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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of DNA Replication and Repair
edited by Sneha Saxena
submission deadline 31 Jan 2027 | Viewed by 58 | Submission Open
Keywords: DNA replication; DNA repair; replication stress response; genomic instability; DNA damage response
(This special issue belongs to the Section Molecular Genetics and Genomics)
Photodynamic Therapy for Cancer: Nanomedicine-Based Photosensitizers and Cancer Targeting
edited by
submission deadline 31 Jan 2027 | Viewed by 58 | Submission Open
Keywords: photodynamic therapy; nanomedicine; cancer; drug delivery system; stimuli-sensitive; diagnosis; reactive oxygen species
(This special issue belongs to the Section Molecular Oncology)
Advanced Molecular Mechanisms and Therapeutic Strategies in Host–Pathogen–Drug Interactions
edited by
submission deadline 31 Jan 2027 | Viewed by 56 | Submission Open
Keywords: host–pathogen interactions; molecular pathogenesis; immune evasion; microbial virulence; host-directed therapy; antimicrobial resistance; antiviral therapeutics; cellular signaling; drug–pathogen interactions; precision infectious-disease therapy
(This special issue belongs to the Section Molecular Microbiology)
Emerging Therapeutic Strategies for Glioblastoma
edited by Inan Olmez
submission deadline 31 Jan 2027 | Viewed by 56 | Submission Open
Keywords: glioblastoma; preclinical; combination therapy; overcoming resistance; translational
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Cellular Mechanisms in Skin Endocrinology and Dermatology submission deadline 31 Jan 2027 | Viewed by 56 | Submission Open
Keywords: skin endocrinology; molecular dermatology; hormonal signaling; skin aging; inflammatory dermatoses; skin microbiome; cutaneous immune response; esthetic and regenerative dermatology; oncodermatology; nanocarrier-based drug delivery
(This special issue belongs to the Section Molecular Biology)
AI-Guided Molecular Design and Advanced Nanodelivery of Functional Nucleic Acids and Bioactive Compounds
edited by and
submission deadline 31 Jan 2027 | Viewed by 55 | Submission Open
Keywords: artificial intelligence; molecular design; machine learning; functional nucleic acids; molecular recognition; nanodelivery systems; bioactive compounds; nanomedicine
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Systemic Lupus Erythematosus Pathogenesis submission deadline 31 Jan 2027 | Viewed by 55 | Submission Open
Keywords: systemic lupus erythematosus; pathogenesis; cellular and molecular mechanisms; immune dysregulation; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dietary Bioactives and Microbiome in Health
edited by
submission deadline 31 Jan 2027 | Viewed by 53 | Submission Open
Keywords: dietary bioactives; microbiome; multi-omics; proteomics; metabolomics; artificial intelligence; precision nutrition; food by-products; nanotechnology; systems biology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Chronic Wound Healing: Immune Responses, Biomarkers and Novel Therapies
edited by Marek Kucharzewski
submission deadline 31 Jan 2027 | Viewed by 53 | Submission Open
Keywords: chronic wounds; wound healing; inflammation; immune signaling; biomarkers; angiogenesis; extracellular matrix; oxidative stress; cellular senescence; regenerative medicine
(This special issue belongs to the Section Molecular Immunology)
Artificial Intelligence and Machine Learning in Genomics and Molecular Genetics
edited by Lei Ma
submission deadline 31 Jan 2027 | Viewed by 52 | Submission Open
Keywords: genomics; molecular genetics; multi-omics analysis; computational biology
(This special issue belongs to the Section Molecular Informatics)
Cholesterol and Oxysterols as Signaling Molecules in Human Pathophysiology
edited by
submission deadline 31 Jan 2027 | Viewed by 51 | Submission Open
Keywords: cholesterol; oxysterols; cancer; cardiovascular disease; neurodegenerative disease; lysosomal disease; cell signaling; age-related diseases; therapy; cell death
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Parkinson's Disease submission deadline 31 Jan 2027 | Viewed by 51 | Submission Open
Keywords: Parkinson’s disease; molecular mechanisms; neurodegeneration; biomarkers; translational research; α-synuclein; neuroinflammation; mitochondrial dysfunction; computational modelling
