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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epigenetic Mechanisms in Pain
edited by Hsien-Yu Peng
submission deadline 31 Dec 2025 | Viewed by 163 | Submission Open
Keywords: chronic pain; epigenetics; molecular biomarkers; neural plasticity; ion channel function; synaptic transmission; therapeutic strategies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms Underlying the Involvement of Cytomegalovirus in the Progression of Multiple Sclerosis
edited by
submission deadline 31 Dec 2025 | Viewed by 161 | Submission Open
Keywords: multiple sclerosis; central nervous system; autoimmune; genetic and environmental factors; herpesviruses; CMV; immunopathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathogenesis of Central Nervous System Disorders, Interplay and Multifaceted Role of Glial Cells and Neuroprotective Mechanisms
edited by Matilde Balbi
submission deadline 31 Dec 2025 | Viewed by 160 | Submission Open
Keywords: neurodegenerative disease; CNS disorders; glial cells; glia-cross talk; extracellular vesicles; calcium pathway; neuroinflammation; autophagy; excitotoxicity; glial phenotype
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular, Immune and Molecular Pathways of Injury and Disease in Forensic and Legal Medicine
edited by
submission deadline 31 Dec 2025 | Viewed by 158 | Submission Open
Keywords: molecular autopsy; cellular injury pathways; ischemia and hypoxia markers; molecular profiling of fatal injuries; forensic genetics and toxicogenomic
(This special issue belongs to the Section Molecular Biology)
Endometrial Cancer: From Molecular Insights to Treatment
edited by Giuseppe Angelico
submission deadline 31 Dec 2025 | Viewed by 155 | Submission Open
Keywords: endometrial cancer; molecular classification; TCGA; precision oncology; immunotherapy; targeted therapy; biomarkers; tumor microenvironment; genomics; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Approaches to RNA-Based Therapeutics
edited by
submission deadline 31 Dec 2025 | Viewed by 154 | Submission Open
Keywords: RNA therapeutic; RNA drug; antisense therapy; siRNA; delivery; oligonucleotides; mRNA vaccine
(This special issue belongs to the Section Molecular Biology)
Emerging Therapeutic Approaches and Novel Targets in Fibrosis Treatment submission deadline 31 Dec 2025 | Viewed by 154 | Submission Open
Keywords: organ fibrosis; tissue fibrosis; regenerative medicine; fibroblasts; chronic inflammation; immune mechanisms; wound healing; injured epithelium or endothelium; epithelial– mesenchymal transformation; treatment; therapies; therapeutic approaches; diagnosis; prognosis; antifibrotic agents
(This special issue belongs to the Section Molecular Immunology)
RNA Biology: Unraveling the Complex Interplay Between Proteins and RNAs in Gene Expression and Regulation, 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 153 | Submission Open
Keywords: RNA biology; protein– RNA interplay; gene expression; post-transcriptional modifications; non-coding RNAs
(This special issue belongs to the Section Molecular Genetics and Genomics)
Novel Biochemical, Genetic, and Molecular Biology Approaches in Human Reproduction
edited by Athanasios Zikopoulos
submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open
Keywords: reproductive biology; infertilit; epigenetics in reproduction; maternal-fetal health; precision medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Therapeutic Targets in Brain Tumor Pathogenesis
edited by Mugurel Petrinel Radoi
submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open
Keywords: brain tumors; molecular pathogenesis; glioma biomarkers; tumor microenvironment; neuro-oncology; targeted therapy; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
New Therapeutic Strategies for Cystic Fibrosis
edited by Kavisha Arora
submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open
Keywords: cystic fibrosis; CFTR; modulator therapy; non-responder mutations; mRNA therapy; gene editing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Skin Allergies: Cross-Disciplinary Approaches to Diagnosis and Therapy
edited by , Belén De la Hoz and
submission deadline 31 Dec 2025 | Viewed by 147 | Submission Open
Keywords: skin allergy; dermatology; allergy management; allergic reaction; topical immune response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Pharmacology for Neuropathic and Chronic Pain Management submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open
Keywords: neuropathic pain; diabetic neuropathy; chronic pain; DPP-4 inhibitors; SGLT2 inhibitors; pain pharmacology; neuroinflammation; glial activation; ion channels; cannabinoids; endogenous peptides; epigenetic modulation; extended-release formulations; drug repurposing; analgesic mechanisms
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Applications of Microbial and Marine-Derived Natural Products with Health Benefits
edited by Simona Negreş
submission deadline 31 Dec 2025 | Viewed by 143 | Submission Open
Keywords: microbial products; marine-derived products; pharmacological activity; key molecules; molecular mechanisms; drug discovery; nutraceuticals; therapy; prophylaxis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Hidradenitis Suppurativa: Molecular Mechanisms and Therapeutic Strategies submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open
