Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Special Issue "Paracrine Effects of Human Stem/Progenitor Cells—From Bench to Bedside"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2019).
Various human stem/progenitor cell (SPC) populations have been employed in different experimental models as well as clinical trials aimed at regeneration of damaged tissues, including central nervous system, heart, liver, etc. Despite the potential structural replacement of the impaired cells in some cases, basic and clinical research investigations broadly indicate that SPCs exert a regenerative effect on damaged tissues by paracrine mechanisms. Essentially, a variety of soluble proteins, involving cytokines, chemokines, growth factors, immunologic factors, as well as bioactive lipids, microRNA, and mRNA are released by SPCs and influence the cell–cells crosstalk and the tissue microenvironment. Therefore, these humoral factors play a crucial role in inflammation, angiogenesis, vascular function, and other processes that affect the course of organ self-regeneration. Interestingly, analogous therapeutic effects are sometimes observed after applying different SPC populations, as a consequence of similar paracrine interactions.
We therefore invite investigators to contribute original research as well as review articles that focus on efforts to understand and elucidate different aspects of paracrine mechanisms accompanying human SPCs circulation or adjuvant therapies.
Prof. Dr. Bogusław Machaliński
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- stem cell-based adjuvant therapy
- trophic effects
- tissue regeneration
- neuroprotective factors
- angiogenesis modulating agents