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Pediatric Kidney Diseases: From Development to Disease and Therapy
edited by
submission deadline 31 Jan 2027 | Viewed by 47 | Submission Open
Keywords: pediatric kidney disease; kidney development; kidney organoids/tubuloids; congenital anomalies of the kidney and urinary tract (CAKUT); inherited tubulopathies; Wilms tumor; acute kidney injury (AKI); nephron progenitor cells (NPS); podocytes; kidney tubules; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tissue Immunity in Viral Infection and Disease
edited by
submission deadline 31 Jan 2027 | Viewed by 46 | Submission Open
Keywords: tissue immunity; viral pathogenesis; host–virus interactions; tissue-resident immunity; epithelial barrier immunity; organ-specific infection; innate immunity; adaptive immunity; spatial biology; multi-omics
(This special issue belongs to the Section Molecular Immunology)
Inflammatory Bowel Disease and Microbiome: 2nd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 45 | Submission Open
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker
(This special issue belongs to the Section Molecular Microbiology)
New Insight in Environmental Nanotechnology
edited by Ramachandran Sivaramakriahnan
submission deadline 31 Jan 2027 | Viewed by 44 | Submission Open
Keywords: macroalgae; nanotechnology; green synthesis; nanoparticles; environmental remediation; biorefinery; biofuels; algal biomass; biomedical applications; drug delivery; antimicrobial activity; biosensors; wastewater treatment; heavy metal removal; carbon sequestration; circular bioeconomy; sustainable biotechnology; renewable energy; biopolymers; eco-friendly nanomaterials
(This special issue belongs to the Section Molecular Nanoscience)
Neuroinflammation and Neuroprotection: Molecular Mechanisms, Therapeutic Targets and Translational Perspectives
edited by
submission deadline 31 Jan 2027 | Viewed by 42 | Submission Open
Keywords: neuroinflammation; neuroprotection; central nervous system; autoimmune diseases; spinal cord injury; traumatic brain injury; neurodegeneration; immunomodulation; glial cells; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Animal Virology: Unraveling Pathogens, Hosts, and Interventions
edited by Xingwen Bai and Hong Yuan
submission deadline 31 Jan 2027 | Viewed by 41 | Submission Open
Keywords: animal virology; One Health; viral discovery; pathogenesis; zoonosis; host immune response; viral evolution; diagnostics; vaccine development; antiviral therapies
(This special issue belongs to the Section Molecular Microbiology)
Genetic Analysis of Neurodevelopmental Disorders
edited by
submission deadline 31 Jan 2027 | Viewed by 41 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder; psychiatric disorder; genetic architecture; next generation sequencing; candidate gene
(This special issue belongs to the Section Molecular Genetics and Genomics)
Precision Cardiovascular Medicine: Molecular Insights and AI-Driven Analytics
edited by
submission deadline 31 Jan 2027 | Viewed by 39 | Submission Open
Keywords: cardiovascular disease; molecular research; cardiovascular genetics; cardiovascular epigenetics; regenerative medicine; biomarkers; artificial intelligence; digital health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stroke: From Pathogenic Mechanisms to Therapeutic Strategies
edited by
submission deadline 31 Jan 2027 | Viewed by 35 | Submission Open
Keywords: stroke; risk factors; thrombolysis; thrombectomy; outcomes
(This special issue belongs to the Section Molecular Neurobiology)
Diagnosis and Treatment of Diabetes and Its Complications
edited by
submission deadline 31 Jan 2027 | Viewed by 35 | Submission Open
Keywords: molecular mechanisms of diabetes; diabetes pathogenesis; diabetes-associated diseases; diabetic complications; novel treatments of diabetes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research on Surfactants: Design, Synthesis, and Properties
edited by Frans Smit
submission deadline 31 Jan 2027 | Viewed by 34 | Submission Open
Keywords: surfactants; amphiphiles; molecular design; organic synthesis; self-assembly; micellisation; interfacial properties; structure-property relationships; bio-based surfactants; functional materials
(This special issue belongs to the Section Materials Science)
Alternative Splicing: From Biological Functions to Human Disease to Therapeutic Targeting
edited by Elisabetta Morini