Keywords: hidradenitis suppurativa; molecular mechanisms; therapeutic strategies; pathophysiology; autoinflammatory disorders; immunology; dermatology inflammation; skin disease; molecular pathways; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research on Phenolic Profiles and Anti-Inflammatory Activities of Plants
edited by Chi-Rei Wu and Li-Wei Lin
submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open
Keywords: plants; phenolic profiles; inflammation; cardiovascular disorders; cancer; diabetes; neurodegenerative disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Perspective of Alzheimer’s Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 136 | Submission Open
Keywords: Alzheimer’ s disease; amyloid peptide (toxic conformation); mutations (gamma-secretase); GWAS; risk factors; new treatment (monoclonal antibodies)
(This special issue belongs to the Section Molecular Neurobiology)
RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications
edited by Karl M Thompson
submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open
Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics
(This special issue belongs to the Section Molecular Biology)
Pharmacological Agents for Soft Tissue and Articular Injections: From Mechanisms to Clinical Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open
Keywords: injectable pharmacological agents; musculoskeletal disorders; injection therapies; platelet-rich plasma (PRP); hyaluronic acid
(This special issue belongs to the Section Molecular Pharmacology)
Multiple Myeloma: Cancer Therapy and the Tumour Microenvironment
edited by Ruba Al Abdulla
submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open
Keywords: multiple myeloma; cancer resistance; therapeutic strategies; stroma cells; cancer microenvironment; cancer immunity
(This special issue belongs to the Section Molecular Oncology)
Emerging Environmental Exposures and Molecular Disruption Mechanisms in Human Health submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open
Keywords: environmental exposure; epigenetic; exposome; molecular biomarkers; molecular toxicology
(This special issue belongs to the Section Molecular Toxicology)
Oxidative–Inflammatory Crosstalk in Retinal Pigment Epithelium: Models, Mechanisms, and Modulators
edited by
submission deadline 31 Dec 2025 | Viewed by 127 | Submission Open
Keywords: retinal pigment epithelium (RPE); oxidative stress; inflammation; immunometabolism; mitochondrial dysfunction; inflammasome; IL-8/VEGF signaling; heavy-metal toxicity; extracellular vesicles; antioxidant therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Engineering in Insoluble Antibacterial Particle for Medical Devices
edited by Ole T. Jensen
submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open
Keywords: antibacterial; quaternary ammonium silica particles; bactericidal mechanism; antibacterial particle; medical devices
(This special issue belongs to the Section Materials Science)
Molecular Advances in Diagnosis and Treatment of Gynaecological Cancers
edited by
submission deadline 31 Dec 2025 | Viewed by 115 | Submission Open
Keywords: gynecological oncology; molecular biomarkers; precision medicine; tumor microenvironment; targeted therapy; early detection; immunotherapy; genomic profiling; drug resistance; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Gene Variants and Phenotypic Diversity: Insights into CFTR, SLC Transporters and Disease
edited by Veronique Ladeveze
submission deadline 31 Dec 2025 | Viewed by 114 | Submission Open
Keywords: mutations; polymorphisms; alternative splicing; exon skipping; intron retention; CFTR (ABCC7); cystic fibrosis; SLC16a3; Alzheimer’ s disease; pulmonary and brain cancer
(This special issue belongs to the Section Molecular Genetics and Genomics)
Structural and Functional Analysis of Amino Acids and Proteins: 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 112 | Submission Open
Keywords: protein structure; protein function; amino acids network; deep learning; bioinformatics; protein– protein interaction; drug discovery; biomarker
(This special issue belongs to the Section Molecular Informatics)
Recent Advances in Nanomaterials for Cancer Treatment and Translational Medicine
edited by
submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open
Keywords: nanozymes; extracellular vesicles; drug delivery systems; cancer treatment; oxidative stress-related diseases; translational medicine
(This special issue belongs to the Section Molecular Nanoscience)
Epigenetic and Transcriptional Regulation in Aquaculture: Immunity, Stress and Disease Prevention
edited by
submission deadline 31 Dec 2025 | Viewed by 103 | Submission Open
Keywords: epigenetics; transcriptional regulation; trained immunity; DNA methylation; histone modifications; non-coding RNAs; disease prevention; aquaculture
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress submission deadline 31 Dec 2025 | Viewed by 100 | Submission Open
Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways
(This special issue belongs to the Section Molecular Toxicology)
Genetic Variants Involved in Breast and Ovarian Cancers submission deadline 31 Dec 2025 | Viewed by 96 | Submission Open
Keywords: breast and ovarian cancers; genetics; genomics; biomarkers; mutations; genetic variants; translational markers
(This special issue belongs to the Section Molecular Oncology)
Cancer Stem Cells as Key Immunotherapy Targets
edited by Cosmin Andrei Cismaru
submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open
