Special Issue "Role for the Enzyme Myeloperoxidase to Elicit Pathologies"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: cardiac ischemia reperfusion; fibrosis; oxidative stress; endogenous antioxidants
The neutrophil-derived heme enzyme myeloperoxidase is an efficient peroxidase that is considered to form part of responses to injury and infection in the acute to early phases. This leukocyte enzyme produces a range of potent oxidants in the presence of both hydrogen peroxide and biological halides or thiocyanate. Myeloperoxidase is gaining increased attention as an important oxidative mediator of range of pathologies, including inflammatory damage to the brain, reperfusion injury to a range of organs, vascular dysfunction, adverse ventricular remodeling, and atrial fibrillation. Thus, interest in this enzyme, its role in host damage, and the resolution of the inflammatory response has increased. Accordingly, the development of potential therapies to limit both neutrophil and myeloperoxidase activity in tissue pathology has gained significant traction in the recent literature. This Special Issue will highlight the role for myeloperoxidase in disease progression, identify important biomarkers to monitor host tissue damage elicited by this peroxidase, and expand on novel strategies to limit enzyme activity and its relationship to disease.
Prof. Dr. Paul K. Witting
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- heme peroxidase
- hypohalous acid
- oxidative damage
- acute host tissue damage