Molecular Regulation and Intercellular Crosstalk in Bone Metabolism and Skeletal Remodeling
A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 112
Editors
Interests: bone metabolism; osteoarthritis; osteoporosis; osteoblast and osteoclast differentiation; chondrocyte biology; subchondral bone remodeling; vascular calcification; bone-vascular crosstalk; PTH signaling; nSMase2
Interests: bone metabolism; osteoarthritis; osteoporosis; osteoblast and osteoclast differentiation; chondrocyte biology; subchondral bone remodeling; vascular calcification; bone-vascular crosstalk; PTH signaling; nSMase2
Special Issue Information
Dear Colleagues,
Bone metabolism is maintained by coordinated molecular and cellular interactions among osteoblasts, osteoclasts, osteocytes, chondrocytes, and vascular cells. Disruption of these regulatory networks contributes to osteoporosis, osteoarthritis, abnormal subchondral bone remodeling, and vascular calcification. However, the molecular mechanisms linking cartilage degeneration, bone remodeling, inflammation, metabolism, and vascular dysfunction remain incompletely understood. This Special Issue aims to highlight recent advances in the molecular mechanisms controlling bone formation, bone resorption, cartilage–bone crosstalk, and skeletal tissue homeostasis. We welcome original research articles and reviews focusing on intracellular signaling pathways, transcriptional and epigenetic regulation, osteoblast–osteoclast coupling, subchondral bone remodeling, and bone–vascular interactions. Studies using cellular models, animal models, patient-derived samples, single-cell analysis, spatial biology, proteomics, transcriptomics, metabolomics, or integrated multi-omics approaches are particularly encouraged. By bringing together emerging molecular insights and translational perspectives, this Special Issue seeks to deepen our understanding of bone metabolic regulation and identify novel biomarkers and therapeutic targets for skeletal and related systemic diseases.
Dr. Xiangguo Che
Guest Editor
Dr. Xian Jin
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- bone metabolism
- osteoblast differentiation
- osteoclastogenesis
- osteoarthritis
- osteoporosis
- subchondral bone remodeling
- bone–vascular crosstalk
- inflammatory signaling
- extracellular vesicles
- multi-omics
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