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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Crop Stress Tolerance: From Mechanisms to Breeding
edited by Awais Farooq and
submission deadline 28 Feb 2027 | Viewed by 157 | Submission Open
Keywords: root phenomics; plant–microbiome interactions; rhizosphere biology; crop genetics; genome-wide association mapping; computational biology; functional genomics and gene editing; abiotic stress adaptation; biological nitrification inhibition; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Xenobiotic Toxicity and Biological Detoxification submission deadline 28 Feb 2027 | Viewed by 154 | Submission Open
Keywords: molecular toxicology; xenobiotics; toxicogenomics; biomarkers; oxidative stress; mitochondrial dysfunction; adverse outcome pathways; biodegradation; biological detoxification; environmental health
(This special issue belongs to the Section Molecular Toxicology)
Advanced Nanocomposite Materials for Photocatalytic and Antimicrobial Applications
edited by
submission deadline 28 Feb 2027 | Viewed by 150 | Submission Open
Keywords: nanocomposites; photocatalysis; antimicrobial materials; hybrid nanomaterials; semiconductor nanomaterials; green synthesis; reactive oxygen species; photocatalytic hydrogen production; environmental remediation; water treatment; air purification; antibiofilm activity; surface functionalization; structure–property relationships; advanced functional materials
(This special issue belongs to the Section Molecular Nanoscience)
Discovery, Synthesis, and Design of Novel Antibacterial Agents
edited by Md. Amdadul Huq
submission deadline 28 Feb 2027 | Viewed by 149 | Submission Open
Keywords: antibacterial agents; antimicrobial resistance; molecular drug discovery; biological synthesis; chemical synthesis; biofilm inhibitors; molecular mechanisms of action; antibacterial therapeutics
(This special issue belongs to the Section Biochemistry)
Multi-Omics Approaches to Pancreatic and Colorectal Cancer: From Molecular Heterogeneity to Precision Oncology submission deadline 28 Feb 2027 | Viewed by 134 | Submission Open
Keywords: pancreatic cancer; colorectal cancer; multi-omics; spatial transcriptomics; single-cell sequencing; proteogenomics; metabolomics; microbiome; tumor microenvironment; immunopeptidome; molecular subtyping; biomarkers; precision oncology; artificial intelligence; immunotherapy response; early-onset colorectal cancer
(This special issue belongs to the Section Molecular Oncology)
Current Research on the Cellular and Molecular Basis of Allergic Diseases
edited by Guillermo Horacio Docena and
submission deadline 28 Feb 2027 | Viewed by 118 | Submission Open
Keywords: allergy; immunology; biomarkers; genomics; epigenetics; microbiome; immunotherapy; asthma; atopic dermatitis; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Multi-Omics Application in Livestock
edited by Yunxiang Zhao and Qingyou Liu
submission deadline 28 Feb 2027 | Viewed by 113 | Submission Open
Keywords: multi-omics; livestock; functional genomics; transcriptomics; metabolomics; epigenomics; microbiome; single-cell transcriptomics; spatial transcriptomics; precision breeding
(This special issue belongs to the Section Molecular Biology)
Molecular Regulation and Intercellular Crosstalk in Bone Metabolism and Skeletal Remodeling
edited by Xiangguo Che and
submission deadline 28 Feb 2027 | Viewed by 112 | Submission Open
Keywords: bone metabolism; osteoblast differentiation; osteoclastogenesis; osteoarthritis; osteoporosis; subchondral bone remodeling; bone–vascular crosstalk; inflammatory signaling; extracellular vesicles; multi-omics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Adsorption Science: From Molecular Mechanisms to Practical Applications submission deadline 28 Feb 2027 | Viewed by 99 | Submission Open
Keywords: adsorption mechanisms; surface science; molecular mechanisms; heterogeneous catalysis; water treatment; interfacial phenomena; molecular modeling; functional nanomaterials; kinetics and thermodynamics
(This special issue belongs to the Section Molecular Biophysics)
Deep Learning-Enabled Smart Phenotyping: From Multi-Omics Data Integration to Molecular Mechanism Elucidation
edited by Jie Jiang and
submission deadline 28 Feb 2027 | Viewed by 91 | Submission Open
Keywords: deep learning; smart phenotyping; multi-omics integration; computer vision; convolutional neural networks; transformers; graph neural networks; multimodal fusion; high-throughput phenotyping; genome-wide association studies; molecular mechanism; regulatory network inference; explainable AI; gene discovery; crop improvement; temporal dynamics; representation learning; systems biology; intelligent agriculture
(This special issue belongs to the Section Molecular Informatics)
Advanced Research in Nanomaterials in Drug Delivery
edited by Abul Kalam Azad
submission deadline 28 Feb 2027 | Viewed by 88 | Submission Open
