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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Environmental Microorganisms and Pathogen Infections

edited by

Jadwiga Wyszkowska

and

Magdalena Zaborowska

submission deadline 31 Dec 2026 | 1 articles | Viewed by 819 | Submission Open

Keywords: environmental microbiome; pathogens; resistance genes; molecular adaptation; microbial interactions; anthropogenic pollution; functional gene expression; ecosystem health

(This special issue belongs to the Section Molecular Microbiology)

Ion Channels in Human Health and Diseases

edited by

Ye Chun Ruan

and Jinghui Guo

submission deadline 31 Dec 2026 | 1 articles | Viewed by 801 | Submission Open

Keywords: ion channels; channelopathies; electrophysiology; organ systems; human diseases; membrane excitability; pharmacology and drug discovery; translational medicine

(This special issue belongs to the Section Molecular Biology)

Research Progress of Nanocarriers

edited by

Diana Rita Barata Costa

submission deadline 31 Dec 2026 | 1 articles | Viewed by 799 | Submission Open

Keywords: controlled release; drug delivery systems; multimodal nanoplatforms; nanoparticles; precision medicine; stimuli-responsive nanocarriers; theranostics; therapeutic delivery; translational na-nomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Bridging Molecular and Translational Research in Chronic Kidney Disease and Dysmetabolism

edited by

Gianluigi Zaza

Francesca Tinti

, Lida Tartaglione and

Silvia Lai

submission deadline 31 Dec 2026 | 2 articles | Viewed by 793 | Submission Open

Keywords: chronic kidney disease; translational research; dysmetabolism; biotechnologies; bone diseases; inflammation; oxidative stress; omics; personalize medicine; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanomaterials in Tissue Engineering and Regenerative Medicine: Recent Advances and Future Prospects

edited by

Kapil D. Patel

submission deadline 31 Dec 2026 | 1 articles | Viewed by 789 | Submission Open

Keywords: nanoparticles; nanofibers; nanotubes; nanocomposites; hydrogels; ceramics; bioactive glass nanoparticles; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Biomaterials for Neural Regeneration and Axogenesis: From Cellular Support to Functional Recovery

edited by Noela Rodríguez-Losada

submission deadline 31 Dec 2026 | Viewed by 777 | Submission Open

Keywords: neural regeneration; axogenesis; neurorepair; neuroprotection; biocompatible materials; extracellular matrix mimetics; graphene-based scaffolds; conductive polymers; hybrid hydrogels; carbon nanomaterials; neuroengineering

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis and Activity of Natural Products and Analogues

edited by

Jin-pyo An

submission deadline 31 Dec 2026 | 1 articles | Viewed by 759 | Submission Open

Keywords: natural products; functional food; synthesis; high-resolution mass spectrometry; bioactive compound

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Individualised Therapies for Rare Disorders

edited by Paul Gissen

submission deadline 31 Dec 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: individualised therapies; personalised medicine; rare diseases; omics; gene therapy; molecular pathways; mechanistic discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Photodynamic Therapy for Antibacterial and Anticancer Applications

edited by

Sandile Phinda Songca

submission deadline 31 Dec 2026 | Viewed by 734 | Submission Open

Keywords: photodynamic therapy (PDT); sonodynamic therapy (SDT); radiodynamic therapy (RDT); chemodynamic therapy (CDT); photosensitizers; sonosensitizers; radiosensitizers; antimicrobial PDT; antimicrobial SDT; antimicrobial RDT; anticancer therapy; drug resistance; bacterial biofilms; reactive oxygen species; nanocarriers; nanoscale metal–organic frameworks; immunogenic cell death; targeted drug delivery; combination therapeutics

(This special issue belongs to the Section Molecular Biology)

Azoles and Fused Heterocycles in Antimicrobial Drug Discovery: Synthesis, Mechanisms, and Applications

edited by

Esra Tatar

submission deadline 31 Dec 2026 | 1 articles | Viewed by 734 | Submission Open

Keywords: drug design and discovery; bioactive molecules; azoles and fused heterocycles; antimicrobials

