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Special Issue "Non-Coding RNA Biogenesis and Function"
Deadline for manuscript submissions: 31 January 2020.
In the last few decades, we have witnessed an extraordinary progress in the knowledge of how the noncoding part of the eukaryotic genome determines the organism’s complexity. In particular, higher eukaryote genomes produce different classes of regulatory noncoding RNAs (ncRNA), with examples including short RNA molecules of 22–35 nucleotides (nts), such as microRNAs and PIWI-interacting RNAs (piRNAs), as well as transcripts such as the long noncoding RNAs (lncRNAs), which are generally referred to as noncoding molecules longer than 200 nts, and the newly emerging class of circular RNAs (circRNAs). All these ncRNAs hold important regulatory roles in a wide range of biological processes, operating at any step throughout the genetic expression process from transcription to RNA maturation and translation. However, the regulatory functions of many ncRNAs are not yet known, and this provides a rich environment for the development of new bioinformatics tools and experimental approaches for functional studies.
More importantly, deregulation of ncRNAs has been associated with a variety of different diseases, and emerging studies suggest that they represent a new potential class of diagnostic and prognostic biomarkers.
The present Special Issue is aimed at collecting latest advances and outstanding researches investigating biogenesis and function of different classes of ncRNAs and their possible involvement in disease pathogenesis. Original research and review manuscripts are welcome.
Dr. Mariangela Morlando
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Long noncoding RNAs (lncRNAs)
- PIWI-interacting RNAs (piRNAs)
- Circular RNAs (circRNAs)
- RNA maturation and translation
- Deregulation of ncRNAs
- Disease pathogenesis
- Biological processes
- Non-coding RNA biogenesis
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Circular RNA in myeloid malignancies: emerging roles and unanswered questions
Eileen Wedge1, Lasse Sommer Kristiansen2 and Kirsten Grønbæk1
- Department of Hematology, Rigshospitalet, Copenhagen
- Aarhus University
Abstract：The myeloid malignancies include a spectrum of disease from clonal cytopenia of undetermined significance to myelodysplastic syndrome and acute myeloid leukemia, as well as myeloproliferative neoplasms. They represent an ongoing challenge in both biological understanding and clinical treatment, due to high levels of phenotypic and genotypic heterogeneity at both population and intratumoral levels and complex interactions with the bone marrow microenvironment. Mutations in spliceosome components and epigenetic regulators are abundant in CCUS and MDS, and roles have been identified for other types of non-coding RNA in these diseases. Circular RNAs are stable molecules produced by 3’ to 5’ backsplicing, related to complementary flanking sequences or intron skipping events. Numerous circRNA functions have been discovered in recent years, including microRNA sponging and roles in immune signaling pathways. Distinct circRNA expression profiles have been described for the different cell types of normal human hematopoiesis, and several studies have identified circRNAs associated with phenotypes, treatment response or prognosis in AML. This review discusses existing evidence for the significance of circular RNA in myeloid malignancies, as well as exploring promising directions for future investigation.