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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Strategies for the Discovery, Optimization, and Efficient Use of Green Pesticides

edited by

Hongjian Song

submission deadline 28 Feb 2026 | Viewed by 117 | Submission Open

Keywords: natural-product-based pesticides; total synthesis; structural optimization; bioactivity evaluation; structure– activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Alcohol Use Disorder: From Molecular Mechanisms to Therapeutics

edited by

Giampiero Ferraguti

submission deadline 28 Feb 2026 | Viewed by 116 | Submission Open

Keywords: alcohol; addiction; FASD; alcohol-related damage

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Foods: Molecular Insights into Nutrition and Health

edited by Patroklos Vareltzis

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: functional foods; bioactive compounds; disease prevention; nutritional health; food innovation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Dermatological Perspectives on Connective Tissue Diseases

edited by Yoshihide Asano

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Advances in Osteogenesis: 2nd Edition

edited by

Andrea Del Fattore

submission deadline 28 Feb 2026 | Viewed by 110 | Submission Open

Keywords: osteogenesis; osteoblast; bone formation; disease; bone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Studies on Wnt Signaling

edited by Katalin Mészáros

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: Wnt signaling pathway; inhibitor; cancer; treatment; drugs

(This special issue belongs to the Section Molecular Biology)

Neurodegenerative Diseases: Molecular Mechanisms, Drug Targets and Therapeutic Strategies

edited by

Andrea Kwakowsky

submission deadline 28 Feb 2026 | Viewed by 106 | Submission Open

Keywords: beta amyloid peptide; tau protein; alpha-synuclein protein; huntingtin protein; autophagy; neuromodulators; neurotrophins; natural compounds; neuroinflammation; vascular dysfunction; neuronal death; drug development; therapeutic biomarkers; blood– brain barrier; small-molecule therapeutics

(This special issue belongs to the Section Molecular Neurobiology)

Insights into Multiple Myeloma: Immune Microenvironment, Disease Mechanisms, and Therapeutic Innovations

edited by

Ichiro Hanamura

submission deadline 28 Feb 2026 | Viewed by 106 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; disease biology; disease progression; treatment resistance; CAR-T cells; bispecific antibodies (BsAbs); antibody-drug conjugates (ADCs); tumor– host interaction

(This special issue belongs to the Section Molecular Oncology)

Oral and Dental Infectious Diseases: Molecular Pathology, Diagnosis and Therapy (2nd Edition)

edited by

Keiji Murakami

and

Hiromichi Yumoto

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: oral; dental; periodontitis; tooth decay; periodontal diseases; gingivitis; oral microorganism; oral infections; dental infections; dental caries; microbial pathogenicity; porphyromonas gingivalis; antimicrobials; oral biofilm

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Molecules to Cognition: Biomarkers and Neuropsychological Tools in Neurological Disorders

edited by

Silvia Boschi

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: biomarkers; neuropsychological assessment; neurological disorders; neuroimaging; cognitive function; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Structural Studies of Phosphorus Compounds Today

edited by

Irina Rusakova

submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open

Keywords: 31P NMR; NMR; organophosphorus compounds; transition-metal complexes with organophosphorus ligands; relativistic effects; solvent effects; quantum chemistry methods for NMR; chemical structure studies; chemistry of organophosphorus compounds

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms of Vascular Sclerosis

edited by Michishige Terasaki

submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open

Keywords: atherosclerosis; genes; dyslipidemia; diabetes; macrophages; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

Neutrophil Extracellular Traps (NETs) in Human Disease: From Molecular Mechanisms to Therapeutic Translation

edited by

Michael Boettcher

and Julia Elrod

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: neutrophil extracellular traps (NETs); molecular mechanisms; human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma

edited by Agnieszka Rusak

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Responses, Viral Infection and Neurodegenerative Diseases

edited by

Xin Dang

and Barbara Hanson

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential

edited by Gabriela Cristina Brailoiu and Eugen Brailoiu

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: Sigma-1R; intracellular receptor; molecular mechanisms; calcium signaling; neurological diseases; neurodegenerative diseases; pain; cancer; addiction

(This special issue belongs to the Section Molecular Biology)

Cancer Nanomedicine: Imaging, Targeting and Therapeutic Applications

edited by

Marvin Xavierselvan

and

Steven Fiering

submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open

Keywords: cancer nanomedicine; multimodal imaging; nanoparticle drug delivery; tumor targeting; theranostic nanoparticles; combination therapies

