformed by major breakthroughs that not only provide new paradigms and key mechanistic insights into gene expression and cellular metabolic control but also open exciting new avenues towards therapeutic strategies against an expanding array of tRNA-associated human diseases. This special issue aspires to include recent advances on tRNA biology with impact on therapeutics and to highlight the importance of tRNA molecules, not only as essential mediators of the genetic code but also as essential regulators of the genetic information.
The Special Issue is in cooperation with the “30th tRNA Conference” (https://trna2026.gr/). We welcome submissions from conference participants, as well as latest findings and novel insights from researchers worldwide.
Prof. Dr. Constantinos Stathopoulos
Dr. Michael Ibba
Dr. Jinwei Zhang
Dr. Vassiliki Stamatopoulou
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- tRNA
- genetic code
- RNA therapies
- transcription
- translation
- RNA-mediated regulation
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