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Pathophysiology of Pituitary Tumors and the Role of Pituitary Hormones in Cancer

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 6563

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Special Issue Editors

Dr. Tatiana Fiordelisio Coll

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Guest Editor

Facultad de Ciencias, Universidad Nacional Autónoma de México, Coyoacán, Mexico
Interests: polycistic ovary syndrome; reproductive diabetic dysfunction; diabetic retinopathy; thyroid conditions; adenoma; euroendocrine system

Dr. María Inés Pérez-Millán

E-Mail Website1 Website2
Guest Editor

Institute of Biomedical Investgations (UBA-CONICET), University of Buenos Aires, Buenos Aires, Argentina
Interests: genetics; stem cells; pituitary development

Special Issue Information

Dear Colleagues,

Pituitary adenomas are among the most frequent intracranial tumors. These adenomas variably and adversely affect morbidity and mortality depending on cell type, hormone secretory activity, and growth behavior. For most clinically apparent adenomas, multimodal therapy controlling hormone secretion and adenoma growth leads to improved quality of life and normalized mortality. However, the pathogenesis of pituitary adenomas is largely unknown and evidence indicates that the pituitary tumorigenesis is a complex process involving multiple factors, including genetic and epigenetic changes.

In recent years, evidence of the incidence of pituitary hormones in different types of cancers started to emerge. However, it is controversial if they protect tumor development or the opposite, have an oncogenic effect. More studies are needed to conclude their role in cancer.

This article collection welcomes studies with a focus on the Pathophysiology of Pituitary Tumor and the role of pituitary hormones in cancer, using animal models, and human and in vitro systems.

Dr. Tatiana Fiordelisio Coll
Dr. María Inés Pérez-Millán
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

pituitary
tumors
cancer
hormones

Published Papers (3 papers)

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Research

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16 pages, 11163 KiB

Open AccessArticle

Association between Intracellular Calcium Signaling and Tumor Recurrence in Human Non-Functioning Pituitary Adenomas

by Yorgui Santiago-Andres, Ana Aquiles, Keiko Taniguchi-Ponciano, Latife Salame, Gerardo Guinto, Moises Mercado and Tatiana Fiordelisio

Int. J. Mol. Sci. 2024, 25(7), 3968; https://doi.org/10.3390/ijms25073968 - 3 Apr 2024

Viewed by 2932

Abstract

Clinically non-functioning pituitary adenomas (CNFPAs) are the second most frequent sellar tumor among studies on community-dwelling adults. They are characterized by the absence of hormonal hypersecretion syndrome, and patients present with compressive symptoms, such as a headache and visual field defects. Immunohistochemically, most CNFPAs are of gonadotrope differentiation, with only a few of them being truly null cell adenomas. Although these tumors express receptors for one or more hypothalamic releasing hormones, to what extent this has an impact on the biological and clinical behavior of these neoplasms remains to be defined. In this research, we evaluated the basal and hypothalamic secretagogue-stimulated intracellular calcium mobilization in 13 CNFPAs, trying to correlate this response to the phenotypic features of the patients. Our results indicate that the recurrence of a CNFPA correlates positively with cellular responsiveness, as measured by spontaneous intracellular calcium activity and the ability to respond to multiple hypothalamic secretagogues. We conclude that this finding may be a useful tool for predicting the clinicopathologic behavior of CNFPAs, by testing the variation of cellular responsiveness to hypothalamic secretagogues. Full article

(This article belongs to the Special Issue Pathophysiology of Pituitary Tumors and the Role of Pituitary Hormones in Cancer)

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7 pages, 289 KiB

Open AccessArticle

A Common Variant in the CDK8 Gene Is Associated with Sporadic Pituitary Adenomas in the Portuguese Population: A Case-Control Study

by Leonor M. Gaspar, Catarina I. Gonçalves, Fernando Fonseca, Davide Carvalho, Luísa Cortez, Ana Palha, Inês F. Barros, Ema Nobre, João S. Duarte, Cláudia Amaral, Maria J. Bugalho, Olinda Marques, Bernardo D. Pereira and Manuel C. Lemos

