Molecular Advances Related to Bone Regeneration

Dear Colleagues,

Bone is a dynamic tissue and the molecular mechanisms underlying its remodeling and regeneration are numerous. In orthopedic and maxillofacial surgery, bone tissue regeneration remains a major challenge. Bone defects can be caused by several adverse events (trauma, cancer, infections, congenital diseases or abnormal skeletal development). Several factors involved in bone regeneration process are able to regulate signaling cascades modifying cellular responses such as differentiation and proliferation. Particular interest is focused on the characteristics of bone extracellular matrix and the pathways related to its synthesis.

Nevertheless, there are still many aspects and new pathways to be clarified that could open new perspectives to new therapies aimed at regulating and stimulating bone regeneration.

Moreover, bone regeneration has to be considered part of regenerative medicine, with studies of new biomaterials and effects of physical stimuli such as electomagnetic waves and gravity on cell biology opening new therapeutic perspectives.

Dr. Gianluigi Pasta
Dr. Virginie Sottile
Guest Editors

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