(This special issue belongs to the Section Molecular Nanoscience)

Hepatocardiac Interactions and the Utility of Hepatic Biomarkers in Cardiovascular Disease

edited by

Wioletta Szczurek-Wasilewicz

submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open

Keywords: hepatocardiac interactions; hepatic biomarkers; cardiovascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Abiotic Stress Tolerance: 3rd Edition

edited by

Michael Moustakas

submission deadline 28 Feb 2026 | Viewed by 100 | Submission Open

Keywords: acclimation; drought; salinity; pesticides; high–low temperature; high–low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Current Research on Neuroprotective Phytochemicals and Their Multi-Target Mechanisms

edited by

Gerardo Álvarez-Rivera

and

Alejandro Cifuentes

submission deadline 28 Feb 2026 | Viewed by 99 | Submission Open

Keywords: Alzheimer’ s disease; neuroprotective phytochemicals; green extraction; technologies; blood– brain barrier permeability; bioavailability; multi-target mechanisms; omics approaches; nanodelivery systems; brain health; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Liver Pathophysiology and Its Role in Systemic Diseases

edited by Vassilios Sevastianos

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: liver disease; endocrine functions; liver-targeted drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles and Mechanisms of Non-Coding RNAs in Cancer

edited by Stefano Sechi and Daniela Scarabino

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: cancer; non-coding RNA (ncRNA); translational medicine; oncological therapy; biomarker; piRNA; lncRNA; circRNA

(This special issue belongs to the Section Molecular Genetics and Genomics)

Transcriptional Regulation in Plant Development: 3rd Edition

edited by

Konstantinos E. Vlachonasios

submission deadline 28 Feb 2026 | Viewed by 97 | Submission Open

Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant– environment interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Products—the Underestimated Source of New Solutions for the Innovative Antimicrobial Therapies

edited by

Piotr Okińczyc

, Jarosław Widelski and

Jakub Szperlik

submission deadline 28 Feb 2026 | Viewed by 96 | Submission Open

Keywords: plant; medicines; natural product; antimicrobial activity; drug resistance; chemical analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges

edited by

Alessandra Micera

and

Filippo Biamonte

submission deadline 28 Feb 2026 | Viewed by 96 | Submission Open

Keywords: gut microbiota; brain; eye diseases; neuroinflammation; neurodegeneration; chronic inflammation; chronic pain; probiotics; gastrointestinal disorders; metabolic diseases; machine learning; artificial intelligence

(This special issue belongs to the Section Molecular Neurobiology)

Application of Spectroscopic Methods in Molecular Biology Research

edited by

Łukasz Laskowski

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: spectroscopy; molecular characterization; biomaterials; computational chemistry; structure– property relationships; biomolecular interactions; biomedical applications

(This special issue belongs to the Section Molecular Biology)

Bioactive Phytochemicals in Plant Extracts: A Comprehensive Analysis of Their Diverse Chemical Structures and Therapeutic and Functional Effects

edited by

Truc Cong Ho

submission deadline 28 Feb 2026 | Viewed by 93 | Submission Open

Keywords: extraction; phytochemicals; bioactive compounds; second metabolites; nutraceuticals; polyphenols; flavonoids; biological effects; therapeutic effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Inorganic Chemistry: From Molecules to Materials

edited by

Zoi Lada

submission deadline 28 Feb 2026 | Viewed by 92 | Submission Open

Keywords: inorganic chemistry; molecular design and reactivity; metal– organic frameworks (MOFs); spin crossover compounds; functional materials; structure– property relationships

(This special issue belongs to the Section Materials Science)

Design, Synthesis, Application and Mechanism of Functional Polymers

edited by Jingyuan Liu

submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open

Keywords: functional polymers; polymer synthesis; structure– property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage

(This special issue belongs to the Section Materials Science)

Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease: 2nd Edition

edited by

Marco Ragusa

and

Cristina Barbagallo

submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Immunity to Parasitic Infections

edited by Jamie A. Whitelaw and Stuart Woods

submission deadline 28 Feb 2026 | Viewed by 90 | Submission Open

Keywords: parasitology; immunology; vaccines; cell therapy; gene editing; parasitic diseases; immune responses; inflammation; molecular mechanisms; immune evasion; host cell invasion and manipulation

(This special issue belongs to the Section Molecular Immunology)

