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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Liver Disease: Pathogenesis, Progression, and Therapeutic Strategies

edited by

Andrea Dalbeni

submission deadline 20 Oct 2025 | Viewed by 110 | Submission Open

Keywords: liver disease; molecular pathogenesis; therapeutic strategies; liver fibrosis; hepatocellular carcinoma; MASLD and MetALD; molecular biomarkers; tailored medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic and Molecular Insights into Emerging and Reemerging Pathogens

edited by

Fabio Scarpa

submission deadline 20 Oct 2025 | Viewed by 105 | Submission Open

Keywords: pathogens genomic analysis; evolution transmission dynamics; pathogenic mechanisms; viruses; bacteria; fungi; parasites; next-generation sequencing; metagenomics; bioinformatics; genetic variations; adaptive mutations; host– pathogen interactions; emerging pathogens; molecular epidemiology; host immune responses; pathogen genetics

(This special issue belongs to the Section Molecular Immunology)

Neurological Diseases: From Physiology to Therapy

edited by

Vasileios Papaliagkas

submission deadline 20 Oct 2025 | Viewed by 94 | Submission Open

Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Graphene-based Nanocomposites

edited by

Oleksandr Ivasenko

submission deadline 20 Oct 2025 | Viewed by 90 | Submission Open

Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering

(This special issue belongs to the Section Molecular Nanoscience)

Next-Generation Cancer Immunotherapies: Tracking, Targeting and Reprogramming the Immune Response

edited by

Paulo Rodrigues-Santos

submission deadline 20 Oct 2025 | Viewed by 89 | Submission Open

Keywords: immunotherapy; cancer treatment; immune evasion; therapy resistance; immune monitoring; CAR-T; CAR-NK; immune cell engineering; synthetic immunology; programmable immune circuits; tumor– immune system interactions; biomarker-guided therapy; translational applications; hematological malignancies; solid malignancies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Impact of Circulating Biomarkers and Metabolites on Cardiometabolic Disease and Cancer: New Insights and Therapeutic Opportunities

edited by Melania Gaggini and

Cristina Vassalle

submission deadline 20 Oct 2025 | Viewed by 85 | Submission Open

Keywords: lipidomic; metabolomic; lipotoxicity; oxidative stress; amino acids; metabolic disease; cardiovascular risk; tumorigenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Sight of Biomarkers in Cardiovascular Disease

edited by

Raffaele Serra

submission deadline 20 Oct 2025 | Viewed by 83 | Submission Open

Keywords: precision medicine; precision nursing; biomarkers; molecular biology; biochemistry; genetics; molecular sciences; molecular research; vascular disease; vascular surgery; wounds; diabetic foot ulcers; peripheral artery disease; chronic venous disease; abdominal aortic aneurysm; thoracic aortic aneurysm; peripheral aneurysm; social and molecular determinants of health; molecular sociology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Acute Lung Injury

edited by

Emilia Lecuona

submission deadline 20 Oct 2025 | Viewed by 82 | Submission Open

Keywords: acute lung injury; ARDS; primary graft dysfunction; immune cells; neutrophils; pulmonary edema; alveolar epithelium; lung endothelium

(This special issue belongs to the Section Molecular Immunology)

The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights

edited by Ramos-López Omar

submission deadline 20 Oct 2025 | Viewed by 81 | Submission Open

Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanodrug Bioavailability and Biocompatibility in Cancer and CNS Disorders

edited by

Athina Angelopoulou

submission deadline 20 Oct 2025 | Viewed by 79 | Submission Open

Keywords: nanomedicine; bioavailability; biocompatibility; tumor microenvironment; Blood– Brain Barrier; targeted drug delivery; neurodegenerative diseases

(This special issue belongs to the Section Molecular Nanoscience)

Regulation and Targeting of Ferroptosis in Tumor and Beyond (Second Edition)

edited by

Yong Teng

submission deadline 20 Oct 2025 | Viewed by 72 | Submission Open

Keywords: ferroptosis; iron; tumor survival and cell death; oxidation; drug development; anti-cancer strategies

(This special issue belongs to the Section Molecular Oncology)

Osteoarthritis: From Molecular Mechanism to Novel Therapy (2nd Edition)

edited by

Berardo Di Matteo

submission deadline 20 Oct 2025 | Viewed by 67 | Submission Open

Keywords: osteoarthritis; joint inflammation; cartilage and chondrocyte function; cartilage regeneration and repair; post-traumatic osteoarthritis; synovium

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Evolutionary Genomics in Plants: From Single Gene to Genome

edited by

Bei Gao

submission deadline 20 Oct 2025 | Viewed by 64 | Submission Open

Keywords: evolutionary genomics; plant adaptation; genome evolution; crop improvement; bioinformatics; polyploidy

