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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders

edited by Marta Pardo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 29986 | Submission Open

Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets

(This special issue belongs to the Section Molecular Neurobiology)

Natural-Derived Bioactive Compounds in Disease Treatment

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Jan 2026 | 7 articles | Viewed by 29142 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Molecular Pharmacology)

Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Jan 2026 | 5 articles | Viewed by 22746 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood– brain barrier; blood– cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Jan 2026 | 8 articles | Viewed by 21982 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition

edited by

Catherine Davis

submission deadline 20 Jan 2026 | 7 articles | Viewed by 20486 | Submission Open

Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Immunology)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment

edited by

Ilaria Mormile

submission deadline 20 Jan 2026 | 8 articles | Viewed by 20394 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation; molecular pathway; biomarkers; target therapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms for Skin Protection and Aging

edited by Wonchul Lim and

Tae-Gyu Lim

submission deadline 20 Jan 2026 | 4 articles | Viewed by 20149 | Submission Open

Keywords: skin photo-aging; skin inflammation; molecular biology; inner beauty; natural product; skin microbiome; skin wrinkle formation; skin dehydration; skin pigmentation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

A Molecular Perspective on the Genetics of Kidney Diseases

edited by Joaquim Calado

submission deadline 20 Jan 2026 | 6 articles | Viewed by 18186 | Submission Open

Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Mechanisms and Therapeutics in Neurological Diseases—4th Edition

edited by

Barbara Mroczko

submission deadline 20 Jan 2026 | 8 articles | Viewed by 17583 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Flow Cytometry: Applications and Challenges

edited by

Alessandra Falda

submission deadline 20 Jan 2026 | 7 articles | Viewed by 17311 | Submission Open

Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)

edited by

Jan Tesarik

submission deadline 20 Jan 2026 | 5 articles | Viewed by 17220 | Submission Open

Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility

(This special issue belongs to the Section Molecular Biology)

Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition

edited by

Bernhard Biersack

submission deadline 20 Jan 2026 | 8 articles | Viewed by 16889 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Research on Neurotransmitters

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 20 Jan 2026 | 6 articles | Viewed by 16811 | Submission Open

Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Genomic Research of Rare Diseases

edited by Shira Rockowitz and Piotr Sliz

submission deadline 20 Jan 2026 | 7 articles | Viewed by 16332 | Submission Open

Keywords: rare disease ontology; variants of uncertain significance; candidate genes; whole genome sequencing; long read whole genome sequencing; machine learning; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies

edited by

Renata Stawerska

submission deadline 20 Jan 2026 | 8 articles | Viewed by 15980 | Submission Open

Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers

edited by

Susana Coimbra

Flávio Reis

and

Alice Santos-Silva

submission deadline 20 Jan 2026 | 6 articles | Viewed by 15841 | Submission Open

Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in the Prevention of Chronic Diseases

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 20 Jan 2026 | 6 articles | Viewed by 15518 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection

edited by

Vito D’Agnano

submission deadline 20 Jan 2026 | 9 articles | Viewed by 15425 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunology; pathophysiology; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insight into Epigenomic Studies of Human Disease

edited by

Mitsuko Masutani

and Takashi Ito

submission deadline 20 Jan 2026 | 7 articles | Viewed by 15018 | Submission Open

Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)

edited by

Manuela Dicarlo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 14467 | Submission Open

Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety

(This special issue belongs to the Section Molecular Neurobiology)

Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition

edited by

Balik Dzhambazov

submission deadline 20 Jan 2026 | 7 articles | Viewed by 14218 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into the Treatment of Metabolic Syndrome and Diabetes

edited by

Igor Kovalchuk

submission deadline 20 Jan 2026 | 5 articles | Viewed by 13955 | Submission Open

Keywords: metabolic dysfunction; metabolic disorder; diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: Cardiovascular Diseases

edited by

Melania Gaggini

and

Cristina Vassalle

submission deadline 20 Jan 2026 | 5 articles | Viewed by 13306 | Submission Open

Keywords: cardiovascular disease; metabolism; cardiometabolic risk; coronary artery disease; CVD