(This special issue belongs to the Section Molecular Pharmacology)

Metallopharmaceuticals: Current Trends and Future Perspectives in Cancer Immunoediting

edited by

Marialuisa Piccolo

and

Claudia Riccardi

submission deadline 31 Dec 2026 | Viewed by 730 | Submission Open

Keywords: metal-based drugs; anticancer activity; mechanisms of action; tumor microenvironment; immune cell regulation; cancer immunity; metal–protein interactions; metal–nucleic acid interactions

(This special issue belongs to the Section Molecular Pharmacology)

Research Progress of Orthopedic Materials

edited by Robert Karpiński

submission deadline 31 Dec 2026 | Viewed by 717 | Submission Open

Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings

(This special issue belongs to the Section Materials Science)

Molecular Engineering of Biomaterials for Advanced Additive Manufacturing

edited by

Johari Yap Abdullah

submission deadline 31 Dec 2026 | 1 articles | Viewed by 693 | Submission Open

Keywords: molecular engineering; biomaterials; polymer chemistry; additive manufacturing; 3D printing; supramolecular interactions; surface chemistry; biocompatibility; degradation mechanisms; functional polymers; bioactive materials; computational modeling; tissue engineering; regenerative medicine

(This special issue belongs to the Section Materials Science)

Metal Toxicity and Particle Toxicity

edited by Alicja Piotrowska-Niczyporuk

submission deadline 31 Dec 2026 | 1 articles | Viewed by 678 | Submission Open

Keywords: metals; particles; toxicity; microplastic; environment pollution; animals; plants; algae

(This special issue belongs to the Section Molecular Toxicology)

Decoding Animal Reproduction: From Molecular Mechanisms to Breeding Innovations

edited by

Mingtian Deng

submission deadline 31 Dec 2026 | 1 articles | Viewed by 677 | Submission Open

Keywords: embryo; epigenetics; multi-omics; breeding

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Neuroendocrine Regulations in Health and Pathology

edited by

Michael Ugrumov

and

Serguei Fetissov

submission deadline 31 Dec 2026 | 1 articles | Viewed by 616 | Submission Open

Keywords: neuroendocrine system; brain; hypothalamus; adenohypophysis; endocrine glands; (neuro)hormones; ontogenesis; neuroendocrine disorders

(This special issue belongs to the Section Molecular Neurobiology)

Enzyme Inhibitory Assessment and Molecular Docking Studies of Natural and Synthetic Heterocyclic Compounds

edited by

Milen G. Bogdanov

submission deadline 31 Dec 2026 | Viewed by 604 | Submission Open

Keywords: heterocycles; enzyme inhibition; docking studies; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Research Progress on Cancer Biomarkers and Molecular Targets

edited by

José Vargas

submission deadline 31 Dec 2026 | 1 articles | Viewed by 595 | Submission Open

Keywords: cancer biomarkers; molecular targets; cellular senescence; autophagy; epigenetics; prognosis; tumor microenvironment; therapy resistance; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Targeted Anticancer Therapeutics: Mechanisms, Resistance, Tumor Microenvironment, and Translational Advances

edited by Shakti Prasad Pattanayak

submission deadline 31 Dec 2026 | 1 articles | Viewed by 567 | Submission Open

Keywords: cancer metabolism; drug resistance; tumor microenvironment; immunometabolism; targeted therapy; anticancer therapeutics; autophagy; oxidative stress; cancer immunotherapy; translational oncology

(This special issue belongs to the Section Molecular Oncology)

Interfacial Chemistry, Conformational Dynamics, and Molecular Assemblies of Amphiphilic Molecules

edited by

Mihalj Poša

submission deadline 31 Dec 2026 | 1 articles | Viewed by 565 | Submission Open

Keywords: amphiphiles; surfactants; surface equations of state (SEOS); binary mixture of amphiphiles; conformations of amphiphiles; micellar aggregates; solubilization; thermodynamics of micelle formation; Jesús Gracia-Fadrique's surface pressure; enthalpy–entropy compensation

