Dialogue Between Inflammation and Immunity: From Mechanism to Therapy

Dear Colleagues,

The dynamic dialogue between inflammation and the immune system is essential for health and disease management. Inflammation is vital for pathogen clearance and tissue repair but can also contribute to chronic disease when dysregulated. The immune system orchestrates inflammation as a defensive mechanism to combat infections and tissue injury. The interplay between immune cells, cytokines, and signaling pathways governs the balance between protective and pathological inflammation.

Chronic inflammation underlies many autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and multiple sclerosis (MS). Dysregulated cytokine production, loss of immune tolerance, and persistent activation of autoreactive lymphocytes drive tissue damage in these conditions. Inflammation is a key component of the tumor microenvironment, influencing cancer initiation, progression, and metastasis. Pro-inflammatory cytokines such as IL-6 and TNF-α promote tumor growth, angiogenesis, and immune evasion. In contrast, immune checkpoint pathways (e.g., PD-1/PD-L1) facilitate tumor-induced immunosuppression. The metabolic disorders and cardiovascular diseases are also supported by chronic inflammation.

A deeper understanding of the intricate mechanisms underlying the interplay between inflammation and immunity is vital for developing innovative treatments, paving the way for personalized and effective therapies in immune-related diseases.

This Special Issue will offer a collection of cutting-edge research articles or reviews that explore molecular crosstalk between inflammation and immunity, elucidate the mechanisms underlying their regulation, and discuss emerging therapeutic strategies aimed at modulating these interactions for clinical benefit.

Dr. Nikolina Mihaylova
Guest Editor

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