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Zoology

edited by

Valeria Maselli

submission deadline 20 Jan 2026 | 9 articles | Viewed by 13140 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog

(This special issue belongs to the Section Molecular Biology)

The Structures and Biologic Activity of Marine Natural Products

edited by

Alexanra S. Silchenko

and

Vladimir Kalinin

submission deadline 20 Jan 2026 | 4 articles | Viewed by 12951 | Submission Open

Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis

edited by

Hidemasa Bono

submission deadline 20 Jan 2026 | 4 articles | Viewed by 12706 | Submission Open

Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases

(This special issue belongs to the Section Molecular Informatics)

Molecular Progression of Genetics in Breeding of Farm Animals

edited by

Karel Novák

submission deadline 20 Jan 2026 | 6 articles | Viewed by 12038 | Submission Open

Keywords: farm animal; livestock; genome sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Neurologic and Neurodegenerative Disorders

edited by

Ioana-Miruna Balmus

and

Ioannis Mavroudis

submission deadline 20 Jan 2026 | 4 articles | Viewed by 11591 | Submission Open

Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Bacterial Infection

edited by

María Soledad Ramírez

submission deadline 20 Jan 2026 | 5 articles | Viewed by 11487 | Submission Open

Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | 3 articles | Viewed by 11363 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Forensic Pathology and Toxicology: An Update

edited by

Angelo Montana

submission deadline 20 Jan 2026 | 5 articles | Viewed by 11303 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

New Advances in the Treatment and Diagnosis of Neuromuscular Diseases

edited by Silvia Consalvi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 11046 | Submission Open

Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10934 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10916 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 20 Jan 2026 | 5 articles | Viewed by 10580 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Human Health and Disease

edited by

Kazuhiko Nakadate

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10486 | Submission Open

Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition

edited by

Hsinjung Ho

submission deadline 20 Jan 2026 | 5 articles | Viewed by 10433 | Submission Open

Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic

(This special issue belongs to the Section Biochemistry)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by

Miguel Hueso

and

Alfredo Vellido

submission deadline 20 Jan 2026 | 1 articles | Viewed by 10345 | Submission Open

Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning

(This special issue belongs to the Section Molecular Informatics)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10324 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches

edited by

László Vécsei

and

Masaru Tanaka

submission deadline 20 Jan 2026 | 6 articles | Viewed by 9886 | Submission Open

Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)

(This special issue belongs to the Section Molecular Neurobiology)

Respiratory Virus Infection

edited by Nikolaos Siafakas

submission deadline 20 Jan 2026 | 6 articles | Viewed by 9801 | Submission Open

Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus

(This special issue belongs to the Section Molecular Microbiology)

Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition

edited by

Paramjit S. Tappia

and

Bram Ramjiawan

submission deadline 20 Jan 2026 | 6 articles | Viewed by 9062 | Submission Open

Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein and Protein Interactions

edited by Wu Xu

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8747 | Submission Open

Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics

(This special issue belongs to the Section Molecular Biology)

Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms

edited by

Mariusz Cycoń

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8696 | Submission Open

Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils

(This special issue belongs to the Section Molecular Microbiology)

Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies

edited by

Maria Teresa Sciortino

submission deadline 20 Jan 2026 | 2 articles | Viewed by 8643 | Submission Open

Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions

(This special issue belongs to the Section Molecular Immunology)

Molecular Research in Bone and Soft Tissue Tumors

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8581 | Submission Open

Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition

edited by

Martin Bartas

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8329 | Submission Open

Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Electrochemical-Related Materials

edited by Celia García-Hernandez

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8215 | Submission Open

Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications

(This special issue belongs to the Section Materials Science)

Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition

edited by

Andrea Paola Rojas Gil

submission deadline 20 Jan 2026 | 1 articles | Viewed by 8123 | Submission Open

Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7922 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 501-550 on page 11 of 68.

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