(This special issue belongs to the Section Biochemistry)

Amino Acid Nutrition and Human Health

edited by

Terrence Piva

submission deadline 31 Dec 2026 | Viewed by 560 | Submission Open

Keywords: amino acids; dietary intake; metabolic disease; starvation; obesity; supplementation; parental nutrition; gene expression; tumour metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Physiological Effects of Exercise in Cachexia

edited by

Marilia Seelaender

and

Fábio Santos Lira

submission deadline 31 Dec 2026 | Viewed by 551 | Submission Open

Keywords: cachexia; skeletal muscle mass; skeletal muscle strength; exercise; muscle metabolism

(This special issue belongs to the Section Molecular Biology)

Sustainable Polymers: From Molecular Fundamentals to Real-World Applications

edited by

Zahid Iqbal Khan

submission deadline 31 Dec 2026 | Viewed by 549 | Submission Open

Keywords: sustainable polymers; recycled plastics; bio-based polymers; polymer blends; nanocomposites; membrane technology; water purification; CO2 capture

(This special issue belongs to the Section Materials Science)

Functional Genomics of Rare Variants in Human Disease

edited by

Salvatore Saccone

submission deadline 31 Dec 2026 | 1 articles | Viewed by 538 | Submission Open

Keywords: rare genetic variants; functional genomics; variant interpretation; next-generation sequencing; genome editing; neurodevelopmental disorders; Mendelian diseases; multi-omics integration; gene regulation; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Adipose Tissue Dysfunction in Obesity and Metabolic Diseases

edited by Andressa Bolsoni-Lopes

submission deadline 31 Dec 2026 | Viewed by 532 | Submission Open

Keywords: adipose tissue dysfunction; obesity; metabolic diseases; insulin resistance; adipose tissue inflammation; lipid metabolism; fatty acid signaling; extracellular matrix remodeling; metabolic dysfunction-associated steatotic liver disease (MASLD); G protein-coupled receptors (GPCRs)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

David P Marciano

and Saurabh Aggarwal

submission deadline 31 Dec 2026 | Viewed by 526 | Submission Open

Keywords: pulmonary arterial hypertension (PAH); pulmonary vascular remodeling; endothelial cells; endothelial dysfunction; smooth muscle cells; hyperplasia; pericytes; fibroblasts; monocytes; macrophage; neutrophil; mechanotransduction; oxidative stress; cytokines; extracellular vesicles; extracellular matrix; epigenetics; metabolism; biomarkers; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic and Molecular Insights into Emerging and Reemerging Pathogens

edited by

Fabio Scarpa

submission deadline 31 Dec 2026 | Viewed by 521 | Submission Open

Keywords: pathogens genomic analysis; evolution transmission dynamics; pathogenic mechanisms; viruses; bacteria; fungi; parasites; next-generation sequencing; metagenomics; bioinformatics; genetic variations; adaptive mutations; host–pathogen interactions; emerging pathogens; molecular epidemiology; host immune responses; pathogen genetics

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Three-Dimensional Cell Culture: From Bioengineering Innovation and Therapeutic Application

edited by Jong-Young Kwak

submission deadline 31 Dec 2026 | 1 articles | Viewed by 521 | Submission Open

Keywords: 3D culture; biomaterials; scaffold; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Mechanisms and Applications of Heterosis in Plants

edited by

Wenxin Liu

submission deadline 31 Dec 2026 | Viewed by 520 | Submission Open

Keywords: heterosis; mechanism; prediction; application; breeding; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Beyond Docking Scores: Decision-Centric Computer-Aided Drug Discovery

edited by

Rescifina Antonio

and

Rocco Buccheri

submission deadline 31 Dec 2026 | 1 articles | Viewed by 517 | Submission Open

Keywords: computer-aided drug discovery; hit prioritization; prospective validation; polypharmacology; selectivity profiling; developability; false-positive reduction; multi-parameter optimization; uncertainty-aware ranking; translational medicinal chemistry

(This special issue belongs to the Section Molecular Informatics)