submission deadline 31 Jan 2027 | Viewed by 28 | Submission Open
Keywords: alternative splicing; pre-mRNA processing; splicing factors; human diseases; therapeutic targeting; antisense oligonucleotides: small molecule splicing modulators; RNA binding proteins; isoform regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Antifibrotic Drugs and Mechanisms in Pulmonary Fibrosis
edited by
submission deadline 31 Jan 2027 | Viewed by 22 | Submission Open
Keywords: pulmonary fibrosis; fibrogenesis; TGF-β signaling; antifibrotic agents; drug discovery; computational biology; precision therapy
(This special issue belongs to the Section Molecular Pharmacology)
Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections submission deadline 20 Feb 2027 | 2 articles | Viewed by 5423 | Submission Open
Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition
edited by
submission deadline 20 Feb 2027 | 3 articles | Viewed by 2186 | Submission Open
Keywords: plant–pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms Underlying Abiotic Stress Tolerance in Plants: From Gene Regulation to Adaptive Traits
edited by Shijiang Cao
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2134 | Submission Open
Keywords: forest molecular biology; tree physiology; plant developmental biology; plant-microbe interactions; abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Crop Stress: From Genomic Mechanisms to Breeding
edited by Meng Jiang
submission deadline 20 Feb 2027 | Viewed by 58 | Submission Open
Keywords: crop stress; molecular mechanisms; genomics; stress signaling; transcription factors; gene editing; molecular breeding; multi-omics; climate resilience; functional genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Oxidative Stress-Driven Pathophysiological Dysregulation
edited by and
submission deadline 20 Feb 2027 | Viewed by 48 | Submission Open
Keywords: oxidative stress; inflammation; reactive oxygen species; antioxidants
(This special issue belongs to the Section Molecular Biology)
Sleep Apnea and Sleep-Disordered Breathing
edited by
submission deadline 20 Feb 2027 | Viewed by 37 | Submission Open
Keywords: sleep apnea; sleep-disordered breathing; intermittent hypoxia; oxidative stress; inflammation; biomarkers; molecular mechanisms; cardiovascular disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Bioinformatics and Genomics
edited by Darío Augusto Fernández do Porto and María Mercedes Palomino
submission deadline 25 Feb 2027 | Viewed by 94 | Submission Open
Keywords: microbial genomics; bioinformatics; metagenomics; antimicrobial resistance; pathogen evolution; multi-omics; systems biology; structural bioinformatics; artificial intelligence; drug discovery
(This special issue belongs to the Section Molecular Genetics and Genomics)
Epigenetic and Transcriptional Dysregulation in Cancer and Therapeutic Opportunities
edited by
submission deadline 25 Feb 2027 | Viewed by 91 | Submission Open
Keywords: cancer epigenetics; transcriptional dysregulation; chromatin remodeling; DNA methylation; histone modifications; epigenetic therapy; oncogenic transcription factors; tumor progression
(This special issue belongs to the Section Molecular Oncology)
Biofunctionality of Bioactives from Agri-Food Industrial Sources
edited by
submission deadline 25 Feb 2027 | Viewed by 74 | Submission Open
Keywords: bioactive compounds; oxidative stress; inflammation process; cellular and animal models; functional ingredients
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Microbiome as the Diagnostic Biomarker in Non-Communicable Diseases
edited by
submission deadline 25 Feb 2027 | Viewed by 61 | Submission Open
Keywords: microbiome; non-communicable diseases; molecular signatures; multi-omics; diagnostic biomarker
(This special issue belongs to the Section Molecular Microbiology)
The Role of Structural and Computational Biology in Elucidating Biomolecular Mechanisms submission deadline 25 Feb 2027 | Viewed by 50 | Submission Open
Keywords: structural basis of disease; integrated structural biology; structure–function relationships; proteins and peptides; molecular design; nucleic acids
(This special issue belongs to the Section Macromolecules)
From Waste to Product: End-Use-Oriented Valorization of Plant-Based Agro-Industrial Residues Through Analytical Approaches
edited by and Alfonso Trezza
submission deadline 26 Feb 2027 | Viewed by 167 | Submission Open