Electromagnetic Field Interactions with Biomolecules

edited by

Svetlana Jovanović

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: nonionizing electromagnetic fields; biomolecules; proteins; oxidative stress; Fe metabolism; amyloid-β peptide

(This special issue belongs to the Section Materials Science)

Therapeutic Strategies for Surgical Tissue Damage, Repair and Regeneration

edited by Alex K. Wong

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: surgical injury; tissue regeneration; vasculogenesis; wound healing in compromised settings; molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research into the Synthesis and Activities of Anticancer Compounds

edited by

Daniel Plano Amatriain

submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open

Keywords: cancer; synthesis; cell biology; molecular biology; chemistry; preclinical development

(This special issue belongs to the Section Molecular Biology)

Endometriosis: Focusing on Molecular and Cellular Research, 2nd Edition

edited by

Alfonso Baldi

submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open

Keywords: endometriosis; reproductive system; endometrial cell; novel treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Signaling and Inflammation in Cardiac Pathophysiology

edited by

Maria Luisa Barcena

submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open

Keywords: cardiac metabolism; inflammation; metabolic signaling; heart disease; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Antioxidant and Antidiabetic Potential of Natural Products in the Management of Diabetes and Its Complications

edited by

Ochuko Lucky Erukainure

submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open

Keywords: diabetes; natural products; obesity; medicinal plants; oxidative stress; antioxidants

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Perspective on Skeletal Muscle Regeneration

edited by Xuhui Liu

submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open

Keywords: skeletal muscle regeneration; satellite cells; stem cell niche; fibro/adipogenic progenitors; aging; muscle stem cells; cell– cell interactions; fibrosis and fatty infiltration; translational therapeutics

(This special issue belongs to the Section Molecular Biology)

Mechanisms and Applications of Heterosis in Plants

edited by

Wenxin Liu

submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open

Keywords: heterosis; mechanism; prediction; application; breeding; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Sex Differences in Preclinical and Clinical Studies

edited by

Flavia Franconi

Valeria Raparelli

and

Ilaria Campesi

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: cellular and in vitro studies; genetic and epigenetic studies; intersectional studies; observational studies; pharmacological studies; pragmatic studies; randomized control trials; disease management

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Utilization of Environmental Microbial Resources

edited by

Hikmate Abriouel

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: environmental microbiology; molecular microbial resources; microbial metabolites; microbial diversity; microbial ecology; bioremediation; agricultural microbiology; omics technologies; biofilm formation; microbiome applications

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology

edited by

Mariano Mastinu

submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open

Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia

(This special issue belongs to the Section Molecular Biology)

Molecular Perspectives on Female Infertility and Fertility

edited by

Seung-Yup Ku

submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open

Keywords: female infertility; molecular mechanisms of reproduction; oocyte maturation and development; reproductive aging; polycystic ovary syndrome; endometriosis; epigenetic regulation in reproduction; oxidative stress and mitochondrial dysfunction; reproductive biomarkers; precision medicine and regenerative therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Perspectives of Colloids for Biological Applications, 2nd Edition

edited by

Agnieszka Ewa Wia̧cek

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: colloids; emulsions; dispersions; stability; size distribution; zeta potential; optical/rheological properties; medicine; pharmaceuticals; cosmetics

(This special issue belongs to the Section Materials Science)

Advances in Anticancer Drug Discovery: Design, Synthesis and Molecular Insights

edited by

Michele De Franco

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: anticancer agents; drug design; drug synthesis; structure-activity relationship (SAR); target interactions; medicinal chemistry; lead optimization; targeted therapy; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

RNA Biology and Regulation, 2nd Edition

edited by

Naoyuki Kataoka

submission deadline 28 Feb 2026 | Viewed by 82 | Submission Open

Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Angiogenesis: Mechanisms and Targets in a Wide Spectrum of Diseases

edited by Lei Phillip Wang

submission deadline 28 Feb 2026 | Viewed by 81 | Submission Open

Keywords: angiogenesis; immune– vascular interactions; cancer; autoimmune disease; neurodegenera-tion; blood– brain barrier; biomarkers; therapeutic targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Brain–Immune Crosstalk and Ischemic Injury

edited by

Yvonne Couch

submission deadline 28 Feb 2026 | Viewed by 81 | Submission Open

Keywords: stroke; ischemia; haemorrhage; inflammation; cytokines; macrophages; neutrophils; microglia; immunity

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 1751-1800 on page 36 of 65.

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