Molecular Advances on Sickle Cell Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 128
Special Issue Editor
Interests: maternal-fetal medicine; prenatal therapy; sickle cell disease; fetal stem cell transplantation; gene therapy; pregnancy immunology; fetal medicine; prenatal genetics; translational research
Special Issue Information
Dear Colleagues,
Sickle cell disease (SCD) remains one of the most common and clinically significant inherited hemoglobinopathies worldwide. Despite major advances in our understanding of its molecular basis, patients continue to face significant morbidity and reduced quality of life due to vaso-occlusive complications, organ damage, and limited curative options. Over the past decade, rapid progress in molecular biology, genomics, and therapeutic innovation has transformed the landscape of SCD research, opening new possibilities for early diagnosis, disease modification, and gene-based therapies.
This Special Issue of the International Journal of Molecular Sciences aims to highlight cutting-edge advances in the molecular understanding of sickle cell disease, spanning from pathophysiological mechanisms to translational applications. We welcome original research and comprehensive reviews that address emerging diagnostic biomarkers, genetic and epigenetic regulation, novel therapeutic targets, advances in gene and cell therapies, and innovative strategies to mitigate disease complications. By bringing together these contributions, we hope to foster a deeper understanding of the molecular underpinnings of SCD and stimulate collaborations that will ultimately accelerate progress toward more effective treatments and improved patient outcomes.
Dr. Panicos Shangaris
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- sickle cell disease
- hemoglobinopathy
- vaso-occlusion
- fetal hemoglobin induction
- genome editing
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