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Neuroimaging

edited by

Chrissa Sioka

submission deadline 22 Oct 2025 | Viewed by 74 | Submission Open

Keywords: positron emission tomography pulmonary immunology; single photon emission computed tomography; artificial intelligence; neuro-oncology imaging; neurodegenerative disorders imaging; molecular neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathogenesis of Mycobacteria

edited by Ivana Palucci

submission deadline 24 Oct 2025 | Viewed by 128 | Submission Open

Keywords: mycobacteria; mycobacterial pathogenesis; host– pathogen interactions

(This special issue belongs to the Section Molecular Microbiology)

Recent Molecular Basis of Neurocognitive Mechanism

edited by

Poppy Schoenberg

submission deadline 25 Oct 2025 | 1 articles | Viewed by 1246 | Submission Open

Keywords: cognitive functioning; epigenomics; high-throughput omics; metabolomics; molecular pathways; multi-modal datasets; neurocognition; neurodegeneration; neurorehabilitation; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Neurobiology)

Medical Applications of Polymer Materials

edited by Zhen Zhang

submission deadline 25 Oct 2025 | 1 articles | Viewed by 621 | Submission Open

Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics

(This special issue belongs to the Section Macromolecules)

Advances in Understanding Respiratory Virus–Host Interactions

edited by Kun Li

submission deadline 25 Oct 2025 | Viewed by 276 | Submission Open

Keywords: respiratory viruses; virus– host interactions; molecular mechanisms; viral replication; host– immune response; molecular pathogenesis; molecular signaling; antiviral strategies

(This special issue belongs to the Section Molecular Microbiology)

Multiple Sclerosis: Molecular Basis and New Therapy

edited by Vito A. G. Ricigliano

submission deadline 25 Oct 2025 | Viewed by 153 | Submission Open

Keywords: multiple sclerosis; inflammation; microglia; Epstein– Barr virus; neurodegeneration; remyelination; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gut–Brain Axis: Pathophysiological Mechanisms in Neurological Disorders and Metabolic Diseases

edited by

Giovanna Traina

submission deadline 25 Oct 2025 | Viewed by 107 | Submission Open

Keywords: gut– brain axis; intestinal microbiota; mood diseases; immune system; microbial molecules; behavior; metabolic diseases; signaling pathways; inflammation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Medical Microbiology and Infectious Diseases: The Role of Artificial Intelligence and Machine Learning

edited by

Alberto Rizzo

submission deadline 25 Oct 2025 | Viewed by 104 | Submission Open

Keywords: molecular diagnostics; pathogen genomics; antimicrobial resistance; host– pathogen interaction; infectious diseases surveillance; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Informatics)

New Molecular Research of Foodborne Pathogens

edited by

Djuro Josic

submission deadline 25 Oct 2025 | Viewed by 97 | Submission Open

Keywords: foodborne pathogens; molecular mechanisms; antimicrobial resistance; pathogen detection; host–microbe interactions

(This special issue belongs to the Section Molecular Microbiology)

Zebrafish as a Novel Model for Toxicological Research

edited by Leobardo Manuel Gómez-Oliván

submission deadline 25 Oct 2025 | Viewed by 56 | Submission Open

Keywords: zebrafish; toxicological assessment; organic and inorganic contaminants; oxidative stress; developmental toxicity; neurotoxicity; reproductive toxicity; genotoxicity; alternative testing models; One Health

(This special issue belongs to the Section Molecular Toxicology)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 25 Oct 2025 | Viewed by 56 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Exploring Cannabinoids: Molecular Mechanisms and Potential Therapeutic Applications

edited by

Grace Blest Hopley

submission deadline 27 Oct 2025 | 1 articles | Viewed by 515 | Submission Open

Keywords: cannabinoids; endocannabinoid system; δ 9-tetrahydrocannabinol (THC); cannabidiol (CBD); inflammation; chronic pain; neurodegenerative disorders; epilepsy; psychosis; cancer-related symptoms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Insights into the Role of Exosomes in Intercellular Communication

edited by

Orit Uziel

submission deadline 30 Oct 2025 | 11 articles | Viewed by 24273 | Submission Open

Keywords: exosomes; extravesicles; intracellular communication

(This special issue belongs to the Section Molecular Biology)

Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies

edited by

Masaru Tanaka

submission deadline 30 Oct 2025 | 7 articles | Viewed by 21198 | Submission Open

Keywords: molecular psychiatry; biomarkers; pharmacogenomics; precision medicine; gene-environment Interaction; neuroinflammation; immune modulation; neuroimaging; molecular imaging; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research of Gastrointestinal Disease 2.0

edited by

Kulmira Nurgali

and

Ainsley Robinson

submission deadline 30 Oct 2025 | 6 articles | Viewed by 12769 | Submission Open

Keywords: gastrointestinal health; gastrointestinal disorders; gastrointestinal disease; gastrointestinal homeostasis; molecular targets; mechanisms; pathways; molecular markers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Obesity and Metabolic Diseases

edited by

Liliya Mihaylova

submission deadline 30 Oct 2025 | 7 articles | Viewed by 11672 | Submission Open

Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; non-alcoholic fatty liver disease (NAFLD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 6th Edition

edited by

Ida Daniela Perrotta

submission deadline 30 Oct 2025 | 5 articles | Viewed by 11523 | Submission Open

Keywords: atherosclerosis; vascular smooth muscle cell; inflammation; endothelium; cell senescence; apoptosis; lipid metabolism; oxidative stress; nitric oxide; exosomes; vascular calcification; cytokines; growth factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Evolution, Genetics and Pathogenesis of Viruses

edited by

Marta Szabat

submission deadline 30 Oct 2025 | 7 articles | Viewed by 10637 | Submission Open

Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents

(This special issue belongs to the Section Molecular Microbiology)

New Advances in Research on Alzheimer’s Disease: 2nd Edition

edited by

Stella Gagliardi

and

Carlo Morasso

submission deadline 30 Oct 2025 | 5 articles | Viewed by 10425 | Submission Open

Keywords: therapy; prevention; new molecules; Alzheimer’ s disease; genetics; nanoformulation; targets; dementia; biomarker discovery

(This special issue belongs to the Section Molecular Neurobiology)

New Molecular Advances in Lung Cancer

edited by

Alessandra Bearz

submission deadline 30 Oct 2025 | 3 articles | Viewed by 10095 | Submission Open

Keywords: lung cancer; oncogene; tyrosine kinase inhibitors

(This special issue belongs to the Section Molecular Oncology)

Emerging Topics in Metal Complexes: Pharmacological Activity, 2nd Edition

edited by

Agnieszka Scibior

Juan Llopis

and

Manuel Aureliano

submission deadline 30 Oct 2025 | 4 articles | Viewed by 8977 | Submission Open

Keywords: metal complexes; polyoxometalates; biological activity; pharmacokinetic parameters; mechanistic analysis; cancer/neurodegenerative diseases; innovative strategies; laboratory diagnostics; clinical studies

(This special issue belongs to the Section Molecular Pharmacology)

Research in Membrane Transporters—Unveiling the Molecular Mechanisms and Practical Application

edited by

Ewa Maciaszczyk-Dziubinska

and Donata Wawrzycka

submission deadline 30 Oct 2025 | 4 articles | Viewed by 7601 | Submission Open

Keywords: membrane transporters; transporter function; transporter regulation; transporter-mediated drug transport; transport-related diseases; biomolecular studies; pharmacokinetics; membrane proteostasis

(This special issue belongs to the Section Molecular Biology)

Cytochrome P450: Metabolism, Structure-Function, Evolution and Applications

edited by

Khajamohiddin Syed

and

David Lamb

submission deadline 30 Oct 2025 | 4 articles | Viewed by 6868 | Submission Open

Keywords: cytochrome P450 monooxygenase; metabolism; structure-function; evolution; applications

(This special issue belongs to the Section Biochemistry)

Adaptations of Plant Metabolism and Their Consequences on Nutritive Potential and Bioactivity, 2nd Edition

edited by

Ivana Sola

submission deadline 30 Oct 2025 | 2 articles | Viewed by 6587 | Submission Open

Keywords: plant primary metabolism; plant specialized metabolism; phytochemistry; plant bioactive components; plant metabolic plasticity; plant nutritional value; bioactivity of plant extracts; plant– stress response; abiotic stress; climate change; global warming; environmental pressure; biotic stress; anthropogenic influence on plant metabolites; predictive models

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Studies in Drug Design and Discovery

edited by

Elena Cichero

submission deadline 30 Oct 2025 | 3 articles | Viewed by 5880 | Submission Open

Keywords: molecular docking; homology modeling; repositioning; virtual screening; QSAR; molecular dynamics; ADME prediction

(This special issue belongs to the Section Molecular Informatics)

Design, Synthesis and Applications of Dendrimer Materials

edited by Valérie Maraval and

Anne-Marie Caminade

submission deadline 30 Oct 2025 | 4 articles | Viewed by 5855 | Submission Open

Keywords: dendrimers; dendrons; hyperbranched molecules; dendrimers in catalysis; fluorescent dendrimers; biological properties of dendrimers; dendrimers in materials sciences; encapsulation in dendrimers; nanomedicine with dendrimers