Keywords: nanomaterials; drug delivery; nanomedicine; targeted drug delivery; polymeric nanoparticles; lipid nanoparticles; controlled drug release; biomaterials; gene delivery; translational nanomedicine
(This special issue belongs to the Section Molecular Nanoscience)
Artificial Intelligence in Molecular Medicine and Human Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 82 | Submission Open
Keywords: artificial intelligence; molecular medicine; human diseases; machine learning; deep learning; precision medicine; biomarker discovery; multi-omics integration; genomics; transcriptomics; proteomics; metabolomics; molecular signatures; disease mechanisms; systems biology; molecular networks; therapeutic targets; predictive modeling; explainable AI
(This special issue belongs to the Section Molecular Informatics)
Mechanobiology of the Cell Membrane and Cytoskeleton: From Force Sensing to Therapeutic Targeting
edited by
submission deadline 28 Feb 2027 | Viewed by 80 | Submission Open
Keywords: mechanical forces; magnetic fields; cell cytoskeleton; cell division; gene expression
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Plant–Soil–Water Interactions Under Agricultural Water Stress
edited by Saif Ullah and
submission deadline 28 Feb 2027 | Viewed by 76 | Submission Open
Keywords: molecular plant–water interactions; plant–soil–water nexus; aquaporins; water-use efficiency (WUE); drought stress signaling; abscisic acid (ABA); root system architecture; plant hydraulics; transcriptomics; proteomics; metabolomics; epigenetic regulation; rhizosphere microbiome; salinity tolerance; climate-resilient crops
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research Advances in Additive Manufacturing
edited by and Wenzhi Xu
submission deadline 28 Feb 2027 | Viewed by 75 | Submission Open
Keywords: additive manufacturing; molecular mechanisms; microstructural design; polymerization kinetics; molecular dynamics simulation
(This special issue belongs to the Section Materials Science)
Advanced Research on Bioactive Natural Products for Human Health submission deadline 28 Feb 2027 | Viewed by 70 | Submission Open
Keywords: bioactive natural products; phytochemicals; molecular mechanisms; functional characterization; experimental models; natural compounds; biological activity; methodology development; structure–activity relationship; human health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
From Multi-Omics Discovery and Functional Validation to Translational Applications in Cancer
edited by Luísa Pereira, Lúcio Lara Santos and
submission deadline 28 Feb 2027 | Viewed by 69 | Submission Open
Keywords: cancer; omics; functional testing; experimental models; underrepresented ancestries; artificial intelligence/machine learning; translational research
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Networks Regulating Plant Organ Growth
edited by Yueya Zhang
submission deadline 28 Feb 2027 | Viewed by 67 | Submission Open
Keywords: plant organ growth; molecular regulatory; organ morphogenesis; developmental regulation; cell growth and differentiation; signaling regulation; environmental responses
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Design and Mechanistic Insights into Sustainable Polymers
edited by Lucia Caporaso
submission deadline 28 Feb 2027 | Viewed by 65 | Submission Open
Keywords: sustainable polymers; molecular design; polymerization catalysis; reaction mechanisms; computational chemistry; density functional theory; ring-opening polymerization; CO2 utilization; chemical recycling; circular polymer economy
(This special issue belongs to the Section Materials Science)
Latest Advances in Novel Luminescent Materials
edited by K. Naveen Kumar
submission deadline 28 Feb 2027 | 1 articles | Viewed by 63 | Submission Open
Keywords: luminescent materials; rare-earth ions; nanophosphors; quantum dots; glass-ceramics; photoluminescence; upconversion luminescence; optical materials; photonic applications; light-emitting devices
(This special issue belongs to the Section Materials Science)
Exercise, Aging and Molecular Homeostasis
edited by and Daniela Vitucci
submission deadline 28 Feb 2027 | Viewed by 62 | Submission Open
Keywords: exercise; aging; molecular homeostasis; mitochondria; multi-omics; senescence; inflammation; skeletal muscle
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Metabolic Inflammation in Diabetic Complications, Metabolic Disorders, and Cancer Progression
edited by Dong-Keon Lee and
submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: metabolic inflammation; inflammatory signaling; type 2 diabetes; insulin resistance; diabetic complications; oxidative stress; mitochondrial dysfunction; cancer progression
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Disease Models and Molecular Mechanisms in Cardiovascular Development and Remodeling submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: heart failure; CRISPR; LNPS; polymer; regeneration; fibrosis; therapy; animal model; target therapy; angiogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Biofilm Management: Current Challenges and Future Directions in Eradication Strategies