Seed Development and Germination

edited by

Muhammad Ali Mumtaz

submission deadline 31 Dec 2026 | 1 articles | Viewed by 510 | Submission Open

Keywords: seed development; seed germination; seed quality assessment; seedborne pathogens; abiotic stress and seeds; seed omics

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Biomarkers of Inflammation and Cancer: From Molecular Pathways to Clinical Stratification

edited by

Ciriaco Carru

and

Donatella Coradduzza

submission deadline 31 Dec 2026 | Viewed by 497 | Submission Open

Keywords: chronic inflammation; cancer biomarkers; inflammatory indices; non-coding RNAs; clinical translation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Machine Learning–Based Perspectives in Plant Biology

edited by Silas Pessini Rodrigues

submission deadline 31 Dec 2026 | Viewed by 489 | Submission Open

Keywords: machine learning; artificial intelligence; plant molecular biology; multi-omics integration; feature selection; gene prioritization; plant stress responses; high-throughput phenotyping; crop improvement; biotechnology

(This special issue belongs to the Section Molecular Informatics)

Ovarian Insufficiency: From Molecular Pathology to Novel Therapeutic Approach

edited by Aleksandar Ljubić

submission deadline 31 Dec 2026 | Viewed by 486 | Submission Open

Keywords: ovarian insufficiency; premature ovarian insufficiency; molecular pathology; regenerative medicine; stem cell therapy; platelet-rich plasma; epigenetics; intraovarian treatment; ovarian stem cells; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sustainable Approaches in Medicinal Chemistry: Innovation in Green Chemistry Methodologies

edited by

Davide Moi

submission deadline 31 Dec 2026 | 1 articles | Viewed by 483 | Submission Open

Keywords: green chemistry; drug discovery; drug design; molecular biology; flow chemistry; mechanochemistry

(This special issue belongs to the Section Molecular Pharmacology)

3D Printing and Biomaterials for Hearing and Balance Restoration

edited by

Chenkai Dai

submission deadline 31 Dec 2026 | Viewed by 472 | Submission Open

Keywords: hearing; balancing; 3D printing; biomaterial

(This special issue belongs to the Section Materials Science)

Molecular Study of Foodborne Pathogens

edited by

Valeria Russini

and

Maria Laura De Marchis

submission deadline 31 Dec 2026 | Viewed by 462 | Submission Open

Keywords: foodborne pathogens; microbiology; molecular analysis; foodborne outbreak investigation; epidemiology; listeria monocytogenes; salmonella; campylobacter; virulence genes; antimicrobial gene; WGS; NGS

(This special issue belongs to the Section Molecular Microbiology)

Advances in Immunology in Health and Disease

edited by

Adli Ali

submission deadline 31 Dec 2026 | 1 articles | Viewed by 460 | Submission Open

Keywords: immunodeficiencies; autoimmunity; inflammation; immunometabolism; neuroinflammation; immunotherapy; immunophenotyping; biomarkers; infection; precision medicine; immunogenetics

(This special issue belongs to the Section Molecular Immunology)

Novel Therapeutic Strategies for Hepatocellular Carcinoma

edited by

Soon Kyu Lee

submission deadline 31 Dec 2026 | Viewed by 457 | Submission Open

Keywords: hepatocellular carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; radiotherapy; embolization; surgery; transplantation

(This special issue belongs to the Section Molecular Oncology)

Advances in Plant–Pathogen Interactions (4th Edition)

edited by

Fucheng Lin

submission deadline 31 Dec 2026 | Viewed by 450 | Submission Open

Keywords: host; effection; pathogenicity; pathogen; plant immunity; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Cutting-Edge Research and Advancements in Neurodegenerative Diseases

edited by Meera Soundararajan

submission deadline 31 Dec 2026 | Viewed by 450 | Submission Open

Keywords: neurodegenerative disorders; neurons; Alzheimer’s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington disease

(This special issue belongs to the Section Molecular Neurobiology)

