ncRNAS in Therapeutics

Noncoding RNAs (ncRNA), either short or long, have revealed a regulatory potential that can be used in therapeutics. In this issue of IJMS, we will review current experiences for the treatment of diseases with therapeutic ncRNAs. We will pay special attention to some of the challenges that make the clinical use of therapeutic ncRNAs difficult, including the identification of the most efficient effectors and their stabilization to increase their half-life during treatments, with particular emphasis on their design and the inclusion of chemical modifications that interfere with their degradation. We are particularly interested in the specific targeted-delivery of therapeutic ncRNAs, as well as in the generation of unwanted off-target effects and the different approaches to reduce them. Lastly, we will also explore how ncRNAs could contribute to the development of personalized medicine. Therefore, we invite authors to communicate new research studies, but also reviews will be welcomed, for illuminating future research on this hot topic.

Dr. Miguel Hueso
Dr. Estanislao Navarro
Guest Editors

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