edited by and Hilal Başak Erol
submission deadline 28 Feb 2027 | Viewed by 60 | Submission Open
Keywords: biofilm management; eradication strategies; phenotypic tolerance; standardization of methodologies; synergistic therapy
(This special issue belongs to the Section Molecular Microbiology)
New Insights into Bacterial, Fungal, and Plant Lipids: From Structural Diversity to Biological Functions and Applications submission deadline 28 Feb 2027 | Viewed by 58 | Submission Open
Keywords: lipidomics; glycerolipids; sphingolipids; sterols; oxylipins; plant lipids; fungal lipids; bacterial lipids
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Plant Breeding and Genetic Improvement submission deadline 28 Feb 2027 | Viewed by 57 | Submission Open
Keywords: marker-assisted selection (MAS); CRISPR/Cas genome editing; genomic selection (GS); genome-wide association studies (GWAS); quantitative trait loci (QTL) mapping; abiotic and biotic stress tolerance; functional genomics; transcriptomics and metabolomics; plant genetic resources; crop quality improvement; climate-resilient agriculture; sustainable crop production; epigenetics and gene regulation; high-throughput phenotyping; agrobiotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Innovations and Precision Medicine in Liver Diseases: From Mechanisms to Clinical Practice submission deadline 28 Feb 2027 | Viewed by 57 | Submission Open
Keywords: liver diseases; precision hepatology; metabolic dysfunction-associated steatotic liver disease (MASLD); molecular biomarkers; molecular imaging; multi-omics; liver regeneration; liver transplantation; artificial intelligence; nanomedicine; targeted drug delivery; GLP-1 therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Marine Natural Products and Their Derivatives
edited by
submission deadline 28 Feb 2027 | Viewed by 57 | Submission Open
Keywords: marine natural products; bioactive compounds; bioactive peptides; marine by-products; functional foods; nutraceuticals; structure–activity relationship; molecular docking; molecular dynamics simulation; circular bioeconomy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nutrition and Chronic Metabolic Diseases Prevention: Molecular Exploration
edited by
submission deadline 28 Feb 2027 | Viewed by 55 | Submission Open
Keywords: nutrition; chronic metabolic diseases; molecular mechanism; phytochemicals; diabetes; atherosclerosis; metabolic health; nicotinamide mononucleotide; signaling pathway
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Imaging Biomarkers in Cardiovascular Disease submission deadline 28 Feb 2027 | Viewed by 53 | Submission Open
Keywords: molecular imaging; cardiovascular disease; precision medicine; radiomics; molecular biomarkers; echocardiography; multi-omics; cardiac MRI
(This special issue belongs to the Section Molecular Biology)
Latest Research on Plant Genomics and Genome Editing, 3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 51 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Neuro-Oncology: Biomarkers and Mechanisms
edited by
submission deadline 28 Feb 2027 | Viewed by 51 | Submission Open
Keywords: brain tumors; glioma; glioblastoma; targeted therapy; precision medicine; molecular biomarkers
(This special issue belongs to the Section Molecular Oncology)
Advanced Research on Cardiovascular Endocrinology and Metabolism
edited by
submission deadline 28 Feb 2027 | Viewed by 49 | Submission Open
Keywords: cardiovascular endocrinology; cardiovascular disease; endocrine signaling; cardiometabolic disorders; diabetes mellitus; obesity; hormones; endothelial dysfunction; cardiac remodeling; inflammation; oxidative stress; biomarkers; precision medicine; translational research; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research in Horticultural Crops
edited by
submission deadline 28 Feb 2027 | Viewed by 49 | Submission Open
Keywords: berry quality and postharvest physiology; developmental and reproductive biology; functional genomics and precision breeding (GWAS, CRISPR); stress responses and secondary metabolism
(This special issue belongs to the Section Molecular Plant Sciences)
Oxidative Stress, Inflammation, and Insulin Resistance in Obesity and Metabolic Syndrome
edited by
submission deadline 28 Feb 2027 | Viewed by 48 | Submission Open
Keywords: oxidative stress; metabolic syndrome; obesity; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Comparative and Functional Genomics of Plants submission deadline 28 Feb 2027 | Viewed by 44 | Submission Open
Keywords: pangenome; genome evolution; systems biology; regulatory pathways; gene function
(This special issue belongs to the Section Molecular Genetics and Genomics)
Application of Natural Product in Nanotechnology
edited by Volodymyr Tkach
submission deadline 28 Feb 2027 | Viewed by 44 | Submission Open
