Differential Regulation of Type I and Type III Interferon Signaling
1
Schaller Research Group at CellNetworks, Department of Infectious Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany
2
Research Group “Cellular Polarity and Viral Infection” (F140), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(6), 1445; https://doi.org/10.3390/ijms20061445
Received: 21 February 2019
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Revised: 15 March 2019
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Accepted: 18 March 2019
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Published: 21 March 2019
(This article belongs to the Special Issue Signaling: From Past to Future)
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III. While type II IFN is specific for immune cells, type I and III IFNs are expressed by both immune and tissue specific cells. Unlike type I IFNs, type III IFNs have a unique tropism where their signaling and functions are mostly restricted to epithelial cells. As such, this class of IFN has recently emerged as a key player in mucosal immunity. Since the discovery of type III IFNs, the last 15 years of research in the IFN field has focused on understanding whether the induction, the signaling and the function of these powerful cytokines are regulated differently compared to type I IFN-mediated immune response. This review will cover the current state of the knowledge of the similarities and differences in the signaling pathways emanating from type I and type III IFN stimulation.
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Keywords:
Interferon; type I IFN; type III IFN; interferon signaling; JAK-STAT; signal transduction
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MDPI and ACS Style
Stanifer, M.L.; Pervolaraki, K.; Boulant, S. Differential Regulation of Type I and Type III Interferon Signaling. Int. J. Mol. Sci. 2019, 20, 1445. https://doi.org/10.3390/ijms20061445
AMA Style
Stanifer ML, Pervolaraki K, Boulant S. Differential Regulation of Type I and Type III Interferon Signaling. International Journal of Molecular Sciences. 2019; 20(6):1445. https://doi.org/10.3390/ijms20061445
Chicago/Turabian StyleStanifer, Megan L., Kalliopi Pervolaraki, and Steeve Boulant. 2019. "Differential Regulation of Type I and Type III Interferon Signaling" International Journal of Molecular Sciences 20, no. 6: 1445. https://doi.org/10.3390/ijms20061445
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