Int. J. Mol. Sci. 2022, 23(19), 11749; https://doi.org/10.3390/ijms231911749 - 4 Oct 2022

Viewed by 1631

Abstract

The majority of pituitary adenomas occur in a sporadic context, and in the absence of known genetic predisposition. Three common variants at the NEBL (rs2359536), PCDH15 (rs10763170) and CDK8 (rs17083838) loci were previously associated with sporadic pituitary adenomas in the Han Chinese population, but these findings have not yet been replicated in any other population. The aim of this case-control study was to assess if these variants are associated with susceptibility to sporadic pituitary adenomas in the Portuguese population. Genotype and allele frequencies were determined in 570 cases and in 546 controls. The CDK8 rs17083838 minor allele (A allele) was significantly associated with sporadic pituitary adenomas, under an additive (odds ratio (OR) 1.73, 95% confidence interval (CI) 1.19–2.50, p = 0.004) and dominant (OR 1.82, 95% CI 1.24–2.68, p = 0.002) inheritance model. The NEBL rs2359536 and PCDH15 rs10763170 variants were not associated with the overall risk for the disease, although a borderline significant association was observed between the PCDH15 rs10763170 minor allele (T allele) and somatotrophinomas (dominant model, OR 1.55, 95% CI 1.02–2.35, p = 0.035). These findings suggest that the CDK8 rs17083838 variant, and possibly the PCDH15 rs10763170 variant, may increase susceptibility to sporadic pituitary adenomas in the Portuguese population. Full article

(This article belongs to the Special Issue Pathophysiology of Pituitary Tumors and the Role of Pituitary Hormones in Cancer)

Review

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36 pages, 3296 KiB

Open AccessReview

Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways

by Simona Serioli, Ludovico Agostini, Alberto Pietrantoni, Federico Valeri, Flavia Costanza, Sabrina Chiloiro, Barbara Buffoli, Amedeo Piazza, Pietro Luigi Poliani, Maria Peris-Celda, Federica Iavarone, Simona Gaudino, Marco Gessi, Giovanni Schinzari, Pier Paolo Mattogno, Antonella Giampietro, Laura De Marinis, Alfredo Pontecorvi, Marco Maria Fontanella, Liverana Lauretti, Guido Rindi, Alessandro Olivi, Antonio Bianchi and Francesco Doglietto Show full author list Hide full author list

Int. J. Mol. Sci. 2023, 24(21), 15719; https://doi.org/10.3390/ijms242115719 - 29 Oct 2023

Cited by 1 | Viewed by 1303

Abstract

Recently, advances in molecular biology and bioinformatics have allowed a more thorough understanding of tumorigenesis in aggressive PitNETs (pituitary neuroendocrine tumors) through the identification of specific essential genes, crucial molecular pathways, regulators, and effects of the tumoral microenvironment. Target therapies have been developed to cure oncology patients refractory to traditional treatments, introducing the concept of precision medicine. Preliminary data on PitNETs are derived from preclinical studies conducted on cell cultures, animal models, and a few case reports or small case series. This study comprehensively reviews the principal pathways involved in aggressive PitNETs, describing the potential target therapies. A search was conducted on Pubmed, Scopus, and Web of Science for English papers published between 1 January 2004, and 15 June 2023. 254 were selected, and the topics related to aggressive PitNETs were recorded and discussed in detail: epigenetic aspects, membrane proteins and receptors, metalloprotease, molecular pathways, PPRK, and the immune microenvironment. A comprehensive comprehension of the molecular mechanisms linked to PitNETs’ aggressiveness and invasiveness is crucial. Despite promising preliminary findings, additional research and clinical trials are necessary to confirm the indications and effectiveness of target therapies for PitNETs. Full article

(This article belongs to the Special Issue Pathophysiology of Pituitary Tumors and the Role of Pituitary Hormones in Cancer)

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