Molecular Research in Hematologic Malignancies

Dear Colleagues,

The molecular regulation of hematopoietic stem cells (HSCs), including their proliferation, self-renewal, and differentiation, plays a central role in the development and progression of hematologic malignancies. A thorough understanding of these regulatory mechanisms, alongside the identification of novel pathways and biomarkers such as mutations, differentially methylated regions, and non-coding RNAs, is crucial for enhancing diagnostic precision, prognostic assessment, and the development of targeted therapies.

The field of molecular diagnostics and therapeutics in hematopoietic malignancies is currently at a pivotal juncture. Despite significant progress, the molecular determinants that predispose specific healthy cell populations to oncogenic reprogramming and the acquisition of aberrant self-renewal capacity remain insufficiently characterized.

This Special Issue aims to highlight recent advances in the molecular regulation of normal hematopoiesis and the mechanisms that promote leukemogenesis. It also seeks to address existing gaps in the knowledge and propose future directions for innovative diagnostic and therapeutic approaches. We welcome the submission of original research articles and comprehensive reviews on the following topics:

• Molecular mechanisms regulating hematopoiesis;
• Drivers of malignant transformation;
• Non-invasive diagnostic and prognostic strategies and innovations;
• Emerging targeted therapies in hematologic malignancies.

Dr. Rachid Lahlil
Dr. Anne Aries
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.