Keywords: waste-to-product; agro-industrial waste; plant by-products; -omics; material characterization; structure-function relationships; bioactive compounds; lignocellulosic biomass; biorefinery; green extraction technologies; circular economy; functional ingredients; biomaterials
(This special issue belongs to the Section Molecular Plant Sciences)
Analysis of Plant Resistance Mechanisms for Crop Biological Breeding
edited by
submission deadline 26 Feb 2027 | Viewed by 106 | Submission Open
Keywords: biological breeding; omics analysis; regulatory network; molecular mechanism; gene editing
(This special issue belongs to the Section Molecular Plant Sciences)
25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism
edited by
submission deadline 28 Feb 2027 | 27 articles | Viewed by 63419 | Submission Open
Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology
edited by
submission deadline 28 Feb 2027 | 24 articles | Viewed by 38017 | Submission Open
Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome–brain–gut axis; virus–host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)
(This special issue belongs to the Section Molecular Microbiology)
Metals and Metal Ions in Human Health, Diseases, and Environment submission deadline 28 Feb 2027 | 7 articles | Viewed by 17839 | Submission Open
Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution
(This special issue belongs to the Section Molecular Biology)
25th Anniversary of IJMS: Updates and Advances in Macromolecules submission deadline 28 Feb 2027 | 5 articles | Viewed by 16685 | Submission Open
Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure–property relationship
(This special issue belongs to the Section Macromolecules)
Challenges and Future Perspectives in Treatment for Lung Cancer: 2nd Edition
edited by Ilaria Marrocco and
submission deadline 28 Feb 2027 | 5 articles | Viewed by 13384 | Submission Open
Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery
(This special issue belongs to the Section Molecular Oncology)
Functions and Applications of Natural Products: 2nd Edition
edited by
submission deadline 28 Feb 2027 | 7 articles | Viewed by 12760 | Submission Open
Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Oxidative and Redox Signalling in Neurological Diseases
edited by
submission deadline 28 Feb 2027 | 4 articles | Viewed by 10282 | Submission Open
Keywords: gasotransmitters; neurological diseases; oxidative stress; redox signalling; reactive oxygen species (ROS); neuroinflammation; mitochondrial dysfunction; cell death/apoptosis; nitrosative stress; endogenous gas signalling; neuromodulation; neurovascular coupling; therapeutic strategies; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathology of the Placenta in Pregnancy Complications submission deadline 28 Feb 2027 | 5 articles | Viewed by 7387 | Submission Open
Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Review Papers in Molecular Immunology, 3rd Edition submission deadline 28 Feb 2027 | 1 articles | Viewed by 6857 | Submission Open
Keywords: molecular immunology; review; immune cells
(This special issue belongs to the Section Molecular Immunology)
Neurodegenerative Diseases: Genetic Bases and Pathogenetic Mechanisms
edited by Emanuele Panza
submission deadline 28 Feb 2027 | 3 articles | Viewed by 6771 | Submission Open
Keywords: neurodegenerative diseases; molecular and cellular pathways; pathogenetic mechanisms
(This special issue belongs to the Section Molecular Neurobiology)
Skin Extracellular Matrix and Basement Membrane
edited by
submission deadline 28 Feb 2027 | 4 articles | Viewed by 6705 | Submission Open
Keywords: extracellular matrix; basement membrane; skin regeneration; cutaneous reconstruction; acellular dermal matrix; wound healing; fibrosis; scar; skin aging; biologic scaffold; tissue repair; regenerative dermatology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuropharmacological Innovations in Treating Neurodegenerative Diseases
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 6691 | Submission Open
Keywords: neuropharmacology; neurodegenerative disorders; targeted drug delivery; blood–brain barrier permeability; synaptic modulation; neuroprotective agents; disease-modifying therapies; molecular mechanisms of neurodegeneration; innovative drug targets; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
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