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Special Issue "Pasteurella multocida and Its Virulence Factors"
Deadline for manuscript submissions: closed (30 June 2017).
Tel. +49-6221-5638361; Fax: +49-6221-5633749
Interests: mechanisms of bacterial immune evasion; the function of Rho GTPases; cytokine receptors in the innate immune system
Special Issues and Collections in MDPI journals
Bacterial toxins can be classified into endotoxins and exotoxins. While the endotoxin lipopolysaccharide is an integral part of the cell wall of all gram-negative bacteria, exotoxins are proteins that possess a catalytic activity towards their respective target cell. Pasteurella multocida can infect a broad range of animals causing various diseases with specific syndromes. While atrophic rhinitis of pigs is connected specifically to toxigenic Pasteurella multocida strains that express the exotoxin PMT (Pasteurella multocida toxin), the pathogenic mechanisms for other diseases are less well understood, although LPS is required for pathogenesis. The host’s immune system recognizes LPS through the pattern recognition receptor toll like receptor (TLR) 4. Other emerging virulence factors that can be detected by the endotoxin receptor TLR4 are proteins, such as outer membrane proteins (Omp), fimbriae or porins. These factors are discussed as potential candidates to generate efficient vaccines.
This Special Issue aims to summarize what is known about the interaction of Pasteurella multocida endotoxins and its exotoxin with cells of the immune system. We welcome articles (research or review) that center on the effects of LPS, PMT, or other emerging virulence factors and the generation of vaccines, respectively.
Dr. Katharina Hieke-Kubatzky
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Pasteurella multocida
- pathogenicity factor
- Pasteurella multocida toxin
- atrophic rhinitis