Keywords: cancer stem cells; immunotherapy; immune escape; tumor antigens; cancer recurrence
(This special issue belongs to the Section Molecular Immunology)
Advanced Molecular Research on Chronic Heart Failure
edited by
submission deadline 1 Jan 2026 | 3 articles | Viewed by 7306 | Submission Open
Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine
edited by
submission deadline 1 Jan 2026 | Viewed by 317 | Submission Open
Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes
(This special issue belongs to the Section Molecular Biology)
Checkpoint Antibodies at the Crossroads: From Mechanisms to Multi-Modal Cancer Therapy
edited by Li Ye and Xuyao Zhang
submission deadline 10 Jan 2026 | 1 articles | Viewed by 2551 | Submission Open
Keywords: immune checkpoint inhibitors; tumor microenvironment; computational immunology; resistance mechanisms; multifunctional antibodies; rational combination design
(This special issue belongs to the Section Molecular Immunology)
From Microbes to Humans: Unveiling the Dynamic World of Carbonic Anhydrases (CAs)
edited by
submission deadline 10 Jan 2026 | Viewed by 738 | Submission Open
Keywords: metalloenzymes; bacteria; pathogens; sulfonamides; inhibitors; activators; anti-infective agents; medicine; anticancer; neurodegenerative diseases; biomedical applications; biotechnology
(This special issue belongs to the Section Biochemistry)
Advances in Allergen Immunotherapy: Current Concepts and Future Directions submission deadline 10 Jan 2026 | Viewed by 155 | Submission Open
Keywords: allergen immunotherapy; oral immunotherapy; Hymenoptera venom; allergy extracts; adjuvants
(This special issue belongs to the Section Molecular Immunology)
Plant Epigenetic Memory Under Abiotic Stress
edited by
submission deadline 11 Jan 2026 | Viewed by 177 | Submission Open
Keywords: plant epigenetics; epigenetic memory; abiotic stress; DNA methylation; histone modification; chromatin remodeling; transgenerational inheritance; stress-responsive genes
(This special issue belongs to the Section Molecular Plant Sciences)
From Electronic Structure to Application: Computational Insights into Bioactive and Functional Molecules
edited by
submission deadline 15 Jan 2026 | 2 articles | Viewed by 2438 | Submission Open
Keywords: molecular design; molecular modeling; substituent effect; reactivity descriptors; biological potential; in silico study; physicochemical properties; ADME; PASS; QSAR
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders
edited by Marta Pardo
submission deadline 20 Jan 2026 | 4 articles | Viewed by 31767 | Submission Open
Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets
(This special issue belongs to the Section Molecular Neurobiology)
Natural-Derived Bioactive Compounds in Disease Treatment submission deadline 20 Jan 2026 | 7 articles | Viewed by 30348 | Submission Open
Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations
(This special issue belongs to the Section Molecular Pharmacology)
Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 23922 | Submission Open
Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood– brain barrier; blood– cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insight into Plant Bioactive Compounds submission deadline 20 Jan 2026 | 8 articles | Viewed by 23092 | Submission Open
Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition
edited by
submission deadline 20 Jan 2026 | 7 articles | Viewed by 21660 | Submission Open
Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis
(This special issue belongs to the Section Molecular Immunology)
Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment
edited by
submission deadline 20 Jan 2026 | 8 articles | Viewed by 21373 | Submission Open
Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation; molecular pathway; biomarkers; target therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms for Skin Protection and Aging
edited by Wonchul Lim and
submission deadline 20 Jan 2026 | 4 articles | Viewed by 21046 | Submission Open
Keywords: skin photo-aging; skin inflammation; molecular biology; inner beauty; natural product; skin microbiome; skin wrinkle formation; skin dehydration; skin pigmentation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
A Molecular Perspective on the Genetics of Kidney Diseases
edited by Joaquim Calado
submission deadline 20 Jan 2026 | 7 articles | Viewed by 18993 | Submission Open
Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 18441 | Submission Open
Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility
(This special issue belongs to the Section Molecular Biology)
New Mechanisms and Therapeutics in Neurological Diseases—4th Edition
edited by
submission deadline 20 Jan 2026 | 8 articles | Viewed by 18336 | Submission Open
Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins
(This special issue belongs to the Section Molecular Neurobiology)
Flow Cytometry: Applications and Challenges
edited by
submission deadline 20 Jan 2026 | 7 articles | Viewed by 18154 | Submission Open
Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies
(This special issue belongs to the Section Molecular Biology)
Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition
edited by
submission deadline 20 Jan 2026 | 8 articles | Viewed by 17750 | Submission Open
Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance
(This special issue belongs to the Section Molecular Pharmacology)
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