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Special Issue "Molecular Research on Muscle Protein and Myopathies 2.0"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: 20 May 2023 | Viewed by 5573
Special Issue Editors
Interests: congenital myopathy; molecular mechanisms of muscle contraction; muscle proteins; polarized microfluorimetry
Special Issues, Collections and Topics in MDPI journals
Interests: congenital myopathies; mutations of tropomyosin; thin filament regulation; conformational rearrangements of contractile proteins; actin-myosin interaction; myosin ATPase activity; contractile dysfunction; therapeutic approaches
Special Issue Information
Muscle contraction is based on the cyclic interaction between actin and myosin, accompanied by ATP hydrolysis in the active center of the myosin motor domain. As a result of this interaction, the myosin filaments slide relative to the actin filaments, and the muscle sarcomeres shorten. Disruption of the molecular mechanisms of actin–myosin regulation in cardiac and skeletal muscles due to mutations in muscle proteins genes is causative of severe diseases—hereditary myopathies—which have an extremely negative effect on the quality of human life. Understanding the primary causes of muscle weakness and hypotension in cardiac and skeletal muscles in hereditary myopathies is necessary for early diagnosis and prognosis of the disease and for the development of therapeutic approaches to restore muscle contractile function. The purpose of this Special Issue is to summarize new data on the functional consequences of mutant toxic proteins for the sarcomere, to elucidate the relationship between mutations and disease phenotypes, and to identify targets for action in order to correct dysfunctions in various myopathies.
Authors are invited to contribute to this Special Issue, which will publish priority studies clarifying the molecular mechanisms of dysfunctions in cardiac and skeletal myopathies.
Topics include, but are not limited to:
- study of structural and functional consequences of amino acid substitutions and deletions in sarcomeric proteins (actin, myosin, tropomyosin, troponin, nebulin, cofilin) associated with various variants of myopathies;
- identification of impaired protein–protein interactions in the presence of mutations in sarcomeric proteins and analysis of further pathways of contractile dysfunction in cardiac and skeletal myopathies;
- identification of targets for the restoration of normal muscle function;
- search and testing of potential drugs for the treatment of muscle dysfunctions.
Dr. Yurii Borovikov
Dr. Olga Karpicheva
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- congenital skeletal myopathy
- desease-causing mutations
- muscle contraction
- calcium regulation
- cross-bridge cycling and kinetics
- thin filament
- ATPase activity
- actin–myosin interaction
- therapeutic approaches