(This special issue belongs to the Section Materials Science)

Gaucher Disease: From Molecular Mechanisms to Treatments

edited by

Ari Zimran

Shoshana Revel-Vilk

and

Jeff Szer

submission deadline 30 Oct 2025 | 4 articles | Viewed by 5452 | Submission Open

Keywords: Gaucher disease; lysosomal storage disorder (LSD); genetic disorders; animal models; gene therapy approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Thrombosis: 3rd Edition

edited by

Isabella Russo

submission deadline 30 Oct 2025 | 5 articles | Viewed by 5240 | Submission Open

Keywords: thrombosis; platelets; coagulation; diabetes; obesity; insulin resistance; metabolic disease; cardiovascular diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Blood Disorders

edited by

Tadej Pajič

submission deadline 30 Oct 2025 | 4 articles | Viewed by 5179 | Submission Open

Keywords: acquired and inherited blood disorders; diagnostic; prognostic and predictive biomarkers; molecular profiling; molecular monitoring; targeted therapy; leukaemia; lymphoma; disorders of haemostasis and thrombosis; genetic predisposition; germline pathogenic variants; molecular mechanisms; (epi)genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances and Perspectives in Rheumatic Diseases

edited by

Luciana Breda

submission deadline 30 Oct 2025 | 3 articles | Viewed by 4973 | Submission Open

Keywords: rheumatic diseases; molecular biology; inflammatory pathways; cytokines; molecular diagnostics; biologics; drug development; genetic factors; epigenetics; environmental influences

(This special issue belongs to the Section Molecular Immunology)

Adsorption Mechanism of Novel Porous Materials in Wastewater Treatment, 2nd Edition

edited by

Anna Deryło-Marczewska

submission deadline 30 Oct 2025 | 5 articles | Viewed by 4704 | Submission Open

Keywords: porous materials; nanominerals; adsorption mechanism; metal– organic framework materials; heavy metals; organic contaminants; pharmaceuticals; molecular simulation; morphology

(This special issue belongs to the Section Materials Science)

Molecular and Cellular Mechanisms of Retinal Diseases

edited by

Maria Consiglia Trotta

submission deadline 30 Oct 2025 | 4 articles | Viewed by 4449 | Submission Open

Keywords: retinopathies; diabetic retinopathy; inflammation; pro-resolving mediators; fibrosis; epithelial– mesenchymal transition; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Materials: State-of-the-Art Research and Development Prospects

edited by

Alina Maria Holban

submission deadline 30 Oct 2025 | 3 articles | Viewed by 4002 | Submission Open

Keywords: nanobiomaterials; antibacterial materials; anticancer nanomaterials; wound dressings; coatings for bioactive implants; molecular imaging; nanosensors

(This special issue belongs to the Section Materials Science)

Plant Development and Abiotic Stress Response Regulation via Alternative Splicing

edited by

Yong-Hwan Moon

submission deadline 30 Oct 2025 | 3 articles | Viewed by 3954 | Submission Open

Keywords: plants; development; abiotic stress responses; alternative splicing; transcriptional regulation; signaling; splicing factors

(This special issue belongs to the Section Molecular Plant Sciences)

Cutting-Edge Research on Nanosensors and Microsensors

edited by

Beata Paczosa-Bator

submission deadline 30 Oct 2025 | 2 articles | Viewed by 3667 | Submission Open

Keywords: nanosensors and microsensors; innovations; nanomaterials; nanotechnology; biomedical devices; point-of-care and point-of-use testing; environmental control

(This special issue belongs to the Section Materials Science)

Repetitive DNA

edited by

Eva Šatović-Vukšić

Miroslav Plohl

and

Manuel A. Garrido-Ramos

submission deadline 30 Oct 2025 | 4 articles | Viewed by 3570 | Submission Open

Keywords: repetitive DNA sequences; satellite DNA; transposable elements; heterochromatin; centromere; satellitome; repeatome; cytogenetics; phylogenetics; transcription; ChIP; bioinformatics; genome biology; genome evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Advances in Gut Microbiota in Human Diseases and Health

edited by

Avinash Karpe

submission deadline 30 Oct 2025 | 2 articles | Viewed by 3164 | Submission Open

Keywords: antimicrobial and multidrug resistance (AMR; MDR); gut microbiome; systems biology; novel technologies; principles and mechanism of action; food and nutrition; food as Medicine

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 1351-1400 on page 28 of 68.

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