Drug Discovery: Natural Products and Compounds—2nd Edition

edited by

Vincenzo Summa

Maria Maisto

and

Vincenzo Piccolo

submission deadline 31 Dec 2026 | 1 articles | Viewed by 444 | Submission Open

Keywords: natural products; drug discovery; bioactive compounds; phytochemicals; marine natural compounds; microorganisms; structure–activity relationships (SARs); pharmacological activity; cheminformatics; metabolomics

(This special issue belongs to the Section Molecular Pharmacology)

Soil Nutrient Cycling and Microbial Driving Mechanisms

edited by

Mohsin Mahmood

submission deadline 31 Dec 2026 | 1 articles | Viewed by 438 | Submission Open

Keywords: soil nutrient cycling; microbial driving mechanisms; soil–plant–microbe interactions; carbon, nitrogen, and phosphorus dynamics; soil biogeochemistry; microbial communities and functions; rhizosphere processes; climate change impacts on soils; sustainable nutrient management; biochar and nanotechnology applications; soil health and fertility; biogeochemical transformations; stress environments (salinity, drought, contamination)

(This special issue belongs to the Section Molecular Microbiology)

Molecular Dynamics of the Oral Microbiome in Periodontal Health and Disease

edited by

John Yun Niu

submission deadline 31 Dec 2026 | Viewed by 437 | Submission Open

Keywords: oral microbiome; periodontics; tissue regeneration; bioinformatics; biomarkers; host–microbiome interactions; molecular dynamics

(This special issue belongs to the Section Molecular Microbiology)

Recent Advances in Optoelectronic Materials

edited by Muhammad Umair Shahid

submission deadline 31 Dec 2026 | Viewed by 430 | Submission Open

Keywords: organic solar cells; DSSCs; perovskite solar cells; donor–acceptor systems; optoelectronic devices; charge separation; sensors; quantum dots; 2D materials; machine learning in materials science

(This special issue belongs to the Section Materials Science)

Research into Biomarkers for Psychiatric Disorders

edited by

João Victor Silva Nani

submission deadline 31 Dec 2026 | Viewed by 426 | Submission Open

Keywords: psychiatric disorders; molecular biomarkers; single-cell transcriptomics; neuroimmune interface; peripheral blood mononuclear cells (PBMCs); precision psychiatry; multi-omics integration; extracellular vesicles; liquid biopsy; neurogenomics

(This special issue belongs to the Section Molecular Neurobiology)

Serum Amyloid A: Established Roles and Emerging Questions in Health and Disease

edited by Preetha Shridas

submission deadline 31 Dec 2026 | Viewed by 424 | Submission Open

Keywords: Serum Amyloid A; high-density lipoprotein; acute inflammation; chronic inflammatory

(This special issue belongs to the Section Biochemistry)

Mechanisms Linking Gut Microbiota to Metabolic Diseases

edited by Jing Ji,

Hongyuhang Ni

and Aman Khan

submission deadline 31 Dec 2026 | Viewed by 413 | Submission Open

Keywords: gut microbiota; metabolic diseases; probiotics; prebiotics; obesity; microbial metabolites; host–microbe interaction; metabolic inflammation; intestinal barrier; hyperuricemia; diabetes; non-alcoholic fatty liver disease

(This special issue belongs to the Section Molecular Microbiology)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Adipose Tissue–Liver Crosstalk: Mechanisms and Therapeutic Opportunities

edited by Lei Hao

submission deadline 31 Dec 2026 | 1 articles | Viewed by 412 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); adipose tissue–liver crosstalk; brown adipose tissue (BAT); beige adipocytes; white adipose tissue (WAT); thermogenesis; adipokines; hepatokines; energy metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Pancreatic Cancer: Biomarkers and New Drug Development

edited by Yi-Ming Arthur Chen

submission deadline 31 Dec 2026 | 1 articles | Viewed by 392 | Submission Open

Keywords: pancreatic ductal adenocarcinoma; biomarkers; transcriptomic subtypes; new drug development; target therapy; immunotherapy; KRAS inhibitors; precision medicine; health supplements

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 1751-1800 on page 36 of 62.

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