Keywords: natural products; nanotechnology; nanomedicine; green synthesis; nanoparticles; drug delivery; phytochemicals; polyphenols; flavonoids; nanoformulations; biomaterials; controlled release; nanotoxicology; sustainable nanotechnology; bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Effects of Nanoparticle Application in Plant Physiology
edited by and Camila Neves Lange
submission deadline 28 Feb 2027 | Viewed by 42 | Submission Open
Keywords: nanotechnology in agriculture; nano-enabled fertilizers; plant–nanoparticle interactions; plant physiology; abiotic stress tolerance; biofortification
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Toxicology: How Environmental Pollutants Shape the Epigenome
edited by José Francisco Herrera Moreno and Diana Marcela Paredes-Céspedes
submission deadline 28 Feb 2027 | Viewed by 42 | Submission Open
Keywords: molecular toxicology; environmental health; environmental pollutants; epigenetics; multi-omics; biomarkers; human health; gene regulation; toxicology; environmental epidemiology
(This special issue belongs to the Section Molecular Toxicology)
Iron Metabolism in Cancer: Mechanisms and Therapeutic Targeting
edited by Michael Petronek
submission deadline 28 Feb 2027 | Viewed by 41 | Submission Open
Keywords: iron metabolism; redox biology; ferroptosis; tumor progression; cancer therapy; iron–sulfur clusters; heme proteins; ferritinophagy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Adipogenesis in Health and Disease: Molecular Mechanisms, Multi-Omics and Precision Medicine submission deadline 28 Feb 2027 | Viewed by 40 | Submission Open
Keywords: adipogenesis; adipocyte; adipose tissue; lipid metabolism; metabolic diseases; genetic diseases; multi-omics; precision medicine; metabolic health
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Brain Tumours submission deadline 28 Feb 2027 | Viewed by 39 | Submission Open
Keywords: IGF; glioblastoma; nephroblastoma; cancer genetics; antisense therapy
(This special issue belongs to the Section Molecular Oncology)
Pyroptosis, Ferroptosis and Necroptosis in Cardiovascular Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 37 | Submission Open
Keywords: pyroptosis; ferroptosis; necroptosis; inflammation; NLRP3 inflammasome; pro-inflammatory cytokines; lipid peroxidation; oxidative stress; receptor-interacting protein kinases (RIPKs); mixed lineage kinase domain-like protein (MLKL)
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular and Cellular Mechanisms of Autoimmune Diseases
edited by Stelvio Tonello and
submission deadline 28 Feb 2027 | Viewed by 36 | Submission Open
Keywords: autoimmunity; NETosis; biomarkers; pathology; autoimmune disease; pharmacological response; immunological modulation
(This special issue belongs to the Section Molecular Immunology)
Pathogenesis of Endometriosis, Disease Stratification, Diagnosis and Therapy
edited by Katharina Proestling and
submission deadline 28 Feb 2027 | Viewed by 36 | Submission Open
Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics; genetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory, Metabolic, and Redox Biomarkers in Oncology submission deadline 28 Feb 2027 | Viewed by 34 | Submission Open
Keywords: oncology; biomarkers; inflammation; cancer metabolism; oxidative stress; redox biology; tumor microenvironment; treatment response; therapeutic resistance; precision oncology
(This special issue belongs to the Section Molecular Oncology)
RNA Regulation and Satellite Cell-Opathies: Molecular Pathogenesis and Therapeutic Frontiers in Neuromuscular Diseases submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open
Keywords: satellite cells; neuromuscular disorders; alternative splicing; satellite cell-opathies; RNA-binding proteins; RNA therapeutics; molecular pathogenesis; myogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Infections and Immune Responses—2nd Edition submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open
Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralising activity
(This special issue belongs to the Section Molecular Immunology)
Mechanisms of Extracellular Electron Transfer Across Phylogenetically Diverse Microorganisms
edited by Fengjie Zhao and Sukrampal Yadav
submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open
Keywords: electroactive microorganisms; extracellular electron transfer; molecular mechanisms; microbial electrochemistry; phylogenetic diversity
(This special issue belongs to the Section Molecular Microbiology)
Metabolic Programming: Control of Gene Expression in Health and Disease
edited by
submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open
Keywords: metabolic programming; gene regulation; immunometabolism; oncometabolism; acetyl-CoA; epigenetics; transcription; NAD; one-carbon metabolism; metabolic biosensors
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
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